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Protein

Probable ATP-dependent kinase TDA10

Gene

TDA10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent kinase whose specificity is not yet known.

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: SGD
  • uridine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30888-MONOMER
BRENDAi2.7.1.31 984

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent kinase TDA10 (EC:2.7.-.-)
Alternative name(s):
Topoisomerase I damage affected protein 10
Gene namesi
Name:TDA10
Ordered Locus Names:YGR205W
ORF Names:G7737
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR205W
SGDiS000003437 TDA10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002140761 – 290Probable ATP-dependent kinase TDA10Add BLAST290

Proteomic databases

MaxQBiP42938
PaxDbiP42938
PRIDEiP42938

Interactioni

Protein-protein interaction databases

BioGridi33458, 17 interactors
DIPiDIP-3866N
IntActiP42938, 5 interactors
MINTiP42938
STRINGi4932.YGR205W

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 24Combined sources17
Turni25 – 27Combined sources3
Beta strandi32 – 37Combined sources6
Helixi44 – 59Combined sources16
Helixi60 – 62Combined sources3
Beta strandi65 – 69Combined sources5
Helixi70 – 73Combined sources4
Helixi77 – 86Combined sources10
Turni87 – 89Combined sources3
Helixi91 – 93Combined sources3
Beta strandi94 – 96Combined sources3
Helixi104 – 114Combined sources11
Beta strandi125 – 128Combined sources4
Turni133 – 135Combined sources3
Helixi136 – 138Combined sources3
Beta strandi147 – 152Combined sources6
Beta strandi154 – 162Combined sources9
Turni172 – 174Combined sources3
Beta strandi176 – 178Combined sources3
Helixi182 – 195Combined sources14
Turni196 – 198Combined sources3
Beta strandi204 – 212Combined sources9
Helixi216 – 232Combined sources17
Helixi238 – 246Combined sources9
Helixi249 – 262Combined sources14
Beta strandi265 – 275Combined sources11
Beta strandi281 – 287Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ODFX-ray2.25A1-290[»]
ProteinModelPortaliP42938
SMRiP42938
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42938

Family & Domainsi

Sequence similaritiesi

Belongs to the GLYK kinase family.Curated

Phylogenomic databases

InParanoidiP42938
KOiK15918
OMAiLANVYRW
OrthoDBiEOG092C1PMV

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P42938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKSKTVLD YTIEFLDKYI PEWFETGNKC PLFIFFSGPQ GSGKSFTSIQ
60 70 80 90 100
IYNHLMEKYG GEKSIGYASI DDFYLTHEDQ LKLNEQFKNN KLLQGRGLPG
110 120 130 140 150
THDMKLLQEV LNTIFNNNEH PDQDTVVLPK YDKSQFKGEG DRCPTGQKIK
160 170 180 190 200
LPVDIFILEG WFLGFNPILQ GIENNDLLTG DMVDVNAKLF FYSDLLWRNP
210 220 230 240 250
EIKSLGIVFT TDNINNVYGW RLQQEHELIS KVGKGMTDEQ VHAFVDRYMP
260 270 280 290
SYKLYLNDFV RSESLGSIAT LTLGIDSNRN VYSTKTRCIE
Length:290
Mass (Da):33,337
Last modified:November 1, 1995 - v1
Checksum:iEEB2DB5995122A29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12878 Genomic DNA Translation: AAA66317.1
Z49133 Genomic DNA Translation: CAA88998.1
Z72990 Genomic DNA Translation: CAA97232.1
AY558273 Genomic DNA Translation: AAS56599.1
BK006941 Genomic DNA Translation: DAA08299.1
PIRiB29550
RefSeqiNP_011721.3, NM_001181334.3

Genome annotation databases

EnsemblFungiiYGR205W; YGR205W; YGR205W
GeneIDi853119
KEGGisce:YGR205W

Similar proteinsi

Entry informationi

Entry nameiTDA10_YEAST
AccessioniPrimary (citable) accession number: P42938
Secondary accession number(s): D6VUY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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