P42857 (NSG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuron-specific protein family member 1

Alternative name(s):
Brain neuron cytoplasmic protein 1

Gene names

Name:	NSG1
Synonyms:	D4S234

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the NSG family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dopamine receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Traceable author statement. Source: ProtInc
Molecular function	dopamine receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Neuron-specific protein family member 1		PRO_0000164363
Regions
	Topological domain	1 – 82	82	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	104 – 185	82	Lumenal Potential

Sequences

	Sequence		Length	Mass (Da)
	P42857 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4B7086C18BC11605	FASTA	185	20,913
	10 20 30 40 50 60 MVKLGNNFAE KGTKQPLLED GFDTIPLMTP LDVNQLQFPP PDKVVVKTKT EYEPDRKKGK 70 80 90 100 110 120 ARPPQIAEFT VSITEGVTER FKVSVLVLFA LAFLTCVVFL VVYKVYKYDR ACPDGFVLKN 130 140 150 160 170 180 TQCIPEGLES YYAEQDSSAR EKFYTVINHY NLAKQSITRS VSPWMSVLSE EKLSEQETEA AEKSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons." Carlock L., Vo T., Lorincz M., Walker P.D., Bessert D., Wisniewski D., Dunbar J.C. Brain Res. Mol. Brain Res. 42:202-212(1996) [PubMed: 9013775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M98529 Genomic DNA. Translation: AAA60152.1. M98528 Genomic DNA. Translation: AAA60355.1. BC001745 mRNA. Translation: AAH01745.1. BC034227 mRNA. Translation: AAH34227.1.
IPI	IPI00002334.
RefSeq	NP_001035190.1. NM_001040101.1. NP_055207.1. NM_014392.3.
UniGene	Hs.518595.
3D structure databases
ProteinModelPortal	P42857.
ModBase	Search...
Protein-protein interaction databases
STRING	P42857.
Polymorphism databases
DMDM	1168680.
Proteomic databases
PRIDE	P42857.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397958; ENSP00000381049; ENSG00000168824. ENST00000433139; ENSP00000408833; ENSG00000168824.
GeneID	27065.
KEGG	hsa:27065.
UCSC	uc003ghz.1. human.
Organism-specific databases
CTD	27065.
GeneCards	GC04P004324.
H-InvDB	HIX0004048.
HPA	HPA035775.
MIM	607645. gene.
neXtProt	NX_P42857.
Phylogenomic databases
eggNOG	prNOG19696.
GeneTree	ENSGT00390000000483.
HOGENOM	HBG713191.
HOVERGEN	HBG012403.
InParanoid	P42857.
OMA	TIMSEEK.
OrthoDB	EOG415GFN.
PhylomeDB	P42857.
Gene expression databases
ArrayExpress	P42857.
Bgee	P42857.
Genevestigator	P42857.
GermOnline	ENSG00000168824. Homo sapiens.
Family and domain databases
InterPro	IPR009431. D1-dopamine_rcpt_interact. [Graphical view]
Pfam	PF06387. Calcyon. 1 hit. [Graphical view]
PIRSF	PIRSF002383. Calcyon. 1 hit.
ProtoNet	Search...
Other
NextBio	49634.
SOURCE	Search...

Entry information

Entry name

NSG1_HUMAN

Accession

Primary (citable) accession number: P42857
Secondary accession number(s): Q49AQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.