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Protein

CDC25-like phosphatase YCH1

Gene

YCH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase.1 Publication

Kineticsi

  1. KM=3.5 mM for p-nitrophenylphosphate (PNPP)1 Publication

    pH dependencei

    Optimum pH is 7.5.1 Publication

    GO - Molecular functioni

    • phosphatase activity Source: SGD
    • protein tyrosine phosphatase activity Source: SGD
    • thiosulfate sulfurtransferase activity Source: SGD

    GO - Biological processi

    • dephosphorylation Source: SGD
    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30887-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDC25-like phosphatase YCH1 (EC:3.1.3.-)
    Alternative name(s):
    CDC25 homolog 1
    Gene namesi
    Name:YCH1
    Ordered Locus Names:YGR203W
    ORF Names:G7731
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome VII

    Organism-specific databases

    EuPathDBiFungiDB:YGR203W.
    SGDiS000003435. YCH1.

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002028441 – 148CDC25-like phosphatase YCH1Add BLAST148

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1N-acetylmethionineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP42937.
    PRIDEiP42937.

    Interactioni

    Protein-protein interaction databases

    BioGridi33456. 28 interactors.
    DIPiDIP-885N.
    IntActiP42937. 8 interactors.
    MINTiMINT-514352.

    Structurei

    Secondary structure

    1148
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi3 – 5Combined sources3
    Beta strandi8 – 12Combined sources5
    Helixi14 – 23Combined sources10
    Turni27 – 29Combined sources3
    Beta strandi33 – 37Combined sources5
    Helixi41 – 43Combined sources3
    Helixi56 – 61Combined sources6
    Helixi63 – 78Combined sources16
    Beta strandi80 – 82Combined sources3
    Beta strandi84 – 89Combined sources6
    Beta strandi91 – 95Combined sources5
    Helixi96 – 106Combined sources11
    Helixi110 – 113Combined sources4
    Beta strandi116 – 121Combined sources6
    Helixi124 – 132Combined sources9
    Turni136 – 138Combined sources3
    Beta strandi139 – 141Combined sources3
    Helixi144 – 147Combined sources4

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3F4AX-ray1.80A/B1-148[»]
    3FS5X-ray1.90A1-148[»]
    ProteinModelPortaliP42937.
    SMRiP42937.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42937.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini29 – 137RhodanesePROSITE-ProRule annotationAdd BLAST109

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    InParanoidiP42937.
    KOiK18065.
    OMAiWQEVYGE.
    OrthoDBiEOG092C5E20.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    [Graphical view]
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42937-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MDSYSITNVK YLDPTELHRW MQEGHTTTLR EPFQVVDVRG SDYMGGHIKD
    60 70 80 90 100
    GWHYAYSRLK QDPEYLRELK HRLLEKQADG RGALNVIFHC MLSQQRGPSA
    110 120 130 140
    AMLLLRSLDT AELSRCRLWV LRGGFSRWQS VYGDDESVTA GYLPDLWR
    Length:148
    Mass (Da):17,249
    Last modified:November 1, 1995 - v1
    Checksum:i41527DB282CBFF11
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z49133 Genomic DNA. Translation: CAA88996.1.
    Z72988 Genomic DNA. Translation: CAA97230.1.
    AY558510 Genomic DNA. Translation: AAS56836.1.
    BK006941 Genomic DNA. Translation: DAA08296.1.
    PIRiS53926.
    RefSeqiNP_011719.1. NM_001181332.1.

    Genome annotation databases

    EnsemblFungiiYGR203W; YGR203W; YGR203W.
    GeneIDi853117.
    KEGGisce:YGR203W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z49133 Genomic DNA. Translation: CAA88996.1.
    Z72988 Genomic DNA. Translation: CAA97230.1.
    AY558510 Genomic DNA. Translation: AAS56836.1.
    BK006941 Genomic DNA. Translation: DAA08296.1.
    PIRiS53926.
    RefSeqiNP_011719.1. NM_001181332.1.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3F4AX-ray1.80A/B1-148[»]
    3FS5X-ray1.90A1-148[»]
    ProteinModelPortaliP42937.
    SMRiP42937.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi33456. 28 interactors.
    DIPiDIP-885N.
    IntActiP42937. 8 interactors.
    MINTiMINT-514352.

    Proteomic databases

    MaxQBiP42937.
    PRIDEiP42937.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblFungiiYGR203W; YGR203W; YGR203W.
    GeneIDi853117.
    KEGGisce:YGR203W.

    Organism-specific databases

    EuPathDBiFungiDB:YGR203W.
    SGDiS000003435. YCH1.

    Phylogenomic databases

    InParanoidiP42937.
    KOiK18065.
    OMAiWQEVYGE.
    OrthoDBiEOG092C5E20.

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30887-MONOMER.

    Miscellaneous databases

    EvolutionaryTraceiP42937.
    PROiP42937.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    [Graphical view]
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiYCH1_YEAST
    AccessioniPrimary (citable) accession number: P42937
    Secondary accession number(s): D6VUY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: November 2, 2016
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2310 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.