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P42861

- G6PI_LEIME

UniProt

P42861 - G6PI_LEIME

Protein

Glucose-6-phosphate isomerase

Gene

PGI

Organism
Leishmania mexicana
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei410 – 4101Proton donorBy similarity
    Active sitei441 – 4411By similarity
    Active sitei569 – 5691By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:PGI
    OrganismiLeishmania mexicana
    Taxonomic identifieri5665 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Glucose-6-phosphate isomerasePRO_0000180546Add
    BLAST

    Proteomic databases

    PRIDEiP42861.

    Structurei

    Secondary structure

    1
    605
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi50 – 523
    Helixi54 – 6613
    Helixi71 – 777
    Helixi81 – 844
    Beta strandi86 – 905
    Beta strandi97 – 1015
    Beta strandi104 – 1063
    Helixi109 – 12113
    Helixi124 – 1329
    Turni139 – 1424
    Helixi147 – 1504
    Helixi165 – 18521
    Beta strandi198 – 2025
    Helixi205 – 2073
    Helixi209 – 2179
    Helixi219 – 2213
    Beta strandi224 – 2318
    Helixi237 – 2437
    Helixi248 – 2503
    Beta strandi251 – 2566
    Beta strandi258 – 2603
    Helixi263 – 28220
    Helixi290 – 2945
    Beta strandi295 – 2984
    Helixi302 – 3076
    Helixi312 – 3143
    Helixi324 – 3263
    Helixi331 – 3333
    Helixi334 – 36128
    Helixi364 – 3663
    Helixi368 – 38114
    Beta strandi387 – 3948
    Helixi395 – 3973
    Helixi400 – 41213
    Beta strandi430 – 4323
    Helixi438 – 4414
    Helixi444 – 4496
    Beta strandi450 – 4523
    Beta strandi456 – 4638
    Beta strandi465 – 4706
    Helixi471 – 48818
    Helixi492 – 50110
    Turni508 – 5125
    Helixi513 – 5164
    Beta strandi525 – 5306
    Helixi534 – 55522
    Helixi563 – 5653
    Helixi566 – 57510
    Helixi576 – 5783
    Helixi590 – 60213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Q50X-ray2.60A44-604[»]
    1T10X-ray2.35A1-605[»]
    ProteinModelPortaliP42861.
    SMRiP42861. Positions 44-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42861.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42861-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDYFSKLKE HVVESTEING CTPSIATATF NAPYEVARKT KMLGVTDSSL    50
    LNLPAWKRLQ SLYEKYGNDS ILSHFEKDHQ RFQRYSIEID LHSDDNFLFL 100
    DYSKSHINDE IKDALVALAE ERGVRAFAKA MFDGQRVNST ENRAVLHVAL 150
    RNRSNRPIIV DGKDVMSDVN NVLAQMKDFT ERVRSGEWKG QTGKSIYNIV 200
    NIGIGGSDLG PVMVTEALKP FSKRDLHCFF VSNVDGTHMA EVLKQVNLEE 250
    TIFIIASKTF TTQETLTNAM SARNALMSYL KENGISTDGA VAKHFVALST 300
    NTEKVREFGI DTVNMFAFWD WVGGRYSVWS AIGLSVMLSI GYDNFVEFLT 350
    GAHVMDNHFA STPTEQNLPM MLALVGIWYN NFFGSETQAV LPYDQYLWRL 400
    PAYLQQLDME SNGKGVTKKS GAVAVQTGPI VFGEAGTNGQ HAFYQLIHQG 450
    TKIIPCDFIG CVQTQNRVGD HHRTLMSNFF AQTEALMVGK NAEEVRQELV 500
    KSGMSGDAIE NMIPHKTFTG SRPSNSILVN ALTPRALGAI IAMYEHKVLV 550
    QGAIWGINSY DQWGVELGKV LAKSILPQLK SGNIVSDHDG STNGLINMFN 600
    TRAHL 605
    Length:605
    Mass (Da):67,287
    Last modified:November 1, 1995 - v1
    Checksum:i5C43210BF13FED71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78206 Genomic DNA. Translation: CAA55042.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78206 Genomic DNA. Translation: CAA55042.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Q50 X-ray 2.60 A 44-604 [» ]
    1T10 X-ray 2.35 A 1-605 [» ]
    ProteinModelPortali P42861.
    SMRi P42861. Positions 44-604.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P42861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Miscellaneous databases

    EvolutionaryTracei P42861.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Subcellular distribution and characterization of glucosephosphate isomerase in Leishmania mexicana mexicana."
      Nyame K., Do Thi C.D., Opperdoes F.R., Michels P.A.M.
      Mol. Biochem. Parasitol. 67:269-279(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NHOM/BZ/84/BEL46.

    Entry informationi

    Entry nameiG6PI_LEIME
    AccessioniPrimary (citable) accession number: P42861
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3