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Protein

Putative aryl-alcohol dehydrogenase AAD14

Gene

AAD14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Proton donorBy similarity1
Sitei103Lowers pKa of active site TyrBy similarity1
Binding sitei151SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi236 – 246NADPBy similarityAdd BLAST11

GO - Molecular functioni

  • aryl-alcohol dehydrogenase (NAD+) activity Source: SGD

GO - Biological processi

  • cellular aldehyde metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:YNL331C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aryl-alcohol dehydrogenase AAD14 (EC:1.1.1.-)
Gene namesi
Name:AAD14
Ordered Locus Names:YNL331C
ORF Names:N0300
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL331C.
SGDiS000005275. AAD14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703691 – 376Putative aryl-alcohol dehydrogenase AAD14Add BLAST376

Proteomic databases

PRIDEiP42884.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-1994,EBI-18140

Protein-protein interaction databases

BioGridi35510. 3 interactors.
DIPiDIP-2146N.
IntActiP42884. 3 interactors.
MINTiMINT-504689.

Structurei

3D structure databases

ProteinModelPortaliP42884.
SMRiP42884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000049995.
HOGENOMiHOG000250275.
InParanoidiP42884.
OMAiSNYLGWQ.
OrthoDBiEOG092C2C0Y.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.

Sequencei

Sequence statusi: Complete.

P42884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM
60 70 80 90 100
NKEQAFELLD AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI
110 120 130 140 150
ATKFTGDYKK YEVGGGKSAN YCGNHKRSLH VSVRDSLRKL QTDWIDILYI
160 170 180 190 200
HWWDYMSSIE EVMDSLHILV QQGKVLYLGV SDTPAWVVSA ANYYATSHGK
210 220 230 240 250
TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG GRFQSKKAME
260 270 280 290 300
ERKKNGEGLR TFVGGPEQTE LEVKISEALT KIAEEHGTES VTAIAIAYVR
310 320 330 340 350
SKAKNVFPLI GGRKIEHLKQ NIEALSIKLT PEQIEYLESI VPFDVGFPKS
360 370
LIGDDPAVTK KLSPLTSMSA RIAFDN
Length:376
Mass (Da):41,991
Last modified:November 1, 1995 - v1
Checksum:i2265406386938313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83226 Genomic DNA. Translation: CAA58227.1.
Z71607 Genomic DNA. Translation: CAA96264.1.
BK006947 Genomic DNA. Translation: DAA10232.1.
PIRiS51335.
RefSeqiNP_014068.1. NM_001183169.1.

Genome annotation databases

EnsemblFungiiYNL331C; YNL331C; YNL331C.
GeneIDi855385.
KEGGisce:YNL331C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83226 Genomic DNA. Translation: CAA58227.1.
Z71607 Genomic DNA. Translation: CAA96264.1.
BK006947 Genomic DNA. Translation: DAA10232.1.
PIRiS51335.
RefSeqiNP_014068.1. NM_001183169.1.

3D structure databases

ProteinModelPortaliP42884.
SMRiP42884.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35510. 3 interactors.
DIPiDIP-2146N.
IntActiP42884. 3 interactors.
MINTiMINT-504689.

Proteomic databases

PRIDEiP42884.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL331C; YNL331C; YNL331C.
GeneIDi855385.
KEGGisce:YNL331C.

Organism-specific databases

EuPathDBiFungiDB:YNL331C.
SGDiS000005275. AAD14.

Phylogenomic databases

GeneTreeiENSGT00510000049995.
HOGENOMiHOG000250275.
InParanoidiP42884.
OMAiSNYLGWQ.
OrthoDBiEOG092C2C0Y.

Enzyme and pathway databases

BioCyciYEAST:YNL331C-MONOMER.

Miscellaneous databases

PROiP42884.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAAD14_YEAST
AccessioniPrimary (citable) accession number: P42884
Secondary accession number(s): D6W0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.