Reviewed, UniProtKB/Swiss-Prot P42833 (HXT14_YEAST)

Names and origin

Protein names

Recommended name:
    Hexose transporter HXT14

Gene names

Name:	HXT14
Synonyms:	HXT9
Ordered Locus Names:	YNL318C
ORF Names:	N0345

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hexose transport Inferred from genetic interaction. Source: SGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay. Source: SGD
Molecular function	galactose transmembrane transporter activity Inferred from genetic interaction. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Hexose transporter HXT14		PRO_0000050403
Regions
	Topological domain	1 – 56	56	Cytoplasmic Potential
	Transmembrane	57 – 76	20	1 Potential
	Topological domain	77 – 119	43	Extracellular Potential
	Transmembrane	120 – 140	21	2 Potential
	Topological domain	141 – 146	6	Cytoplasmic Potential
	Transmembrane	147 – 167	21	3 Potential
	Topological domain	168 – 177	10	Extracellular Potential
	Transmembrane	178 – 198	21	4 Potential
	Topological domain	199 – 204	6	Cytoplasmic Potential
	Transmembrane	205 – 225	21	5 Potential
	Topological domain	226 – 243	18	Extracellular Potential
	Transmembrane	244 – 264	21	6 Potential
	Topological domain	265 – 357	93	Cytoplasmic Potential
	Transmembrane	358 – 374	17	7 Potential
	Topological domain	375 – 380	6	Extracellular Potential
	Transmembrane	381 – 398	18	8 Potential
	Topological domain	399 – 405	7	Cytoplasmic Potential
	Transmembrane	406 – 426	21	9 Potential
	Topological domain	427 – 440	14	Extracellular Potential
	Transmembrane	441 – 461	21	10 Potential
	Topological domain	462 – 478	17	Cytoplasmic Potential
	Transmembrane	479 – 499	21	11 Potential
	Topological domain	500	1	Extracellular Potential
	Transmembrane	501 – 521	21	12 Potential
	Topological domain	522 – 540	19	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P42833-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 91A68BA27099EEF8	FASTA	540	60,979
	10 20 30 40 50 60 MTAQIPYQHS SGYISHFHNN ELDAGRGRDY NVTIKYLDDK EENIEGQAAK ISHNASLHIP 70 80 90 100 110 120 VLLCLVISLG GFIFGWDIGT IGGMTNMVSF QEKFGTTNII HDDETIFVST KKLTDLQIGL 130 140 150 160 170 180 IISIFNISCG VGALTLSKIG DWIGRKGGIW FALVVYCIGI TIQILSYGRW YFLTLGRAVT 190 200 210 220 230 240 GIGVGVTTVL VPMFLSENSP LKIRGSMVST YQLIVTFGIL MGNILNFICE RCYKDPTQNI 250 260 270 280 290 300 AWQLPLFLGY IWAIIIGMSL VYVPESPQYL AKIKNDVPSA KYSFARMNGI PATDSMVIEF 310 320 330 340 350 360 IDDLLENNYN NEETNNESKK QSLVKRNTFE FIMGKPKLWL RLIIGMMIMA FQQLSGINYF 370 380 390 400 410 420 FYYGTSVFKG VGIKDPYITS IILSSVNFLS TILGIYYVEK WGHKTCLLYG STNLLFYMMT 430 440 450 460 470 480 YATVGTFGRE TDFSNIVLII VTCCFIFWFA ITLGPVTFVL VSELFPLRTR AISMAICTFI 490 500 510 520 530 540 NWMFNFLISL LTPMIVSKID FKLGYIFAAC LLALIIFSWI LVPETRKKNE QEINKIFEPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames." Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C. Yeast 11:1077-1085(1995) [PubMed: 7502583] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / FY1676.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z46259 Genomic DNA. No translation available. Z71595 Genomic DNA. Translation: CAA96250.1.
PIR	S63299.
RefSeq	NP_014081.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:8115N.
IntAct	P42833. 1 interaction.
Genome annotation databases
Ensembl	YNL318C; YNL318C; YNL318C; Saccharomyces cerevisiae. [Genome view]
GeneID	855398.
KEGG	sce:YNL318C.
NMPDR	fig|4932.3.peg.5143.
Organism-specific databases
CYGD	YNL318c.
SGD	S000005262. HXT14.
Phylogenomic databases
HOGENOM	P42833.
OrthoDB	EOG92579F
Gene expression databases
ArrayExpress	P42833.
Genevestigator	P42833.
GermOnline	YNL318C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016196. MFS_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. False negative. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	979217.

Entry information

Entry name

HXT14_YEAST

Accession

Primary (citable) accession number: P42833

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)