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P42845

- STB1_YEAST

UniProt

P42845 - STB1_YEAST

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Protein

Protein STB1

Gene

STB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the regulation and timing of MBF-dependent transcription in late G1 of the cell cycle.1 Publication

GO - Molecular functioni

  1. transcription factor binding Source: SGD
  2. transcription factor binding transcription factor activity Source: SGD

GO - Biological processi

  1. positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  2. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STB1
Alternative name(s):
SIN3-binding protein 1
Gene namesi
Name:STB1
Ordered Locus Names:YNL309W
ORF Names:N0384
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL309w.
SGDiS000005253. STB1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. MBF transcription complex Source: SGD
  3. SBF transcription complex Source: SGD
  4. Sin3-type complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 420419Protein STB1PRO_0000072251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei7 – 71Phosphoserine1 Publication
Modified residuei72 – 721Phosphoserine1 Publication
Modified residuei99 – 991Phosphothreonine3 Publications
Modified residuei102 – 1021Phosphoserine1 Publication
Modified residuei419 – 4191Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylated by CDC28 in a cell cycle-dependent manner, inhibiting the interaction with SWI6.6 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP42845.
PaxDbiP42845.

Expressioni

Gene expression databases

GenevestigatoriP42845.

Interactioni

Subunit structurei

Interacts with the ANK repeats of SWI6. The interaction with SWI6 is required for function. Interacts with SIN3.3 Publications

Protein-protein interaction databases

BioGridi35530. 74 interactions.
DIPiDIP-2485N.
IntActiP42845. 4 interactions.
MINTiMINT-533060.
STRINGi4932.YNL309W.

Structurei

3D structure databases

ProteinModelPortaliP42845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 7069Interaction with SWI6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1594Poly-Asn
Compositional biasi165 – 1695Poly-Asn

Phylogenomic databases

eggNOGiNOG39630.
HOGENOMiHOG000000865.
InParanoidiP42845.
OMAiNFNMGDY.
OrthoDBiEOG7C8GW8.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42845-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQPQMSPEK EQELASKILH RAELAQMTRQ LKLGLSNVPS TKRKQDSTTK
60 70 80 90 100
KRSGEDAEDV DEDHKTLLEA ISPAKKPLHD DTNKMTVISP VKFVEKPNTP
110 120 130 140 150
PSSRQRKAED RSQQIKPRKE DTPSTPRASA TPIILPHASS HYQRPHDKNF
160 170 180 190 200
MTPKRNNNNS SNHSNNNNNI KKKAAGSKDA PQDSDNTAGA DLLMYLATSP
210 220 230 240 250
YNKSSHHGTP MAVRMPTTPR SYHYASQLSL NGNTASTSND AVRFSHIKPS
260 270 280 290 300
ASSPQSTFKS NLLPNFPDES LMDSPSLYLS NNNGSVQATL SPQQRRKPTT
310 320 330 340 350
NTLHPPSNVP TTPSRELNGT NFNLLRTPNF NMGDYLHNLF SPSPRVPAQQ
360 370 380 390 400
GASNTSASIP SVPAMVPGSS SNTSAIATAA ISSHTTNNFL DMNANGIPLI
410 420
VGPGTDRIGE GESIDDKLTD
Length:420
Mass (Da):45,684
Last modified:September 13, 2005 - v2
Checksum:iB1F5E52C8A920400
GO

Sequence cautioni

The sequence AAA75482.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA86386.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA96238.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33439 Genomic DNA. Translation: AAA75482.1. Different initiation.
Z46259 Genomic DNA. Translation: CAA86386.1. Different initiation.
Z71585 Genomic DNA. Translation: CAA96238.1. Different initiation.
BK006947 Genomic DNA. Translation: DAA10252.1.
PIRiS51302.
RefSeqiNP_014090.2. NM_001183147.1.

Genome annotation databases

EnsemblFungiiYNL309W; YNL309W; YNL309W.
GeneIDi855407.
KEGGisce:YNL309W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33439 Genomic DNA. Translation: AAA75482.1 . Different initiation.
Z46259 Genomic DNA. Translation: CAA86386.1 . Different initiation.
Z71585 Genomic DNA. Translation: CAA96238.1 . Different initiation.
BK006947 Genomic DNA. Translation: DAA10252.1 .
PIRi S51302.
RefSeqi NP_014090.2. NM_001183147.1.

3D structure databases

ProteinModelPortali P42845.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35530. 74 interactions.
DIPi DIP-2485N.
IntActi P42845. 4 interactions.
MINTi MINT-533060.
STRINGi 4932.YNL309W.

Proteomic databases

MaxQBi P42845.
PaxDbi P42845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL309W ; YNL309W ; YNL309W .
GeneIDi 855407.
KEGGi sce:YNL309W.

Organism-specific databases

CYGDi YNL309w.
SGDi S000005253. STB1.

Phylogenomic databases

eggNOGi NOG39630.
HOGENOMi HOG000000865.
InParanoidi P42845.
OMAi NFNMGDY.
OrthoDBi EOG7C8GW8.

Enzyme and pathway databases

BioCyci YEAST:G3O-33296-MONOMER.

Miscellaneous databases

NextBioi 979244.

Gene expression databases

Genevestigatori P42845.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins."
    Kasten M.M., Stillman D.J.
    Mol. Gen. Genet. 256:376-386(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH SIN3.
  2. "Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames."
    Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C.
    Yeast 11:1077-1085(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein."
    Ho Y., Costanzo M., Moore L., Kobayashi R., Andrews B.J.
    Mol. Cell. Biol. 19:5267-5278(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 249-259, INTERACTION WITH SWI6, PHOSPHORYLATION BY CDC28.
  6. "G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1."
    Costanzo M., Schub O., Andrews B.J.
    Mol. Cell. Biol. 23:5064-5077(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SWI6.
  7. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. Cited for: PHOSPHORYLATION BY CDC28.
  11. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  12. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-99 AND THR-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; THR-99 AND SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTB1_YEAST
AccessioniPrimary (citable) accession number: P42845
Secondary accession number(s): D6W0N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3