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P42950

- GSM1_YEAST

UniProt

P42950 - GSM1_YEAST

Protein

Glucose starvation modulator protein 1

Gene

GSM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Transcription factor which regulates nonfermentable carbon utilization By similarity. Binds specifically to 5'-CGGN8CGG-3' and 5'-CGGN9CGG-3' sequences in the promoter region.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi20 – 4829Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: SGD
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. oxidative phosphorylation Source: SGD
    2. regulation of transcription from RNA polymerase II promoter Source: SGD
    3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Sporulation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31557-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose starvation modulator protein 1
    Gene namesi
    Name:GSM1
    Ordered Locus Names:YJL103C
    ORF Names:J0824
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL103c.
    SGDiS000003639. GSM1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Glucose starvation modulator protein 1PRO_0000114998Add
    BLAST

    Proteomic databases

    PaxDbiP42950.

    Expressioni

    Gene expression databases

    GenevestigatoriP42950.

    Interactioni

    Protein-protein interaction databases

    BioGridi33653. 17 interactions.
    IntActiP42950. 2 interactions.
    STRINGi4932.YJL103C.

    Structurei

    3D structure databases

    ProteinModelPortaliP42950.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini466 – 53873PASAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ERT1/acuK family.Curated
    Contains 1 PAS (PER-ARNT-SIM) domain.Curated
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG48118.
    GeneTreeiENSGT00530000068325.
    HOGENOMiHOG000141759.
    OMAiFIMELMY.
    OrthoDBiEOG70KGZB.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKLPSELK QTRKSIQTAC EFCHTKHIQC DVGRPCQNCL KRNIGKFCRD    50
    KKRKSRKRIE KHGTQPYLNL GKRLVIHDVP SKTVSPSSVH LQRDFLSSDQ 100
    EKPGKTPAHN TNIQYTYNIN DNFQSAGSIP RITNFNTNNR QTVLENTSNN 150
    ISASQAVHLM NDPIIPTVRK STLNLKSHFL EQHKAMQQPL ATNCLVATSN 200
    VPVHSGMDDS NKSDDDVDDE TNIHFDSMWC NDEYMKLKDI VDISTPFLPN 250
    NSQIFSLQES EYPNPSASTR GNSSLHLTNL LNSTKSVNDQ KDSSIGHSTS 300
    TFNTYDEVVS RPFISLDMLH LNRGANANTH PSHNAKLESE CDSSSHSDAD 350
    LEKHDTDFIS PSKFRELVKT PQDLYDNKCL IKPHNYKLAY TKLLTTLRKK 400
    FLEGAEIDKS ASVKDEHSTQ KHNLRYDLEV IIRSILERYA PIFISLTSNM 450
    IEEDLLLQEV TLQRALLDLE NMAKLVSCTP MCIWRRSGEI CFVSNEFYSL 500
    TGFNKNLLLD RTSFIFEYLD HKSVSNYFQI FNELLAFGYN DINKRKKLLM 550
    LNACSSTSSK ITEGFSFTTD GKAIFTKCNL LLSNGLYLKC ACCWTVKRDS 600
    FNIPILVMGQ FLPIFEMD 618
    Length:618
    Mass (Da):70,382
    Last modified:November 1, 1995 - v1
    Checksum:i200F6AEE06582E38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti611 – 6111F → L in AAU09751. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85021 Genomic DNA. Translation: CAA59391.1.
    Z49378 Genomic DNA. Translation: CAA89398.1.
    AY723834 Genomic DNA. Translation: AAU09751.1.
    BK006943 Genomic DNA. Translation: DAA08697.1.
    PIRiS53384.
    RefSeqiNP_012432.1. NM_001181536.1.

    Genome annotation databases

    EnsemblFungiiYJL103C; YJL103C; YJL103C.
    GeneIDi853341.
    KEGGisce:YJL103C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85021 Genomic DNA. Translation: CAA59391.1 .
    Z49378 Genomic DNA. Translation: CAA89398.1 .
    AY723834 Genomic DNA. Translation: AAU09751.1 .
    BK006943 Genomic DNA. Translation: DAA08697.1 .
    PIRi S53384.
    RefSeqi NP_012432.1. NM_001181536.1.

    3D structure databases

    ProteinModelPortali P42950.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33653. 17 interactions.
    IntActi P42950. 2 interactions.
    STRINGi 4932.YJL103C.

    Proteomic databases

    PaxDbi P42950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL103C ; YJL103C ; YJL103C .
    GeneIDi 853341.
    KEGGi sce:YJL103C.

    Organism-specific databases

    CYGDi YJL103c.
    SGDi S000003639. GSM1.

    Phylogenomic databases

    eggNOGi NOG48118.
    GeneTreei ENSGT00530000068325.
    HOGENOMi HOG000141759.
    OMAi FIMELMY.
    OrthoDBi EOG70KGZB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31557-MONOMER.

    Miscellaneous databases

    NextBioi 973727.

    Gene expression databases

    Genevestigatori P42950.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)."
      Rasmussen S.W.
      Yeast 11:873-883(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Computationally analyzing the possible biological function of YJL103C--an ORF potentially involved in the regulation of energy process in yeast."
      Deng Y., He T., Wu Y., Vanka P., Yang G., Huang Y., Yao H., Brown S.J.
      Int. J. Mol. Med. 15:123-127(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PREDICTION OF FUNCTION.
    6. "Linking DNA-binding proteins to their recognition sequences by using protein microarrays."
      Ho S.-W., Jona G., Chen C.T.L., Johnston M., Snyder M.
      Proc. Natl. Acad. Sci. U.S.A. 103:9940-9945(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    7. "Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification."
      van Bakel H., van Werven F.J., Radonjic M., Brok M.O., van Leenen D., Holstege F.C.P., Timmers H.T.M.
      Nucleic Acids Res. 36:E21-E21(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.

    Entry informationi

    Entry nameiGSM1_YEAST
    AccessioniPrimary (citable) accession number: P42950
    Secondary accession number(s): D6VW81, Q66R68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3