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Protein

Probable fimbrial chaperone YraI

Gene

yraI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G7638-MONOMER.
ECOL316407:JW3112-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone YraI
Gene namesi
Name:yraI
Ordered Locus Names:b3143, JW3112
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12774. yraI.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000929725 – 231Probable fimbrial chaperone YraIAdd BLAST207

Proteomic databases

PaxDbiP42914.
PRIDEiP42914.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261996. 20 interactors.
IntActiP42914. 5 interactors.
STRINGi511145.b3143.

Structurei

3D structure databases

ProteinModelPortaliP42914.
SMRiP42914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108VCD. Bacteria.
ENOG4111N65. LUCA.
HOGENOMiHOG000260152.
InParanoidiP42914.
OMAiVIYEASK.
PhylomeDBiP42914.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRTFAVIL TLLCSFCIGQ ALAGGIVLQR TRVIYDASRK EAALPVANKG
60 70 80 90 100
AETPYLLQSW VDNIDGKSRA PFIITPPLFR LEAGDDSSLR IIKTADNLPE
110 120 130 140 150
NKESLFYINV RAIPAKKKSD DVNANELTLV FKTRIKMFYR PAHLKGRVND
160 170 180 190 200
AWKSLEFKRS DHSLNIYNPT EYYVVFAGLA VDKTDLTSKI EYIAPGEHKQ
210 220 230
LPLPASGGKN VKWAAINDYG GSSGTETRPL Q
Length:231
Mass (Da):25,677
Last modified:November 1, 1995 - v1
Checksum:i2416AC160661DE1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57946.1.
U00096 Genomic DNA. Translation: AAC76177.1.
AP009048 Genomic DNA. Translation: BAE77189.1.
PIRiC65104.
RefSeqiNP_417612.1. NC_000913.3.
WP_000044775.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76177; AAC76177; b3143.
BAE77189; BAE77189; BAE77189.
GeneIDi947657.
KEGGiecj:JW3112.
eco:b3143.
PATRICi32121704. VBIEscCol129921_3238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57946.1.
U00096 Genomic DNA. Translation: AAC76177.1.
AP009048 Genomic DNA. Translation: BAE77189.1.
PIRiC65104.
RefSeqiNP_417612.1. NC_000913.3.
WP_000044775.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42914.
SMRiP42914.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261996. 20 interactors.
IntActiP42914. 5 interactors.
STRINGi511145.b3143.

Proteomic databases

PaxDbiP42914.
PRIDEiP42914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76177; AAC76177; b3143.
BAE77189; BAE77189; BAE77189.
GeneIDi947657.
KEGGiecj:JW3112.
eco:b3143.
PATRICi32121704. VBIEscCol129921_3238.

Organism-specific databases

EchoBASEiEB2627.
EcoGeneiEG12774. yraI.

Phylogenomic databases

eggNOGiENOG4108VCD. Bacteria.
ENOG4111N65. LUCA.
HOGENOMiHOG000260152.
InParanoidiP42914.
OMAiVIYEASK.
PhylomeDBiP42914.

Enzyme and pathway databases

BioCyciEcoCyc:G7638-MONOMER.
ECOL316407:JW3112-MONOMER.

Miscellaneous databases

PROiP42914.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYRAI_ECOLI
AccessioniPrimary (citable) accession number: P42914
Secondary accession number(s): Q2M967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.