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Protein

N-acetylgalactosamine permease IIC component 1

Gene

agaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AGAC-MONOMER.
ECOL316407:JW3108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine permease IIC component 1
Alternative name(s):
EIIC-Aga
PTS system N-acetylgalactosamine-specific EIIC component 1
Gene namesi
Name:agaC
Synonyms:yraE
Ordered Locus Names:b3139, JW3108
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12770. agaC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010PeriplasmicSequence analysis
Transmembranei11 – 3121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini32 – 332CytoplasmicSequence analysis
Transmembranei34 – 5421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini55 – 6612PeriplasmicSequence analysisAdd
BLAST
Transmembranei67 – 8721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini88 – 947CytoplasmicSequence analysis
Transmembranei95 – 11521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini116 – 14126PeriplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini163 – 17715CytoplasmicSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini199 – 20911PeriplasmicSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini231 – 26737CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267N-acetylgalactosamine permease IIC component 1PRO_0000186660Add
BLAST

Proteomic databases

PaxDbiP42910.

Interactioni

Protein-protein interaction databases

BioGridi4262422. 14 interactions.
STRINGi511145.b3139.

Structurei

3D structure databases

ProteinModelPortaliP42910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 237237PTS EIIC type-4PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIIC type-4 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105ETZ. Bacteria.
COG3715. LUCA.
HOGENOMiHOG000097553.
KOiK10985.
OMAiMEITSAQ.
OrthoDBiEOG6HB9NQ.
PhylomeDBiP42910.

Family and domain databases

InterProiIPR004700. PTS_IIC_sorb.
[Graphical view]
PfamiPF03609. EII-Sor. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00822. EII-Sor. 1 hit.
PROSITEiPS51106. PTS_EIIC_TYPE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEITLLQGL SLAALVFVLG IDFWLEALFL FRPIIVCTLT GAILGDIQTG
60 70 80 90 100
LITGGLTELA FAGLTPAGGV QPPNPIMAGL MTTVIAWSTG VDAKTAIGLG
110 120 130 140 150
LPFSLLMQYV ILFFYSAFSL FMTKADKCAK EADTAAFSRL NWTTMLIVAS
160 170 180 190 200
AYAVIAFLCT YLAQGAMQAL VKAMPAWLTH GFEVAGGILP AVGFGLLLRV
210 220 230 240 250
MFKAQYIPYL IAGFLFVCYI QVSNLLPVAV LGAGFAVYEF FNAKSRQQAQ
260
PQPVASKNEE EDYSNGI
Length:267
Mass (Da):28,645
Last modified:November 1, 1995 - v1
Checksum:iC44F4D0827FE56C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57942.1.
U00096 Genomic DNA. Translation: AAC76173.1.
AP009048 Genomic DNA. Translation: BAE77185.1.
PIRiG65103.
RefSeqiNP_417608.1. NC_000913.3.
WP_000544489.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76173; AAC76173; b3139.
BAE77185; BAE77185; BAE77185.
GeneIDi947652.
KEGGiecj:JW3108.
eco:b3139.
PATRICi32121696. VBIEscCol129921_3234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57942.1.
U00096 Genomic DNA. Translation: AAC76173.1.
AP009048 Genomic DNA. Translation: BAE77185.1.
PIRiG65103.
RefSeqiNP_417608.1. NC_000913.3.
WP_000544489.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262422. 14 interactions.
STRINGi511145.b3139.

Proteomic databases

PaxDbiP42910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76173; AAC76173; b3139.
BAE77185; BAE77185; BAE77185.
GeneIDi947652.
KEGGiecj:JW3108.
eco:b3139.
PATRICi32121696. VBIEscCol129921_3234.

Organism-specific databases

EchoBASEiEB2623.
EcoGeneiEG12770. agaC.

Phylogenomic databases

eggNOGiENOG4105ETZ. Bacteria.
COG3715. LUCA.
HOGENOMiHOG000097553.
KOiK10985.
OMAiMEITSAQ.
OrthoDBiEOG6HB9NQ.
PhylomeDBiP42910.

Enzyme and pathway databases

BioCyciEcoCyc:AGAC-MONOMER.
ECOL316407:JW3108-MONOMER.

Miscellaneous databases

PROiP42910.

Family and domain databases

InterProiIPR004700. PTS_IIC_sorb.
[Graphical view]
PfamiPF03609. EII-Sor. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00822. EII-Sor. 1 hit.
PROSITEiPS51106. PTS_EIIC_TYPE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli."
    Reizer J., Ramseier T.M., Reizer A., Charbit A., Saier M.H. Jr.
    Microbiology 142:231-250(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiPTPC1_ECOLI
AccessioniPrimary (citable) accession number: P42910
Secondary accession number(s): Q2M971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 20, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.