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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31565-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
Gene namesi
Name:CCT7
Ordered Locus Names:YJL111W
ORF Names:J0804
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL111W.
SGDiS000003647. CCT7.

Subcellular locationi

GO - Cellular componenti

  • chaperonin-containing T-complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550T-complex protein 1 subunit etaPRO_0000128372Add
BLAST

Proteomic databases

MaxQBiP42943.
PeptideAtlasiP42943.
PRIDEiP42943.

PTM databases

iPTMnetiP42943.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi33645. 39 interactions.
DIPiDIP-6758N.
IntActiP42943. 25 interactions.
MINTiMINT-639028.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80G/O/g/o1-550[»]
4V8RX-ray3.80AH/Ah/BH/Bh1-550[»]
4V94X-ray3.80G/O/g/o1-550[»]
ProteinModelPortaliP42943.
SMRiP42943. Positions 10-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074832.
HOGENOMiHOG000226730.
InParanoidiP42943.
KOiK09499.
OMAiFEQCVWE.
OrthoDBiEOG773XR5.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF22. PTHR11353:SF22. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFGSQTPTI VVLKEGTDAS QGKGQIISNI NACVAVQEAL KPTLGPLGSD
60 70 80 90 100
ILIVTSNQKT TISNDGATIL KLLDVVHPAA KTLVDISRAQ DAEVGDGTTS
110 120 130 140 150
VTILAGELMK EAKPFLEEGI SSHLIMKGYR KAVSLAVEKI NELAVDITSE
160 170 180 190 200
KSSGRELLER CARTAMSSKL IHNNADFFVK MCVDAVLSLD RNDLDDKLIG
210 220 230 240 250
IKKIPGGAME ESLFINGVAF KKTFSYAGFE QQPKKFNNPK ILSLNVELEL
260 270 280 290 300
KAEKDNAEVR VEHVEDYQAI VDAEWQLIFE KLRQVEETGA NIVLSKLPIG
310 320 330 340 350
DLATQFFADR NIFCAGRVSA DDMNRVIQAV GGSIQSTTSD IKPEHLGTCA
360 370 380 390 400
LFEEMQIGSE RYNLFQGCPQ AKTCTLLLRG GAEQVIAEVE RSLHDAIMIV
410 420 430 440 450
KRALQNKLIV AGGGATEMEV SKCLRDYSKT IAGKQQMIIN AFAKALEVIP
460 470 480 490 500
RQLCENAGFD AIEILNKLRL AHSKGEKWYG VVFETENIGD NFAKFVWEPA
510 520 530 540 550
LVKINALNSA TEATNLILSV DETITNKGSE SANAGMMPPQ GAGRGRGMPM
Length:550
Mass (Da):59,736
Last modified:November 1, 1995 - v1
Checksum:iA428FEC2ACD54B4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA. Translation: CAA59383.1.
Z49386 Genomic DNA. Translation: CAA89406.1.
BK006943 Genomic DNA. Translation: DAA08689.1.
PIRiS53376.
RefSeqiNP_012424.1. NM_001181544.1.

Genome annotation databases

EnsemblFungiiYJL111W; YJL111W; YJL111W.
GeneIDi853333.
KEGGisce:YJL111W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA. Translation: CAA59383.1.
Z49386 Genomic DNA. Translation: CAA89406.1.
BK006943 Genomic DNA. Translation: DAA08689.1.
PIRiS53376.
RefSeqiNP_012424.1. NM_001181544.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80G/O/g/o1-550[»]
4V8RX-ray3.80AH/Ah/BH/Bh1-550[»]
4V94X-ray3.80G/O/g/o1-550[»]
ProteinModelPortaliP42943.
SMRiP42943. Positions 10-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33645. 39 interactions.
DIPiDIP-6758N.
IntActiP42943. 25 interactions.
MINTiMINT-639028.

PTM databases

iPTMnetiP42943.

Proteomic databases

MaxQBiP42943.
PeptideAtlasiP42943.
PRIDEiP42943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL111W; YJL111W; YJL111W.
GeneIDi853333.
KEGGisce:YJL111W.

Organism-specific databases

EuPathDBiFungiDB:YJL111W.
SGDiS000003647. CCT7.

Phylogenomic databases

GeneTreeiENSGT00550000074832.
HOGENOMiHOG000226730.
InParanoidiP42943.
KOiK09499.
OMAiFEQCVWE.
OrthoDBiEOG773XR5.

Enzyme and pathway databases

BioCyciYEAST:G3O-31565-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.

Miscellaneous databases

NextBioi973703.
PROiP42943.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF22. PTHR11353:SF22. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)."
    Rasmussen S.W.
    Yeast 11:873-883(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon."
    Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C.
    Yeast 12:1471-1474(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiTCPH_YEAST
AccessioniPrimary (citable) accession number: P42943
Secondary accession number(s): D6VW73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.