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Protein

N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1

Gene

agaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AGAB-MONOMER

Protein family/group databases

TCDBi4.A.6.1.5 the pts mannose-fructose-sorbose (man) family

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1 (EC:2.7.1.-)
Alternative name(s):
EIIB-Aga
PTS system N-acetylgalactosamine-specific EIIB component 1
Gene namesi
Name:agaB
Synonyms:yraD
Ordered Locus Names:b3138, JW3107
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG12769 agaB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866581 – 158N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1Add BLAST158

Proteomic databases

PaxDbiP42909
PRIDEiP42909

Interactioni

Protein-protein interaction databases

BioGridi4259399, 11 interactors
IntActiP42909, 5 interactors
STRINGi316385.ECDH10B_3311

Structurei

3D structure databases

ProteinModelPortaliP42909
SMRiP42909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 158PTS EIIB type-4PROSITE-ProRule annotationAdd BLAST158

Domaini

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.

Phylogenomic databases

eggNOGiENOG4108UZY Bacteria
COG3444 LUCA
HOGENOMiHOG000096437
InParanoidiP42909
KOiK10984
OMAiEAKNDQM
PhylomeDBiP42909

Family and domain databases

CDDicd00001 PTS_IIB_man, 1 hit
Gene3Di3.40.35.10, 1 hit
InterProiView protein in InterPro
IPR004720 PTS_IIB_sorbose-sp
IPR036667 PTS_IIB_sorbose-sp_sf
IPR018455 PTS_IIB_sorbose-sp_subgr
PfamiView protein in Pfam
PF03830 PTSIIB_sorb, 1 hit
SUPFAMiSSF52728 SSF52728, 1 hit
TIGRFAMsiTIGR00854 pts-sorbose, 1 hit
PROSITEiView protein in PROSITE
PS51101 PTS_EIIB_TYPE_4, 1 hit

Sequencei

Sequence statusi: Complete.

P42909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPNILLTR IDNRLVHGQV GVTWTSTIGA NLLVVVDDVV ANDDIQQKLM
60 70 80 90 100
GITAETYGFG IRFFTIEKTI NVIGKAAPHQ KIFLICRTPQ TVRKLVEGGI
110 120 130 140 150
DLKDVNVGNM HFSEGKKQIS SKVYVDDQDL TDLRFIKQRG VNVFIQDVPG

DQKEQIPD
Length:158
Mass (Da):17,622
Last modified:November 1, 1995 - v1
Checksum:i897BA2D5FED89159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA Translation: AAF81090.1
U18997 Genomic DNA Translation: AAA57941.1
U00096 Genomic DNA Translation: AAC76172.1
AP009048 Genomic DNA Translation: BAE77184.1
PIRiF65103
RefSeqiNP_417607.1, NC_000913.3
WP_000203711.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76172; AAC76172; b3138
BAE77184; BAE77184; BAE77184
GeneIDi947653
KEGGiecj:JW3107
eco:b3138
PATRICifig|1411691.4.peg.3592

Entry informationi

Entry nameiPTPB1_ECOLI
AccessioniPrimary (citable) accession number: P42909
Secondary accession number(s): Q2M972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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