Reviewed,
UniProtKB/Swiss-Prot P42957 (MTLD_BACSU)
Last modified
January 19, 2010.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mannitol-1-phosphate 5-dehydrogenase EC=1.1.1.17 | ||||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 373 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196 |
| Sequence similarities | Belongs to the mannitol dehydrogenase family. |
| Sequence caution | The sequence BAA07351.1 differs from that shown. Reason: Frameshift at position 346. The sequence BAA09030.1 differs from that shown. Reason: Frameshift at position 346. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 373 | 373 | Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196 | PRO_0000170698 | |||||
Regions | |||||||||
| Nucleotide binding | 3 – 14 | 12 | NAD By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 149 | 1 | V → L in BAA07351. Ref.1 | ||||||
| Sequence conflict | 149 | 1 | V → L in BAA09030. Ref.2 | ||||||
| Sequence conflict | 273 – 302 | 30 | KIIGR…LGEND → NQRSLLKSFHFGRCDPRSEV TSQKTGRKC in BAA07351. Ref.1 | ||||||
| Sequence conflict | 273 – 302 | 30 | KIIGR…LGEND → NQRSLLKSFHFGRCDPRSEV TSQKTGRKC in BAA09030. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs." Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N., Yamane K. Microbiology 141:3241-3245(1995) [PubMed: 8574415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | Yamane K. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes." Yamane K., Kumano M., Kurita K. Microbiology 142:3047-3056(1996) [PubMed: 8969502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [4] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [5] | "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract] Cited for: SEQUENCE REVISION TO 149; 273-302 AND C-TERMINUS. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D38161 Genomic DNA. Translation: BAA07351.1. Frameshift. D50453 Genomic DNA. Translation: BAA09030.1. Frameshift. AL009126 Genomic DNA. Translation: CAB12207.2. |
| PIR | I39888. |
| RefSeq | NP_388281.2. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 939968. |
| GenomeReviews | Gene locus BSU03990 in contig AL009126_GR. |
| KEGG | bsu:BSU03990. |
| NMPDR | fig|224308.1.peg.400. |
Organism-specific databases | |
| SubtiList | BG11216. mtlD. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG568825. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.17. 150. |
Family and domain databases | |
| HAMAP | MF_00196. Mannitol_dehydrog. [Tree] |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view] |
| PRINTS | PR00084. MTLDHDRGNASE. |
| PROSITE | PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTLD_BACSU | ||||||||
| Accession | Primary (citable) accession number: P42957 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |

Clusters with


