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Protein

Colipase

Gene

CLPS

Organism
Myocastor coypus (Coypu) (Nutria)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiMyocastor coypus (Coypu) (Nutria)
Taxonomic identifieri10157 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaMyocastoridaeMyocastor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000000570018 – 22Enterostatin, activation peptideSequence analysis5
ChainiPRO_000000570123 – 111ColipaseAdd BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation

Structurei

3D structure databases

ProteinModelPortaliP42889.
SMRiP42889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005373.

Family and domain databases

CDDicd00039. COLIPASE. 1 hit.
InterProiView protein in InterPro
IPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiView protein in Pfam
PF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
PRINTSiPR00128. COLIPASE.
SMARTiView protein in SMART
SM00023. COLIPASE. 1 hit.
PROSITEiView protein in PROSITE
PS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLALVLL TLAVAYAAPD PRGLIINLDN GELCLNSAQC KSQCCQHDSP
60 70 80 90 100
LGLARCADKA RENSGCSPQT IYGIYYLCPC ERGLTCDGDK SIIGAITNTN
110
YGICQDPQSK K
Length:111
Mass (Da):11,899
Last modified:November 1, 1995 - v1
Checksum:i7FF37DE7C169616B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82998 mRNA. Translation: CAA58119.1.
PIRiI48204.

Similar proteinsi

Entry informationi

Entry nameiCOL_MYOCO
AccessioniPrimary (citable) accession number: P42889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families