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Protein

Phosphoserine phosphatase

Gene

SER2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase 1 (SER3), D-3-phosphoglycerate dehydrogenase 2 (SER33)
  2. Phosphoserine aminotransferase (SER1)
  3. Phosphoserine phosphatase (SER2)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971NucleophileBy similarity
Metal bindingi97 – 971MagnesiumBy similarity
Active sitei99 – 991Proton donorBy similarity
Metal bindingi99 – 991Magnesium; via carbonyl oxygenBy similarity
Binding sitei106 – 1061SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Metal bindingi255 – 2551MagnesiumBy similarity
Binding sitei258 – 2581SubstrateBy similarity

GO - Molecular functioni

  • magnesium ion binding Source: GO_Central
  • phosphoserine phosphatase activity Source: SGD

GO - Biological processi

  • L-serine biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Serine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YGR208W-MONOMER.
BRENDAi3.1.3.3. 984.
ReactomeiR-SCE-977347. Serine biosynthesis.
UniPathwayiUPA00135; UER00198.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine phosphatase (EC:3.1.3.3)
Short name:
PSP
Short name:
PSPase
Alternative name(s):
O-phosphoserine phosphohydrolase
Gene namesi
Name:SER2
Ordered Locus Names:YGR208W
ORF Names:G7744
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR208W.
SGDiS000003440. SER2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Phosphoserine phosphatasePRO_0000156885Add
BLAST

Proteomic databases

MaxQBiP42941.

PTM databases

iPTMnetiP42941.

Interactioni

Protein-protein interaction databases

BioGridi33461. 160 interactions.
DIPiDIP-2085N.
IntActiP42941. 10 interactions.
MINTiMINT-545797.

Structurei

3D structure databases

ProteinModelPortaliP42941.
SMRiP42941. Positions 93-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni186 – 1872Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the SerB family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003115.
HOGENOMiHOG000231114.
InParanoidiP42941.
KOiK01079.
OMAiCINEPDL.
OrthoDBiEOG092C4Q4W.

Family and domain databases

Gene3Di1.10.150.210. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR023190. Pser_Pase_dom_2.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01488. HAD-SF-IB. 1 hit.

Sequencei

Sequence statusi: Complete.

P42941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKFVITCIA HGENLPKETI DQIAKEITES SAKDVSINGT KKLSARATDI
60 70 80 90 100
FIEVAGSIVQ KDLKNKLTNV IDSHNDVDVI VSVDNEYRQA KKLFVFDMDS
110 120 130 140 150
TLIYQEVIEL IAAYAGVEEQ VHEITERAMN NELDFKESLR ERVKLLQGLQ
160 170 180 190 200
VDTLYDEIKQ KLEVTKGVPE LCKFLHKKNC KLAVLSGGFI QFAGFIKDQL
210 220 230 240 250
GLDFCKANLL EVDTDGKLTG KTLGPIVDGQ CKSETLLQLC NDYNVPVEAS
260 270 280 290 300
CMVGDGGNDL PAMATAGFGI AWNAKPKVQK AAPCKLNTKS MTDILYILGY

TDDEIYNRQ
Length:309
Mass (Da):34,207
Last modified:November 1, 1995 - v1
Checksum:i11CD560B3A96172B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36473 Genomic DNA. Translation: AAA79062.1.
Z49133 Genomic DNA. Translation: CAA89001.1.
Z72993 Genomic DNA. Translation: CAA97235.1.
BK006941 Genomic DNA. Translation: DAA08302.1.
PIRiS53931.
RefSeqiNP_011724.1. NM_001181337.1.

Genome annotation databases

EnsemblFungiiYGR208W; YGR208W; YGR208W.
GeneIDi853122.
KEGGisce:YGR208W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36473 Genomic DNA. Translation: AAA79062.1.
Z49133 Genomic DNA. Translation: CAA89001.1.
Z72993 Genomic DNA. Translation: CAA97235.1.
BK006941 Genomic DNA. Translation: DAA08302.1.
PIRiS53931.
RefSeqiNP_011724.1. NM_001181337.1.

3D structure databases

ProteinModelPortaliP42941.
SMRiP42941. Positions 93-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33461. 160 interactions.
DIPiDIP-2085N.
IntActiP42941. 10 interactions.
MINTiMINT-545797.

PTM databases

iPTMnetiP42941.

Proteomic databases

MaxQBiP42941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR208W; YGR208W; YGR208W.
GeneIDi853122.
KEGGisce:YGR208W.

Organism-specific databases

EuPathDBiFungiDB:YGR208W.
SGDiS000003440. SER2.

Phylogenomic databases

GeneTreeiENSGT00390000003115.
HOGENOMiHOG000231114.
InParanoidiP42941.
KOiK01079.
OMAiCINEPDL.
OrthoDBiEOG092C4Q4W.

Enzyme and pathway databases

UniPathwayiUPA00135; UER00198.
BioCyciYEAST:YGR208W-MONOMER.
BRENDAi3.1.3.3. 984.
ReactomeiR-SCE-977347. Serine biosynthesis.

Miscellaneous databases

PROiP42941.

Family and domain databases

Gene3Di1.10.150.210. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR023190. Pser_Pase_dom_2.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01488. HAD-SF-IB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSERB_YEAST
AccessioniPrimary (citable) accession number: P42941
Secondary accession number(s): D6VUZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 13800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.