Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative aryl-alcohol dehydrogenase AAD14

Gene

AAD14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton donorBy similarity
Sitei103 – 1031Lowers pKa of active site TyrBy similarity
Binding sitei151 – 1511SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi236 – 24611NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • aryl-alcohol dehydrogenase (NAD+) activity Source: SGD

GO - Biological processi

  • cellular aldehyde metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:YNL331C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aryl-alcohol dehydrogenase AAD14 (EC:1.1.1.-)
Gene namesi
Name:AAD14
Ordered Locus Names:YNL331C
ORF Names:N0300
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL331C.
SGDiS000005275. AAD14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Putative aryl-alcohol dehydrogenase AAD14PRO_0000070369Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-1994,EBI-18140

Protein-protein interaction databases

BioGridi35510. 3 interactions.
DIPiDIP-2146N.
IntActiP42884. 3 interactions.
MINTiMINT-504689.

Structurei

3D structure databases

ProteinModelPortaliP42884.
SMRiP42884. Positions 24-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000049995.
HOGENOMiHOG000250275.
InParanoidiP42884.
OMAiITTHRST.
OrthoDBiEOG7DRJCT.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.

Sequencei

Sequence statusi: Complete.

P42884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM
60 70 80 90 100
NKEQAFELLD AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI
110 120 130 140 150
ATKFTGDYKK YEVGGGKSAN YCGNHKRSLH VSVRDSLRKL QTDWIDILYI
160 170 180 190 200
HWWDYMSSIE EVMDSLHILV QQGKVLYLGV SDTPAWVVSA ANYYATSHGK
210 220 230 240 250
TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG GRFQSKKAME
260 270 280 290 300
ERKKNGEGLR TFVGGPEQTE LEVKISEALT KIAEEHGTES VTAIAIAYVR
310 320 330 340 350
SKAKNVFPLI GGRKIEHLKQ NIEALSIKLT PEQIEYLESI VPFDVGFPKS
360 370
LIGDDPAVTK KLSPLTSMSA RIAFDN
Length:376
Mass (Da):41,991
Last modified:November 1, 1995 - v1
Checksum:i2265406386938313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83226 Genomic DNA. Translation: CAA58227.1.
Z71607 Genomic DNA. Translation: CAA96264.1.
BK006947 Genomic DNA. Translation: DAA10232.1.
PIRiS51335.
RefSeqiNP_014068.1. NM_001183169.1.

Genome annotation databases

EnsemblFungiiYNL331C; YNL331C; YNL331C.
GeneIDi855385.
KEGGisce:YNL331C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83226 Genomic DNA. Translation: CAA58227.1.
Z71607 Genomic DNA. Translation: CAA96264.1.
BK006947 Genomic DNA. Translation: DAA10232.1.
PIRiS51335.
RefSeqiNP_014068.1. NM_001183169.1.

3D structure databases

ProteinModelPortaliP42884.
SMRiP42884. Positions 24-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35510. 3 interactions.
DIPiDIP-2146N.
IntActiP42884. 3 interactions.
MINTiMINT-504689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL331C; YNL331C; YNL331C.
GeneIDi855385.
KEGGisce:YNL331C.

Organism-specific databases

EuPathDBiFungiDB:YNL331C.
SGDiS000005275. AAD14.

Phylogenomic databases

GeneTreeiENSGT00510000049995.
HOGENOMiHOG000250275.
InParanoidiP42884.
OMAiITTHRST.
OrthoDBiEOG7DRJCT.

Enzyme and pathway databases

BioCyciYEAST:YNL331C-MONOMER.

Miscellaneous databases

NextBioi979184.
PROiP42884.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase."
    van Dyck L., Pascual-Ahuir A., Purnelle B., Goffeau A.
    Yeast 11:987-991(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiAAD14_YEAST
AccessioniPrimary (citable) accession number: P42884
Secondary accession number(s): D6W0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.