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Protein

Uncharacterized fimbrial-like protein YraH

Gene

yraH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7637-MONOMER.
ECOL316407:JW3111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YraH
Gene namesi
Name:yraH
Ordered Locus Names:b3142, JW3111
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12773. yraH.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000926123 – 194Uncharacterized fimbrial-like protein YraHAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 78Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP42913.
PRIDEiP42913.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261995. 13 interactors.
STRINGi511145.b3142.

Structurei

3D structure databases

ProteinModelPortaliP42913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105Q10. Bacteria.
ENOG4111VA0. LUCA.
HOGENOMiHOG000260127.
OMAiMKINGLP.
PhylomeDBiP42913.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVTKTAIA GLLALFAGNA AATDGEIVFD GEILKSACEI NDSDKKIEVA
60 70 80 90 100
LGHYNAEQFR NIGERSPKIP FTIPLVNCPM TGWEHDNGNV EASFRLWLET
110 120 130 140 150
RDNGTVPNFP NLAKVGSFAG IAATGVGIRI DDAESGNIMP LNAMGNDNTV
160 170 180 190
YQIPAESNGI VNVDLIAYYV STVVPSEITP GEADAIVNVT LDYR
Length:194
Mass (Da):20,744
Last modified:November 1, 1995 - v1
Checksum:i02B10A946D45C4C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57945.1.
U00096 Genomic DNA. Translation: AAC76176.1.
AP009048 Genomic DNA. Translation: BAE77188.1.
PIRiB65104.
RefSeqiNP_417611.1. NC_000913.3.
WP_001045432.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76176; AAC76176; b3142.
BAE77188; BAE77188; BAE77188.
GeneIDi947658.
KEGGiecj:JW3111.
eco:b3142.
PATRICi32121702. VBIEscCol129921_3237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57945.1.
U00096 Genomic DNA. Translation: AAC76176.1.
AP009048 Genomic DNA. Translation: BAE77188.1.
PIRiB65104.
RefSeqiNP_417611.1. NC_000913.3.
WP_001045432.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261995. 13 interactors.
STRINGi511145.b3142.

Proteomic databases

PaxDbiP42913.
PRIDEiP42913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76176; AAC76176; b3142.
BAE77188; BAE77188; BAE77188.
GeneIDi947658.
KEGGiecj:JW3111.
eco:b3142.
PATRICi32121702. VBIEscCol129921_3237.

Organism-specific databases

EchoBASEiEB2626.
EcoGeneiEG12773. yraH.

Phylogenomic databases

eggNOGiENOG4105Q10. Bacteria.
ENOG4111VA0. LUCA.
HOGENOMiHOG000260127.
OMAiMKINGLP.
PhylomeDBiP42913.

Enzyme and pathway databases

BioCyciEcoCyc:G7637-MONOMER.
ECOL316407:JW3111-MONOMER.

Miscellaneous databases

PROiP42913.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYRAH_ECOLI
AccessioniPrimary (citable) accession number: P42913
Secondary accession number(s): Q2M968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.