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P42859

- HD_MOUSE

UniProt

P42859 - HD_MOUSE

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Protein
Huntingtin
Gene
Htt, Hd, Hdh
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in microtubule-mediated transport or vesicle function.

GO - Molecular functioni

  1. diazepam binding Source: MGI
  2. protein binding Source: IntAct
  3. transcription factor binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: MGI
  2. L-glutamate import Source: MGI
  3. anatomical structure morphogenesis Source: MGI
  4. anterior/posterior pattern specification Source: MGI
  5. apoptotic process Source: MGI
  6. associative learning Source: MGI
  7. axon cargo transport Source: MGI
  8. brain development Source: MGI
  9. cell aging Source: MGI
  10. central nervous system development Source: MGI
  11. citrulline metabolic process Source: MGI
  12. determination of adult lifespan Source: MGI
  13. dopamine receptor signaling pathway Source: MGI
  14. endoplasmic reticulum organization Source: MGI
  15. endosomal transport Source: MGI
  16. gastrulation Source: MGI
  17. grooming behavior Source: MGI
  18. hormone metabolic process Source: MGI
  19. insulin secretion Source: MGI
  20. iron ion homeostasis Source: MGI
  21. lactate biosynthetic process from pyruvate Source: MGI
  22. learning Source: MGI
  23. learning or memory Source: MGI
  24. locomotory behavior Source: MGI
  25. mitochondrial transport Source: MGI
  26. mitochondrion organization Source: MGI
  27. negative regulation of apoptotic process Source: MGI
  28. negative regulation of neuron apoptotic process Source: MGI
  29. negative regulation of neuron death Source: MGI
  30. neural plate formation Source: MGI
  31. neurogenesis Source: MGI
  32. neuron apoptotic process Source: MGI
  33. neuron development Source: MGI
  34. olfactory lobe development Source: MGI
  35. paraxial mesoderm formation Source: MGI
  36. peptide hormone secretion Source: MGI
  37. protein import into nucleus Source: MGI
  38. quinolinate biosynthetic process Source: MGI
  39. regulation of mitochondrial membrane permeability Source: MGI
  40. regulation of mitochondrial membrane potential Source: MGI
  41. regulation of synaptic plasticity Source: MGI
  42. response to calcium ion Source: MGI
  43. social behavior Source: MGI
  44. spermatogenesis Source: MGI
  45. striatum development Source: MGI
  46. urea cycle Source: MGI
  47. vesicle transport along microtubule Source: MGI
  48. visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Huntingtin
Alternative name(s):
Huntington disease protein homolog
Short name:
HD protein homolog
Gene namesi
Name:Htt
Synonyms:Hd, Hdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96067. Htt.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner.

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. inclusion body Source: MGI
  5. mitochondrion Source: GOC
  6. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31193119Huntingtin
PRO_0000083943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91N6-acetyllysine By similarity
Modified residuei155 – 1551N6-acetyllysine By similarity
Modified residuei213 – 2131N6-acetyllysine By similarity
Modified residuei322 – 3221N6-acetyllysine By similarity
Modified residuei411 – 4111Phosphoserine By similarity
Modified residuei421 – 4211N6-acetyllysine By similarity
Modified residuei1159 – 11591Phosphoserine; by CDK5 By similarity
Modified residuei1179 – 11791Phosphoserine; by CDK5 By similarity
Modified residuei1853 – 18531Phosphoserine By similarity

Post-translational modificationi

Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP42859.
PaxDbiP42859.
PRIDEiP42859.

PTM databases

PhosphoSiteiP42859.

Expressioni

Tissue specificityi

The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney.

Developmental stagei

Predominant expression in neuronal tissues at all developmental stages. In 14.5 day old embryos, it is also detected in non-neuronal tissues. This expression is down-regulated in later stages of development.

Gene expression databases

CleanExiMM_HTT.
GenevestigatoriP42859.

Interactioni

Subunit structurei

Interacts with PQBP1 and SETD2 By similarity. Binds SH3GLB1. Interacts with PFN1. Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp3P706772EBI-5327353,EBI-1790419
Ctnnb1Q022483EBI-5327353,EBI-397872
Pak2Q8CIN42EBI-5327353,EBI-1559317

Protein-protein interaction databases

BioGridi200268. 171 interactions.
DIPiDIP-41430N.
IntActiP42859. 17 interactions.
MINTiMINT-270833.
STRINGi10090.ENSMUSP00000078945.

Structurei

3D structure databases

ProteinModelPortaliP42859.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati183 – 22038HEAT 1
Add
BLAST
Repeati225 – 26238HEAT 2
Add
BLAST
Repeati782 – 81938HEAT 3
Add
BLAST
Repeati882 – 92039HEAT 4
Add
BLAST
Repeati1404 – 144138HEAT 5
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2372 – 238110Nuclear export signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 247Poly-Gln
Compositional biasi25 – 4521Poly-Pro
Add
BLAST
Compositional biasi49 – 5911Poly-Pro
Add
BLAST
Compositional biasi1417 – 14204Poly-Thr
Compositional biasi1696 – 16994Poly-Gly
Compositional biasi2615 – 26206Poly-Glu

Domaini

The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations By similarity.

Sequence similaritiesi

Belongs to the huntingtin family.
Contains 5 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG82191.
HOGENOMiHOG000082472.
HOVERGENiHBG005953.
InParanoidiP42859.
PhylomeDBiP42859.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERiPTHR10170. PTHR10170. 1 hit.
PfamiPF12372. DUF3652. 2 hits.
[Graphical view]
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P42859-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPQP PQPPPQGQPP     50
PPPPPLPGPA EEPLHRPKKE LSATKKDRVN HCLTICENIV AQSLRNSPEF 100
QKLLGIAMEL FLLCSNDAES DVRMVADECL NKVIKALMDS NLPRLQLELY 150
KEIKKNGAPR SLRAALWRFA ELAHLVRPQK CRPYLVNLLP CLTRTSKRPE 200
ESVQETLAAA VPKIMASFGN FANDNEIKVL LKAFIANLKS SSPTVRRTAA 250
GSAVSICQHS RRTQYFYNWL LNVLLGLLVP MEEEHSTLLI LGVLLTLRCL 300
VPLLQQQVKD TSLKGSFGVT RKEMEVSPST EQLVQVYELT LHHTQHQDHN 350
VVTGALELLQ QLFRTPPPEL LQALTTPGGL GQLTLVQEEA RGRGRSGSIV 400
ELLAGGGSSC SPVLSRKQKG KVLLGEEEAL EDDSESRSDV SSSAFAASVK 450
SEIGGELAAS SGVSTPGSVG HDIITEQPRS QHTLQADSVD LSGCDLTSAA 500
TDGDEEDILS HSSSQFSAVP SDPAMDLNDG TQASSPISDS SQTTTEGPDS 550
AVTPSDSSEI VLDGADSQYL GMQIGQPQED DEEGAAGVLS GEVSDVFRNS 600
SLALQQAHLL ERMGHSRQPS DSSIDKYVTR DEVAEASDPE SKPCRIKGDI 650
GQPNDDDSAP LVHCVRLLSA SFLLTGEKKA LVPDRDVRVS VKALALSCIG 700
AAVALHPESF FSRLYKVPLN TTESTEEQYV SDILNYIDHG DPQVRGATAI 750
LCGTLVYSIL SRSRLRVGDW LGNIRTLTGN TFSLVDCIPL LQKTLKDESS 800
VTCKLACTAV RHCVLSLCSS SYSDLGLQLL IDMLPLKNSS YWLVRTELLD 850
TLAEIDFRLV SFLEAKAESL HRGAHHYTGF LKLQERVLNN VVIYLLGDED 900
PRVRHVAATS LTRLVPKLFY KCDQGQADPV VAVARDQSSV YLKLLMHETQ 950
PPSHFSVSTI TRIYRGYSLL PSITDVTMEN NLSRVVAAVS HELITSTTRA 1000
LTFGCCEALC LLSAAFPVCT WSLGWHCGVP PLSASDESRK SCTVGMASMI 1050
LTLLSSAWFP LDLSAHQDAL ILAGNLLAAS APKSLRSSWT SEEEANSAAT 1100
RQEEIWPALG DRTLVPLVEQ LFSHLLKVIN ICAHVLDDVT PGPAIKAALP 1150
SLTNPPSLSP IRRKGKEKEP GEQASTPMSP KKVGEASAAS RQSDTSGPVT 1200
ASKSSSLGSF YHLPSYLKLH DVLKATHANY KVTLDLQNST EKFGGFLRSA 1250
LDVLSQILEL ATLQDIGKCV EEVLGYLKSC FSREPMMATV CVQQLLKTLF 1300
GTNLASQFDG LSSNPSKSQC RAQRLGSSSV RPGLYHYCFM APYTHFTQAL 1350
ADASLRNMVQ AEQERDASGW FDVLQKVSAQ LKTNLTSVTK NRADKNAIHN 1400
HIRLFEPLVI KALKQYTTTT SVQLQKQVLD LLAQLVQLRV NYCLLDSDQV 1450
FIGFVLKQFE YIEVGQFRES EAIIPNIFFF LVLLSYERYH SKQIIGIPKI 1500
IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF VLRGTNKADA GKELETQKEV 1550
VVSMLLRLIQ YHQVLEMFIL VLQQCHKENE DKWKRLSRQV ADIILPMLAK 1600
QQMHIDSHEA LGVLNTLFEI LAPSSLRPVD MLLRSMFITP STMASVSTVQ 1650
LWISGILAIL RVLISQSTED IVLCRIQELS FSPHLLSCPV INRLRGGGGN 1700
VTLGECSEGK QKSLPEDTFS RFLLQLVGIL LEDIVTKQLK VDMSEQQHTF 1750
YCQELGTLLM CLIHIFKSGM FRRITAAATR LFTSDGCEGS FYTLESLNAR 1800
VRSMVPTHPA LVLLWCQILL LINHTDHRWW AEVQQTPKRH SLSCTKSLNP 1850
QKSGEEEDSG SAAQLGMCNR EIVRRGALIL FCDYVCQNLH DSEHLTWLIV 1900
NHIQDLISLS HEPPVQDFIS AIHRNSAASG LFIQAIQSRC ENLSTPTTLK 1950
KTLQCLEGIH LSQSGAVLTL YVDRLLGTPF RALARMVDTL ACRRVEMLLA 2000
ANLQSSMAQL PEEELNRIQE HLQNSGLAQR HQRLYSLLDR FRLSTVQDSL 2050
SPLPPVTSHP LDGDGHTSLE TVSPDKDWYL QLVRSQCWTR SDSALLEGAE 2100
LVNRIPAEDM NDFMMSSEFN LSLLAPCLSL GMSEIANGQK SPLFEAARGV 2150
ILNRVTSVVQ QLPAVHQVFQ PFLPIEPTAY WNKLNDLLGD TTSYQSLTIL 2200
ARALAQYLVV LSKVPAHLHL PPEKEGDTVK FVVMTVEALS WHLIHEQIPL 2250
SLDLQAGLDC CCLALQVPGL WGVLSSPEYV THACSLIHCV RFILEAIAVQ 2300
PGDQLLGPES RSHTPRAVRK EEVDSDIQNL SHVTSACEMV ADMVESLQSV 2350
LALGHKRNST LPSFLTAVLK NIVISLARLP LVNSYTRVPP LVWKLGWSPK 2400
PGGDFGTVFP EIPVEFLQEK EILKEFIYRI NTLGWTNRTQ FEETWATLLG 2450
VLVTQPLVME QEESPPEEDT ERTQIHVLAV QAITSLVLSA MTVPVAGNPA 2500
VSCLEQQPRN KPLKALDTRF GRKLSMIRGI VEQEIQEMVS QRENTATHHS 2550
HQAWDPVPSL LPATTGALIS HDKLLLQINP EREPGNMSYK LGQVSIHSVW 2600
LGNNITPLRE EEWDEEEEEE SDVPAPTSPP VSPVNSRKHR AGVDIHSCSQ 2650
FLLELYSRWI LPSSAARRTP VILISEVVRS LLVVSDLFTE RTQFEMMYLT 2700
LTELRRVHPS EDEILIQYLV PATCKAAAVL GMDKTVAEPV SRLLESTLRS 2750
SHLPSQIGAL HGILYVLECD LLDDTAKQLI PVVSDYLLSN LKGIAHCVNI 2800
HSQQHVLVMC ATAFYLMENY PLDVGPEFSA SVIQMCGVML SGSEESTPSI 2850
IYHCALRGLE RLLLSEQLSR LDTESLVKLS VDRVNVQSPH RAMAALGLML 2900
TCMYTGKEKA SPGRASDPSP ATPDSESVIV AMERVSVLFD RIRKGFPCEA 2950
RVVARILPQF LDDFFPPQDV MNKVIGEFLS NQQPYPQFMA TVVYKVFQTL 3000
HSAGQSSMVR DWVMLSLSNF TQRTPVAMAM WSLSCFLVSA STSPWVSAIL 3050
PHVISRMGKL EQVDVNLFCL VATDFYRHQI EEEFDRRAFQ SVFEVVAAPG 3100
SPYHRLLACL QNVHKVTTC 3119
Length:3,119
Mass (Da):344,690
Last modified:October 1, 1996 - v2
Checksum:iECA42B5916F50F4F
GO
Isoform Short (identifier: P42859-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1522-2001: Missing.

Note: Cannot be explained by a simple splicing event.

Show »
Length:2,639
Mass (Da):290,701
Checksum:i1D09B89A8EBE0A71
GO

Polymorphismi

The first poly-Pro repeat stretch differs in length by one unit (three) in Mus spretus strain compared to other strains (four). The poly-Gln region does not appear to be polymorphic, explaining the absence of a murine HD-like disorder.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1522 – 2001480Missing in isoform Short.
VSP_004282Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → G in AAA37799. 1 Publication
Sequence conflicti2 – 21A → G in AAA37800. 1 Publication
Sequence conflicti2 – 21A → G in AAA91085. 1 Publication
Sequence conflicti29 – 291A → P in AAA89100. 1 Publication
Sequence conflicti116 – 1161N → D in AAA89100. 1 Publication
Sequence conflicti116 – 1161N → D in AAA91085. 1 Publication
Sequence conflicti138 – 1381M → L in AAA37799. 1 Publication
Sequence conflicti138 – 1381M → L in AAA37800. 1 Publication
Sequence conflicti521 – 5211S → P in AAA37799. 1 Publication
Sequence conflicti521 – 5211S → P in AAA37800. 1 Publication
Sequence conflicti524 – 5241A → P in AAA37799. 1 Publication
Sequence conflicti524 – 5241A → P in AAA37800. 1 Publication
Sequence conflicti533 – 5331A → P in AAA37799. 1 Publication
Sequence conflicti533 – 5331A → P in AAA37800. 1 Publication
Sequence conflicti607 – 6071A → T in AAA37799. 1 Publication
Sequence conflicti607 – 6071A → T in AAA37800. 1 Publication
Sequence conflicti769 – 7691D → E in AAA89100. 1 Publication
Sequence conflicti972 – 9721S → R in AAA37799. 1 Publication
Sequence conflicti972 – 9721S → R in AAA37800. 1 Publication
Sequence conflicti1106 – 11061W → C in AAA37799. 1 Publication
Sequence conflicti1106 – 11061W → C in AAA37800. 1 Publication
Sequence conflicti1240 – 12401T → N in AAA37799. 1 Publication
Sequence conflicti1240 – 12401T → N in AAA37800. 1 Publication
Sequence conflicti1384 – 13841N → T in AAA37799. 1 Publication
Sequence conflicti1384 – 13841N → T in AAA37800. 1 Publication
Sequence conflicti1827 – 18271H → Y in AAA37799. 1 Publication
Sequence conflicti1979 – 19802PF → SS in AAA37799. 1 Publication
Sequence conflicti2062 – 20621D → G in AAA37799. 1 Publication
Sequence conflicti2062 – 20621D → G in AAA37800. 1 Publication
Sequence conflicti2570 – 25701S → N in AAA37799. 1 Publication
Sequence conflicti2570 – 25701S → N in AAA37800. 1 Publication
Sequence conflicti2866 – 28661E → V in AAA37799. 1 Publication
Sequence conflicti2866 – 28661E → V in AAA37800. 1 Publication
Sequence conflicti2877 – 28771V → G in AAA37799. 1 Publication
Sequence conflicti2877 – 28771V → G in AAA37800. 1 Publication
Sequence conflicti2882 – 28821D → G in AAA37799. 1 Publication
Sequence conflicti2882 – 28821D → G in AAA37800. 1 Publication
Sequence conflicti2887 – 28871Q → H in AAA37799. 1 Publication
Sequence conflicti2887 – 28871Q → H in AAA37800. 1 Publication
Sequence conflicti2915 – 29151A → T in AAA37799. 1 Publication
Sequence conflicti2915 – 29151A → T in AAA37800. 1 Publication
Sequence conflicti3025 – 30251P → S in AAC52218. 1 Publication
Sequence conflicti3062 – 30632QV → LM in AAA37799. 1 Publication
Sequence conflicti3062 – 30632QV → LM in AAA37800. 1 Publication
Sequence conflicti3095 – 30962VV → EE in AAA37799. 1 Publication
Sequence conflicti3095 – 30962VV → EE in AAA37800. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23312 mRNA. Translation: AAA37799.1.
L23313 mRNA. Translation: AAA37800.1.
L28827 mRNA. Translation: AAA89100.1. Sequence problems.
U24233 mRNA. Translation: AAC52218.1.
AH003368 Genomic DNA. Translation: AAA91085.1.
PIRiI49729.
UniGeneiMm.209071.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23312 mRNA. Translation: AAA37799.1 .
L23313 mRNA. Translation: AAA37800.1 .
L28827 mRNA. Translation: AAA89100.1 . Sequence problems.
U24233 mRNA. Translation: AAC52218.1 .
AH003368 Genomic DNA. Translation: AAA91085.1 .
PIRi I49729.
UniGenei Mm.209071.

3D structure databases

ProteinModelPortali P42859.
ModBasei Search...

Protein-protein interaction databases

BioGridi 200268. 171 interactions.
DIPi DIP-41430N.
IntActi P42859. 17 interactions.
MINTi MINT-270833.
STRINGi 10090.ENSMUSP00000078945.

Chemistry

ChEMBLi CHEMBL1250362.

PTM databases

PhosphoSitei P42859.

Proteomic databases

MaxQBi P42859.
PaxDbi P42859.
PRIDEi P42859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96067. Htt.

Phylogenomic databases

eggNOGi NOG82191.
HOGENOMi HOG000082472.
HOVERGENi HBG005953.
InParanoidi P42859.
PhylomeDBi P42859.

Miscellaneous databases

ChiTaRSi HTT. mouse.
NextBioi 287727.
PROi P42859.
SOURCEi Search...

Gene expression databases

CleanExi MM_HTT.
Genevestigatori P42859.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view ]
PANTHERi PTHR10170. PTHR10170. 1 hit.
Pfami PF12372. DUF3652. 2 hits.
[Graphical view ]
PRINTSi PR00375. HUNTINGTIN.
SUPFAMi SSF48371. SSF48371. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat."
    Lin B., Nasir J., Macdonald H., Hutchinson G., Graham R.K., Rommens J.M., Hayden M.R.
    Hum. Mol. Genet. 3:85-92(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: C57BL/6.
    Tissue: Brain and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form."
    Trottier Y., Devys D., Imbert G., Saudou F., An I., Lutz Y., Weber C., Agid Y., Hirsch E.C., Mandel J.-L.
    Nat. Genet. 10:104-110(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms."
    Lin B., Nasir J., Kalchman M.A., McDonald H., Zeisler J., Goldberg Y.P., Hayden M.R.
    Genomics 25:707-715(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-181.
  5. "Characterization of endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1."
    Modregger J., Schmidt A.A., Ritter B., Huttner W.B., Plomann M.
    J. Biol. Chem. 278:4160-4167(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3GLB1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHD_MOUSE
AccessioniPrimary (citable) accession number: P42859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi