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Protein

Hexose transporter HXT14

Gene

HXT14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: GO_Central
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33304-MONOMER.
ReactomeiR-SCE-189200. Cellular hexose transport.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Protein family/group databases

TCDBi2.A.1.1.109. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT14
Gene namesi
Name:HXT14
Synonyms:HXT9
Ordered Locus Names:YNL318C
ORF Names:N0345
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL318C.
SGDiS000005262. HXT14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Transmembranei57 – 76Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini77 – 119ExtracellularSequence analysisAdd BLAST43
Transmembranei120 – 140Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini141 – 146CytoplasmicSequence analysis6
Transmembranei147 – 167Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini168 – 177ExtracellularSequence analysis10
Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini199 – 204CytoplasmicSequence analysis6
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 243ExtracellularSequence analysisAdd BLAST18
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 357CytoplasmicSequence analysisAdd BLAST93
Transmembranei358 – 374Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini375 – 380ExtracellularSequence analysis6
Transmembranei381 – 398Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini399 – 405CytoplasmicSequence analysis7
Transmembranei406 – 426Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini427 – 440ExtracellularSequence analysisAdd BLAST14
Transmembranei441 – 461Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini462 – 478CytoplasmicSequence analysisAdd BLAST17
Transmembranei479 – 499Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini500ExtracellularSequence analysis1
Transmembranei501 – 521Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini522 – 540CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504031 – 540Hexose transporter HXT14Add BLAST540

Proteomic databases

TopDownProteomicsiP42833.

Interactioni

Protein-protein interaction databases

BioGridi35521. 20 interactors.
DIPiDIP-8115N.
IntActiP42833. 2 interactors.
MINTiMINT-1359436.
STRINGi4932.YNL318C.

Structurei

3D structure databases

ProteinModelPortaliP42833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00890000139648.
HOGENOMiHOG000202870.
InParanoidiP42833.
OMAiSGINYFF.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P42833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQIPYQHS SGYISHFHNN ELDAGRGRDY NVTIKYLDDK EENIEGQAAK
60 70 80 90 100
ISHNASLHIP VLLCLVISLG GFIFGWDIGT IGGMTNMVSF QEKFGTTNII
110 120 130 140 150
HDDETIFVST KKLTDLQIGL IISIFNISCG VGALTLSKIG DWIGRKGGIW
160 170 180 190 200
FALVVYCIGI TIQILSYGRW YFLTLGRAVT GIGVGVTTVL VPMFLSENSP
210 220 230 240 250
LKIRGSMVST YQLIVTFGIL MGNILNFICE RCYKDPTQNI AWQLPLFLGY
260 270 280 290 300
IWAIIIGMSL VYVPESPQYL AKIKNDVPSA KYSFARMNGI PATDSMVIEF
310 320 330 340 350
IDDLLENNYN NEETNNESKK QSLVKRNTFE FIMGKPKLWL RLIIGMMIMA
360 370 380 390 400
FQQLSGINYF FYYGTSVFKG VGIKDPYITS IILSSVNFLS TILGIYYVEK
410 420 430 440 450
WGHKTCLLYG STNLLFYMMT YATVGTFGRE TDFSNIVLII VTCCFIFWFA
460 470 480 490 500
ITLGPVTFVL VSELFPLRTR AISMAICTFI NWMFNFLISL LTPMIVSKID
510 520 530 540
FKLGYIFAAC LLALIIFSWI LVPETRKKNE QEINKIFEPE
Length:540
Mass (Da):60,979
Last modified:October 1, 1996 - v2
Checksum:i91A68BA27099EEF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA. No translation available.
Z71595 Genomic DNA. Translation: CAA96250.1.
BK006947 Genomic DNA. Translation: DAA10243.1.
PIRiS63299.
RefSeqiNP_014081.1. NM_001183156.1.

Genome annotation databases

EnsemblFungiiYNL318C; YNL318C; YNL318C.
GeneIDi855398.
KEGGisce:YNL318C.

Similar proteinsi

Entry informationi

Entry nameiHXT14_YEAST
AccessioniPrimary (citable) accession number: P42833
Secondary accession number(s): D6W0M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names