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P42934

- PMT6_YEAST

UniProt

P42934 - PMT6_YEAST

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Protein
Dolichyl-phosphate-mannose--protein mannosyltransferase 6
Gene
PMT6, YGR199W, G7722
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins By similarity.

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. protein O-linked glycosylation Source: SGD
  2. protein O-linked mannosylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:YGR199W-MONOMER.
BRENDAi2.4.1.109. 984.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 6 (EC:2.4.1.109)
Gene namesi
Name:PMT6
Ordered Locus Names:YGR199W
ORF Names:G7722
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR199w.
SGDiS000003431. PMT6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 5857Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Topological domaini80 – 16485Lumenal Reviewed prediction
Add
BLAST
Transmembranei165 – 18521Helical; Reviewed prediction
Add
BLAST
Topological domaini186 – 1949Cytoplasmic Reviewed prediction
Transmembranei195 – 21521Helical; Reviewed prediction
Add
BLAST
Topological domaini216 – 25136Lumenal Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Reviewed prediction
Add
BLAST
Topological domaini273 – 29321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei294 – 31421Helical; Reviewed prediction
Add
BLAST
Topological domaini315 – 618304Lumenal Reviewed prediction
Add
BLAST
Transmembranei619 – 63921Helical; Reviewed prediction
Add
BLAST
Topological domaini640 – 65617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei657 – 67721Helical; Reviewed prediction
Add
BLAST
Topological domaini678 – 6869Lumenal Reviewed prediction
Transmembranei687 – 70721Helical; Reviewed prediction
Add
BLAST
Topological domaini708 – 7158Cytoplasmic Reviewed prediction
Transmembranei716 – 73621Helical; Reviewed prediction
Add
BLAST
Topological domaini737 – 75923Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 759758Dolichyl-phosphate-mannose--protein mannosyltransferase 6
PRO_0000121496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi404 – 4041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiP42934.
PaxDbiP42934.

Expressioni

Gene expression databases

GenevestigatoriP42934.

Interactioni

Protein-protein interaction databases

BioGridi33452. 48 interactions.
DIPiDIP-5551N.
IntActiP42934. 1 interaction.
MINTiMINT-561799.
STRINGi4932.YGR199W.

Structurei

3D structure databases

ProteinModelPortaliP42934.
SMRiP42934. Positions 342-525.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini340 – 39455MIR 1
Add
BLAST
Domaini409 – 46759MIR 2
Add
BLAST
Domaini482 – 54059MIR 3
Add
BLAST

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
GeneTreeiENSGT00740000115531.
HOGENOMiHOG000157526.
KOiK00728.
OMAiSEWWEWP.
OrthoDBiEOG7BP89X.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42934-1 [UniParc]FASTAAdd to Basket

« Hide

MSKAKGTGFS SIDTEDENLR ERYVNQPKAN ASDIQDEQLD CFEQLEEKHR    50
TKKNEEYTAL KILRDVIGPL LLTITSFYLR FQHIDQNNYV VWDEAHFGKF 100
GSYYIKHEYY HDVHPPLGKM LIALSEWMAG FDGQFDFSSN NAYPENVNFK 150
LMRQFNATFG ALCTPVAFFT AKWMGFNYFT VYLIATMVTL EHSYIVLSKF 200
ILLDSMLLFF SMTTFACMIK LYTLRKQQMT KKWSLWMLLT GLSIGCVCSV 250
KWVGLFITVV VGLYTCIELF LLYCDKELPR IKYYKHWLIR IINLIVIPFL 300
IYLYCFKIHF VLLYKSGTGD STTNTLFQIN LEGTQIEAGP RDVAFGSELT 350
IRSHGLSPNL LHSHIQVYPE GSGQRQITGY GFADSNNVWK FEFSRSSGLE 400
LDQNGTLNGK IIPITDGVEV RLSHKNTGSN LHSHDVPSHV SRGNYEVSGY 450
GSQSVGDEKD DWIVEIVKQM DSPNPVYSNE NSTILHPVST FFRLRHKVLG 500
CYLASTGLTY PAWGFKQAEI VCKDSWSRRD KSTWWNVEDH WNHNLETAED 550
YVPPKSNFWT DFILTNFAMA SSNNALVPDE DKYDSLSSDA WEWPTLHKGL 600
RMCSWAGYIT RYYLMGSPFN TWISTVSLII FPFIILFILY RWRRQTLYLS 650
DDQIWQITIQ GIFPFISWMT HYLPFAMMGR VTYVHHYVPA LYFAMLVFGF 700
VLDFTLTRVH WMVKYPIYLS LFGGCIYIYN LFAPICQGMH GDKAEYLPLQ 750
WLSTWDIAP 759
Length:759
Mass (Da):88,026
Last modified:November 1, 1995 - v1
Checksum:i7A23DCEDD90F01C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49133 Genomic DNA. Translation: CAA88992.1.
Z72984 Genomic DNA. Translation: CAA97226.1.
BK006941 Genomic DNA. Translation: DAA08292.1.
PIRiS53922.
RefSeqiNP_011715.1. NM_001181328.1.

Genome annotation databases

EnsemblFungiiYGR199W; YGR199W; YGR199W.
GeneIDi853113.
KEGGisce:YGR199W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49133 Genomic DNA. Translation: CAA88992.1 .
Z72984 Genomic DNA. Translation: CAA97226.1 .
BK006941 Genomic DNA. Translation: DAA08292.1 .
PIRi S53922.
RefSeqi NP_011715.1. NM_001181328.1.

3D structure databases

ProteinModelPortali P42934.
SMRi P42934. Positions 342-525.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33452. 48 interactions.
DIPi DIP-5551N.
IntActi P42934. 1 interaction.
MINTi MINT-561799.
STRINGi 4932.YGR199W.

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

Proteomic databases

MaxQBi P42934.
PaxDbi P42934.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR199W ; YGR199W ; YGR199W .
GeneIDi 853113.
KEGGi sce:YGR199W.

Organism-specific databases

CYGDi YGR199w.
SGDi S000003431. PMT6.

Phylogenomic databases

eggNOGi COG1928.
GeneTreei ENSGT00740000115531.
HOGENOMi HOG000157526.
KOi K00728.
OMAi SEWWEWP.
OrthoDBi EOG7BP89X.

Enzyme and pathway databases

BioCyci YEAST:YGR199W-MONOMER.
BRENDAi 2.4.1.109. 984.

Miscellaneous databases

NextBioi 973133.

Gene expression databases

Genevestigatori P42934.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs."
    Guerreiro P., Barreiros T., Soares H., Cyrne L., Maia e Silva A., Rodrigues-Pousada C.
    Yeast 12:273-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPMT6_YEAST
AccessioniPrimary (citable) accession number: P42934
Secondary accession number(s): D6VUY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi