T-complex protein 1 subunit theta - Mus musculus (Mouse)

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P42932 (TCPQ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
T-complex protein 1 subunit theta
Short name=TCP-1-theta

Alternative name(s):
CCT-theta

Gene names

Name:	Cct8
Synonyms:	Cctq

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin By similarity.
Subunit structure	Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton › centrosome By similarity.
Sequence similarities	Belongs to the TCP-1 chaperonin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	binding of sperm to zona pellucida Inferred from direct assay PubMed 21880732. Source: MGI protein folding Inferred from electronic annotation. Source: InterPro
Cellular_component	aggresome Inferred from electronic annotation. Source: Compara centrosome Inferred from electronic annotation. Source: Compara chaperonin-containing T-complex Inferred from direct assay PubMed 7828721 Ref.1. Source: MGI intermediate filament cytoskeleton Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: Compara sperm part Inferred from direct assay PubMed 21880732. Source: MGI zona pellucida receptor complex Inferred from direct assay PubMed 21880732. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 548

547

T-complex protein 1 subunit theta

PRO_0000128374

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphotyrosine By similarity

Modified residue

318

N6-acetyllysine By similarity

Modified residue

400

N6-acetyllysine By similarity

Modified residue

466

N6-acetyllysine By similarity

Modified residue

505

Phosphotyrosine By similarity

Cross-link

225

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Cross-link

235

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P42932 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 4B5265250CFF1FE2
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FASTA

548

59,555

        10         20         30         40         50         60 
MALHVPKAPG FAQMLKDGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINRL 

        70         80         90        100        110        120 
EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR 

       130        140        150        160        170        180 
IGLSVSEVIS GYEIACKKAH EILPELVCCS AKNLRDVDEV SSLLRTSIMS KQYGSETFLA 

       190        200        210        220        230        240 
KLIAQACVSI FPDSGNFNVD NIRVCKILGS GIYSSSVLHG MVFKKETEGD VTSVKDAKIA 

       250        260        270        280        290        300 
VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIAGTGANV IVTGGKVADI 

       310        320        330        340        350        360 
ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPKLTPPV QEEMGHCDSV YLSEVGDTQV 

       370        380        390        400        410        420 
VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA 

       430        440        450        460        470        480 
KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYSV HQEGNKNVGL 

       490        500        510        520        530        540 
DIEAEVPAVK DMLEASILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK 


DWDDDQND

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1." Kubota H., Hynes G., Willison K. Gene 154:231-236(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
[3]	Lubec G., Kang S.U., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 8-16; 63-74; 156-165; 172-181; 207-224; 261-296; 308-314; 368-400; 408-421; 441-450; 477-504 AND 510-520, MASS SPECTROMETRY. Strain: C57BL/6 and OF1. Tissue: Brain and Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z37164 mRNA. Translation: CAA85521.1. BC009007 mRNA. Translation: AAH09007.1.
IPI	IPI00469268.
PIR	JC4073.
RefSeq	NP_033970.3. NM_009840.3.
UniGene	Mm.328673.
3D structure databases
ProteinModelPortal	P42932.
SMR	P42932. Positions 6-528.
ModBase	Search...
Protein-protein interaction databases
IntAct	P42932. 4 interactions.
PTM databases
PhosphoSite	P42932.
2D gel databases
REPRODUCTION-2DPAGE	P42932.
Proteomic databases
PaxDb	P42932.
PRIDE	P42932.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000026704; ENSMUSP00000026704; ENSMUSG00000025613.
GeneID	12469.
KEGG	mmu:12469.
Organism-specific databases
CTD	10694.
MGI	MGI:107183. Cct8.
Phylogenomic databases
eggNOG	COG0459.
HOVERGEN	HBG103107.
InParanoid	P42932.
KO	K09500.
OMA	KDWDDDQ.
OrthoDB	EOG466VKQ.
Gene expression databases
ArrayExpress	P42932.
Bgee	P42932.
CleanEx	MM_CCT8.
Genevestigator	P42932.
GermOnline	ENSMUSG00000025613. Mus musculus.
Family and domain databases
InterPro	IPR012721. Chap_CCT_theta. IPR017998. Chaperone_TCP-1. IPR002194. Chaperonin_TCP-1_CS. IPR002423. Cpn60/TCP-1. [Graphical view]
PANTHER	PTHR11353. PTHR11353. 1 hit. PTHR11353:SF19. PTHR11353:SF19. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. [Graphical view]
PRINTS	PR00304. TCOMPLEXTCP1.
SUPFAM	SSF48592. GroEL-ATPase. 1 hit.
TIGRFAMs	TIGR02346. chap_CCT_theta. 1 hit.
PROSITE	PS00750. TCP1_1. 1 hit. PS00751. TCP1_2. 1 hit. PS00995. TCP1_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CCT8. mouse.
NextBio	281350.
SOURCE	Search...

Entry information

Entry name

TCPQ_MOUSE

Accession

Primary (citable) accession number: P42932

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents