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P42859

- HD_MOUSE

UniProt

P42859 - HD_MOUSE

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Protein

Huntingtin

Gene

Htt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in microtubule-mediated transport or vesicle function.

GO - Molecular functioni

  1. diazepam binding Source: MGI
  2. transcription factor binding Source: MGI

GO - Biological processi

  1. anatomical structure morphogenesis Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. apoptotic process Source: MGI
  4. associative learning Source: MGI
  5. axon cargo transport Source: MGI
  6. brain development Source: MGI
  7. cell aging Source: MGI
  8. central nervous system development Source: MGI
  9. citrulline metabolic process Source: MGI
  10. determination of adult lifespan Source: MGI
  11. dopamine receptor signaling pathway Source: MGI
  12. endoplasmic reticulum organization Source: MGI
  13. endosomal transport Source: MGI
  14. ER to Golgi vesicle-mediated transport Source: MGI
  15. gastrulation Source: MGI
  16. grooming behavior Source: MGI
  17. hormone metabolic process Source: MGI
  18. insulin secretion Source: MGI
  19. iron ion homeostasis Source: MGI
  20. lactate biosynthetic process from pyruvate Source: MGI
  21. learning Source: MGI
  22. learning or memory Source: MGI
  23. L-glutamate import Source: MGI
  24. locomotory behavior Source: MGI
  25. mitochondrial transport Source: MGI
  26. mitochondrion organization Source: MGI
  27. negative regulation of apoptotic process Source: MGI
  28. negative regulation of neuron apoptotic process Source: MGI
  29. negative regulation of neuron death Source: MGI
  30. neural plate formation Source: MGI
  31. neurogenesis Source: MGI
  32. neuron apoptotic process Source: MGI
  33. neuron development Source: MGI
  34. olfactory lobe development Source: MGI
  35. paraxial mesoderm formation Source: MGI
  36. peptide hormone secretion Source: MGI
  37. protein import into nucleus Source: MGI
  38. quinolinate biosynthetic process Source: MGI
  39. regulation of mitochondrial membrane permeability Source: MGI
  40. regulation of mitochondrial membrane potential Source: MGI
  41. regulation of synaptic plasticity Source: MGI
  42. response to calcium ion Source: MGI
  43. social behavior Source: MGI
  44. spermatogenesis Source: MGI
  45. striatum development Source: MGI
  46. urea cycle Source: MGI
  47. vesicle transport along microtubule Source: MGI
  48. visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Huntingtin
Alternative name(s):
Huntington disease protein homolog
Short name:
HD protein homolog
Gene namesi
Name:Htt
Synonyms:Hd, Hdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96067. Htt.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner.

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. inclusion body Source: MGI
  5. mitochondrion Source: GOC
  6. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31193119HuntingtinPRO_0000083943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91N6-acetyllysineBy similarity
Modified residuei155 – 1551N6-acetyllysineBy similarity
Modified residuei213 – 2131N6-acetyllysineBy similarity
Modified residuei322 – 3221N6-acetyllysineBy similarity
Modified residuei411 – 4111PhosphoserineBy similarity
Modified residuei421 – 4211N6-acetyllysineBy similarity
Modified residuei1159 – 11591Phosphoserine; by CDK5By similarity
Modified residuei1179 – 11791Phosphoserine; by CDK5By similarity
Modified residuei1853 – 18531PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP42859.
PaxDbiP42859.
PRIDEiP42859.

PTM databases

PhosphoSiteiP42859.

Expressioni

Tissue specificityi

The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney.

Developmental stagei

Predominant expression in neuronal tissues at all developmental stages. In 14.5 day old embryos, it is also detected in non-neuronal tissues. This expression is down-regulated in later stages of development.

Gene expression databases

CleanExiMM_HTT.
GenevestigatoriP42859.

Interactioni

Subunit structurei

Interacts with PQBP1 and SETD2 (By similarity). Binds SH3GLB1. Interacts with PFN1. Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp3P706772EBI-5327353,EBI-1790419
Ctnnb1Q022483EBI-5327353,EBI-397872
Pak2Q8CIN42EBI-5327353,EBI-1559317

Protein-protein interaction databases

BioGridi200268. 172 interactions.
DIPiDIP-41430N.
IntActiP42859. 18 interactions.
MINTiMINT-270833.
STRINGi10090.ENSMUSP00000078945.

Structurei

3D structure databases

ProteinModelPortaliP42859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati183 – 22038HEAT 1Add
BLAST
Repeati225 – 26238HEAT 2Add
BLAST
Repeati782 – 81938HEAT 3Add
BLAST
Repeati882 – 92039HEAT 4Add
BLAST
Repeati1404 – 144138HEAT 5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2372 – 238110Nuclear export signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 247Poly-Gln
Compositional biasi25 – 4521Poly-ProAdd
BLAST
Compositional biasi49 – 5911Poly-ProAdd
BLAST
Compositional biasi1417 – 14204Poly-Thr
Compositional biasi1696 – 16994Poly-Gly
Compositional biasi2615 – 26206Poly-Glu

Domaini

The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations.By similarity

Sequence similaritiesi

Belongs to the huntingtin family.Curated
Contains 5 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG82191.
HOGENOMiHOG000082472.
HOVERGENiHBG005953.
InParanoidiP42859.
PhylomeDBiP42859.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERiPTHR10170. PTHR10170. 1 hit.
PfamiPF12372. DUF3652. 2 hits.
[Graphical view]
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P42859-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPQP PQPPPQGQPP
60 70 80 90 100
PPPPPLPGPA EEPLHRPKKE LSATKKDRVN HCLTICENIV AQSLRNSPEF
110 120 130 140 150
QKLLGIAMEL FLLCSNDAES DVRMVADECL NKVIKALMDS NLPRLQLELY
160 170 180 190 200
KEIKKNGAPR SLRAALWRFA ELAHLVRPQK CRPYLVNLLP CLTRTSKRPE
210 220 230 240 250
ESVQETLAAA VPKIMASFGN FANDNEIKVL LKAFIANLKS SSPTVRRTAA
260 270 280 290 300
GSAVSICQHS RRTQYFYNWL LNVLLGLLVP MEEEHSTLLI LGVLLTLRCL
310 320 330 340 350
VPLLQQQVKD TSLKGSFGVT RKEMEVSPST EQLVQVYELT LHHTQHQDHN
360 370 380 390 400
VVTGALELLQ QLFRTPPPEL LQALTTPGGL GQLTLVQEEA RGRGRSGSIV
410 420 430 440 450
ELLAGGGSSC SPVLSRKQKG KVLLGEEEAL EDDSESRSDV SSSAFAASVK
460 470 480 490 500
SEIGGELAAS SGVSTPGSVG HDIITEQPRS QHTLQADSVD LSGCDLTSAA
510 520 530 540 550
TDGDEEDILS HSSSQFSAVP SDPAMDLNDG TQASSPISDS SQTTTEGPDS
560 570 580 590 600
AVTPSDSSEI VLDGADSQYL GMQIGQPQED DEEGAAGVLS GEVSDVFRNS
610 620 630 640 650
SLALQQAHLL ERMGHSRQPS DSSIDKYVTR DEVAEASDPE SKPCRIKGDI
660 670 680 690 700
GQPNDDDSAP LVHCVRLLSA SFLLTGEKKA LVPDRDVRVS VKALALSCIG
710 720 730 740 750
AAVALHPESF FSRLYKVPLN TTESTEEQYV SDILNYIDHG DPQVRGATAI
760 770 780 790 800
LCGTLVYSIL SRSRLRVGDW LGNIRTLTGN TFSLVDCIPL LQKTLKDESS
810 820 830 840 850
VTCKLACTAV RHCVLSLCSS SYSDLGLQLL IDMLPLKNSS YWLVRTELLD
860 870 880 890 900
TLAEIDFRLV SFLEAKAESL HRGAHHYTGF LKLQERVLNN VVIYLLGDED
910 920 930 940 950
PRVRHVAATS LTRLVPKLFY KCDQGQADPV VAVARDQSSV YLKLLMHETQ
960 970 980 990 1000
PPSHFSVSTI TRIYRGYSLL PSITDVTMEN NLSRVVAAVS HELITSTTRA
1010 1020 1030 1040 1050
LTFGCCEALC LLSAAFPVCT WSLGWHCGVP PLSASDESRK SCTVGMASMI
1060 1070 1080 1090 1100
LTLLSSAWFP LDLSAHQDAL ILAGNLLAAS APKSLRSSWT SEEEANSAAT
1110 1120 1130 1140 1150
RQEEIWPALG DRTLVPLVEQ LFSHLLKVIN ICAHVLDDVT PGPAIKAALP
1160 1170 1180 1190 1200
SLTNPPSLSP IRRKGKEKEP GEQASTPMSP KKVGEASAAS RQSDTSGPVT
1210 1220 1230 1240 1250
ASKSSSLGSF YHLPSYLKLH DVLKATHANY KVTLDLQNST EKFGGFLRSA
1260 1270 1280 1290 1300
LDVLSQILEL ATLQDIGKCV EEVLGYLKSC FSREPMMATV CVQQLLKTLF
1310 1320 1330 1340 1350
GTNLASQFDG LSSNPSKSQC RAQRLGSSSV RPGLYHYCFM APYTHFTQAL
1360 1370 1380 1390 1400
ADASLRNMVQ AEQERDASGW FDVLQKVSAQ LKTNLTSVTK NRADKNAIHN
1410 1420 1430 1440 1450
HIRLFEPLVI KALKQYTTTT SVQLQKQVLD LLAQLVQLRV NYCLLDSDQV
1460 1470 1480 1490 1500
FIGFVLKQFE YIEVGQFRES EAIIPNIFFF LVLLSYERYH SKQIIGIPKI
1510 1520 1530 1540 1550
IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF VLRGTNKADA GKELETQKEV
1560 1570 1580 1590 1600
VVSMLLRLIQ YHQVLEMFIL VLQQCHKENE DKWKRLSRQV ADIILPMLAK
1610 1620 1630 1640 1650
QQMHIDSHEA LGVLNTLFEI LAPSSLRPVD MLLRSMFITP STMASVSTVQ
1660 1670 1680 1690 1700
LWISGILAIL RVLISQSTED IVLCRIQELS FSPHLLSCPV INRLRGGGGN
1710 1720 1730 1740 1750
VTLGECSEGK QKSLPEDTFS RFLLQLVGIL LEDIVTKQLK VDMSEQQHTF
1760 1770 1780 1790 1800
YCQELGTLLM CLIHIFKSGM FRRITAAATR LFTSDGCEGS FYTLESLNAR
1810 1820 1830 1840 1850
VRSMVPTHPA LVLLWCQILL LINHTDHRWW AEVQQTPKRH SLSCTKSLNP
1860 1870 1880 1890 1900
QKSGEEEDSG SAAQLGMCNR EIVRRGALIL FCDYVCQNLH DSEHLTWLIV
1910 1920 1930 1940 1950
NHIQDLISLS HEPPVQDFIS AIHRNSAASG LFIQAIQSRC ENLSTPTTLK
1960 1970 1980 1990 2000
KTLQCLEGIH LSQSGAVLTL YVDRLLGTPF RALARMVDTL ACRRVEMLLA
2010 2020 2030 2040 2050
ANLQSSMAQL PEEELNRIQE HLQNSGLAQR HQRLYSLLDR FRLSTVQDSL
2060 2070 2080 2090 2100
SPLPPVTSHP LDGDGHTSLE TVSPDKDWYL QLVRSQCWTR SDSALLEGAE
2110 2120 2130 2140 2150
LVNRIPAEDM NDFMMSSEFN LSLLAPCLSL GMSEIANGQK SPLFEAARGV
2160 2170 2180 2190 2200
ILNRVTSVVQ QLPAVHQVFQ PFLPIEPTAY WNKLNDLLGD TTSYQSLTIL
2210 2220 2230 2240 2250
ARALAQYLVV LSKVPAHLHL PPEKEGDTVK FVVMTVEALS WHLIHEQIPL
2260 2270 2280 2290 2300
SLDLQAGLDC CCLALQVPGL WGVLSSPEYV THACSLIHCV RFILEAIAVQ
2310 2320 2330 2340 2350
PGDQLLGPES RSHTPRAVRK EEVDSDIQNL SHVTSACEMV ADMVESLQSV
2360 2370 2380 2390 2400
LALGHKRNST LPSFLTAVLK NIVISLARLP LVNSYTRVPP LVWKLGWSPK
2410 2420 2430 2440 2450
PGGDFGTVFP EIPVEFLQEK EILKEFIYRI NTLGWTNRTQ FEETWATLLG
2460 2470 2480 2490 2500
VLVTQPLVME QEESPPEEDT ERTQIHVLAV QAITSLVLSA MTVPVAGNPA
2510 2520 2530 2540 2550
VSCLEQQPRN KPLKALDTRF GRKLSMIRGI VEQEIQEMVS QRENTATHHS
2560 2570 2580 2590 2600
HQAWDPVPSL LPATTGALIS HDKLLLQINP EREPGNMSYK LGQVSIHSVW
2610 2620 2630 2640 2650
LGNNITPLRE EEWDEEEEEE SDVPAPTSPP VSPVNSRKHR AGVDIHSCSQ
2660 2670 2680 2690 2700
FLLELYSRWI LPSSAARRTP VILISEVVRS LLVVSDLFTE RTQFEMMYLT
2710 2720 2730 2740 2750
LTELRRVHPS EDEILIQYLV PATCKAAAVL GMDKTVAEPV SRLLESTLRS
2760 2770 2780 2790 2800
SHLPSQIGAL HGILYVLECD LLDDTAKQLI PVVSDYLLSN LKGIAHCVNI
2810 2820 2830 2840 2850
HSQQHVLVMC ATAFYLMENY PLDVGPEFSA SVIQMCGVML SGSEESTPSI
2860 2870 2880 2890 2900
IYHCALRGLE RLLLSEQLSR LDTESLVKLS VDRVNVQSPH RAMAALGLML
2910 2920 2930 2940 2950
TCMYTGKEKA SPGRASDPSP ATPDSESVIV AMERVSVLFD RIRKGFPCEA
2960 2970 2980 2990 3000
RVVARILPQF LDDFFPPQDV MNKVIGEFLS NQQPYPQFMA TVVYKVFQTL
3010 3020 3030 3040 3050
HSAGQSSMVR DWVMLSLSNF TQRTPVAMAM WSLSCFLVSA STSPWVSAIL
3060 3070 3080 3090 3100
PHVISRMGKL EQVDVNLFCL VATDFYRHQI EEEFDRRAFQ SVFEVVAAPG
3110
SPYHRLLACL QNVHKVTTC
Length:3,119
Mass (Da):344,690
Last modified:October 1, 1996 - v2
Checksum:iECA42B5916F50F4F
GO
Isoform Short (identifier: P42859-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1522-2001: Missing.

Note: Cannot be explained by a simple splicing event.

Show »
Length:2,639
Mass (Da):290,701
Checksum:i1D09B89A8EBE0A71
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → G in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2 – 21A → G in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2 – 21A → G in AAA91085. (PubMed:7759106)Curated
Sequence conflicti29 – 291A → P in AAA89100. (PubMed:8009370)Curated
Sequence conflicti116 – 1161N → D in AAA89100. (PubMed:8009370)Curated
Sequence conflicti116 – 1161N → D in AAA91085. (PubMed:7759106)Curated
Sequence conflicti138 – 1381M → L in AAA37799. (PubMed:8162057)Curated
Sequence conflicti138 – 1381M → L in AAA37800. (PubMed:8162057)Curated
Sequence conflicti521 – 5211S → P in AAA37799. (PubMed:8162057)Curated
Sequence conflicti521 – 5211S → P in AAA37800. (PubMed:8162057)Curated
Sequence conflicti524 – 5241A → P in AAA37799. (PubMed:8162057)Curated
Sequence conflicti524 – 5241A → P in AAA37800. (PubMed:8162057)Curated
Sequence conflicti533 – 5331A → P in AAA37799. (PubMed:8162057)Curated
Sequence conflicti533 – 5331A → P in AAA37800. (PubMed:8162057)Curated
Sequence conflicti607 – 6071A → T in AAA37799. (PubMed:8162057)Curated
Sequence conflicti607 – 6071A → T in AAA37800. (PubMed:8162057)Curated
Sequence conflicti769 – 7691D → E in AAA89100. (PubMed:8009370)Curated
Sequence conflicti972 – 9721S → R in AAA37799. (PubMed:8162057)Curated
Sequence conflicti972 – 9721S → R in AAA37800. (PubMed:8162057)Curated
Sequence conflicti1106 – 11061W → C in AAA37799. (PubMed:8162057)Curated
Sequence conflicti1106 – 11061W → C in AAA37800. (PubMed:8162057)Curated
Sequence conflicti1240 – 12401T → N in AAA37799. (PubMed:8162057)Curated
Sequence conflicti1240 – 12401T → N in AAA37800. (PubMed:8162057)Curated
Sequence conflicti1384 – 13841N → T in AAA37799. (PubMed:8162057)Curated
Sequence conflicti1384 – 13841N → T in AAA37800. (PubMed:8162057)Curated
Sequence conflicti1827 – 18271H → Y in AAA37799. (PubMed:8162057)Curated
Sequence conflicti1979 – 19802PF → SS in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2062 – 20621D → G in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2062 – 20621D → G in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2570 – 25701S → N in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2570 – 25701S → N in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2866 – 28661E → V in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2866 – 28661E → V in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2877 – 28771V → G in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2877 – 28771V → G in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2882 – 28821D → G in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2882 – 28821D → G in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2887 – 28871Q → H in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2887 – 28871Q → H in AAA37800. (PubMed:8162057)Curated
Sequence conflicti2915 – 29151A → T in AAA37799. (PubMed:8162057)Curated
Sequence conflicti2915 – 29151A → T in AAA37800. (PubMed:8162057)Curated
Sequence conflicti3025 – 30251P → S in AAC52218. (PubMed:7647777)Curated
Sequence conflicti3062 – 30632QV → LM in AAA37799. (PubMed:8162057)Curated
Sequence conflicti3062 – 30632QV → LM in AAA37800. (PubMed:8162057)Curated
Sequence conflicti3095 – 30962VV → EE in AAA37799. (PubMed:8162057)Curated
Sequence conflicti3095 – 30962VV → EE in AAA37800. (PubMed:8162057)Curated

Polymorphismi

The first poly-Pro repeat stretch differs in length by one unit (three) in Mus spretus strain compared to other strains (four). The poly-Gln region does not appear to be polymorphic, explaining the absence of a murine HD-like disorder.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1522 – 2001480Missing in isoform Short. 1 PublicationVSP_004282Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23312 mRNA. Translation: AAA37799.1.
L23313 mRNA. Translation: AAA37800.1.
L28827 mRNA. Translation: AAA89100.1. Sequence problems.
U24233 mRNA. Translation: AAC52218.1.
AH003368 Genomic DNA. Translation: AAA91085.1.
PIRiI49729.
UniGeneiMm.209071.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23312 mRNA. Translation: AAA37799.1 .
L23313 mRNA. Translation: AAA37800.1 .
L28827 mRNA. Translation: AAA89100.1 . Sequence problems.
U24233 mRNA. Translation: AAC52218.1 .
AH003368 Genomic DNA. Translation: AAA91085.1 .
PIRi I49729.
UniGenei Mm.209071.

3D structure databases

ProteinModelPortali P42859.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200268. 172 interactions.
DIPi DIP-41430N.
IntActi P42859. 18 interactions.
MINTi MINT-270833.
STRINGi 10090.ENSMUSP00000078945.

Chemistry

ChEMBLi CHEMBL1250362.

PTM databases

PhosphoSitei P42859.

Proteomic databases

MaxQBi P42859.
PaxDbi P42859.
PRIDEi P42859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96067. Htt.

Phylogenomic databases

eggNOGi NOG82191.
HOGENOMi HOG000082472.
HOVERGENi HBG005953.
InParanoidi P42859.
PhylomeDBi P42859.

Miscellaneous databases

ChiTaRSi HTT. mouse.
NextBioi 287727.
PROi P42859.
SOURCEi Search...

Gene expression databases

CleanExi MM_HTT.
Genevestigatori P42859.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view ]
PANTHERi PTHR10170. PTHR10170. 1 hit.
Pfami PF12372. DUF3652. 2 hits.
[Graphical view ]
PRINTSi PR00375. HUNTINGTIN.
SUPFAMi SSF48371. SSF48371. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat."
    Lin B., Nasir J., Macdonald H., Hutchinson G., Graham R.K., Rommens J.M., Hayden M.R.
    Hum. Mol. Genet. 3:85-92(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: C57BL/6.
    Tissue: Brain and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form."
    Trottier Y., Devys D., Imbert G., Saudou F., An I., Lutz Y., Weber C., Agid Y., Hirsch E.C., Mandel J.-L.
    Nat. Genet. 10:104-110(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms."
    Lin B., Nasir J., Kalchman M.A., McDonald H., Zeisler J., Goldberg Y.P., Hayden M.R.
    Genomics 25:707-715(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-181.
  5. "Characterization of endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1."
    Modregger J., Schmidt A.A., Ritter B., Huttner W.B., Plomann M.
    J. Biol. Chem. 278:4160-4167(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3GLB1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHD_MOUSE
AccessioniPrimary (citable) accession number: P42859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3