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Protein

Probable ATP-dependent kinase TDA10

Gene

TDA10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent kinase whose specificity is not yet known.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: SGD
  • kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30888-MONOMER.
BRENDAi2.7.1.31. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent kinase TDA10 (EC:2.7.-.-)
Alternative name(s):
Topoisomerase I damage affected protein 10
Gene namesi
Name:TDA10
Ordered Locus Names:YGR205W
ORF Names:G7737
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR205W.
SGDiS000003437. TDA10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002140761 – 290Probable ATP-dependent kinase TDA10Add BLAST290

Proteomic databases

MaxQBiP42938.
PRIDEiP42938.

Interactioni

Protein-protein interaction databases

BioGridi33458. 10 interactors.
DIPiDIP-3866N.
IntActiP42938. 4 interactors.
MINTiMINT-486081.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 24Combined sources17
Turni25 – 27Combined sources3
Beta strandi32 – 37Combined sources6
Helixi44 – 59Combined sources16
Helixi60 – 62Combined sources3
Beta strandi65 – 69Combined sources5
Helixi70 – 73Combined sources4
Helixi77 – 86Combined sources10
Turni87 – 89Combined sources3
Helixi91 – 93Combined sources3
Beta strandi94 – 96Combined sources3
Helixi104 – 114Combined sources11
Beta strandi125 – 128Combined sources4
Turni133 – 135Combined sources3
Helixi136 – 138Combined sources3
Beta strandi147 – 152Combined sources6
Beta strandi154 – 162Combined sources9
Turni172 – 174Combined sources3
Beta strandi176 – 178Combined sources3
Helixi182 – 195Combined sources14
Turni196 – 198Combined sources3
Beta strandi204 – 212Combined sources9
Helixi216 – 232Combined sources17
Helixi238 – 246Combined sources9
Helixi249 – 262Combined sources14
Beta strandi265 – 275Combined sources11
Beta strandi281 – 287Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ODFX-ray2.25A1-290[»]
ProteinModelPortaliP42938.
SMRiP42938.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42938.

Family & Domainsi

Sequence similaritiesi

Belongs to the GLYK kinase family.Curated

Phylogenomic databases

InParanoidiP42938.
KOiK15918.
OMAiHAYLPKL.
OrthoDBiEOG092C1PMV.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P42938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKSKTVLD YTIEFLDKYI PEWFETGNKC PLFIFFSGPQ GSGKSFTSIQ
60 70 80 90 100
IYNHLMEKYG GEKSIGYASI DDFYLTHEDQ LKLNEQFKNN KLLQGRGLPG
110 120 130 140 150
THDMKLLQEV LNTIFNNNEH PDQDTVVLPK YDKSQFKGEG DRCPTGQKIK
160 170 180 190 200
LPVDIFILEG WFLGFNPILQ GIENNDLLTG DMVDVNAKLF FYSDLLWRNP
210 220 230 240 250
EIKSLGIVFT TDNINNVYGW RLQQEHELIS KVGKGMTDEQ VHAFVDRYMP
260 270 280 290
SYKLYLNDFV RSESLGSIAT LTLGIDSNRN VYSTKTRCIE
Length:290
Mass (Da):33,337
Last modified:November 1, 1995 - v1
Checksum:iEEB2DB5995122A29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12878 Genomic DNA. Translation: AAA66317.1.
Z49133 Genomic DNA. Translation: CAA88998.1.
Z72990 Genomic DNA. Translation: CAA97232.1.
AY558273 Genomic DNA. Translation: AAS56599.1.
BK006941 Genomic DNA. Translation: DAA08299.1.
PIRiB29550.
RefSeqiNP_011721.3. NM_001181334.3.

Genome annotation databases

EnsemblFungiiYGR205W; YGR205W; YGR205W.
GeneIDi853119.
KEGGisce:YGR205W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12878 Genomic DNA. Translation: AAA66317.1.
Z49133 Genomic DNA. Translation: CAA88998.1.
Z72990 Genomic DNA. Translation: CAA97232.1.
AY558273 Genomic DNA. Translation: AAS56599.1.
BK006941 Genomic DNA. Translation: DAA08299.1.
PIRiB29550.
RefSeqiNP_011721.3. NM_001181334.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ODFX-ray2.25A1-290[»]
ProteinModelPortaliP42938.
SMRiP42938.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33458. 10 interactors.
DIPiDIP-3866N.
IntActiP42938. 4 interactors.
MINTiMINT-486081.

Proteomic databases

MaxQBiP42938.
PRIDEiP42938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR205W; YGR205W; YGR205W.
GeneIDi853119.
KEGGisce:YGR205W.

Organism-specific databases

EuPathDBiFungiDB:YGR205W.
SGDiS000003437. TDA10.

Phylogenomic databases

InParanoidiP42938.
KOiK15918.
OMAiHAYLPKL.
OrthoDBiEOG092C1PMV.

Enzyme and pathway databases

BioCyciYEAST:G3O-30888-MONOMER.
BRENDAi2.7.1.31. 984.

Miscellaneous databases

EvolutionaryTraceiP42938.
PROiP42938.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTDA10_YEAST
AccessioniPrimary (citable) accession number: P42938
Secondary accession number(s): D6VUY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.