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P42831

- CCL2_PIG

UniProt

P42831 - CCL2_PIG

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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Biological processi

  1. astrocyte cell migration Source: Ensembl
  2. cellular response to fibroblast growth factor stimulus Source: Ensembl
  3. cellular response to interferon-gamma Source: Ensembl
  4. cellular response to interleukin-1 Source: Ensembl
  5. cellular response to organic cyclic compound Source: Ensembl
  6. cellular response to tumor necrosis factor Source: Ensembl
  7. cytokine-mediated signaling pathway Source: Ensembl
  8. cytoskeleton organization Source: Ensembl
  9. helper T cell extravasation Source: Ensembl
  10. inflammatory response Source: UniProtKB-KW
  11. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  12. macrophage chemotaxis Source: Ensembl
  13. MAPK cascade Source: Ensembl
  14. monocyte chemotaxis Source: Ensembl
  15. negative regulation of angiogenesis Source: Ensembl
  16. negative regulation of glial cell apoptotic process Source: Ensembl
  17. negative regulation of natural killer cell chemotaxis Source: Ensembl
  18. negative regulation of neuron apoptotic process Source: Ensembl
  19. positive regulation of apoptotic cell clearance Source: Ensembl
  20. positive regulation of calcium ion import Source: Ensembl
  21. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  22. positive regulation of macrophage chemotaxis Source: Ensembl
  23. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  24. positive regulation of T cell activation Source: Ensembl
  25. protein kinase B signaling Source: Ensembl
  26. regulation of cell shape Source: Ensembl
  27. regulation of vascular endothelial growth factor production Source: Ensembl
  28. response to wounding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_226269. Chemokine receptors bind chemokines.
REACT_227964. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:SCYA2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 2PRO_0000005153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018779.

Structurei

3D structure databases

ProteinModelPortaliP42831.
SMRiP42831. Positions 24-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP42831.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42831-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLTAATFCTQ VLAQPDAINS PVTCCYTLTS KKISMQRLMS
60 70 80 90
YRRVTSSKCP KEAVIFKTIA GKEICAEPKQ KWVQDSISHL DKKNQTPKP
Length:99
Mass (Da):10,976
Last modified:November 1, 1995 - v1
Checksum:i4C0AC6278D4F0A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48479 mRNA. Translation: CAA88370.1.
X79416 mRNA. Translation: CAA55945.1.
PIRiJC2136.
RefSeqiNP_999379.1. NM_214214.1.
UniGeneiSsc.657.

Genome annotation databases

EnsembliENSSSCT00000019290; ENSSSCP00000018779; ENSSSCG00000017723.
GeneIDi397422.
KEGGissc:397422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48479 mRNA. Translation: CAA88370.1 .
X79416 mRNA. Translation: CAA55945.1 .
PIRi JC2136.
RefSeqi NP_999379.1. NM_214214.1.
UniGenei Ssc.657.

3D structure databases

ProteinModelPortali P42831.
SMRi P42831. Positions 24-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000018779.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000019290 ; ENSSSCP00000018779 ; ENSSSCG00000017723 .
GeneIDi 397422.
KEGGi ssc:397422.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

eggNOGi NOG46819.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P42831.
KOi K14624.
OMAi NKEICAD.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_226269. Chemokine receptors bind chemokines.
REACT_227964. ATF4 activates genes.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Porcine luteal cells express monocyte chemoattractant protein-1 (MCP-1): analysis by polymerase chain reaction and cDNA cloning."
    Hosang K., Knoke I., Klaudiny J., Wempe F., Wuttke W., Scheit K.H.
    Biochem. Biophys. Res. Commun. 199:962-968(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zach O.R.F.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCL2_PIG
AccessioniPrimary (citable) accession number: P42831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3