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P42861

- G6PI_LEIME

UniProt

P42861 - G6PI_LEIME

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Protein

Glucose-6-phosphate isomerase

Gene

PGI

Organism
Leishmania mexicana
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101Proton donorBy similarity
Active sitei441 – 4411By similarity
Active sitei569 – 5691By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI
OrganismiLeishmania mexicana
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Glucose-6-phosphate isomerasePRO_0000180546Add
BLAST

Proteomic databases

PRIDEiP42861.

Structurei

Secondary structure

1
605
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi50 – 523
Helixi54 – 6613
Helixi71 – 777
Helixi81 – 844
Beta strandi86 – 905
Beta strandi97 – 1015
Beta strandi104 – 1063
Helixi109 – 12113
Helixi124 – 1329
Turni139 – 1424
Helixi147 – 1504
Helixi165 – 18521
Beta strandi198 – 2025
Helixi205 – 2073
Helixi209 – 2179
Helixi219 – 2213
Beta strandi224 – 2318
Helixi237 – 2437
Helixi248 – 2503
Beta strandi251 – 2566
Beta strandi258 – 2603
Helixi263 – 28220
Helixi290 – 2945
Beta strandi295 – 2984
Helixi302 – 3076
Helixi312 – 3143
Helixi324 – 3263
Helixi331 – 3333
Helixi334 – 36128
Helixi364 – 3663
Helixi368 – 38114
Beta strandi387 – 3948
Helixi395 – 3973
Helixi400 – 41213
Beta strandi430 – 4323
Helixi438 – 4414
Helixi444 – 4496
Beta strandi450 – 4523
Beta strandi456 – 4638
Beta strandi465 – 4706
Helixi471 – 48818
Helixi492 – 50110
Turni508 – 5125
Helixi513 – 5164
Beta strandi525 – 5306
Helixi534 – 55522
Helixi563 – 5653
Helixi566 – 57510
Helixi576 – 5783
Helixi590 – 60213

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q50X-ray2.60A44-604[»]
1T10X-ray2.35A1-605[»]
ProteinModelPortaliP42861.
SMRiP42861. Positions 44-604.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42861.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42861-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDYFSKLKE HVVESTEING CTPSIATATF NAPYEVARKT KMLGVTDSSL
60 70 80 90 100
LNLPAWKRLQ SLYEKYGNDS ILSHFEKDHQ RFQRYSIEID LHSDDNFLFL
110 120 130 140 150
DYSKSHINDE IKDALVALAE ERGVRAFAKA MFDGQRVNST ENRAVLHVAL
160 170 180 190 200
RNRSNRPIIV DGKDVMSDVN NVLAQMKDFT ERVRSGEWKG QTGKSIYNIV
210 220 230 240 250
NIGIGGSDLG PVMVTEALKP FSKRDLHCFF VSNVDGTHMA EVLKQVNLEE
260 270 280 290 300
TIFIIASKTF TTQETLTNAM SARNALMSYL KENGISTDGA VAKHFVALST
310 320 330 340 350
NTEKVREFGI DTVNMFAFWD WVGGRYSVWS AIGLSVMLSI GYDNFVEFLT
360 370 380 390 400
GAHVMDNHFA STPTEQNLPM MLALVGIWYN NFFGSETQAV LPYDQYLWRL
410 420 430 440 450
PAYLQQLDME SNGKGVTKKS GAVAVQTGPI VFGEAGTNGQ HAFYQLIHQG
460 470 480 490 500
TKIIPCDFIG CVQTQNRVGD HHRTLMSNFF AQTEALMVGK NAEEVRQELV
510 520 530 540 550
KSGMSGDAIE NMIPHKTFTG SRPSNSILVN ALTPRALGAI IAMYEHKVLV
560 570 580 590 600
QGAIWGINSY DQWGVELGKV LAKSILPQLK SGNIVSDHDG STNGLINMFN

TRAHL
Length:605
Mass (Da):67,287
Last modified:November 1, 1995 - v1
Checksum:i5C43210BF13FED71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78206 Genomic DNA. Translation: CAA55042.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78206 Genomic DNA. Translation: CAA55042.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q50 X-ray 2.60 A 44-604 [» ]
1T10 X-ray 2.35 A 1-605 [» ]
ProteinModelPortali P42861.
SMRi P42861. Positions 44-604.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P42861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Miscellaneous databases

EvolutionaryTracei P42861.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Subcellular distribution and characterization of glucosephosphate isomerase in Leishmania mexicana mexicana."
    Nyame K., Do Thi C.D., Opperdoes F.R., Michels P.A.M.
    Mol. Biochem. Parasitol. 67:269-279(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NHOM/BZ/84/BEL46.

Entry informationi

Entry nameiG6PI_LEIME
AccessioniPrimary (citable) accession number: P42861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3