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Protein

Urease subunit alpha

Gene

ureC

Organism
Staphylococcus xylosus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit alpha (ureC), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi138 – 1381Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi140 – 1401Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi221 – 2211Nickel 1; via carbamate groupUniRule annotation
Metal bindingi221 – 2211Nickel 2; via carbamate groupUniRule annotation
Binding sitei223 – 2231SubstrateUniRule annotation
Metal bindingi250 – 2501Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi276 – 2761Nickel 2; via tele nitrogenUniRule annotation
Active sitei324 – 3241Proton donorUniRule annotation
Metal bindingi364 – 3641Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Protein family/group databases

MEROPSiM38.982.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
OrganismiStaphylococcus xylosus
Taxonomic identifieri1288 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 571570Urease subunit alphaPRO_0000067560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei221 – 2211N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP42873.
SMRiP42873. Positions 5-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 571439UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKMTQSQY TSLYGPTVGD SVRLGDTNLF ARVEKDYATY GDEAAFGGGK
60 70 80 90 100
SIRDGMAQNP NVTRDDKQVA DLVITNALIL DYDKIVKADI GVKNGYIMKI
110 120 130 140 150
GKAGNPDIMD NVDIIIGATT DIISAEGKIV TAGGIDTHVH FVNPEQSQVA
160 170 180 190 200
LESGITTHIG GGTGASEGAK ATTVTPGPWH LHRMLLAAES LPLNIGFTGK
210 220 230 240 250
GQAVNHTALV EQIHAGAIGL KVHEDWGATP SALDHALQVA DDYDVQIALH
260 270 280 290 300
ADTLNEAGFM EETMAAVKDR VLHMYHTEGA GGGHAPDLIK SAAYSNILPS
310 320 330 340 350
STNPTLPYTV NTIDEHLDMV MITHHLNASI PEDIAFADSR IRKETIAAED
360 370 380 390 400
VLQDIGVFSM VSSDSQAMGR VGEVITRTWQ VAHRMKEQRG SLDGDSEYND
410 420 430 440 450
NNRIKRYIAK YTINPAITHG ISDYVGSIDE GKLADIIMWE PAFFAVKPDV
460 470 480 490 500
IVKGGLINPA INGDANGSIP TSEPLKYRKM YGQLGGNMQG TSMTFVSTTA
510 520 530 540 550
YENDIGKLLG LKRKLRPVHN IRKLTKADMK NNSATPKIDV DPQTYEVFVD
560 570
GEKITSEPAT ELPLTQRYFL F
Length:571
Mass (Da):61,813
Last modified:January 23, 2007 - v3
Checksum:i37E24A0805E2EF10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74600 Genomic DNA. Translation: CAA52680.1.
PIRiS38485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74600 Genomic DNA. Translation: CAA52680.1.
PIRiS38485.

3D structure databases

ProteinModelPortaliP42873.
SMRiP42873. Positions 5-571.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM38.982.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE1_STAXY
AccessioniPrimary (citable) accession number: P42873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.