Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetylgalactosamine permease IID component

Gene

agaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AGAD-MONOMER.
ECOL316407:JW3109-MONOMER.

Protein family/group databases

TCDBi4.A.6.1.5. the pts mannose-fructose-sorbose (man) family.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine permease IID component
Alternative name(s):
EIID-Aga
PTS system N-acetylgalactosamine-specific EIID component
Gene namesi
Name:agaD
Synonyms:yraF
Ordered Locus Names:b3140, JW3109
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12771. agaD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei98 – 118HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei131 – 151HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei178 – 198HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei215 – 235HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei243 – 263HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866621 – 263N-acetylgalactosamine permease IID componentAdd BLAST263

Proteomic databases

PaxDbiP42911.
PRIDEiP42911.

Interactioni

Protein-protein interaction databases

BioGridi4261993. 7 interactors.
IntActiP42911. 2 interactors.
STRINGi511145.b3140.

Structurei

3D structure databases

ProteinModelPortaliP42911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 263PTS EIIDPROSITE-ProRule annotationAdd BLAST261

Domaini

The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIID domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F3R. Bacteria.
COG3716. LUCA.
HOGENOMiHOG000098669.
KOiK10986.
OMAiTTWLMRI.
PhylomeDBiP42911.

Family and domain databases

InterProiIPR004704. PTS_IID_man.
[Graphical view]
PfamiPF03613. EIID-AGA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00828. EIID-AGA. 1 hit.
PROSITEiPS51108. PTS_EIID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEISKKDI TRLGFRSSLL QASFNYERMQ AGGFTWAMLP ILKKIYKDDK
60 70 80 90 100
PGLSAAMKDN LEFINTHPNL VGFLMGLLIS MEEKGENRDT IKGLKVALFG
110 120 130 140 150
PIAGIGDAIF WFTLLPIMAG ICSSFASQGN LLGPILFFAV YLLIFFLRVG
160 170 180 190 200
WTHVGYSVGV KAIDKVRENS QMIARSATIL GITVIGGLIA SYVHINVVTS
210 220 230 240 250
FAIDNTHSVA LQQDFFDKVF PNILPMAYTL LMYYFLRVKK AHPVLLIGVT
260
FVLSIVCSAF GIL
Length:263
Mass (Da):29,001
Last modified:November 1, 1995 - v1
Checksum:i11573AF3503C53F1
GO

Sequence cautioni

The sequence AAA57943 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA. Translation: AAF81092.1.
U18997 Genomic DNA. Translation: AAA57943.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76174.1.
AP009048 Genomic DNA. Translation: BAE77186.1.
PIRiH65103.
RefSeqiNP_417609.1. NC_000913.3.
WP_000534347.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76174; AAC76174; b3140.
BAE77186; BAE77186; BAE77186.
GeneIDi947649.
KEGGiecj:JW3109.
eco:b3140.
PATRICi32121698. VBIEscCol129921_3235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA. Translation: AAF81092.1.
U18997 Genomic DNA. Translation: AAA57943.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76174.1.
AP009048 Genomic DNA. Translation: BAE77186.1.
PIRiH65103.
RefSeqiNP_417609.1. NC_000913.3.
WP_000534347.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261993. 7 interactors.
IntActiP42911. 2 interactors.
STRINGi511145.b3140.

Protein family/group databases

TCDBi4.A.6.1.5. the pts mannose-fructose-sorbose (man) family.

Proteomic databases

PaxDbiP42911.
PRIDEiP42911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76174; AAC76174; b3140.
BAE77186; BAE77186; BAE77186.
GeneIDi947649.
KEGGiecj:JW3109.
eco:b3140.
PATRICi32121698. VBIEscCol129921_3235.

Organism-specific databases

EchoBASEiEB2624.
EcoGeneiEG12771. agaD.

Phylogenomic databases

eggNOGiENOG4105F3R. Bacteria.
COG3716. LUCA.
HOGENOMiHOG000098669.
KOiK10986.
OMAiTTWLMRI.
PhylomeDBiP42911.

Enzyme and pathway databases

BioCyciEcoCyc:AGAD-MONOMER.
ECOL316407:JW3109-MONOMER.

Miscellaneous databases

PROiP42911.

Family and domain databases

InterProiIPR004704. PTS_IID_man.
[Graphical view]
PfamiPF03613. EIID-AGA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00828. EIID-AGA. 1 hit.
PROSITEiPS51108. PTS_EIID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPD_ECOLI
AccessioniPrimary (citable) accession number: P42911
Secondary accession number(s): Q2M970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.