Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial DnaJ homolog 2

Gene

MDJ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial biogenesis and protein folding. Participates in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, probably by stimulating activity of mtHSP70 (SSC1).2 Publications

GO - Molecular functioni

  • ATPase activator activity Source: SGD

GO - Biological processi

  • protein import into mitochondrial matrix Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Stress response, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33312-MONOMER.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial DnaJ homolog 2
Gene namesi
Name:MDJ2
Ordered Locus Names:YNL328C
ORF Names:N0315
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL328C.
SGDiS000005272. MDJ2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: SGD
  • presequence translocase-associated import motor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710941 – 146Mitochondrial DnaJ homolog 2Add BLAST146

Proteomic databases

MaxQBiP42834.
PRIDEiP42834.

Interactioni

Subunit structurei

Interacts with PAM16/TIM16 and is recruited by the PAM complex.1 Publication

Protein-protein interaction databases

BioGridi35513. 19 interactors.
DIPiDIP-4690N.
MINTiMINT-556272.

Structurei

3D structure databases

ProteinModelPortaliP42834.
SMRiP42834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 146JPROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017303.
HOGENOMiHOG000115841.
InParanoidiP42834.
OMAiKAMVRNH.
OrthoDBiEOG092C5SDV.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPIIIGLG VTMVALSVKS GLNAWTVYKT LSPLTIAKLN NIRIENPTAG
60 70 80 90 100
YRDALKFKSS LIDEELKNRL NQYQGGFAPR MTEPEALLIL DISAREINHL
110 120 130 140
DEKLLKKKHR KAMVRNHPDR GGSPYMAAKI NEAKEVLERS VLLRKR
Length:146
Mass (Da):16,474
Last modified:November 1, 1995 - v1
Checksum:i36AC6362E15CEE71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA. Translation: CAA86370.1.
Z71604 Genomic DNA. Translation: CAA96260.1.
AY692768 Genomic DNA. Translation: AAT92787.1.
BK006947 Genomic DNA. Translation: DAA10235.1.
PIRiS55861.
RefSeqiNP_014071.1. NM_001183166.1.

Genome annotation databases

EnsemblFungiiYNL328C; YNL328C; YNL328C.
GeneIDi855388.
KEGGisce:YNL328C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA. Translation: CAA86370.1.
Z71604 Genomic DNA. Translation: CAA96260.1.
AY692768 Genomic DNA. Translation: AAT92787.1.
BK006947 Genomic DNA. Translation: DAA10235.1.
PIRiS55861.
RefSeqiNP_014071.1. NM_001183166.1.

3D structure databases

ProteinModelPortaliP42834.
SMRiP42834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35513. 19 interactors.
DIPiDIP-4690N.
MINTiMINT-556272.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBiP42834.
PRIDEiP42834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL328C; YNL328C; YNL328C.
GeneIDi855388.
KEGGisce:YNL328C.

Organism-specific databases

EuPathDBiFungiDB:YNL328C.
SGDiS000005272. MDJ2.

Phylogenomic databases

GeneTreeiENSGT00390000017303.
HOGENOMiHOG000115841.
InParanoidiP42834.
OMAiKAMVRNH.
OrthoDBiEOG092C5SDV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33312-MONOMER.

Miscellaneous databases

PROiP42834.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDJ2_YEAST
AccessioniPrimary (citable) accession number: P42834
Secondary accession number(s): D6W0L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 573 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.