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Protein

Putative aryl-alcohol dehydrogenase AAD14

Gene

AAD14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Proton donorBy similarity1
Sitei103Lowers pKa of active site TyrBy similarity1
Binding sitei151SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi236 – 246NADPBy similarityAdd BLAST11

GO - Molecular functioni

  • aryl-alcohol dehydrogenase (NAD+) activity Source: SGD

GO - Biological processi

  • cellular aldehyde metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciYEAST:YNL331C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aryl-alcohol dehydrogenase AAD14 (EC:1.1.1.-)
Gene namesi
Name:AAD14
Ordered Locus Names:YNL331C
ORF Names:N0300
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL331C
SGDiS000005275 AAD14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703691 – 376Putative aryl-alcohol dehydrogenase AAD14Add BLAST376

Proteomic databases

PaxDbiP42884
PRIDEiP42884

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-1994,EBI-18140

Protein-protein interaction databases

BioGridi35510, 42 interactors
DIPiDIP-2146N
IntActiP42884, 5 interactors
MINTiP42884
STRINGi4932.YNL331C

Structurei

3D structure databases

ProteinModelPortaliP42884
SMRiP42884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000049995
HOGENOMiHOG000250275
InParanoidiP42884
OMAiMRYNQLG
OrthoDBiEOG092C2C0Y

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
SUPFAMiSSF51430 SSF51430, 1 hit

Sequencei

Sequence statusi: Complete.

P42884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM
60 70 80 90 100
NKEQAFELLD AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI
110 120 130 140 150
ATKFTGDYKK YEVGGGKSAN YCGNHKRSLH VSVRDSLRKL QTDWIDILYI
160 170 180 190 200
HWWDYMSSIE EVMDSLHILV QQGKVLYLGV SDTPAWVVSA ANYYATSHGK
210 220 230 240 250
TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG GRFQSKKAME
260 270 280 290 300
ERKKNGEGLR TFVGGPEQTE LEVKISEALT KIAEEHGTES VTAIAIAYVR
310 320 330 340 350
SKAKNVFPLI GGRKIEHLKQ NIEALSIKLT PEQIEYLESI VPFDVGFPKS
360 370
LIGDDPAVTK KLSPLTSMSA RIAFDN
Length:376
Mass (Da):41,991
Last modified:November 1, 1995 - v1
Checksum:i2265406386938313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83226 Genomic DNA Translation: CAA58227.1
Z71607 Genomic DNA Translation: CAA96264.1
BK006947 Genomic DNA Translation: DAA10232.1
PIRiS51335
RefSeqiNP_014068.1, NM_001183169.1

Genome annotation databases

EnsemblFungiiYNL331C; YNL331C; YNL331C
GeneIDi855385
KEGGisce:YNL331C

Similar proteinsi

Entry informationi

Entry nameiAAD14_YEAST
AccessioniPrimary (citable) accession number: P42884
Secondary accession number(s): D6W0L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health