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Protein

Phosphoserine phosphatase

Gene

SER2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 13800 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase 1 (SER3), D-3-phosphoglycerate dehydrogenase 2 (SER33)
  2. Phosphoserine aminotransferase (SER1)
  3. Phosphoserine phosphatase (SER2)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97NucleophileBy similarity1
Metal bindingi97MagnesiumBy similarity1
Active sitei99Proton donorBy similarity1
Metal bindingi99Magnesium; via carbonyl oxygenBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Binding sitei232SubstrateBy similarity1
Metal bindingi255MagnesiumBy similarity1
Binding sitei258SubstrateBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoserine phosphatase activity Source: SGD

GO - Biological processi

  • L-serine biosynthetic process Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YGR208W-MONOMER
BRENDAi3.1.3.3 984
ReactomeiR-SCE-977347 Serine biosynthesis
UniPathwayiUPA00135; UER00198

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine phosphatase (EC:3.1.3.3)
Short name:
PSP
Short name:
PSPase
Alternative name(s):
O-phosphoserine phosphohydrolase
Gene namesi
Name:SER2
Ordered Locus Names:YGR208W
ORF Names:G7744
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR208W
SGDiS000003440 SER2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568851 – 309Phosphoserine phosphataseAdd BLAST309

Proteomic databases

MaxQBiP42941
PaxDbiP42941
PRIDEiP42941

PTM databases

iPTMnetiP42941

Interactioni

Protein-protein interaction databases

BioGridi33461, 269 interactors
DIPiDIP-2085N
IntActiP42941, 10 interactors
STRINGi4932.YGR208W

Structurei

3D structure databases

ProteinModelPortaliP42941
SMRiP42941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 187Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003115
HOGENOMiHOG000231114
InParanoidiP42941
KOiK01079
OMAiSHSKGEM
OrthoDBiEOG092C4Q4W

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
SUPFAMiSSF56784 SSF56784, 1 hit

Sequencei

Sequence statusi: Complete.

P42941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKFVITCIA HGENLPKETI DQIAKEITES SAKDVSINGT KKLSARATDI
60 70 80 90 100
FIEVAGSIVQ KDLKNKLTNV IDSHNDVDVI VSVDNEYRQA KKLFVFDMDS
110 120 130 140 150
TLIYQEVIEL IAAYAGVEEQ VHEITERAMN NELDFKESLR ERVKLLQGLQ
160 170 180 190 200
VDTLYDEIKQ KLEVTKGVPE LCKFLHKKNC KLAVLSGGFI QFAGFIKDQL
210 220 230 240 250
GLDFCKANLL EVDTDGKLTG KTLGPIVDGQ CKSETLLQLC NDYNVPVEAS
260 270 280 290 300
CMVGDGGNDL PAMATAGFGI AWNAKPKVQK AAPCKLNTKS MTDILYILGY

TDDEIYNRQ
Length:309
Mass (Da):34,207
Last modified:November 1, 1995 - v1
Checksum:i11CD560B3A96172B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36473 Genomic DNA Translation: AAA79062.1
Z49133 Genomic DNA Translation: CAA89001.1
Z72993 Genomic DNA Translation: CAA97235.1
BK006941 Genomic DNA Translation: DAA08302.1
PIRiS53931
RefSeqiNP_011724.1, NM_001181337.1

Genome annotation databases

EnsemblFungiiYGR208W; YGR208W; YGR208W
GeneIDi853122
KEGGisce:YGR208W

Similar proteinsi

Entry informationi

Entry nameiSERB_YEAST
AccessioniPrimary (citable) accession number: P42941
Secondary accession number(s): D6VUZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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