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P42831 (CCL2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name=MCP-1
Small-inducible cytokine A2
Gene names
Name:CCL2
Synonyms:SCYA2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes, but not neutrophils.

Subunit structure

Monomer or homodimer; in equilibrium By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

astrocyte cell migration

Inferred from electronic annotation. Source: Ensembl

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

helper T cell extravasation

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

lipopolysaccharide-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

monocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of glial cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of natural killer cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic cell clearance

Inferred from electronic annotation. Source: Ensembl

positive regulation of immune complex clearance by monocytes and macrophages

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

regulation of cell shape

Inferred from electronic annotation. Source: Ensembl

regulation of vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9976C-C motif chemokine 2
PRO_0000005153

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Disulfide bond34 ↔ 59 By similarity
Disulfide bond35 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42831 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4C0AC6278D4F0A09

FASTA9910,976
        10         20         30         40         50         60 
MKVSAALLCL LLTAATFCTQ VLAQPDAINS PVTCCYTLTS KKISMQRLMS YRRVTSSKCP 

        70         80         90 
KEAVIFKTIA GKEICAEPKQ KWVQDSISHL DKKNQTPKP 

« Hide

References

[1]"Porcine luteal cells express monocyte chemoattractant protein-1 (MCP-1): analysis by polymerase chain reaction and cDNA cloning."
Hosang K., Knoke I., Klaudiny J., Wempe F., Wuttke W., Scheit K.H.
Biochem. Biophys. Res. Commun. 199:962-968(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Zach O.R.F.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48479 mRNA. Translation: CAA88370.1.
X79416 mRNA. Translation: CAA55945.1.
PIRJC2136.
RefSeqNP_999379.1. NM_214214.1.
UniGeneSsc.657.

3D structure databases

ProteinModelPortalP42831.
SMRP42831. Positions 24-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000018779.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000019290; ENSSSCP00000018779; ENSSSCG00000017723.
GeneID397422.
KEGGssc:397422.

Organism-specific databases

CTD6347.

Phylogenomic databases

eggNOGNOG46819.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
KOK14624.
OMANKEICAD.
OrthoDBEOG7C5MC2.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL2_PIG
AccessionPrimary (citable) accession number: P42831
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families