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Protein

Glucose-6-phosphate isomerase

Gene

PGI

Organism
Leishmania mexicana
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PGI)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase (ald)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei410Proton donorBy similarity1
Active sitei441By similarity1
Active sitei569By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI
OrganismiLeishmania mexicana
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805461 – 605Glucose-6-phosphate isomeraseAdd BLAST605

Proteomic databases

PRIDEiP42861.

Structurei

Secondary structure

1605
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi50 – 52Combined sources3
Helixi54 – 66Combined sources13
Helixi71 – 77Combined sources7
Helixi81 – 84Combined sources4
Beta strandi86 – 90Combined sources5
Beta strandi97 – 101Combined sources5
Beta strandi104 – 106Combined sources3
Helixi109 – 121Combined sources13
Helixi124 – 132Combined sources9
Turni139 – 142Combined sources4
Helixi147 – 150Combined sources4
Helixi165 – 185Combined sources21
Beta strandi198 – 202Combined sources5
Helixi205 – 207Combined sources3
Helixi209 – 217Combined sources9
Helixi219 – 221Combined sources3
Beta strandi224 – 231Combined sources8
Helixi237 – 243Combined sources7
Helixi248 – 250Combined sources3
Beta strandi251 – 256Combined sources6
Beta strandi258 – 260Combined sources3
Helixi263 – 282Combined sources20
Helixi290 – 294Combined sources5
Beta strandi295 – 298Combined sources4
Helixi302 – 307Combined sources6
Helixi312 – 314Combined sources3
Helixi324 – 326Combined sources3
Helixi331 – 333Combined sources3
Helixi334 – 361Combined sources28
Helixi364 – 366Combined sources3
Helixi368 – 381Combined sources14
Beta strandi387 – 394Combined sources8
Helixi395 – 397Combined sources3
Helixi400 – 412Combined sources13
Beta strandi430 – 432Combined sources3
Helixi438 – 441Combined sources4
Helixi444 – 449Combined sources6
Beta strandi450 – 452Combined sources3
Beta strandi456 – 463Combined sources8
Beta strandi465 – 470Combined sources6
Helixi471 – 488Combined sources18
Helixi492 – 501Combined sources10
Turni508 – 512Combined sources5
Helixi513 – 516Combined sources4
Beta strandi525 – 530Combined sources6
Helixi534 – 555Combined sources22
Helixi563 – 565Combined sources3
Helixi566 – 575Combined sources10
Helixi576 – 578Combined sources3
Helixi590 – 602Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q50X-ray2.60A44-604[»]
1T10X-ray2.35A1-605[»]
ProteinModelPortaliP42861.
SMRiP42861.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42861.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYFSKLKE HVVESTEING CTPSIATATF NAPYEVARKT KMLGVTDSSL
60 70 80 90 100
LNLPAWKRLQ SLYEKYGNDS ILSHFEKDHQ RFQRYSIEID LHSDDNFLFL
110 120 130 140 150
DYSKSHINDE IKDALVALAE ERGVRAFAKA MFDGQRVNST ENRAVLHVAL
160 170 180 190 200
RNRSNRPIIV DGKDVMSDVN NVLAQMKDFT ERVRSGEWKG QTGKSIYNIV
210 220 230 240 250
NIGIGGSDLG PVMVTEALKP FSKRDLHCFF VSNVDGTHMA EVLKQVNLEE
260 270 280 290 300
TIFIIASKTF TTQETLTNAM SARNALMSYL KENGISTDGA VAKHFVALST
310 320 330 340 350
NTEKVREFGI DTVNMFAFWD WVGGRYSVWS AIGLSVMLSI GYDNFVEFLT
360 370 380 390 400
GAHVMDNHFA STPTEQNLPM MLALVGIWYN NFFGSETQAV LPYDQYLWRL
410 420 430 440 450
PAYLQQLDME SNGKGVTKKS GAVAVQTGPI VFGEAGTNGQ HAFYQLIHQG
460 470 480 490 500
TKIIPCDFIG CVQTQNRVGD HHRTLMSNFF AQTEALMVGK NAEEVRQELV
510 520 530 540 550
KSGMSGDAIE NMIPHKTFTG SRPSNSILVN ALTPRALGAI IAMYEHKVLV
560 570 580 590 600
QGAIWGINSY DQWGVELGKV LAKSILPQLK SGNIVSDHDG STNGLINMFN

TRAHL
Length:605
Mass (Da):67,287
Last modified:November 1, 1995 - v1
Checksum:i5C43210BF13FED71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78206 Genomic DNA. Translation: CAA55042.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78206 Genomic DNA. Translation: CAA55042.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q50X-ray2.60A44-604[»]
1T10X-ray2.35A1-605[»]
ProteinModelPortaliP42861.
SMRiP42861.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP42861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Miscellaneous databases

EvolutionaryTraceiP42861.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_LEIME
AccessioniPrimary (citable) accession number: P42861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.