Glucose starvation modulator protein 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P42950 (GSM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Glucose starvation modulator protein 1

Gene names

Name:	GSM1
Ordered Locus Names:	YJL103C
ORF Names:	J0824

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	618 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Transcription factor which regulates nonfermentable carbon utilization By similarity. Binds specifically to 5'-CGGN₈CGG-3' and 5'-CGGN₉CGG-3' sequences in the promoter region. Ref.5

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the ERT1/acuK family.

Contains 1 PAS (PER-ARNT-SIM) domain.

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Sporulation Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	oxidative phosphorylation Inferred from expression pattern Ref.5. Source: SGD regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype Ref.6. Source: SGD sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred by curator Ref.6. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 19111667 PubMed 19158363. Source: SGD sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype Ref.6. Source: SGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 618

618

Glucose starvation modulator protein 1

PRO_0000114998

Regions

Domain

466 – 538

PAS

DNA binding

20 – 48

Zn(2)-C6 fungal-type Ref.6 Ref.8

Amino acid modifications

Modified residue

273

Phosphoserine Ref.7

Experimental info

Sequence conflict

611

F → L in AAU09751. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P42950 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 200F6AEE06582E38
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FASTA

618

70,382

        10         20         30         40         50         60 
MTKKLPSELK QTRKSIQTAC EFCHTKHIQC DVGRPCQNCL KRNIGKFCRD KKRKSRKRIE 

        70         80         90        100        110        120 
KHGTQPYLNL GKRLVIHDVP SKTVSPSSVH LQRDFLSSDQ EKPGKTPAHN TNIQYTYNIN 

       130        140        150        160        170        180 
DNFQSAGSIP RITNFNTNNR QTVLENTSNN ISASQAVHLM NDPIIPTVRK STLNLKSHFL 

       190        200        210        220        230        240 
EQHKAMQQPL ATNCLVATSN VPVHSGMDDS NKSDDDVDDE TNIHFDSMWC NDEYMKLKDI 

       250        260        270        280        290        300 
VDISTPFLPN NSQIFSLQES EYPNPSASTR GNSSLHLTNL LNSTKSVNDQ KDSSIGHSTS 

       310        320        330        340        350        360 
TFNTYDEVVS RPFISLDMLH LNRGANANTH PSHNAKLESE CDSSSHSDAD LEKHDTDFIS 

       370        380        390        400        410        420 
PSKFRELVKT PQDLYDNKCL IKPHNYKLAY TKLLTTLRKK FLEGAEIDKS ASVKDEHSTQ 

       430        440        450        460        470        480 
KHNLRYDLEV IIRSILERYA PIFISLTSNM IEEDLLLQEV TLQRALLDLE NMAKLVSCTP 

       490        500        510        520        530        540 
MCIWRRSGEI CFVSNEFYSL TGFNKNLLLD RTSFIFEYLD HKSVSNYFQI FNELLAFGYN 

       550        560        570        580        590        600 
DINKRKKLLM LNACSSTSSK ITEGFSFTTD GKAIFTKCNL LLSNGLYLKC ACCWTVKRDS 

       610 
FNIPILVMGQ FLPIFEMD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)." Rasmussen S.W. Yeast 11:873-883(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Computationally analyzing the possible biological function of YJL103C--an ORF potentially involved in the regulation of energy process in yeast." Deng Y., He T., Wu Y., Vanka P., Yang G., Huang Y., Yao H., Brown S.J. Int. J. Mol. Med. 15:123-127(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PREDICTION OF FUNCTION.
[6]	"Linking DNA-binding proteins to their recognition sequences by using protein microarrays." Ho S.-W., Jona G., Chen C.T.L., Johnston M., Snyder M. Proc. Natl. Acad. Sci. U.S.A. 103:9940-9945(2006) [PubMed] [Europe PMC] [Abstract] Cited for: DNA-BINDING.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, MASS SPECTROMETRY.
[8]	"Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification." van Bakel H., van Werven F.J., Radonjic M., Brok M.O., van Leenen D., Holstege F.C.P., Timmers H.T.M. Nucleic Acids Res. 36:E21-E21(2008) [PubMed] [Europe PMC] [Abstract] Cited for: DNA-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85021 Genomic DNA. Translation: CAA59391.1. Z49378 Genomic DNA. Translation: CAA89398.1. AY723834 Genomic DNA. Translation: AAU09751.1. BK006943 Genomic DNA. Translation: DAA08697.1.
PIR	S53384.
RefSeq	NP_012432.1. NM_001181536.1.
3D structure databases
ProteinModelPortal	P42950.
ModBase	Search...
Protein-protein interaction databases
IntAct	P42950. 2 interactions.
STRING	4932.YJL103C.
Proteomic databases
PaxDb	P42950.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL103C; YJL103C; YJL103C.
GeneID	853341.
KEGG	sce:YJL103C.
Organism-specific databases
CYGD	YJL103c.
SGD	S000003639. GSM1.
Phylogenomic databases
eggNOG	NOG48118.
GeneTree	ENSGT00530000068325.
HOGENOM	HOG000141759.
OMA	NERPCKN.
OrthoDB	EOG49PF7D.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31557-MONOMER.
Gene expression databases
Genevestigator	P42950.
GermOnline	YJL103C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	4.10.240.10. 1 hit.
InterPro	IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Pfam	PF00172. Zn_clus. 1 hit. [Graphical view]
SMART	SM00066. GAL4. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
PROSITE	PS50112. PAS. False negative. PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	973727.

Entry information

Entry name

GSM1_YEAST

Accession

Primary (citable) accession number: P42950
Secondary accession number(s): D6VW81, Q66R68

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents