P42884 (AAD14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative aryl-alcohol dehydrogenase AAD14
EC=1.1.1.-

Gene names

Name:	AAD14
Ordered Locus Names:	YNL331C
ORF Names:	N0300

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the aldo/keto reductase 2 family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-1994,EBI-1994
SRP1	Q02821	1	EBI-1994,EBI-1797

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Putative aryl-alcohol dehydrogenase AAD14		PRO_0000070369
Regions
	Nucleotide binding	236 – 246	11	NADP By similarity
Sites
	Active site	76	1	Proton donor By similarity
	Binding site	151	1	Substrate By similarity
	Site	103	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42884 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2265406386938313	FASTA	376	41,991
	10 20 30 40 50 60 MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM NKEQAFELLD 70 80 90 100 110 120 AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI ATKFTGDYKK YEVGGGKSAN 130 140 150 160 170 180 YCGNHKRSLH VSVRDSLRKL QTDWIDILYI HWWDYMSSIE EVMDSLHILV QQGKVLYLGV 190 200 210 220 230 240 SDTPAWVVSA ANYYATSHGK TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG 250 260 270 280 290 300 GRFQSKKAME ERKKNGEGLR TFVGGPEQTE LEVKISEALT KIAEEHGTES VTAIAIAYVR 310 320 330 340 350 360 SKAKNVFPLI GGRKIEHLKQ NIEALSIKLT PEQIEYLESI VPFDVGFPKS LIGDDPAVTK 370 KLSPLTSMSA RIAFDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase." van Dyck L., Pascual-Ahuir A., Purnelle B., Goffeau A. Yeast 11:987-991(1995) [PubMed: 8533474] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83226 Genomic DNA. Translation: CAA58227.1. Z71607 Genomic DNA. Translation: CAA96264.1. BK006947 Genomic DNA. Translation: DAA10232.1.
PIR	S51335.
RefSeq	NP_014068.1. NM_001183169.1.
3D structure databases
ProteinModelPortal	P42884.
SMR	P42884. Positions 17-343.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2146N.
IntAct	P42884. 4 interactions.
MINT	MINT-504689.
STRING	P42884.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL331C; YNL331C; YNL331C.
GeneID	855385.
KEGG	sce:YNL331C.
NMPDR	fig|4932.3.peg.5130.
Organism-specific databases
CYGD	YNL331c.
SGD	S000005275. AAD14.
Phylogenomic databases
eggNOG	fuNOG05818.
GeneTree	EFGT00050000001340.
HOGENOM	HBG605727.
OMA	AQFVVYQ.
OrthoDB	EOG45TGWW.
Gene expression databases
ArrayExpress	P42884.
Genevestigator	P42884.
GermOnline	YNL331C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
KO	K00100.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
ProtoNet	Search...
Other
NextBio	979184.

Entry information

Entry name

AAD14_YEAST

Accession

Primary (citable) accession number: P42884
Secondary accession number(s): D6W0L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program