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Protein

N-acetylgalactosamine permease IID component

Gene

agaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AGAD-MONOMER

Protein family/group databases

TCDBi4.A.6.1.5 the pts mannose-fructose-sorbose (man) family

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine permease IID component
Alternative name(s):
EIID-Aga
PTS system N-acetylgalactosamine-specific EIID component
Gene namesi
Name:agaD
Synonyms:yraF
Ordered Locus Names:b3140, JW3109
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12771 agaD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei98 – 118HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei131 – 151HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei178 – 198HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei215 – 235HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei243 – 263HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866621 – 263N-acetylgalactosamine permease IID componentAdd BLAST263

Proteomic databases

PaxDbiP42911
PRIDEiP42911

Interactioni

Protein-protein interaction databases

BioGridi4261993, 7 interactors
IntActiP42911, 2 interactors
STRINGi316385.ECDH10B_3313

Structurei

3D structure databases

ProteinModelPortaliP42911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 263PTS EIIDPROSITE-ProRule annotationAdd BLAST261

Domaini

The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F3R Bacteria
COG3716 LUCA
HOGENOMiHOG000098669
KOiK10986
OMAiSEQMAIV
PhylomeDBiP42911

Family and domain databases

InterProiView protein in InterPro
IPR004704 PTS_IID_man
PfamiView protein in Pfam
PF03613 EIID-AGA, 1 hit
TIGRFAMsiTIGR00828 EIID-AGA, 1 hit
PROSITEiView protein in PROSITE
PS51108 PTS_EIID, 1 hit

Sequencei

Sequence statusi: Complete.

P42911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEISKKDI TRLGFRSSLL QASFNYERMQ AGGFTWAMLP ILKKIYKDDK
60 70 80 90 100
PGLSAAMKDN LEFINTHPNL VGFLMGLLIS MEEKGENRDT IKGLKVALFG
110 120 130 140 150
PIAGIGDAIF WFTLLPIMAG ICSSFASQGN LLGPILFFAV YLLIFFLRVG
160 170 180 190 200
WTHVGYSVGV KAIDKVRENS QMIARSATIL GITVIGGLIA SYVHINVVTS
210 220 230 240 250
FAIDNTHSVA LQQDFFDKVF PNILPMAYTL LMYYFLRVKK AHPVLLIGVT
260
FVLSIVCSAF GIL
Length:263
Mass (Da):29,001
Last modified:November 1, 1995 - v1
Checksum:i11573AF3503C53F1
GO

Sequence cautioni

The sequence AAA57943 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA Translation: AAF81092.1
U18997 Genomic DNA Translation: AAA57943.1 Different initiation.
U00096 Genomic DNA Translation: AAC76174.1
AP009048 Genomic DNA Translation: BAE77186.1
PIRiH65103
RefSeqiNP_417609.1, NC_000913.3
WP_000534347.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76174; AAC76174; b3140
BAE77186; BAE77186; BAE77186
GeneIDi947649
KEGGiecj:JW3109
eco:b3140
PATRICifig|1411691.4.peg.3590

Similar proteinsi

Entry informationi

Entry nameiPTPD_ECOLI
AccessioniPrimary (citable) accession number: P42911
Secondary accession number(s): Q2M970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health