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Protein

N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2

Gene

agaV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7632-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2 (EC:2.7.1.-)
Alternative name(s):
EIIB-Aga'
PTS system N-acetylgalactosamine-specific EIIB component 2
Gene namesi
Name:agaV
Synonyms:yhaY
Ordered Locus Names:b3133, JW3102
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12764 agaV

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866591 – 157N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2Add BLAST157

Proteomic databases

PaxDbiP42904
PRIDEiP42904

Interactioni

Protein-protein interaction databases

BioGridi4261156, 10 interactors
IntActiP42904, 2 interactors
STRINGi316385.ECDH10B_3306

Structurei

3D structure databases

ProteinModelPortaliP42904
SMRiP42904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 157PTS EIIB type-4PROSITE-ProRule annotationAdd BLAST157

Domaini

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.

Phylogenomic databases

eggNOGiENOG4108RG5 Bacteria
COG3444 LUCA
HOGENOMiHOG000096437
InParanoidiP42904
KOiK02745
OMAiLVCKSPA
PhylomeDBiP42904

Family and domain databases

CDDicd00001 PTS_IIB_man, 1 hit
Gene3Di3.40.35.10, 1 hit
InterProiView protein in InterPro
IPR004720 PTS_IIB_sorbose-sp
IPR036667 PTS_IIB_sorbose-sp_sf
IPR018455 PTS_IIB_sorbose-sp_subgr
PfamiView protein in Pfam
PF03830 PTSIIB_sorb, 1 hit
SUPFAMiSSF52728 SSF52728, 1 hit
TIGRFAMsiTIGR00854 pts-sorbose, 1 hit
PROSITEiView protein in PROSITE
PS51101 PTS_EIIB_TYPE_4, 1 hit

Sequencei

Sequence statusi: Complete.

P42904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNIVLSRID ERLIHGQVGV QWVGFAGANL VLVANDEVAE DPVQQNLMEM
60 70 80 90 100
VLAEGIAVRF WTLQKVIDNI HRAADRQKIL LVCKTPADFL TLVKGGVPVN
110 120 130 140 150
RINVGNMHYA NGKQQIAKTV SVDAGDIAAF NDLKTAGVEC FVQGVPTEPA

VDLFKLL
Length:157
Mass (Da):17,086
Last modified:November 1, 1995 - v1
Checksum:i3DC895AD0CF15D41
GO

Sequence cautioni

The sequence AAA57936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57936.1 Different initiation.
U00096 Genomic DNA Translation: AAC76167.2
AP009048 Genomic DNA Translation: BAE77180.1
RefSeqiNP_417602.4, NC_000913.3
WP_001336162.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76167; AAC76167; b3133
BAE77180; BAE77180; BAE77180
GeneIDi947648
KEGGiecj:JW3102
eco:b3133
PATRICifig|1411691.4.peg.3598

Similar proteinsi

Entry informationi

Entry nameiPTPB2_ECOLI
AccessioniPrimary (citable) accession number: P42904
Secondary accession number(s): P76669, Q2M976
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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