P42862 (G6PIA_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase, cytosolic A
Short name=GPI-A
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase A
Short name=PGI-A
Phosphohexose isomerase A
Short name=PHI-A

Gene names

Ordered Locus Names:	Os03g0776000, LOC_Os03g56460
ORF Names:	OSJNBa0070N04.5

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from expression pattern. Source: Gramene glycolysis Inferred from expression pattern. Source: Gramene
Cellular component	cytosol Inferred from direct assay. Source: Gramene
Molecular function	glucose-6-phosphate isomerase activity Inferred from direct assay. Source: Gramene
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 567	567	Glucose-6-phosphate isomerase, cytosolic A		PRO_0000180566
Sites
	Active site	360	1	Proton donor By similarity
	Active site	391	1	By similarity
	Active site	516	1	By similarity
Experimental info
	Sequence conflict	374	1	P → S in BAA08148. Ref.1
	Sequence conflict	377	1	S → T in BAA08148. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P42862 [UniParc]. Last modified March 7, 2006. Version 2. Checksum: E01202380A9A9C8E	FASTA	567	62,524
	10 20 30 40 50 60 MASSALICDT EQWKGLQAHV GEIQKTHLRH LMHDVERCKA MTAEYEGIYL DYSRQRATGE 70 80 90 100 110 120 TMEKLFKLAE AAKLKEKIEK MFRGDKINST ENRSVLHVAL RAPRDEVINS NGVNVVPEVW 130 140 150 160 170 180 GVKDKIKQFS ETFRSGSWVG ATGKALTNVV SVGIGGSFLG PLFVHAALQT DPEAAESAKG 190 200 210 220 230 240 RQLRFLANVD PVDVARSIKD LDPETTLVVV VSKTFTTAET MLNARTLKEW IVSSLGPDAV 250 260 270 280 290 300 AKHMIAVSTN LELVEKFGID PKNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFPIVQKFLE 310 320 330 340 350 360 GAASIDKHFR SSSFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKF APHIQQLSME 370 380 390 400 410 420 SNGKGVSIDG VQLPFESGEI DFGEPGTNGQ HSFYQLIHQG RVIPCDFIGV VKSQQPVYLK 430 440 450 460 470 480 GEIVSNHDEL MSNFFAQPDA LAYGKTPEQL HSEKVPEHLI PHKTFQGNRP SLSLLLPSLS 490 500 510 520 530 540 AYEIGQLLAI YEHRIAVQGF LWGINSFDQW GVELGKSLAS QVRKSLHASR VEGKPVLGFN 550 560 SSTTSLLTRY LAVEPSTPYN TTTLPKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of cDNA encoding for phosphoglucose isomerase of rice (Oryza sativa L.)." Nozue F., Umeda M., Nagamura Y., Minobe Y., Uchimiya H. DNA Seq. 6:127-135(1996) [PubMed: 8722567] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species." The rice chromosome 3 sequencing consortium Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S. , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S. Genome Res. 15:1284-1291(2005) [PubMed: 16109971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D45217 mRNA. Translation: BAA08148.1. AC091494 Genomic DNA. Translation: AAN65024.1.
PIR	T03948.
RefSeq	NP_001051434.1. NM_001057969.1.
UniGene	Os.154.
3D structure databases
ProteinModelPortal	P42862.
ModBase	Search...
Protein-protein interaction databases
STRING	P42862.
Proteomic databases
PRIDE	P42862.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os03g56460.1; LOC_Os03g56460.1; LOC_Os03g56460. LOC_Os03g56460.2; LOC_Os03g56460.2; LOC_Os03g56460.
GeneID	4334290.
KEGG	osa:4334290.
Organism-specific databases
Gramene	P42862.
Phylogenomic databases
OMA	GPKIVSQ.
PhylomeDB	P42862.
ProtClustDB	PLN02649.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PIA_ORYSJ

Accession

Primary (citable) accession number: P42862
Secondary accession number(s): Q8H8M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program