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Protein

Putative N-acetylgalactosamine-6-phosphate deacetylase

Gene

agaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Catalytic activityi

N-acetyl-D-galactosamine 6-phosphate + H2O = D-galactosamine 6-phosphate + acetate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciEcoCyc:AGAA-MONOMER.
ECOL316407:JW5527-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative N-acetylgalactosamine-6-phosphate deacetylase (EC:3.5.1.-)
Gene namesi
Name:agaA
Ordered Locus Names:b3135, JW5527
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12766. agaA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Putative N-acetylgalactosamine-6-phosphate deacetylasePRO_0000170920Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi4261157. 4 interactions.
STRINGi316407.85675931.

Structurei

3D structure databases

ProteinModelPortaliP42906.
SMRiP42906. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NagA family.Curated

Phylogenomic databases

eggNOGiCOG1820. LUCA.
HOGENOMiHOG000202514.
InParanoidiP42906.
KOiK02079.
OMAiMCHSTAN.
PhylomeDBiP42906.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

P42906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCYNGMTGL HHREPGMVGA GLTDKRAWLE LIADGHHVHP AAMSLCCCCA
60 70 80 90 100
KERIVLITDA MQAAGMPDGR YTLCGEEVQM HGGVVRTASG GLAGSTLSVD
110 120 130 140 150
AAVRNMVELT GVTPAEAIHM ASLHPARMLG VDGVLGSLKP GKRASVVALD
160
SGLHVQQIWI QGQLASF
Length:167
Mass (Da):17,519
Last modified:October 11, 2004 - v3
Checksum:i1C3CB5AC3168FEEA
GO

Sequence cautioni

The sequence AAA57938 differs from that shown. Reason: Frameshift at position 114. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451S → R in AAA57938 (PubMed:9278503).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57938.1. Frameshift.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77181.1.
PIRiC65103.
RefSeqiWP_001485507.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiBAE77181; BAE77181; BAE77181.
KEGGiecj:JW5527.
PATRICi48665721. VBIEscCol107702_3166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57938.1. Frameshift.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77181.1.
PIRiC65103.
RefSeqiWP_001485507.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42906.
SMRiP42906. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261157. 4 interactions.
STRINGi316407.85675931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE77181; BAE77181; BAE77181.
KEGGiecj:JW5527.
PATRICi48665721. VBIEscCol107702_3166.

Organism-specific databases

EchoBASEiEB2619.
EcoGeneiEG12766. agaA.

Phylogenomic databases

eggNOGiCOG1820. LUCA.
HOGENOMiHOG000202514.
InParanoidiP42906.
KOiK02079.
OMAiMCHSTAN.
PhylomeDBiP42906.

Enzyme and pathway databases

BioCyciEcoCyc:AGAA-MONOMER.
ECOL316407:JW5527-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGAA_ECOLI
AccessioniPrimary (citable) accession number: P42906
Secondary accession number(s): P76670, Q2M975, Q6BF43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, AgaA in K-12 strains is not involved in the degradation of these compounds.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.