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P42945

- UTP10_YEAST

UniProt

P42945 - UTP10_YEAST

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Protein
U3 small nucleolar RNA-associated protein 10
Gene
UTP10, YJL109C, J0808
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Involved in ribosome biosynthesis.4 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. snoRNA binding Source: SGD

GO - Biological processi

  1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  4. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  5. positive regulation of transcription from RNA polymerase I promoter Source: SGD
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-31563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 10
Short name:
U3 snoRNA-associated protein 10
Alternative name(s):
U three protein 10
U3 protein 10 required for transcription
t-UTP10
Gene namesi
Name:UTP10
Ordered Locus Names:YJL109C
ORF Names:J0808
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL109c.
SGDiS000003645. UTP10.

Subcellular locationi

Nucleusnucleolus. Mitochondrion
Note: Associated with ribosomal chromatin, even in the absence of transcription.6 Publications

GO - Cellular componenti

  1. 90S preribosome Source: SGD
  2. mitochondrion Source: UniProtKB-SubCell
  3. nucleolus Source: SGD
  4. preribosome, small subunit precursor Source: SGD
  5. rDNA heterochromatin Source: SGD
  6. small-subunit processome Source: SGD
  7. t-UTP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 17691768U3 small nucleolar RNA-associated protein 10
PRO_0000186207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP42945.
PaxDbiP42945.
PeptideAtlasiP42945.

Expressioni

Gene expression databases

GenevestigatoriP42945.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP4Q066794EBI-1884,EBI-35712

Protein-protein interaction databases

BioGridi33647. 88 interactions.
DIPiDIP-6466N.
IntActiP42945. 57 interactions.
MINTiMINT-671263.
STRINGi4932.YJL109C.

Structurei

3D structure databases

ProteinModelPortaliP42945.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1729 – 176739HEAT
Add
BLAST

Sequence similaritiesi

Belongs to the HEATR1/UTP10 family.
Contains 1 HEAT repeat.

Phylogenomic databases

eggNOGiNOG116525.
GeneTreeiENSGT00390000015845.
HOGENOMiHOG000093519.
KOiK14550.
OMAiKAFDLRR.
OrthoDBiEOG7KM623.

Family and domain databases

Gene3Di1.25.10.10. 8 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012954. BP28_C_dom.
IPR021133. HEAT_type_2.
IPR022125. U3snoRNP10.
[Graphical view]
PfamiPF08146. BP28CT. 1 hit.
PF12397. U3snoRNP10. 1 hit.
[Graphical view]
SMARTiSM01036. BP28CT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42945-1 [UniParc]FASTAAdd to Basket

« Hide

MSSLSDQLAQ VASNNATVAL DRKRRQKLHS ASLIYNSKTA ATQDYDFIFE     50
NASKALEELS QIEPKFAIFS RTLFSESSIS LDRNVQTKEE IKDLDNAINA 100
YLLLASSKWY LAPTLHATEW LVRRFQIHVK NTEMLLLSTL NYYQTPVFKR 150
ILSIIKLPPL FNCLSNFVRS EKPPTALTMI KLFNDMDFLK LYTSYLDQCI 200
KHNATYTNQL LFTTCCFINV VAFNSNNDEK LNQLVPILLE ISAKLLASKS 250
KDCQIAAHTI LVVFATALPL KKTIILAAME TILSNLDAKE AKHSALLTIC 300
KLFQTLKGQG NVDQLPSKIF KLFDSKFDTV SILTFLDKED KPVCDKFITS 350
YTRSIARYDR SKLNIILSLL KKIRLERYEV RLIITDLIYL SEILEDKSQL 400
VELFEYFISI NEDLVLKCLK SLGLTGELFE IRLTTSLFTN ADVNTDIVKQ 450
LSDPVETTKK DTASFQTFLD KHSELINTTN VSMLTETGER YKKVLSLFTE 500
AIGKGYKASS FLTSFFTTLE SRITFLLRVT ISPAAPTALK LISLNNIAKY 550
INSIEKEVNI FTLVPCLICA LRDASIKVRT GVKKILSLIA KRPSTKHYFL 600
SDKLYGENVT IPMLNPKDSE AWLSGFLNEY VTENYDISRI LTPKRNEKVF 650
LMFWANQALL IPSPYAKTVL LDNLNKSPTY ASSYSSLFEE FISHYLENRS 700
SWEKSCIANK TNFEHFERSL VNLVSPKEKQ SFMIDFVLSA LNSDYEQLAN 750
IAAERLISIF ASLNNAQKLK IVQNIVDSSS NVESSYDTVG VLQSLPLDSD 800
IFVSILNQNS ISNEMDQTDF SKRRRRRSST SKNAFLKEEV SQLAELHLRK 850
LTIILEALDK VRNVGSEKLL FTLLSLLSDL ETLDQDGGLP VLYAQETLIS 900
CTLNTITYLK EHGCTELTNV RADILVSAIR NSASPQVQNK LLLVIGSLAT 950
LSSEVILHSV MPIFTFMGAH SIRQDDEFTT KVVERTILTV VPALIKNSKG 1000
NEKEEMEFLL LSFTTALQHV PRHRRVKLFS TLIKTLDPVK ALGSFLFLIA 1050
QQYSSALVNF KIGEARILIE FIKALLVDLH VNEELSGLND LLDIIKLLTS 1100
SKSSSEKKKS LESRVLFSNG VLNFSESEFL TFMNNTFEFI NKITEETDQD 1150
YYDVRRNLRL KVYSVLLDET SDKKLIRNIR EEFGTLLEGV LFFINSVELT 1200
FSCITSQENE EASDSETSLS DHTTEIKEIL FKVLGNVLQI LPVDEFVNAV 1250
LPLLSTSTNE DIRYHLTLVI GSKFELEGSE AIPIVNNVMK VLLDRMPLES 1300
KSVVISQVIL NTMTALVSKY GKKLEGSILT QALTLATEKV SSDMTEVKIS 1350
SLALITNCVQ VLGVKSIAFY PKIVPPSIKL FDASLADSSN PLKEQLQVAI 1400
LLLFAGLIKR IPSFLMSNIL DVLHVIYFSR EVDSSIRLSV ISLIIENIDL 1450
KEVLKVLFRI WSTEIATSND TVAVSLFLST LESTVENIDK KSATSQSPIF 1500
FKLLLSLFEF RSISSFDNNT ISRIEASVHE ISNSYVLKMN DKVFRPLFVI 1550
LVRWAFDGEG VTNAGITETE RLLAFFKFFN KLQENLRGII TSYFTYLLEP 1600
VDMLLKRFIS KDMENVNLRR LVINSLTSSL KFDRDEYWKS TSRFELISVS 1650
LVNQLSNIEN SIGKYLVKAI GALASNNSGV DEHNQILNKL IVEHMKASCS 1700
SNEKLWAIRA MKLIYSKIGE SWLVLLPQLV PVIAELLEDD DEEIEREVRT 1750
GLVKVVENVL GEPFDRYLD 1769
Length:1,769
Mass (Da):200,082
Last modified:November 1, 1995 - v1
Checksum:i064480D1D249B241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85021 Genomic DNA. Translation: CAA59385.1.
Z49384 Genomic DNA. Translation: CAA89404.1.
BK006943 Genomic DNA. Translation: DAA08691.1.
PIRiS53378.
RefSeqiNP_012426.1. NM_001181542.1.

Genome annotation databases

EnsemblFungiiYJL109C; YJL109C; YJL109C.
GeneIDi853335.
KEGGisce:YJL109C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85021 Genomic DNA. Translation: CAA59385.1 .
Z49384 Genomic DNA. Translation: CAA89404.1 .
BK006943 Genomic DNA. Translation: DAA08691.1 .
PIRi S53378.
RefSeqi NP_012426.1. NM_001181542.1.

3D structure databases

ProteinModelPortali P42945.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33647. 88 interactions.
DIPi DIP-6466N.
IntActi P42945. 57 interactions.
MINTi MINT-671263.
STRINGi 4932.YJL109C.

Proteomic databases

MaxQBi P42945.
PaxDbi P42945.
PeptideAtlasi P42945.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL109C ; YJL109C ; YJL109C .
GeneIDi 853335.
KEGGi sce:YJL109C.

Organism-specific databases

CYGDi YJL109c.
SGDi S000003645. UTP10.

Phylogenomic databases

eggNOGi NOG116525.
GeneTreei ENSGT00390000015845.
HOGENOMi HOG000093519.
KOi K14550.
OMAi KAFDLRR.
OrthoDBi EOG7KM623.

Enzyme and pathway databases

BioCyci YEAST:G3O-31563-MONOMER.

Miscellaneous databases

NextBioi 973709.
PROi P42945.

Gene expression databases

Genevestigatori P42945.

Family and domain databases

Gene3Di 1.25.10.10. 8 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012954. BP28_C_dom.
IPR021133. HEAT_type_2.
IPR022125. U3snoRNP10.
[Graphical view ]
Pfami PF08146. BP28CT. 1 hit.
PF12397. U3snoRNP10. 1 hit.
[Graphical view ]
SMARTi SM01036. BP28CT. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 7 hits.
PROSITEi PS50077. HEAT_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)."
    Rasmussen S.W.
    Yeast 11:873-883(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
    Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
    Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
  9. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. "The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes."
    Wade C.H., Umbarger M.A., McAlear M.A.
    Yeast 23:293-306(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation."
    Dez C., Dlakic M., Tollervey D.
    RNA 13:1516-1527(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SNORNA U3 AND PRE-RIBOSOMAL RNA, SUBCELLULAR LOCATION.
  12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUTP10_YEAST
AccessioniPrimary (citable) accession number: P42945
Secondary accession number(s): D6VW75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 18200 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi