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P42860 (GSTT1_LUCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1-1

EC=2.5.1.18
Alternative name(s):
GST class-theta
Gene names
Name:GST1
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Taxonomic identifier7375 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeLuciliinaeLucilia

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Glutathione S-transferase 1-1
PRO_0000185963

Regions

Domain1 – 8080GST N-terminal
Domain86 – 207122GST C-terminal
Region50 – 523Glutathione binding By similarity
Region64 – 663Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P42860 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 89E274EA07F07CE5

FASTA20823,644
        10         20         30         40         50         60 
MDFYYLPGSA PCRSVLMTAK ALGIELNKKL LNLQAGEHLK PEFLKINPQH TIPTLVDGDF 

        70         80         90        100        110        120 
ALWESRAIMV YLVEKYGKND SLFPKCPKKR AVINQRLYFD MGTLYKSFAD YYYPQIFAKA 

       130        140        150        160        170        180 
PADPELYKKM EAAFDFLNTF LEGHQYVAGD SLTVADLALL ASVSTFEVAG FDFSKYANVA 

       190        200 
KWYANAKTVA PGFDENWEGC LEFKKFFN 

« Hide

References

[1]"Purification, molecular cloning and heterologous expression of a glutathione S-transferase from the Australian sheep blowfly (Lucilia cuprina)."
Board P.G., Russell R., Marano R., Oakeshott J.G.
Biochem. J. 299:425-430(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: LS-2.
[2]"Crystal structure of a theta-class glutathione transferase."
Wilce M.J.C., Board P.G., Feil S.C., Parker M.W.
EMBO J. 14:2133-2143(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), SEQUENCE REVISION TO 10-13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23126 mRNA. Translation: AAA29287.1.
PIRS43851.

3D structure databases

ProteinModelPortalP42860.
SMRP42860. Positions 1-207.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP42860.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT1_LUCCU
AccessionPrimary (citable) accession number: P42860
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families