P42942 (YG4I_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized GTP-binding protein YGR210C

Gene names

Ordered Locus Names:	YGR210C
ORF Names:	G7748

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Present with 11600 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 G (guanine nucleotide-binding) domain.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PWP2	P25635	2	EBI-23482,EBI-14332

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Uncharacterized GTP-binding protein YGR210C		PRO_0000122467
Regions
	Domain	16 – 121	106	G
	Nucleotide binding	11 – 18	8	GTP Potential
	Nucleotide binding	83 – 87	5	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	P42942 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EDD967C0D6E6D257	FASTA	411	45,214
	10 20 30 40 50 60 MPRDPLIGIV GKPSSGKSTT LNSLTDAGAA VGAFPFTTIE PNQATGYLQV ECACSRFGKE 70 80 90 100 110 120 DLCKPNYGWC SKGKRHIPIK LLDVAGLVPG AHSGRGLGNK FLDDLRHADA LIHVVDVSGT 130 140 150 160 170 180 TDAEGKNTRG YDPLNDIEWL QDEIRLWVEG NLKKRWGSIV RKHTATKSSI VDTLQAQFGG 190 200 210 220 230 240 YGSHAPMIQK ALDRLKGLPP LEKWDDEWIT RVVKSFMMEK FPTVLALNKI DHPDADKNVS 250 260 270 280 290 300 KIMLKYPDTK AVLTSAVTEV FLRKLKKQGF ILYEEGTEFV DTFEDEPDKL KPLDDKILNR 310 320 330 340 350 360 IENIRDLVLY RFGSTGVVQV LQAATDILGL IPVYTVKNIQ TFTGGNGTNV FRDCFLVKRG 370 380 390 400 410 TPVGKVARYI MGGEVTIASI ETVGGVRVSE ESLVEPGKND ILGFKIAPRS A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the 15.6-kb fragment encompassing the ADE3 gene." Song J.M., Cheung E., Rabinowitz J.C. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / GRF88.
[2]	"Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs." Guerreiro P., Barreiros T., Soares H., Cyrne L., Maia e Silva A., Rodrigues-Pousada C. Yeast 12:273-280(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40843 Genomic DNA. Translation: AAA85585.1. Z49133 Genomic DNA. Translation: CAA89003.1. Z72995 Genomic DNA. Translation: CAA97237.1. BK006941 Genomic DNA. Translation: DAA08304.1.
PIR	S53933.
RefSeq	NP_011726.1. NM_001181339.1.
3D structure databases
ProteinModelPortal	P42942.
SMR	P42942. Positions 7-361.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2600N.
IntAct	P42942. 4 interactions.
MINT	MINT-423509.
STRING	4932.YGR210C.
Proteomic databases
PaxDb	P42942.
PeptideAtlas	P42942.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR210C; YGR210C; YGR210C.
GeneID	853124.
KEGG	sce:YGR210C.
Organism-specific databases
CYGD	YGR210c.
SGD	S000003442. YGR210C.
Phylogenomic databases
eggNOG	COG0012.
GeneTree	ENSGT00550000075919.
HOGENOM	HOG000087627.
KO	K06942.
OMA	NAATMND.
OrthoDB	EOG48H0BW.
Gene expression databases
Genevestigator	P42942.
GermOnline	YGR210C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006073. GTP_binding_domain. IPR013646. MMR_HSR1_C. [Graphical view]
Pfam	PF01926. MMR_HSR1. 1 hit. PF08438. MMR_HSR1_C. 1 hit. [Graphical view]
PRINTS	PR00326. GTP1OBG.
ProtoNet	Search...
Other
NextBio	973166.

Entry information

Entry name

YG4I_YEAST

Accession

Primary (citable) accession number: P42942
Secondary accession number(s): D6VUZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program