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Protein

Glucose-6-phosphate isomerase

Gene

PGI

Organism
Leishmania mexicana
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101Proton donorBy similarity
Active sitei441 – 4411By similarity
Active sitei569 – 5691By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI
OrganismiLeishmania mexicana
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Glucose-6-phosphate isomerasePRO_0000180546Add
BLAST

Proteomic databases

PRIDEiP42861.

Structurei

Secondary structure

1
605
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi50 – 523Combined sources
Helixi54 – 6613Combined sources
Helixi71 – 777Combined sources
Helixi81 – 844Combined sources
Beta strandi86 – 905Combined sources
Beta strandi97 – 1015Combined sources
Beta strandi104 – 1063Combined sources
Helixi109 – 12113Combined sources
Helixi124 – 1329Combined sources
Turni139 – 1424Combined sources
Helixi147 – 1504Combined sources
Helixi165 – 18521Combined sources
Beta strandi198 – 2025Combined sources
Helixi205 – 2073Combined sources
Helixi209 – 2179Combined sources
Helixi219 – 2213Combined sources
Beta strandi224 – 2318Combined sources
Helixi237 – 2437Combined sources
Helixi248 – 2503Combined sources
Beta strandi251 – 2566Combined sources
Beta strandi258 – 2603Combined sources
Helixi263 – 28220Combined sources
Helixi290 – 2945Combined sources
Beta strandi295 – 2984Combined sources
Helixi302 – 3076Combined sources
Helixi312 – 3143Combined sources
Helixi324 – 3263Combined sources
Helixi331 – 3333Combined sources
Helixi334 – 36128Combined sources
Helixi364 – 3663Combined sources
Helixi368 – 38114Combined sources
Beta strandi387 – 3948Combined sources
Helixi395 – 3973Combined sources
Helixi400 – 41213Combined sources
Beta strandi430 – 4323Combined sources
Helixi438 – 4414Combined sources
Helixi444 – 4496Combined sources
Beta strandi450 – 4523Combined sources
Beta strandi456 – 4638Combined sources
Beta strandi465 – 4706Combined sources
Helixi471 – 48818Combined sources
Helixi492 – 50110Combined sources
Turni508 – 5125Combined sources
Helixi513 – 5164Combined sources
Beta strandi525 – 5306Combined sources
Helixi534 – 55522Combined sources
Helixi563 – 5653Combined sources
Helixi566 – 57510Combined sources
Helixi576 – 5783Combined sources
Helixi590 – 60213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q50X-ray2.60A44-604[»]
1T10X-ray2.35A1-605[»]
ProteinModelPortaliP42861.
SMRiP42861. Positions 44-604.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42861.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYFSKLKE HVVESTEING CTPSIATATF NAPYEVARKT KMLGVTDSSL
60 70 80 90 100
LNLPAWKRLQ SLYEKYGNDS ILSHFEKDHQ RFQRYSIEID LHSDDNFLFL
110 120 130 140 150
DYSKSHINDE IKDALVALAE ERGVRAFAKA MFDGQRVNST ENRAVLHVAL
160 170 180 190 200
RNRSNRPIIV DGKDVMSDVN NVLAQMKDFT ERVRSGEWKG QTGKSIYNIV
210 220 230 240 250
NIGIGGSDLG PVMVTEALKP FSKRDLHCFF VSNVDGTHMA EVLKQVNLEE
260 270 280 290 300
TIFIIASKTF TTQETLTNAM SARNALMSYL KENGISTDGA VAKHFVALST
310 320 330 340 350
NTEKVREFGI DTVNMFAFWD WVGGRYSVWS AIGLSVMLSI GYDNFVEFLT
360 370 380 390 400
GAHVMDNHFA STPTEQNLPM MLALVGIWYN NFFGSETQAV LPYDQYLWRL
410 420 430 440 450
PAYLQQLDME SNGKGVTKKS GAVAVQTGPI VFGEAGTNGQ HAFYQLIHQG
460 470 480 490 500
TKIIPCDFIG CVQTQNRVGD HHRTLMSNFF AQTEALMVGK NAEEVRQELV
510 520 530 540 550
KSGMSGDAIE NMIPHKTFTG SRPSNSILVN ALTPRALGAI IAMYEHKVLV
560 570 580 590 600
QGAIWGINSY DQWGVELGKV LAKSILPQLK SGNIVSDHDG STNGLINMFN

TRAHL
Length:605
Mass (Da):67,287
Last modified:October 31, 1995 - v1
Checksum:i5C43210BF13FED71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78206 Genomic DNA. Translation: CAA55042.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78206 Genomic DNA. Translation: CAA55042.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q50X-ray2.60A44-604[»]
1T10X-ray2.35A1-605[»]
ProteinModelPortaliP42861.
SMRiP42861. Positions 44-604.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP42861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Miscellaneous databases

EvolutionaryTraceiP42861.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Subcellular distribution and characterization of glucosephosphate isomerase in Leishmania mexicana mexicana."
    Nyame K., Do Thi C.D., Opperdoes F.R., Michels P.A.M.
    Mol. Biochem. Parasitol. 67:269-279(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NHOM/BZ/84/BEL46.

Entry informationi

Entry nameiG6PI_LEIME
AccessioniPrimary (citable) accession number: P42861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: January 6, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.