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Protein

Protein STB1

Gene

STB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation and timing of MBF-dependent transcription in late G1 of the cell cycle.1 Publication

GO - Molecular functioni

  • transcription factor activity, transcription factor binding Source: SGD
  • transcription factor binding Source: SGD

GO - Biological processi

  • positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STB1
Alternative name(s):
SIN3-binding protein 1
Gene namesi
Name:STB1
Ordered Locus Names:YNL309W
ORF Names:N0384
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL309W.
SGDiS000005253. STB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • MBF transcription complex Source: SGD
  • SBF transcription complex Source: SGD
  • Sin3-type complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000722512 – 420Protein STB1Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei99PhosphothreonineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei419PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated by CDC28 in a cell cycle-dependent manner, inhibiting the interaction with SWI6.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP42845.
PRIDEiP42845.

PTM databases

iPTMnetiP42845.

Interactioni

Subunit structurei

Interacts with the ANK repeats of SWI6. The interaction with SWI6 is required for function. Interacts with SIN3.3 Publications

GO - Molecular functioni

  • transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi35530. 74 interactors.
DIPiDIP-2485N.
IntActiP42845. 4 interactors.
MINTiMINT-533060.

Structurei

3D structure databases

ProteinModelPortaliP42845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 70Interaction with SWI6Add BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 159Poly-Asn4
Compositional biasi165 – 169Poly-Asn5

Phylogenomic databases

HOGENOMiHOG000000865.
InParanoidiP42845.
OMAiNFNMGDY.
OrthoDBiEOG092C2M3U.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPQMSPEK EQELASKILH RAELAQMTRQ LKLGLSNVPS TKRKQDSTTK
60 70 80 90 100
KRSGEDAEDV DEDHKTLLEA ISPAKKPLHD DTNKMTVISP VKFVEKPNTP
110 120 130 140 150
PSSRQRKAED RSQQIKPRKE DTPSTPRASA TPIILPHASS HYQRPHDKNF
160 170 180 190 200
MTPKRNNNNS SNHSNNNNNI KKKAAGSKDA PQDSDNTAGA DLLMYLATSP
210 220 230 240 250
YNKSSHHGTP MAVRMPTTPR SYHYASQLSL NGNTASTSND AVRFSHIKPS
260 270 280 290 300
ASSPQSTFKS NLLPNFPDES LMDSPSLYLS NNNGSVQATL SPQQRRKPTT
310 320 330 340 350
NTLHPPSNVP TTPSRELNGT NFNLLRTPNF NMGDYLHNLF SPSPRVPAQQ
360 370 380 390 400
GASNTSASIP SVPAMVPGSS SNTSAIATAA ISSHTTNNFL DMNANGIPLI
410 420
VGPGTDRIGE GESIDDKLTD
Length:420
Mass (Da):45,684
Last modified:September 13, 2005 - v2
Checksum:iB1F5E52C8A920400
GO

Sequence cautioni

The sequence AAA75482 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA86386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA96238 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33439 Genomic DNA. Translation: AAA75482.1. Different initiation.
Z46259 Genomic DNA. Translation: CAA86386.1. Different initiation.
Z71585 Genomic DNA. Translation: CAA96238.1. Different initiation.
BK006947 Genomic DNA. Translation: DAA10252.1.
PIRiS51302.
RefSeqiNP_014090.2. NM_001183147.1.

Genome annotation databases

EnsemblFungiiYNL309W; YNL309W; YNL309W.
GeneIDi855407.
KEGGisce:YNL309W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33439 Genomic DNA. Translation: AAA75482.1. Different initiation.
Z46259 Genomic DNA. Translation: CAA86386.1. Different initiation.
Z71585 Genomic DNA. Translation: CAA96238.1. Different initiation.
BK006947 Genomic DNA. Translation: DAA10252.1.
PIRiS51302.
RefSeqiNP_014090.2. NM_001183147.1.

3D structure databases

ProteinModelPortaliP42845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35530. 74 interactors.
DIPiDIP-2485N.
IntActiP42845. 4 interactors.
MINTiMINT-533060.

PTM databases

iPTMnetiP42845.

Proteomic databases

MaxQBiP42845.
PRIDEiP42845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL309W; YNL309W; YNL309W.
GeneIDi855407.
KEGGisce:YNL309W.

Organism-specific databases

EuPathDBiFungiDB:YNL309W.
SGDiS000005253. STB1.

Phylogenomic databases

HOGENOMiHOG000000865.
InParanoidiP42845.
OMAiNFNMGDY.
OrthoDBiEOG092C2M3U.

Enzyme and pathway databases

BioCyciYEAST:G3O-33296-MONOMER.

Miscellaneous databases

PROiP42845.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSTB1_YEAST
AccessioniPrimary (citable) accession number: P42845
Secondary accession number(s): D6W0N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.