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P42950

- GSM1_YEAST

UniProt

P42950 - GSM1_YEAST

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Protein

Glucose starvation modulator protein 1

Gene

GSM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor which regulates nonfermentable carbon utilization (By similarity). Binds specifically to 5'-CGGN8CGG-3' and 5'-CGGN9CGG-3' sequences in the promoter region.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 4829Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: SGD
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. oxidative phosphorylation Source: SGD
  2. regulation of transcription from RNA polymerase II promoter Source: SGD
  3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose starvation modulator protein 1
Gene namesi
Name:GSM1
Ordered Locus Names:YJL103C
ORF Names:J0824
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL103c.
SGDiS000003639. GSM1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Glucose starvation modulator protein 1PRO_0000114998Add
BLAST

Proteomic databases

PaxDbiP42950.

Expressioni

Gene expression databases

GenevestigatoriP42950.

Interactioni

Protein-protein interaction databases

BioGridi33653. 17 interactions.
IntActiP42950. 2 interactions.
STRINGi4932.YJL103C.

Structurei

3D structure databases

ProteinModelPortaliP42950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini466 – 53873PASAdd
BLAST

Sequence similaritiesi

Belongs to the ERT1/acuK family.Curated
Contains 1 PAS (PER-ARNT-SIM) domain.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG48118.
GeneTreeiENSGT00530000068325.
HOGENOMiHOG000141759.
InParanoidiP42950.
OMAiFIMELMY.
OrthoDBiEOG70KGZB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42950-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKKLPSELK QTRKSIQTAC EFCHTKHIQC DVGRPCQNCL KRNIGKFCRD
60 70 80 90 100
KKRKSRKRIE KHGTQPYLNL GKRLVIHDVP SKTVSPSSVH LQRDFLSSDQ
110 120 130 140 150
EKPGKTPAHN TNIQYTYNIN DNFQSAGSIP RITNFNTNNR QTVLENTSNN
160 170 180 190 200
ISASQAVHLM NDPIIPTVRK STLNLKSHFL EQHKAMQQPL ATNCLVATSN
210 220 230 240 250
VPVHSGMDDS NKSDDDVDDE TNIHFDSMWC NDEYMKLKDI VDISTPFLPN
260 270 280 290 300
NSQIFSLQES EYPNPSASTR GNSSLHLTNL LNSTKSVNDQ KDSSIGHSTS
310 320 330 340 350
TFNTYDEVVS RPFISLDMLH LNRGANANTH PSHNAKLESE CDSSSHSDAD
360 370 380 390 400
LEKHDTDFIS PSKFRELVKT PQDLYDNKCL IKPHNYKLAY TKLLTTLRKK
410 420 430 440 450
FLEGAEIDKS ASVKDEHSTQ KHNLRYDLEV IIRSILERYA PIFISLTSNM
460 470 480 490 500
IEEDLLLQEV TLQRALLDLE NMAKLVSCTP MCIWRRSGEI CFVSNEFYSL
510 520 530 540 550
TGFNKNLLLD RTSFIFEYLD HKSVSNYFQI FNELLAFGYN DINKRKKLLM
560 570 580 590 600
LNACSSTSSK ITEGFSFTTD GKAIFTKCNL LLSNGLYLKC ACCWTVKRDS
610
FNIPILVMGQ FLPIFEMD
Length:618
Mass (Da):70,382
Last modified:November 1, 1995 - v1
Checksum:i200F6AEE06582E38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti611 – 6111F → L in AAU09751. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA. Translation: CAA59391.1.
Z49378 Genomic DNA. Translation: CAA89398.1.
AY723834 Genomic DNA. Translation: AAU09751.1.
BK006943 Genomic DNA. Translation: DAA08697.1.
PIRiS53384.
RefSeqiNP_012432.1. NM_001181536.1.

Genome annotation databases

EnsemblFungiiYJL103C; YJL103C; YJL103C.
GeneIDi853341.
KEGGisce:YJL103C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA. Translation: CAA59391.1 .
Z49378 Genomic DNA. Translation: CAA89398.1 .
AY723834 Genomic DNA. Translation: AAU09751.1 .
BK006943 Genomic DNA. Translation: DAA08697.1 .
PIRi S53384.
RefSeqi NP_012432.1. NM_001181536.1.

3D structure databases

ProteinModelPortali P42950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33653. 17 interactions.
IntActi P42950. 2 interactions.
STRINGi 4932.YJL103C.

Proteomic databases

PaxDbi P42950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL103C ; YJL103C ; YJL103C .
GeneIDi 853341.
KEGGi sce:YJL103C.

Organism-specific databases

CYGDi YJL103c.
SGDi S000003639. GSM1.

Phylogenomic databases

eggNOGi NOG48118.
GeneTreei ENSGT00530000068325.
HOGENOMi HOG000141759.
InParanoidi P42950.
OMAi FIMELMY.
OrthoDBi EOG70KGZB.

Enzyme and pathway databases

BioCyci YEAST:G3O-31557-MONOMER.

Miscellaneous databases

NextBioi 973727.

Gene expression databases

Genevestigatori P42950.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)."
    Rasmussen S.W.
    Yeast 11:873-883(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Computationally analyzing the possible biological function of YJL103C--an ORF potentially involved in the regulation of energy process in yeast."
    Deng Y., He T., Wu Y., Vanka P., Yang G., Huang Y., Yao H., Brown S.J.
    Int. J. Mol. Med. 15:123-127(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF FUNCTION.
  6. "Linking DNA-binding proteins to their recognition sequences by using protein microarrays."
    Ho S.-W., Jona G., Chen C.T.L., Johnston M., Snyder M.
    Proc. Natl. Acad. Sci. U.S.A. 103:9940-9945(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  7. "Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification."
    van Bakel H., van Werven F.J., Radonjic M., Brok M.O., van Leenen D., Holstege F.C.P., Timmers H.T.M.
    Nucleic Acids Res. 36:E21-E21(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.

Entry informationi

Entry nameiGSM1_YEAST
AccessioniPrimary (citable) accession number: P42950
Secondary accession number(s): D6VW81, Q66R68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3