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Protein

Putative N-acetylgalactosamine-6-phosphate deacetylase

Gene

agaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, AgaA in K-12 strains is not involved in the degradation of these compounds.

Caution

Could be the product of a pseudogene.Curated

Catalytic activityi

N-acetyl-D-galactosamine 6-phosphate + H2O = D-galactosamine 6-phosphate + acetate.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciEcoCyc:AGAA-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative N-acetylgalactosamine-6-phosphate deacetylaseCurated (EC:3.5.1.-By similarity)
Short name:
Aga-6-P deacetylaseCurated
Gene namesi
Name:agaA
Ordered Locus Names:b3135, JW5527
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12766 agaA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001709201 – 167Putative N-acetylgalactosamine-6-phosphate deacetylaseAdd BLAST167

Proteomic databases

PRIDEiP42906

Interactioni

Protein-protein interaction databases

BioGridi4261157, 4 interactors
STRINGi316385.ECDH10B_3308

Structurei

3D structure databases

ProteinModelPortaliP42906
SMRiP42906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1820 LUCA
HOGENOMiHOG000202514
InParanoidiP42906
KOiK02079
OMAiMCHSTAN
PhylomeDBiP42906

Family and domain databases

Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequencei

Sequence statusi: Complete.

P42906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCYNGMTGL HHREPGMVGA GLTDKRAWLE LIADGHHVHP AAMSLCCCCA
60 70 80 90 100
KERIVLITDA MQAAGMPDGR YTLCGEEVQM HGGVVRTASG GLAGSTLSVD
110 120 130 140 150
AAVRNMVELT GVTPAEAIHM ASLHPARMLG VDGVLGSLKP GKRASVVALD
160
SGLHVQQIWI QGQLASF
Length:167
Mass (Da):17,519
Last modified:October 11, 2004 - v3
Checksum:i1C3CB5AC3168FEEA
GO

Sequence cautioni

The sequence AAA57938 differs from that shown. Reason: Frameshift at position 114.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145S → R in AAA57938 (PubMed:9278503).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57938.1 Frameshift.
U00096 Genomic DNA No translation available.
AP009048 Genomic DNA Translation: BAE77181.1
PIRiC65103

Genome annotation databases

EnsemblBacteriaiBAE77181; BAE77181; BAE77181
KEGGiecj:JW5527
PATRICifig|83333.103.peg.4041

Similar proteinsi

Entry informationi

Entry nameiAGAA_ECOLI
AccessioniPrimary (citable) accession number: P42906
Secondary accession number(s): P76670, Q2M975, Q6BF43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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