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Protein

Regenerating islet-derived protein 3-gamma

Gene

Reg3g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial

Keywords - Biological processi

Acute phase, Inflammatory response

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-RNO-6803157. Antimicrobial peptides.

Protein family/group databases

MEROPSiI63.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 3-gamma
Short name:
REG-3-gamma
Alternative name(s):
Pancreatitis-associated protein 3
Regenerating islet-derived protein III-gamma
Short name:
Reg III-gamma
Cleaved into the following 2 chains:
Gene namesi
Name:Reg3g
Synonyms:Pap3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3256. Reg3g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001743627 – 174Regenerating islet-derived protein 3-gamma 16.5 kDa formAdd BLAST148
PropeptideiPRO_000042275527 – 37By similarityAdd BLAST11
ChainiPRO_000042275638 – 174Regenerating islet-derived protein 3-gamma 15 kDa formAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 51PROSITE-ProRule annotation
Disulfide bondi68 ↔ 170PROSITE-ProRule annotation
Disulfide bondi145 ↔ 162PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP42854.
PRIDEiP42854.

Expressioni

Tissue specificityi

Expressed in injured skeletal muscles and sciatic nerve (at protein level). Expressed in the pancreas. Expression increases during the acute phase of pancreatitis.2 Publications

Inductioni

Up-regulated in injured skeletal muscles and peripheral nerve.1 Publication

Gene expression databases

BgeeiENSRNOG00000006579.
GenevisibleiP42854. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008665.

Structurei

3D structure databases

ProteinModelPortaliP42854.
SMRiP42854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 171C-type lectinPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116EPNBy similarity3

Domaini

The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.By similarity

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP42854.
OMAiWEWSNAD.
OrthoDBiEOG091G0MDY.
PhylomeDBiP42854.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRVALTTM SWMLLSSLML LSQVQGEDAK EDVPTSRISC PKGSRAYGSY
60 70 80 90 100
CYALFSVSKS WFDADLACQK RPSGHLVSVL SGSEASFVSS LIKSSGNSGQ
110 120 130 140 150
NVWIGLHDPT LGQEPNRGGW EWSNADVMNY FNWETNPSSV SGSHCGTLTR
160 170
ASGFLRWREN NCISELPYVC KFKA
Length:174
Mass (Da):19,144
Last modified:November 1, 1995 - v1
Checksum:i5CED2E887C46E45C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20869 mRNA. Translation: AAA41809.1.
U09193 Genomic DNA. Translation: AAA79231.1.
PIRiS54979.
RefSeqiNP_775120.1. NM_173097.1.
UniGeneiRn.9729.

Genome annotation databases

EnsembliENSRNOT00000008665; ENSRNOP00000008665; ENSRNOG00000006579.
GeneIDi24620.
KEGGirno:24620.
UCSCiRGD:3256. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20869 mRNA. Translation: AAA41809.1.
U09193 Genomic DNA. Translation: AAA79231.1.
PIRiS54979.
RefSeqiNP_775120.1. NM_173097.1.
UniGeneiRn.9729.

3D structure databases

ProteinModelPortaliP42854.
SMRiP42854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008665.

Protein family/group databases

MEROPSiI63.002.

Proteomic databases

PaxDbiP42854.
PRIDEiP42854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008665; ENSRNOP00000008665; ENSRNOG00000006579.
GeneIDi24620.
KEGGirno:24620.
UCSCiRGD:3256. rat.

Organism-specific databases

CTDi130120.
RGDi3256. Reg3g.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP42854.
OMAiWEWSNAD.
OrthoDBiEOG091G0MDY.
PhylomeDBiP42854.

Enzyme and pathway databases

ReactomeiR-RNO-6803157. Antimicrobial peptides.

Miscellaneous databases

PROiP42854.

Gene expression databases

BgeeiENSRNOG00000006579.
GenevisibleiP42854. RN.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREG3G_RAT
AccessioniPrimary (citable) accession number: P42854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.