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Protein

Uncharacterized fimbrial-like protein YraH

Gene

yraH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7637-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YraH
Gene namesi
Name:yraH
Ordered Locus Names:b3142, JW3111
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12773 yraH

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000926123 – 194Uncharacterized fimbrial-like protein YraHAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 78Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP42913
PRIDEiP42913

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261995, 13 interactors
STRINGi316385.ECDH10B_3315

Structurei

3D structure databases

ProteinModelPortaliP42913
SMRiP42913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105Q10 Bacteria
ENOG4111VA0 LUCA
HOGENOMiHOG000260127
OMAiQACEIDD
PhylomeDBiP42913

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVTKTAIA GLLALFAGNA AATDGEIVFD GEILKSACEI NDSDKKIEVA
60 70 80 90 100
LGHYNAEQFR NIGERSPKIP FTIPLVNCPM TGWEHDNGNV EASFRLWLET
110 120 130 140 150
RDNGTVPNFP NLAKVGSFAG IAATGVGIRI DDAESGNIMP LNAMGNDNTV
160 170 180 190
YQIPAESNGI VNVDLIAYYV STVVPSEITP GEADAIVNVT LDYR
Length:194
Mass (Da):20,744
Last modified:November 1, 1995 - v1
Checksum:i02B10A946D45C4C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57945.1
U00096 Genomic DNA Translation: AAC76176.1
AP009048 Genomic DNA Translation: BAE77188.1
PIRiB65104
RefSeqiNP_417611.1, NC_000913.3
WP_001045432.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76176; AAC76176; b3142
BAE77188; BAE77188; BAE77188
GeneIDi947658
KEGGiecj:JW3111
eco:b3142
PATRICifig|1411691.4.peg.3588

Similar proteinsi

Entry informationi

Entry nameiYRAH_ECOLI
AccessioniPrimary (citable) accession number: P42913
Secondary accession number(s): Q2M968
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health