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Protein

Neuron-specific protein family member 1

Gene

NSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific protein family member 1
Alternative name(s):
Brain neuron cytoplasmic protein 1
Gene namesi
Name:NSG1
Synonyms:D4S234
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
Transmembranei83 – 103Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini104 – 185LumenalSequence analysisAdd BLAST82

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • endosome Source: Ensembl
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: Ensembl
  • nucleus Source: ProtInc
  • postsynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27065.
OpenTargetsiENSG00000168824.

Polymorphism and mutation databases

BioMutaiNSG1.
DMDMi1168680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643631 – 185Neuron-specific protein family member 1Add BLAST185

Proteomic databases

PaxDbiP42857.
PeptideAtlasiP42857.
PRIDEiP42857.

PTM databases

iPTMnetiP42857.
PhosphoSitePlusiP42857.

Expressioni

Gene expression databases

BgeeiENSG00000168824.
ExpressionAtlasiP42857. baseline and differential.
GenevisibleiP42857. HS.

Organism-specific databases

HPAiHPA035775.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BSCL2Q96G97-43EBI-6380741,EBI-10178113
CCDC155Q8N6L05EBI-6380741,EBI-749265

Protein-protein interaction databases

BioGridi117976. 4 interactors.
IntActiP42857. 5 interactors.
STRINGi9606.ENSP00000381049.

Structurei

3D structure databases

ProteinModelPortaliP42857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM0N. Eukaryota.
ENOG410YBAS. LUCA.
GeneTreeiENSGT00390000000483.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiP42857.
OMAiKLRSPKI.
OrthoDBiEOG091G0LR0.
PhylomeDBiP42857.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P42857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKLGNNFAE KGTKQPLLED GFDTIPLMTP LDVNQLQFPP PDKVVVKTKT
60 70 80 90 100
EYEPDRKKGK ARPPQIAEFT VSITEGVTER FKVSVLVLFA LAFLTCVVFL
110 120 130 140 150
VVYKVYKYDR ACPDGFVLKN TQCIPEGLES YYAEQDSSAR EKFYTVINHY
160 170 180
NLAKQSITRS VSPWMSVLSE EKLSEQETEA AEKSA
Length:185
Mass (Da):20,913
Last modified:November 1, 1995 - v1
Checksum:i4B7086C18BC11605
GO
Isoform 2 (identifier: P42857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,467
Checksum:iA6081780937EB3B6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05433343 – 81Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98529 Genomic DNA. Translation: AAA60152.1.
M98528 Genomic DNA. Translation: AAA60355.1.
AK301911 mRNA. Translation: BAG63337.1.
AC105415 Genomic DNA. No translation available.
AC110814 Genomic DNA. No translation available.
BC001745 mRNA. Translation: AAH01745.1.
BC034227 mRNA. Translation: AAH34227.1.
CCDSiCCDS3376.1. [P42857-1]
RefSeqiNP_001035190.1. NM_001040101.1. [P42857-1]
NP_001274692.1. NM_001287763.1. [P42857-1]
NP_055207.1. NM_014392.4. [P42857-1]
XP_016863511.1. XM_017008022.1. [P42857-1]
UniGeneiHs.518595.

Genome annotation databases

GeneIDi27065.
KEGGihsa:27065.
UCSCiuc003ghz.4. human. [P42857-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98529 Genomic DNA. Translation: AAA60152.1.
M98528 Genomic DNA. Translation: AAA60355.1.
AK301911 mRNA. Translation: BAG63337.1.
AC105415 Genomic DNA. No translation available.
AC110814 Genomic DNA. No translation available.
BC001745 mRNA. Translation: AAH01745.1.
BC034227 mRNA. Translation: AAH34227.1.
CCDSiCCDS3376.1. [P42857-1]
RefSeqiNP_001035190.1. NM_001040101.1. [P42857-1]
NP_001274692.1. NM_001287763.1. [P42857-1]
NP_055207.1. NM_014392.4. [P42857-1]
XP_016863511.1. XM_017008022.1. [P42857-1]
UniGeneiHs.518595.

3D structure databases

ProteinModelPortaliP42857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117976. 4 interactors.
IntActiP42857. 5 interactors.
STRINGi9606.ENSP00000381049.

PTM databases

iPTMnetiP42857.
PhosphoSitePlusiP42857.

Polymorphism and mutation databases

BioMutaiNSG1.
DMDMi1168680.

Proteomic databases

PaxDbiP42857.
PeptideAtlasiP42857.
PRIDEiP42857.

Protocols and materials databases

DNASUi27065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27065.
KEGGihsa:27065.
UCSCiuc003ghz.4. human. [P42857-1]

Organism-specific databases

CTDi27065.
DisGeNETi27065.
GeneCardsiNSG1.
HPAiHPA035775.
MIMi607645. gene.
neXtProtiNX_P42857.
OpenTargetsiENSG00000168824.

Phylogenomic databases

eggNOGiENOG410IM0N. Eukaryota.
ENOG410YBAS. LUCA.
GeneTreeiENSGT00390000000483.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiP42857.
OMAiKLRSPKI.
OrthoDBiEOG091G0LR0.
PhylomeDBiP42857.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168824-MONOMER.

Miscellaneous databases

GenomeRNAii27065.
PROiP42857.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168824.
ExpressionAtlasiP42857. baseline and differential.
GenevisibleiP42857. HS.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNSG1_HUMAN
AccessioniPrimary (citable) accession number: P42857
Secondary accession number(s): B4DXC5, Q49AQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.