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P42881

- GPT_SCHPO

UniProt

P42881 - GPT_SCHPO

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Protein
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Gene
gpt2, gpt, SPBC15D4.04
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.

Enzyme regulationi

Inhibited by tunicamycin.

Pathwayi

GO - Molecular functioni

  1. UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity Source: PomBase
  2. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: InterPro
  3. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. N-glycan processing Source: PomBase
  2. dolichyl diphosphate biosynthetic process Source: PomBase
  3. protein N-linked glycosylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC:2.7.8.15)
Alternative name(s):
GlcNAc-1-P transferase
Short name:
G1PT
Short name:
GPT
N-acetylglucosamine-1-phosphate transferase
Gene namesi
Name:gpt2
Synonyms:gpt
ORF Names:SPBC15D4.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC15D4.04.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Transmembranei123 – 14321Helical; Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Transmembranei254 – 27421Helical; Reviewed prediction
Add
BLAST
Transmembranei282 – 30221Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Transmembranei412 – 43221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. integral component of endoplasmic reticulum membrane Source: PomBase
  3. integral component of membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
PRO_0000108764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP42881.

Interactioni

Protein-protein interaction databases

MINTiMINT-4690327.
STRINGi4896.SPBC15D4.04-1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472.
HOGENOMiHOG000163915.
KOiK01001.
OMAiIHERNLT.
OrthoDBiEOG7380DT.
PhylomeDBiP42881.

Family and domain databases

InterProiIPR000715. Glycosyl_transferase_4.
[Graphical view]
PfamiPF00953. Glycos_transf_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42881-1 [UniParc]FASTAAdd to Basket

« Hide

MIESCFNVGI WATGLALLMN QGQSPLLSNV GLSVLAYKAT AMFIPRVGPS    50
FIKRGFSGKD MNKVEKYVIP ETMGAVSALV YFMCMIIFIP VLFYKYLVPN 100
HNPNLPSDGS VAEVAKSQFP HDLLGAYLSA LLSILSVSLL GILDDLFDIR 150
WRHKFFLPAI AAIPLLVVYY VDYGVTYVSV PSIVRPFLKR SLINLGFLYY 200
FYMAAVAIFC PNSINIIAGV NGVEAGQSLV LALVIACNDL FYVLSPKNKD 250
ALRAHLLSLY LVLPLIGVTA GLLKYNWWPS RVFVGDTFCY FAGMVMAVVG 300
ILGHFSKTLM LFFIPQIFNF ALSVPQLFGL VECPRHRLPK LNVKTGLLEN 350
SYTEFSLNEH PLPKKTLLTI SIFEKLRLIR VEYDPSTGRP LRCTNFTIIN 400
FVLYHLGPMR EDHLTICIMG LQLLTGIFGL IIRHFVAPLV YPEDNI 446
Length:446
Mass (Da):49,855
Last modified:November 1, 1995 - v1
Checksum:i16CAB90E5FBFF15F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09454 Genomic DNA. Translation: AAA92799.1.
CU329671 Genomic DNA. Translation: CAA20479.1.
PIRiS71622.
RefSeqiNP_596244.1. NM_001022163.2.

Genome annotation databases

EnsemblFungiiSPBC15D4.04.1; SPBC15D4.04.1:pep; SPBC15D4.04.
GeneIDi2539795.
KEGGispo:SPBC15D4.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09454 Genomic DNA. Translation: AAA92799.1 .
CU329671 Genomic DNA. Translation: CAA20479.1 .
PIRi S71622.
RefSeqi NP_596244.1. NM_001022163.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4690327.
STRINGi 4896.SPBC15D4.04-1.

Proteomic databases

MaxQBi P42881.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC15D4.04.1 ; SPBC15D4.04.1:pep ; SPBC15D4.04 .
GeneIDi 2539795.
KEGGi spo:SPBC15D4.04.

Organism-specific databases

PomBasei SPBC15D4.04.

Phylogenomic databases

eggNOGi COG0472.
HOGENOMi HOG000163915.
KOi K01001.
OMAi IHERNLT.
OrthoDBi EOG7380DT.
PhylomeDBi P42881.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 20800944.
PROi P42881.

Family and domain databases

InterProi IPR000715. Glycosyl_transferase_4.
[Graphical view ]
Pfami PF00953. Glycos_transf_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Asparagine-linked glycosylation in Schizosaccharomyces pombe: functional conservation of the first step in oligosaccharide-lipid assembly."
    Zou J., Scocca J.R., Krag S.S.
    Arch. Biochem. Biophys. 317:487-496(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGPT_SCHPO
AccessioniPrimary (citable) accession number: P42881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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