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P42859 (HD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Huntingtin
Alternative name(s):
Huntington disease protein homolog
Short name=HD protein homolog
Gene names
Name:Htt
Synonyms:Hd, Hdh
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length3119 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in microtubule-mediated transport or vesicle function.

Subunit structure

Interacts with PQBP1 and SETD2 By similarity. Binds SH3GLB1. Interacts with PFN1. Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch By similarity. Ref.5

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner.

Tissue specificity

The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney.

Developmental stage

Predominant expression in neuronal tissues at all developmental stages. In 14.5 day old embryos, it is also detected in non-neuronal tissues. This expression is down-regulated in later stages of development.

Domain

The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations By similarity.

Post-translational modification

Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.

Polymorphism

The first poly-Pro repeat stretch differs in length by one unit (three) in Mus spretus strain compared to other strains (four). The poly-Gln region does not appear to be polymorphic, explaining the absence of a murine HD-like disorder.

Sequence similarities

Belongs to the huntingtin family.

Contains 5 HEAT repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processER to Golgi vesicle-mediated transport

Inferred from mutant phenotype PubMed 11092755. Source: MGI

L-glutamate import

Inferred from mutant phenotype PubMed 10932179. Source: MGI

anatomical structure morphogenesis

Inferred from mutant phenotype PubMed 16109169. Source: MGI

anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 16109169. Source: MGI

apoptotic process

Inferred from mutant phenotype PubMed 7550343. Source: MGI

associative learning

Inferred from mutant phenotype PubMed 17284197. Source: MGI

axon cargo transport

Inferred from mutant phenotype PubMed 15340079. Source: MGI

brain development

Inferred from mutant phenotype PubMed 16978870. Source: MGI

cell aging

Inferred from mutant phenotype PubMed 16403806. Source: MGI

cell death

Inferred from mutant phenotype. Source: MGI

central nervous system development

Inferred from mutant phenotype PubMed 9398841. Source: MGI

citrulline metabolic process

Inferred from mutant phenotype PubMed 17213233. Source: MGI

determination of adult lifespan

Inferred from mutant phenotype PubMed 11062468PubMed 11152661. Source: MGI

dopamine receptor signaling pathway

Inferred from mutant phenotype PubMed 17715336. Source: MGI

endoplasmic reticulum organization

Inferred from mutant phenotype PubMed 16256944. Source: MGI

endosomal transport

Inferred from mutant phenotype PubMed 11092755. Source: MGI

gastrulation

Inferred from mutant phenotype PubMed 7550343PubMed 7618107PubMed 7774020. Source: MGI

grooming behavior

Inferred from mutant phenotype PubMed 10778856. Source: MGI

hormone metabolic process

Inferred from mutant phenotype PubMed 10078572PubMed 10739639. Source: MGI

insulin secretion

Inferred from mutant phenotype PubMed 10078572. Source: MGI

iron ion homeostasis

Inferred from mutant phenotype PubMed 11092755. Source: MGI

lactate biosynthetic process from pyruvate

Inferred from mutant phenotype PubMed 17708681. Source: MGI

learning

Inferred from mutant phenotype PubMed 16624677. Source: MGI

learning or memory

Inferred from mutant phenotype PubMed 16403806. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 10778856PubMed 11062468PubMed 11152661PubMed 11567051PubMed 12223581PubMed 12926013PubMed 16403806PubMed 17715336PubMed 7774020. Source: MGI

mitochondrial transport

Inferred from mutant phenotype PubMed 15340079. Source: MGI

mitochondrion organization

Inferred from mutant phenotype PubMed 11092755. Source: MGI

negative regulation of apoptotic process

Inferred from direct assay PubMed 15242649. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 11152661. Source: MGI

neural plate formation

Inferred from mutant phenotype PubMed 7774020. Source: MGI

neurogenesis

Inferred from mutant phenotype PubMed 11062468. Source: MGI

neuron apoptotic process

Inferred from mutant phenotype PubMed 10082833PubMed 10932179. Source: MGI

neuron development

Inferred from mutant phenotype PubMed 10082833PubMed 16978870PubMed 7774020. Source: MGI

olfactory lobe development

Inferred from mutant phenotype PubMed 12926013. Source: MGI

paraxial mesoderm formation

Inferred from mutant phenotype PubMed 16109169. Source: MGI

peptide hormone secretion

Inferred from mutant phenotype PubMed 10078572PubMed 12223581. Source: MGI

protein import into nucleus

Inferred from mutant phenotype PubMed 11092755. Source: MGI

quinolinate biosynthetic process

Inferred from mutant phenotype PubMed 16697652. Source: MGI

regulation of mitochondrial membrane permeability

Inferred from mutant phenotype PubMed 15935052. Source: MGI

regulation of mitochondrial membrane potential

Inferred from mutant phenotype PubMed 17708681. Source: MGI

regulation of synaptic plasticity

Inferred from mutant phenotype PubMed 10196373PubMed 17442827. Source: MGI

response to calcium ion

Inferred from mutant phenotype PubMed 15935052. Source: MGI

social behavior

Inferred from mutant phenotype PubMed 10196365. Source: MGI

spermatogenesis

Inferred from mutant phenotype PubMed 11062468. Source: MGI

striatum development

Inferred from mutant phenotype PubMed 11030759PubMed 17715336. Source: MGI

urea cycle

Inferred from mutant phenotype PubMed 17213233. Source: MGI

vesicle transport along microtubule

Inferred from direct assay PubMed 15242649. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 7774020. Source: MGI

   Cellular_componentaxon

Inferred from direct assay PubMed 12115678PubMed 8757264. Source: MGI

cytoplasm

Inferred from direct assay PubMed 10699173PubMed 16403806Ref.3PubMed 7662892PubMed 8757264. Source: MGI

cytoplasmic membrane-bounded vesicle

Inferred from direct assay PubMed 15242649. Source: MGI

inclusion body

Inferred from direct assay PubMed 15615787. Source: MGI

mitochondrion

Inferred from mutant phenotype PubMed 15935052. Source: GOC

nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functiondiazepam binding

Inferred from mutant phenotype PubMed 10082833. Source: MGI

protein binding

Inferred from physical interaction PubMed 17124493PubMed 19240112PubMed 20531388. Source: IntAct

transcription factor binding

Inferred from physical interaction PubMed 18595722. Source: MGI

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P42859-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P42859-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1522-2001: Missing.
Note: Cannot be explained by a simple splicing event.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 31193119Huntingtin
PRO_0000083943

Regions

Repeat183 – 22038HEAT 1
Repeat225 – 26238HEAT 2
Repeat782 – 81938HEAT 3
Repeat882 – 92039HEAT 4
Repeat1404 – 144138HEAT 5
Motif2372 – 238110Nuclear export signal By similarity
Compositional bias18 – 247Poly-Gln
Compositional bias25 – 4521Poly-Pro
Compositional bias49 – 5911Poly-Pro
Compositional bias1417 – 14204Poly-Thr
Compositional bias1696 – 16994Poly-Gly
Compositional bias2615 – 26206Poly-Glu

Amino acid modifications

Modified residue91N6-acetyllysine By similarity
Modified residue1551N6-acetyllysine By similarity
Modified residue2131N6-acetyllysine By similarity
Modified residue3221N6-acetyllysine By similarity
Modified residue4111Phosphoserine By similarity
Modified residue4211N6-acetyllysine By similarity
Modified residue11591Phosphoserine; by CDK5 By similarity
Modified residue11791Phosphoserine; by CDK5 By similarity
Modified residue18531Phosphoserine By similarity

Natural variations

Alternative sequence1522 – 2001480Missing in isoform Short.
VSP_004282

Experimental info

Sequence conflict21A → G in AAA37799. Ref.1
Sequence conflict21A → G in AAA37800. Ref.1
Sequence conflict21A → G in AAA91085. Ref.4
Sequence conflict291A → P in AAA89100. Ref.2
Sequence conflict1161N → D in AAA89100. Ref.2
Sequence conflict1161N → D in AAA91085. Ref.4
Sequence conflict1381M → L in AAA37799. Ref.1
Sequence conflict1381M → L in AAA37800. Ref.1
Sequence conflict5211S → P in AAA37799. Ref.1
Sequence conflict5211S → P in AAA37800. Ref.1
Sequence conflict5241A → P in AAA37799. Ref.1
Sequence conflict5241A → P in AAA37800. Ref.1
Sequence conflict5331A → P in AAA37799. Ref.1
Sequence conflict5331A → P in AAA37800. Ref.1
Sequence conflict6071A → T in AAA37799. Ref.1
Sequence conflict6071A → T in AAA37800. Ref.1
Sequence conflict7691D → E in AAA89100. Ref.2
Sequence conflict9721S → R in AAA37799. Ref.1
Sequence conflict9721S → R in AAA37800. Ref.1
Sequence conflict11061W → C in AAA37799. Ref.1
Sequence conflict11061W → C in AAA37800. Ref.1
Sequence conflict12401T → N in AAA37799. Ref.1
Sequence conflict12401T → N in AAA37800. Ref.1
Sequence conflict13841N → T in AAA37799. Ref.1
Sequence conflict13841N → T in AAA37800. Ref.1
Sequence conflict18271H → Y in AAA37799. Ref.1
Sequence conflict1979 – 19802PF → SS in AAA37799. Ref.1
Sequence conflict20621D → G in AAA37799. Ref.1
Sequence conflict20621D → G in AAA37800. Ref.1
Sequence conflict25701S → N in AAA37799. Ref.1
Sequence conflict25701S → N in AAA37800. Ref.1
Sequence conflict28661E → V in AAA37799. Ref.1
Sequence conflict28661E → V in AAA37800. Ref.1
Sequence conflict28771V → G in AAA37799. Ref.1
Sequence conflict28771V → G in AAA37800. Ref.1
Sequence conflict28821D → G in AAA37799. Ref.1
Sequence conflict28821D → G in AAA37800. Ref.1
Sequence conflict28871Q → H in AAA37799. Ref.1
Sequence conflict28871Q → H in AAA37800. Ref.1
Sequence conflict29151A → T in AAA37799. Ref.1
Sequence conflict29151A → T in AAA37800. Ref.1
Sequence conflict30251P → S in AAC52218. Ref.3
Sequence conflict3062 – 30632QV → LM in AAA37799. Ref.1
Sequence conflict3062 – 30632QV → LM in AAA37800. Ref.1
Sequence conflict3095 – 30962VV → EE in AAA37799. Ref.1
Sequence conflict3095 – 30962VV → EE in AAA37800. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: ECA42B5916F50F4F

FASTA3,119344,690
        10         20         30         40         50         60 
MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPQP PQPPPQGQPP PPPPPLPGPA 

        70         80         90        100        110        120 
EEPLHRPKKE LSATKKDRVN HCLTICENIV AQSLRNSPEF QKLLGIAMEL FLLCSNDAES 

       130        140        150        160        170        180 
DVRMVADECL NKVIKALMDS NLPRLQLELY KEIKKNGAPR SLRAALWRFA ELAHLVRPQK 

       190        200        210        220        230        240 
CRPYLVNLLP CLTRTSKRPE ESVQETLAAA VPKIMASFGN FANDNEIKVL LKAFIANLKS 

       250        260        270        280        290        300 
SSPTVRRTAA GSAVSICQHS RRTQYFYNWL LNVLLGLLVP MEEEHSTLLI LGVLLTLRCL 

       310        320        330        340        350        360 
VPLLQQQVKD TSLKGSFGVT RKEMEVSPST EQLVQVYELT LHHTQHQDHN VVTGALELLQ 

       370        380        390        400        410        420 
QLFRTPPPEL LQALTTPGGL GQLTLVQEEA RGRGRSGSIV ELLAGGGSSC SPVLSRKQKG 

       430        440        450        460        470        480 
KVLLGEEEAL EDDSESRSDV SSSAFAASVK SEIGGELAAS SGVSTPGSVG HDIITEQPRS 

       490        500        510        520        530        540 
QHTLQADSVD LSGCDLTSAA TDGDEEDILS HSSSQFSAVP SDPAMDLNDG TQASSPISDS 

       550        560        570        580        590        600 
SQTTTEGPDS AVTPSDSSEI VLDGADSQYL GMQIGQPQED DEEGAAGVLS GEVSDVFRNS 

       610        620        630        640        650        660 
SLALQQAHLL ERMGHSRQPS DSSIDKYVTR DEVAEASDPE SKPCRIKGDI GQPNDDDSAP 

       670        680        690        700        710        720 
LVHCVRLLSA SFLLTGEKKA LVPDRDVRVS VKALALSCIG AAVALHPESF FSRLYKVPLN 

       730        740        750        760        770        780 
TTESTEEQYV SDILNYIDHG DPQVRGATAI LCGTLVYSIL SRSRLRVGDW LGNIRTLTGN 

       790        800        810        820        830        840 
TFSLVDCIPL LQKTLKDESS VTCKLACTAV RHCVLSLCSS SYSDLGLQLL IDMLPLKNSS 

       850        860        870        880        890        900 
YWLVRTELLD TLAEIDFRLV SFLEAKAESL HRGAHHYTGF LKLQERVLNN VVIYLLGDED 

       910        920        930        940        950        960 
PRVRHVAATS LTRLVPKLFY KCDQGQADPV VAVARDQSSV YLKLLMHETQ PPSHFSVSTI 

       970        980        990       1000       1010       1020 
TRIYRGYSLL PSITDVTMEN NLSRVVAAVS HELITSTTRA LTFGCCEALC LLSAAFPVCT 

      1030       1040       1050       1060       1070       1080 
WSLGWHCGVP PLSASDESRK SCTVGMASMI LTLLSSAWFP LDLSAHQDAL ILAGNLLAAS 

      1090       1100       1110       1120       1130       1140 
APKSLRSSWT SEEEANSAAT RQEEIWPALG DRTLVPLVEQ LFSHLLKVIN ICAHVLDDVT 

      1150       1160       1170       1180       1190       1200 
PGPAIKAALP SLTNPPSLSP IRRKGKEKEP GEQASTPMSP KKVGEASAAS RQSDTSGPVT 

      1210       1220       1230       1240       1250       1260 
ASKSSSLGSF YHLPSYLKLH DVLKATHANY KVTLDLQNST EKFGGFLRSA LDVLSQILEL 

      1270       1280       1290       1300       1310       1320 
ATLQDIGKCV EEVLGYLKSC FSREPMMATV CVQQLLKTLF GTNLASQFDG LSSNPSKSQC 

      1330       1340       1350       1360       1370       1380 
RAQRLGSSSV RPGLYHYCFM APYTHFTQAL ADASLRNMVQ AEQERDASGW FDVLQKVSAQ 

      1390       1400       1410       1420       1430       1440 
LKTNLTSVTK NRADKNAIHN HIRLFEPLVI KALKQYTTTT SVQLQKQVLD LLAQLVQLRV 

      1450       1460       1470       1480       1490       1500 
NYCLLDSDQV FIGFVLKQFE YIEVGQFRES EAIIPNIFFF LVLLSYERYH SKQIIGIPKI 

      1510       1520       1530       1540       1550       1560 
IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF VLRGTNKADA GKELETQKEV VVSMLLRLIQ 

      1570       1580       1590       1600       1610       1620 
YHQVLEMFIL VLQQCHKENE DKWKRLSRQV ADIILPMLAK QQMHIDSHEA LGVLNTLFEI 

      1630       1640       1650       1660       1670       1680 
LAPSSLRPVD MLLRSMFITP STMASVSTVQ LWISGILAIL RVLISQSTED IVLCRIQELS 

      1690       1700       1710       1720       1730       1740 
FSPHLLSCPV INRLRGGGGN VTLGECSEGK QKSLPEDTFS RFLLQLVGIL LEDIVTKQLK 

      1750       1760       1770       1780       1790       1800 
VDMSEQQHTF YCQELGTLLM CLIHIFKSGM FRRITAAATR LFTSDGCEGS FYTLESLNAR 

      1810       1820       1830       1840       1850       1860 
VRSMVPTHPA LVLLWCQILL LINHTDHRWW AEVQQTPKRH SLSCTKSLNP QKSGEEEDSG 

      1870       1880       1890       1900       1910       1920 
SAAQLGMCNR EIVRRGALIL FCDYVCQNLH DSEHLTWLIV NHIQDLISLS HEPPVQDFIS 

      1930       1940       1950       1960       1970       1980 
AIHRNSAASG LFIQAIQSRC ENLSTPTTLK KTLQCLEGIH LSQSGAVLTL YVDRLLGTPF 

      1990       2000       2010       2020       2030       2040 
RALARMVDTL ACRRVEMLLA ANLQSSMAQL PEEELNRIQE HLQNSGLAQR HQRLYSLLDR 

      2050       2060       2070       2080       2090       2100 
FRLSTVQDSL SPLPPVTSHP LDGDGHTSLE TVSPDKDWYL QLVRSQCWTR SDSALLEGAE 

      2110       2120       2130       2140       2150       2160 
LVNRIPAEDM NDFMMSSEFN LSLLAPCLSL GMSEIANGQK SPLFEAARGV ILNRVTSVVQ 

      2170       2180       2190       2200       2210       2220 
QLPAVHQVFQ PFLPIEPTAY WNKLNDLLGD TTSYQSLTIL ARALAQYLVV LSKVPAHLHL 

      2230       2240       2250       2260       2270       2280 
PPEKEGDTVK FVVMTVEALS WHLIHEQIPL SLDLQAGLDC CCLALQVPGL WGVLSSPEYV 

      2290       2300       2310       2320       2330       2340 
THACSLIHCV RFILEAIAVQ PGDQLLGPES RSHTPRAVRK EEVDSDIQNL SHVTSACEMV 

      2350       2360       2370       2380       2390       2400 
ADMVESLQSV LALGHKRNST LPSFLTAVLK NIVISLARLP LVNSYTRVPP LVWKLGWSPK 

      2410       2420       2430       2440       2450       2460 
PGGDFGTVFP EIPVEFLQEK EILKEFIYRI NTLGWTNRTQ FEETWATLLG VLVTQPLVME 

      2470       2480       2490       2500       2510       2520 
QEESPPEEDT ERTQIHVLAV QAITSLVLSA MTVPVAGNPA VSCLEQQPRN KPLKALDTRF 

      2530       2540       2550       2560       2570       2580 
GRKLSMIRGI VEQEIQEMVS QRENTATHHS HQAWDPVPSL LPATTGALIS HDKLLLQINP 

      2590       2600       2610       2620       2630       2640 
EREPGNMSYK LGQVSIHSVW LGNNITPLRE EEWDEEEEEE SDVPAPTSPP VSPVNSRKHR 

      2650       2660       2670       2680       2690       2700 
AGVDIHSCSQ FLLELYSRWI LPSSAARRTP VILISEVVRS LLVVSDLFTE RTQFEMMYLT 

      2710       2720       2730       2740       2750       2760 
LTELRRVHPS EDEILIQYLV PATCKAAAVL GMDKTVAEPV SRLLESTLRS SHLPSQIGAL 

      2770       2780       2790       2800       2810       2820 
HGILYVLECD LLDDTAKQLI PVVSDYLLSN LKGIAHCVNI HSQQHVLVMC ATAFYLMENY 

      2830       2840       2850       2860       2870       2880 
PLDVGPEFSA SVIQMCGVML SGSEESTPSI IYHCALRGLE RLLLSEQLSR LDTESLVKLS 

      2890       2900       2910       2920       2930       2940 
VDRVNVQSPH RAMAALGLML TCMYTGKEKA SPGRASDPSP ATPDSESVIV AMERVSVLFD 

      2950       2960       2970       2980       2990       3000 
RIRKGFPCEA RVVARILPQF LDDFFPPQDV MNKVIGEFLS NQQPYPQFMA TVVYKVFQTL 

      3010       3020       3030       3040       3050       3060 
HSAGQSSMVR DWVMLSLSNF TQRTPVAMAM WSLSCFLVSA STSPWVSAIL PHVISRMGKL 

      3070       3080       3090       3100       3110 
EQVDVNLFCL VATDFYRHQI EEEFDRRAFQ SVFEVVAAPG SPYHRLLACL QNVHKVTTC 

« Hide

Isoform Short [UniParc].

Checksum: 1D09B89A8EBE0A71
Show »

FASTA2,639290,701

References

« Hide 'large scale' references
[1]"Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat."
Lin B., Nasir J., Macdonald H., Hutchinson G., Graham R.K., Rommens J.M., Hayden M.R.
Hum. Mol. Genet. 3:85-92(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Strain: C57BL/6.
Tissue: Brain and Spleen.
[2]"Mouse Huntington's disease gene homolog (Hdh)."
Barnes G.T., Duyao M.P., Ambrose C.M., McNeil S., Persichetti F., Srinidhi J., Gusella J.F., Macdonald M.E.
Somat. Cell Mol. Genet. 20:87-97(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form."
Trottier Y., Devys D., Imbert G., Saudou F., An I., Lutz Y., Weber C., Agid Y., Hirsch E.C., Mandel J.-L.
Nat. Genet. 10:104-110(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms."
Lin B., Nasir J., Kalchman M.A., McDonald H., Zeisler J., Goldberg Y.P., Hayden M.R.
Genomics 25:707-715(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-181.
[5]"Characterization of endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1."
Modregger J., Schmidt A.A., Ritter B., Huttner W.B., Plomann M.
J. Biol. Chem. 278:4160-4167(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SH3GLB1.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23312 mRNA. Translation: AAA37799.1.
L23313 mRNA. Translation: AAA37800.1.
L28827 mRNA. Translation: AAA89100.1. Sequence problems.
U24233 mRNA. Translation: AAC52218.1.
AH003368 Genomic DNA. Translation: AAA91085.1.
PIRI49729.
UniGeneMm.209071.

3D structure databases

ProteinModelPortalP42859.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200268. 171 interactions.
DIPDIP-41430N.
IntActP42859. 17 interactions.
MINTMINT-270833.
STRING10090.ENSMUSP00000078945.

Chemistry

ChEMBLCHEMBL1250362.

PTM databases

PhosphoSiteP42859.

Proteomic databases

MaxQBP42859.
PaxDbP42859.
PRIDEP42859.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGmmu:15194.

Organism-specific databases

CTD3064.
MGIMGI:96067. Htt.

Phylogenomic databases

eggNOGNOG82191.
HOGENOMHOG000082472.
HOVERGENHBG005953.
InParanoidP42859.
KOK04533.
PhylomeDBP42859.

Gene expression databases

CleanExMM_HTT.
GenevestigatorP42859.

Family and domain databases

Gene3D1.25.10.10. 4 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERPTHR10170. PTHR10170. 1 hit.
PfamPF12372. DUF3652. 2 hits.
[Graphical view]
PRINTSPR00375. HUNTINGTIN.
SUPFAMSSF48371. SSF48371. 5 hits.
ProtoNetSearch...

Other

ChiTaRSHTT. mouse.
NextBio287727.
PROP42859.
SOURCESearch...

Entry information

Entry nameHD_MOUSE
AccessionPrimary (citable) accession number: P42859
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot