Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuron-specific protein family member 1

Gene

NSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific protein family member 1
Alternative name(s):
Brain neuron cytoplasmic protein 1
Gene namesi
Name:NSG1
Synonyms:D4S234
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini104 – 18582LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • endosome Source: Ensembl
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: Ensembl
  • nucleus Source: ProtInc
  • postsynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiNSG1.
DMDMi1168680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Neuron-specific protein family member 1PRO_0000164363Add
BLAST

Proteomic databases

PaxDbiP42857.
PeptideAtlasiP42857.
PRIDEiP42857.

PTM databases

iPTMnetiP42857.
PhosphoSiteiP42857.

Expressioni

Gene expression databases

BgeeiP42857.
ExpressionAtlasiP42857. baseline and differential.
GenevisibleiP42857. HS.

Organism-specific databases

HPAiHPA035775.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BSCL2Q96G97-43EBI-6380741,EBI-10178113
CCDC155Q8N6L03EBI-6380741,EBI-749265

Protein-protein interaction databases

BioGridi117976. 4 interactions.
IntActiP42857. 4 interactions.
STRINGi9606.ENSP00000381049.

Structurei

3D structure databases

ProteinModelPortaliP42857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM0N. Eukaryota.
ENOG410YBAS. LUCA.
GeneTreeiENSGT00390000000483.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiP42857.
OMAiKLRSPKI.
OrthoDBiEOG7DVDCJ.
PhylomeDBiP42857.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P42857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKLGNNFAE KGTKQPLLED GFDTIPLMTP LDVNQLQFPP PDKVVVKTKT
60 70 80 90 100
EYEPDRKKGK ARPPQIAEFT VSITEGVTER FKVSVLVLFA LAFLTCVVFL
110 120 130 140 150
VVYKVYKYDR ACPDGFVLKN TQCIPEGLES YYAEQDSSAR EKFYTVINHY
160 170 180
NLAKQSITRS VSPWMSVLSE EKLSEQETEA AEKSA
Length:185
Mass (Da):20,913
Last modified:November 1, 1995 - v1
Checksum:i4B7086C18BC11605
GO
Isoform 2 (identifier: P42857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,467
Checksum:iA6081780937EB3B6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 8139Missing in isoform 2. 1 PublicationVSP_054333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98529 Genomic DNA. Translation: AAA60152.1.
M98528 Genomic DNA. Translation: AAA60355.1.
AK301911 mRNA. Translation: BAG63337.1.
AC105415 Genomic DNA. No translation available.
AC110814 Genomic DNA. No translation available.
BC001745 mRNA. Translation: AAH01745.1.
BC034227 mRNA. Translation: AAH34227.1.
CCDSiCCDS3376.1. [P42857-1]
RefSeqiNP_001035190.1. NM_001040101.1. [P42857-1]
NP_001274692.1. NM_001287763.1. [P42857-1]
NP_055207.1. NM_014392.4. [P42857-1]
UniGeneiHs.518595.

Genome annotation databases

GeneIDi27065.
KEGGihsa:27065.
UCSCiuc003ghz.4. human. [P42857-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98529 Genomic DNA. Translation: AAA60152.1.
M98528 Genomic DNA. Translation: AAA60355.1.
AK301911 mRNA. Translation: BAG63337.1.
AC105415 Genomic DNA. No translation available.
AC110814 Genomic DNA. No translation available.
BC001745 mRNA. Translation: AAH01745.1.
BC034227 mRNA. Translation: AAH34227.1.
CCDSiCCDS3376.1. [P42857-1]
RefSeqiNP_001035190.1. NM_001040101.1. [P42857-1]
NP_001274692.1. NM_001287763.1. [P42857-1]
NP_055207.1. NM_014392.4. [P42857-1]
UniGeneiHs.518595.

3D structure databases

ProteinModelPortaliP42857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117976. 4 interactions.
IntActiP42857. 4 interactions.
STRINGi9606.ENSP00000381049.

PTM databases

iPTMnetiP42857.
PhosphoSiteiP42857.

Polymorphism and mutation databases

BioMutaiNSG1.
DMDMi1168680.

Proteomic databases

PaxDbiP42857.
PeptideAtlasiP42857.
PRIDEiP42857.

Protocols and materials databases

DNASUi27065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27065.
KEGGihsa:27065.
UCSCiuc003ghz.4. human. [P42857-1]

Organism-specific databases

CTDi27065.
GeneCardsiNSG1.
HPAiHPA035775.
MIMi607645. gene.
neXtProtiNX_P42857.

Phylogenomic databases

eggNOGiENOG410IM0N. Eukaryota.
ENOG410YBAS. LUCA.
GeneTreeiENSGT00390000000483.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiP42857.
OMAiKLRSPKI.
OrthoDBiEOG7DVDCJ.
PhylomeDBiP42857.

Miscellaneous databases

GenomeRNAii27065.
PROiP42857.
SOURCEiSearch...

Gene expression databases

BgeeiP42857.
ExpressionAtlasiP42857. baseline and differential.
GenevisibleiP42857. HS.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons."
    Carlock L., Vo T., Lorincz M., Walker P.D., Bessert D., Wisniewski D., Dunbar J.C.
    Brain Res. Mol. Brain Res. 42:202-212(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.

Entry informationi

Entry nameiNSG1_HUMAN
AccessioniPrimary (citable) accession number: P42857
Secondary accession number(s): B4DXC5, Q49AQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.