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Protein

Hexose transporter HXT14

Gene

HXT14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • galactose transmembrane transporter activity Source: SGD

GO - Biological processi

  • galactose transport Source: GOC
  • hexose transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33304-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.109. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT14
Gene namesi
Name:HXT14
Synonyms:HXT9
Ordered Locus Names:YNL318C
ORF Names:N0345
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL318C.
SGDiS000005262. HXT14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7620Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini77 – 11943ExtracellularSequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini141 – 1466CytoplasmicSequence analysis
Transmembranei147 – 16721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini168 – 17710ExtracellularSequence analysis
Transmembranei178 – 19821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini199 – 2046CytoplasmicSequence analysis
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 24318ExtracellularSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 35793CytoplasmicSequence analysisAdd
BLAST
Transmembranei358 – 37417Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini375 – 3806ExtracellularSequence analysis
Transmembranei381 – 39818Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini399 – 4057CytoplasmicSequence analysis
Transmembranei406 – 42621Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini427 – 44014ExtracellularSequence analysisAdd
BLAST
Transmembranei441 – 46121Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini462 – 47817CytoplasmicSequence analysisAdd
BLAST
Transmembranei479 – 49921Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini500 – 5001ExtracellularSequence analysis
Transmembranei501 – 52121Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini522 – 54019CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Hexose transporter HXT14PRO_0000050403Add
BLAST

Proteomic databases

TopDownProteomicsiP42833.

Interactioni

Protein-protein interaction databases

BioGridi35521. 3 interactions.
DIPiDIP-8115N.
IntActiP42833. 2 interactions.
MINTiMINT-1359436.

Structurei

3D structure databases

ProteinModelPortaliP42833.
SMRiP42833. Positions 66-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP42833.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQIPYQHS SGYISHFHNN ELDAGRGRDY NVTIKYLDDK EENIEGQAAK
60 70 80 90 100
ISHNASLHIP VLLCLVISLG GFIFGWDIGT IGGMTNMVSF QEKFGTTNII
110 120 130 140 150
HDDETIFVST KKLTDLQIGL IISIFNISCG VGALTLSKIG DWIGRKGGIW
160 170 180 190 200
FALVVYCIGI TIQILSYGRW YFLTLGRAVT GIGVGVTTVL VPMFLSENSP
210 220 230 240 250
LKIRGSMVST YQLIVTFGIL MGNILNFICE RCYKDPTQNI AWQLPLFLGY
260 270 280 290 300
IWAIIIGMSL VYVPESPQYL AKIKNDVPSA KYSFARMNGI PATDSMVIEF
310 320 330 340 350
IDDLLENNYN NEETNNESKK QSLVKRNTFE FIMGKPKLWL RLIIGMMIMA
360 370 380 390 400
FQQLSGINYF FYYGTSVFKG VGIKDPYITS IILSSVNFLS TILGIYYVEK
410 420 430 440 450
WGHKTCLLYG STNLLFYMMT YATVGTFGRE TDFSNIVLII VTCCFIFWFA
460 470 480 490 500
ITLGPVTFVL VSELFPLRTR AISMAICTFI NWMFNFLISL LTPMIVSKID
510 520 530 540
FKLGYIFAAC LLALIIFSWI LVPETRKKNE QEINKIFEPE
Length:540
Mass (Da):60,979
Last modified:October 1, 1996 - v2
Checksum:i91A68BA27099EEF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA. No translation available.
Z71595 Genomic DNA. Translation: CAA96250.1.
BK006947 Genomic DNA. Translation: DAA10243.1.
PIRiS63299.
RefSeqiNP_014081.1. NM_001183156.1.

Genome annotation databases

EnsemblFungiiYNL318C; YNL318C; YNL318C.
GeneIDi855398.
KEGGisce:YNL318C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA. No translation available.
Z71595 Genomic DNA. Translation: CAA96250.1.
BK006947 Genomic DNA. Translation: DAA10243.1.
PIRiS63299.
RefSeqiNP_014081.1. NM_001183156.1.

3D structure databases

ProteinModelPortaliP42833.
SMRiP42833. Positions 66-538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35521. 3 interactions.
DIPiDIP-8115N.
IntActiP42833. 2 interactions.
MINTiMINT-1359436.

Protein family/group databases

TCDBi2.A.1.1.109. the major facilitator superfamily (mfs).

Proteomic databases

TopDownProteomicsiP42833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL318C; YNL318C; YNL318C.
GeneIDi855398.
KEGGisce:YNL318C.

Organism-specific databases

EuPathDBiFungiDB:YNL318C.
SGDiS000005262. HXT14.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP42833.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-33304-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

NextBioi979217.
PROiP42833.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames."
    Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C.
    Yeast 11:1077-1085(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiHXT14_YEAST
AccessioniPrimary (citable) accession number: P42833
Secondary accession number(s): D6W0M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.