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Protein

N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1

Gene

agaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

Catalytic activityi

Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei17 – 171Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AGAB-MONOMER.
ECOL316407:JW3107-MONOMER.

Protein family/group databases

TCDBi4.A.6.1.5. the pts mannose-fructose-sorbose (man) family.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1 (EC:2.7.1.-)
Alternative name(s):
EIIB-Aga
PTS system N-acetylgalactosamine-specific EIIB component 1
Gene namesi
Name:agaB
Synonyms:yraD
Ordered Locus Names:b3138, JW3107
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12769. agaB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1PRO_0000186658Add
BLAST

Proteomic databases

PaxDbiP42909.
PRIDEiP42909.

Interactioni

Protein-protein interaction databases

BioGridi4259399. 11 interactions.
IntActiP42909. 5 interactions.
STRINGi511145.b3138.

Structurei

3D structure databases

ProteinModelPortaliP42909.
SMRiP42909. Positions 5-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 158158PTS EIIB type-4PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.

Sequence similaritiesi

Contains 1 PTS EIIB type-4 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UZY. Bacteria.
COG3444. LUCA.
HOGENOMiHOG000096437.
InParanoidiP42909.
KOiK10984.
OMAiHKASERQ.
PhylomeDBiP42909.

Family and domain databases

Gene3Di3.40.35.10. 1 hit.
InterProiIPR004720. PTS_IIB_sorbose-sp.
IPR018455. PTS_IIB_sorbose-sp_subgr.
[Graphical view]
PfamiPF03830. PTSIIB_sorb. 1 hit.
[Graphical view]
SUPFAMiSSF52728. SSF52728. 1 hit.
TIGRFAMsiTIGR00854. pts-sorbose. 1 hit.
PROSITEiPS51101. PTS_EIIB_TYPE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPNILLTR IDNRLVHGQV GVTWTSTIGA NLLVVVDDVV ANDDIQQKLM
60 70 80 90 100
GITAETYGFG IRFFTIEKTI NVIGKAAPHQ KIFLICRTPQ TVRKLVEGGI
110 120 130 140 150
DLKDVNVGNM HFSEGKKQIS SKVYVDDQDL TDLRFIKQRG VNVFIQDVPG

DQKEQIPD
Length:158
Mass (Da):17,622
Last modified:November 1, 1995 - v1
Checksum:i897BA2D5FED89159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA. Translation: AAF81090.1.
U18997 Genomic DNA. Translation: AAA57941.1.
U00096 Genomic DNA. Translation: AAC76172.1.
AP009048 Genomic DNA. Translation: BAE77184.1.
PIRiF65103.
RefSeqiNP_417607.1. NC_000913.3.
WP_000203711.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76172; AAC76172; b3138.
BAE77184; BAE77184; BAE77184.
GeneIDi947653.
KEGGiecj:JW3107.
eco:b3138.
PATRICi32121694. VBIEscCol129921_3233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA. Translation: AAF81090.1.
U18997 Genomic DNA. Translation: AAA57941.1.
U00096 Genomic DNA. Translation: AAC76172.1.
AP009048 Genomic DNA. Translation: BAE77184.1.
PIRiF65103.
RefSeqiNP_417607.1. NC_000913.3.
WP_000203711.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42909.
SMRiP42909. Positions 5-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259399. 11 interactions.
IntActiP42909. 5 interactions.
STRINGi511145.b3138.

Protein family/group databases

TCDBi4.A.6.1.5. the pts mannose-fructose-sorbose (man) family.

Proteomic databases

PaxDbiP42909.
PRIDEiP42909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76172; AAC76172; b3138.
BAE77184; BAE77184; BAE77184.
GeneIDi947653.
KEGGiecj:JW3107.
eco:b3138.
PATRICi32121694. VBIEscCol129921_3233.

Organism-specific databases

EchoBASEiEB2622.
EcoGeneiEG12769. agaB.

Phylogenomic databases

eggNOGiENOG4108UZY. Bacteria.
COG3444. LUCA.
HOGENOMiHOG000096437.
InParanoidiP42909.
KOiK10984.
OMAiHKASERQ.
PhylomeDBiP42909.

Enzyme and pathway databases

BioCyciEcoCyc:AGAB-MONOMER.
ECOL316407:JW3107-MONOMER.

Miscellaneous databases

PROiP42909.

Family and domain databases

Gene3Di3.40.35.10. 1 hit.
InterProiIPR004720. PTS_IIB_sorbose-sp.
IPR018455. PTS_IIB_sorbose-sp_subgr.
[Graphical view]
PfamiPF03830. PTSIIB_sorb. 1 hit.
[Graphical view]
SUPFAMiSSF52728. SSF52728. 1 hit.
TIGRFAMsiTIGR00854. pts-sorbose. 1 hit.
PROSITEiPS51101. PTS_EIIB_TYPE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPB1_ECOLI
AccessioniPrimary (citable) accession number: P42909
Secondary accession number(s): Q2M972
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.