Reviewed, UniProtKB/Swiss-Prot P42865 (QOR_LEIAM)

Names and origin

Protein names	Recommended name:     Probable quinone oxidoreductase     EC=1.6.5.5 Alternative name(s):     NADPH:quinone reductase     P36
Organism	Leishmania amazonensis
Taxonomic identifier	5659 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NADPH + 2 quinone = NADP+ + 2 semiquinone.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADPH:quinone reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Probable quinone oxidoreductase		PRO_0000160911

Sequences

	Sequence		Length	Mass (Da)
	P42865-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4D9255AB56856625	FASTA	340	36,272
	10 20 30 40 50 60 MSSPSNFKKL QVVSLSKDFR SSTSVVEAHL PEEVPEGMVR VSVKYAGVNA SDLNFTNGSY 70 80 90 100 110 120 FKNVQPPFDC GFEAAGTVVQ IGAGVANVKV GDHVVLMQYG CFAEFLDAPA ERCIPVPELK 130 140 150 160 170 180 PEYSVLPVSA LTAAVALGEV GRVKKGDVAL VTAAAGGTGQ IAVQLLKHVY GCTVIGTCSS 190 200 210 220 230 240 EEKAEFLKSI GCDHVINYKT ESLDGRLHEL CPKGVDVVYE CVGGHTFNDA VRHVAVHARV 250 260 270 280 290 300 VIIGSISSYK SGEVVPFSDP SGTSVTMLLL VKSASLNGFF LPQFHDVIPK YMANLLQYLK 310 320 330 340 AGQVKLFVDK KVFHGLSSVA DAVDHLYSGA NYGKVLVEIQ

References

[1]

"Identification by extrachromosomal amplification and overexpression of a zeta-crystallin/NADPH-oxidoreductase homologue constitutively expressed in Leishmania spp." Liu X., Chang K.P. Mol. Biochem. Parasitol. 66:201-210(1994) [PubMed: 7808470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11705 Genomic DNA. Translation: AAA73554.1.
3D structure databases
SMR	P42865. Positions 2-339.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.6.5.5. 267701.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QOR_LEIAM

Accession

Primary (citable) accession number: P42865

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)