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P42834

- MDJ2_YEAST

UniProt

P42834 - MDJ2_YEAST

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Protein

Mitochondrial DnaJ homolog 2

Gene

MDJ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial biogenesis and protein folding. Participates in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, probably by stimulating activity of mtHSP70 (SSC1).2 Publications

GO - Molecular functioni

  1. ATPase activator activity Source: SGD

GO - Biological processi

  1. positive regulation of ATPase activity Source: GOC
  2. protein import into mitochondrial matrix Source: SGD
  3. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Stress response, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33312-MONOMER.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial DnaJ homolog 2
Gene namesi
Name:MDJ2
Ordered Locus Names:YNL328C
ORF Names:N0315
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL328c.
SGDiS000005272. MDJ2.

Subcellular locationi

Mitochondrion inner membrane 2 Publications

GO - Cellular componenti

  1. mitochondrial inner membrane Source: SGD
  2. presequence translocase-associated import motor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Mitochondrial DnaJ homolog 2PRO_0000071094Add
BLAST

Proteomic databases

MaxQBiP42834.
PaxDbiP42834.

Expressioni

Gene expression databases

GenevestigatoriP42834.

Interactioni

Subunit structurei

Interacts with PAM16/TIM16 and is recruited by the PAM complex.1 Publication

Protein-protein interaction databases

BioGridi35513. 18 interactions.
DIPiDIP-4690N.
MINTiMINT-556272.
STRINGi4932.YNL328C.

Structurei

3D structure databases

ProteinModelPortaliP42834.
SMRiP42834. Positions 74-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 14662JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2214.
GeneTreeiENSGT00390000017303.
HOGENOMiHOG000115841.
InParanoidiP42834.
OMAiDRYRKLM.
OrthoDBiEOG7FFN55.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42834-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLPIIIGLG VTMVALSVKS GLNAWTVYKT LSPLTIAKLN NIRIENPTAG
60 70 80 90 100
YRDALKFKSS LIDEELKNRL NQYQGGFAPR MTEPEALLIL DISAREINHL
110 120 130 140
DEKLLKKKHR KAMVRNHPDR GGSPYMAAKI NEAKEVLERS VLLRKR
Length:146
Mass (Da):16,474
Last modified:November 1, 1995 - v1
Checksum:i36AC6362E15CEE71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46259 Genomic DNA. Translation: CAA86370.1.
Z71604 Genomic DNA. Translation: CAA96260.1.
AY692768 Genomic DNA. Translation: AAT92787.1.
BK006947 Genomic DNA. Translation: DAA10235.1.
PIRiS55861.
RefSeqiNP_014071.1. NM_001183166.1.

Genome annotation databases

EnsemblFungiiYNL328C; YNL328C; YNL328C.
GeneIDi855388.
KEGGisce:YNL328C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46259 Genomic DNA. Translation: CAA86370.1 .
Z71604 Genomic DNA. Translation: CAA96260.1 .
AY692768 Genomic DNA. Translation: AAT92787.1 .
BK006947 Genomic DNA. Translation: DAA10235.1 .
PIRi S55861.
RefSeqi NP_014071.1. NM_001183166.1.

3D structure databases

ProteinModelPortali P42834.
SMRi P42834. Positions 74-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35513. 18 interactions.
DIPi DIP-4690N.
MINTi MINT-556272.
STRINGi 4932.YNL328C.

Protein family/group databases

TCDBi 3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBi P42834.
PaxDbi P42834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL328C ; YNL328C ; YNL328C .
GeneIDi 855388.
KEGGi sce:YNL328C.

Organism-specific databases

CYGDi YNL328c.
SGDi S000005272. MDJ2.

Phylogenomic databases

eggNOGi COG2214.
GeneTreei ENSGT00390000017303.
HOGENOMi HOG000115841.
InParanoidi P42834.
OMAi DRYRKLM.
OrthoDBi EOG7FFN55.

Enzyme and pathway databases

BioCyci YEAST:G3O-33312-MONOMER.

Miscellaneous databases

NextBioi 979193.

Gene expression databases

Genevestigatori P42834.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing analysis of a 15.4 kb fragment of yeast chromosome XIV identifies the RPD3, PAS8 and KRE1 loci, five new open reading frames."
    Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C.
    Yeast 11:567-572(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Mdj2p, a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae."
    Westermann B., Neupert W.
    J. Mol. Biol. 272:477-483(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2."
    Mokranjac D., Sichting M., Popov-Celeketic D., Berg A., Hell K., Neupert W.
    J. Biol. Chem. 280:31608-31614(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE PAM23 COMPLEX, INTERACTION WITH PAM16.

Entry informationi

Entry nameiMDJ2_YEAST
AccessioniPrimary (citable) accession number: P42834
Secondary accession number(s): D6W0L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 573 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3