Reviewed, UniProtKB/Swiss-Prot P42843 (YN51_YEAST)

Names and origin

Protein names

Recommended name:
    F-box protein YNL311C

Gene names

Ordered Locus Names:	YNL311C
ORF Names:	N0376

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with SKP1. Component of the probable SCF(YDL311C) complex containing CDC53, SKP1, RBX1 and YDL311C. Ref.5
Miscellaneous	Present with 432 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P38823	1	EBI-28370,EBI-24686
	P53924	1	EBI-28370,EBI-28867
MET14	Q02196	3	EBI-28370,EBI-9485
SER33	P40510	2	EBI-28370,EBI-16821

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 763	763	F-box protein YNL311C		PRO_0000203366
Regions
	Domain	54 – 100	47	F-box
	Compositional bias	22 – 28	7	Poly-Glu
Experimental info
	Sequence conflict	16	1	V → A in AAT92730. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P42843-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 81102168449051BC	FASTA	763	88,942
	10 20 30 40 50 60 MKRLQLFGRS KYFSLVSSAA KEEEEEEEGC ADAKSLLHST SHDIKSRSLR FNDKSSLMCL 70 80 90 100 110 120 PTKVLLLILR TLDFNTLVTL CQVNSRFYNL ITNEFLFQNV ILDSKLSLLK FNALIHSEFH 130 140 150 160 170 180 TSNIVTHSGD CSTQSRSQNA RFLVRSIEFK NPQSQDSLLK YSKFYNKSGQ DSIIAGSYKL 190 200 210 220 230 240 DSYDKDVKKL NNIRLNDETP IITSERIKLL DKLESNYFHY TYIELMLDII DYLPNLTRVI 250 260 270 280 290 300 LSDVEPNFKI PLWYSVFNDG SRDFFKKIIK GQQSITNEDL RTFQLSKKFV KEYESKYYSL 310 320 330 340 350 360 PRLKILEIKA NNKRQRTFNR QRHHQKLVLR PSLFCCFGII NELKLENVTI DTESLDTPME 370 380 390 400 410 420 FLPLFLKNED NELYSLQSPI TALTLDSCDV VPGNGILRLF HSYFKMVKHL SLLKINSKFD 430 440 450 460 470 480 LLLCSCFPSL SNLTIDCNSK CFTNEQVVGE SYYFQQRSLD TEDDFDDCNS MTETLFEAPS 490 500 510 520 530 540 DSKIITPPPT SSVVLSLNLN YISRTTGNDV SNNPSPDNNK KPAMLTAAQL QNFQRQRIPE 550 560 570 580 590 600 FHSFYHYYRL LWERLPSKNI SINVINIPFT NVYPLSPLSF WEHLARTITS VDETDEDVGD 610 620 630 640 650 660 ENDQETLIGY ENNSIRDNIP NANAVPNLST VMSPESDIHH TYYWNNSVRR CLRDSLIKLK 670 680 690 700 710 720 NRTIEYRDLD VEEFLQNVTL ENFFNDFQDP ENFKDIPNIN LWCFLRNLSK FKAVKIRMLR 730 740 750 760 HFSLCTPRTR YDWELLLKPV LRVNVPIEVR DKDGFVLYSY GQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames." Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C. Yeast 11:1077-1085(1995) [PubMed: 7502583] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / FY1676.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro." Kus B.M., Caldon C.E., Andorn-Broza R., Edwards A.M. Proteins 54:455-467(2004) [PubMed: 14747994] [Abstract] Cited for: INTERACTION WITH SKP1, RECONSTITUTION OF THE SCF(YNL311C) COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z46259 Genomic DNA. Translation: CAA86384.1. Z71587 Genomic DNA. Translation: CAA96240.1. AY692711 Genomic DNA. Translation: AAT92730.1.
PIR	S51300.
RefSeq	NP_014088.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1971N.
IntAct	P42843. 13 interactions.
STRING	P42843.
Proteomic databases
PeptideAtlas	P42843.
PRIDE	P42843.
Genome annotation databases
Ensembl	YNL311C; YNL311C; YNL311C; Saccharomyces cerevisiae. [Genome view]
GeneID	855405.
KEGG	sce:YNL311C.
NMPDR	fig|4932.3.peg.5150.
Organism-specific databases
CYGD	YNL311c.
SGD	S000005255. YNL311C.
Phylogenomic databases
HOGENOM	P42843.
OMA	YDWELLL
OrthoDB	EOG944N2W
Gene expression databases
ArrayExpress	P42843.
Genevestigator	P42843.
GermOnline	YNL311C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001810. F-box. [Graphical view]
Pfam	PF00646. F-box. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. [Graphical view]
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	979238.

Entry information

Entry name

YN51_YEAST

Accession

Primary (citable) accession number: P42843
Secondary accession number(s): Q6B2L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)