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P42833 (HXT14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexose transporter HXT14
Gene names
Name:HXT14
Synonyms:HXT9
Ordered Locus Names:YNL318C
ORF Names:N0345
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from direct assay. Source: SGD

   Molecular functiongalactose transmembrane transporter activity

Inferred from genetic interaction. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Hexose transporter HXT14
PRO_0000050403

Regions

Topological domain1 – 5656Cytoplasmic Potential
Transmembrane57 – 7620Helical; Name=1; Potential
Topological domain77 – 11943Extracellular Potential
Transmembrane120 – 14021Helical; Name=2; Potential
Topological domain141 – 1466Cytoplasmic Potential
Transmembrane147 – 16721Helical; Name=3; Potential
Topological domain168 – 17710Extracellular Potential
Transmembrane178 – 19821Helical; Name=4; Potential
Topological domain199 – 2046Cytoplasmic Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 24318Extracellular Potential
Transmembrane244 – 26421Helical; Name=6; Potential
Topological domain265 – 35793Cytoplasmic Potential
Transmembrane358 – 37417Helical; Name=7; Potential
Topological domain375 – 3806Extracellular Potential
Transmembrane381 – 39818Helical; Name=8; Potential
Topological domain399 – 4057Cytoplasmic Potential
Transmembrane406 – 42621Helical; Name=9; Potential
Topological domain427 – 44014Extracellular Potential
Transmembrane441 – 46121Helical; Name=10; Potential
Topological domain462 – 47817Cytoplasmic Potential
Transmembrane479 – 49921Helical; Name=11; Potential
Topological domain5001Extracellular Potential
Transmembrane501 – 52121Helical; Name=12; Potential
Topological domain522 – 54019Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P42833 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 91A68BA27099EEF8

FASTA54060,979
        10         20         30         40         50         60 
MTAQIPYQHS SGYISHFHNN ELDAGRGRDY NVTIKYLDDK EENIEGQAAK ISHNASLHIP 

        70         80         90        100        110        120 
VLLCLVISLG GFIFGWDIGT IGGMTNMVSF QEKFGTTNII HDDETIFVST KKLTDLQIGL 

       130        140        150        160        170        180 
IISIFNISCG VGALTLSKIG DWIGRKGGIW FALVVYCIGI TIQILSYGRW YFLTLGRAVT 

       190        200        210        220        230        240 
GIGVGVTTVL VPMFLSENSP LKIRGSMVST YQLIVTFGIL MGNILNFICE RCYKDPTQNI 

       250        260        270        280        290        300 
AWQLPLFLGY IWAIIIGMSL VYVPESPQYL AKIKNDVPSA KYSFARMNGI PATDSMVIEF 

       310        320        330        340        350        360 
IDDLLENNYN NEETNNESKK QSLVKRNTFE FIMGKPKLWL RLIIGMMIMA FQQLSGINYF 

       370        380        390        400        410        420 
FYYGTSVFKG VGIKDPYITS IILSSVNFLS TILGIYYVEK WGHKTCLLYG STNLLFYMMT 

       430        440        450        460        470        480 
YATVGTFGRE TDFSNIVLII VTCCFIFWFA ITLGPVTFVL VSELFPLRTR AISMAICTFI 

       490        500        510        520        530        540 
NWMFNFLISL LTPMIVSKID FKLGYIFAAC LLALIIFSWI LVPETRKKNE QEINKIFEPE

« Hide

References

« Hide 'large scale' references
[1]"Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames."
Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C.
Yeast 11:1077-1085(1995) [PubMed: 7502583] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / FY1676.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed: 9169873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46259 Genomic DNA. No translation available.
Z71595 Genomic DNA. Translation: CAA96250.1.
BK006947 Genomic DNA. Translation: DAA10243.1.
PIRS63299.
RefSeqNP_014081.1. NM_001183156.1.

3D structure databases

ProteinModelPortalP42833.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-8115N.
IntActP42833. 1 interaction.
MINTMINT-1359436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL318C; YNL318C; YNL318C.
GeneID855398.
KEGGsce:YNL318C.
NMPDRfig|4932.3.peg.5143.

Organism-specific databases

CYGDYNL318c.
SGDS000005262. HXT14.

Phylogenomic databases

eggNOGfuNOG05614.
GeneTreeEFGT00070000008710.
HOGENOMHBG744444.
OrthoDBEOG4TTKST.

Gene expression databases

ArrayExpressP42833.
GenevestigatorP42833.
GermOnlineYNL318C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. False negative.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979217.

Entry information

Entry nameHXT14_YEAST
AccessionPrimary (citable) accession number: P42833
Secondary accession number(s): D6W0M7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents