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P42831

- CCL2_PIG

UniProt

P42831 - CCL2_PIG

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.

    GO - Biological processi

    1. astrocyte cell migration Source: Ensembl
    2. cellular response to fibroblast growth factor stimulus Source: Ensembl
    3. cellular response to interferon-gamma Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to organic cyclic compound Source: Ensembl
    6. cellular response to tumor necrosis factor Source: Ensembl
    7. cytokine-mediated signaling pathway Source: Ensembl
    8. cytoskeleton organization Source: Ensembl
    9. helper T cell extravasation Source: Ensembl
    10. inflammatory response Source: UniProtKB-KW
    11. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    12. macrophage chemotaxis Source: Ensembl
    13. MAPK cascade Source: Ensembl
    14. monocyte chemotaxis Source: Ensembl
    15. negative regulation of angiogenesis Source: Ensembl
    16. negative regulation of glial cell apoptotic process Source: Ensembl
    17. negative regulation of natural killer cell chemotaxis Source: Ensembl
    18. negative regulation of neuron apoptotic process Source: Ensembl
    19. positive regulation of apoptotic cell clearance Source: Ensembl
    20. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
    21. positive regulation of macrophage chemotaxis Source: Ensembl
    22. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    23. positive regulation of T cell activation Source: Ensembl
    24. protein kinase B signaling Source: Ensembl
    25. regulation of cell shape Source: Ensembl
    26. regulation of vascular endothelial growth factor production Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_226269. Chemokine receptors bind chemokines.
    REACT_227964. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:SCYA2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 12

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 2PRO_0000005153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000018779.

    Structurei

    3D structure databases

    ProteinModelPortaliP42831.
    SMRiP42831. Positions 24-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    KOiK14624.
    OMAiNKEICAD.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLTAATFCTQ VLAQPDAINS PVTCCYTLTS KKISMQRLMS   50
    YRRVTSSKCP KEAVIFKTIA GKEICAEPKQ KWVQDSISHL DKKNQTPKP 99
    Length:99
    Mass (Da):10,976
    Last modified:November 1, 1995 - v1
    Checksum:i4C0AC6278D4F0A09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48479 mRNA. Translation: CAA88370.1.
    X79416 mRNA. Translation: CAA55945.1.
    PIRiJC2136.
    RefSeqiNP_999379.1. NM_214214.1.
    UniGeneiSsc.657.

    Genome annotation databases

    EnsembliENSSSCT00000019290; ENSSSCP00000018779; ENSSSCG00000017723.
    GeneIDi397422.
    KEGGissc:397422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48479 mRNA. Translation: CAA88370.1 .
    X79416 mRNA. Translation: CAA55945.1 .
    PIRi JC2136.
    RefSeqi NP_999379.1. NM_214214.1.
    UniGenei Ssc.657.

    3D structure databases

    ProteinModelPortali P42831.
    SMRi P42831. Positions 24-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000018779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000019290 ; ENSSSCP00000018779 ; ENSSSCG00000017723 .
    GeneIDi 397422.
    KEGGi ssc:397422.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG46819.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    KOi K14624.
    OMAi NKEICAD.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_226269. Chemokine receptors bind chemokines.
    REACT_227964. ATF4 activates genes.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Porcine luteal cells express monocyte chemoattractant protein-1 (MCP-1): analysis by polymerase chain reaction and cDNA cloning."
      Hosang K., Knoke I., Klaudiny J., Wempe F., Wuttke W., Scheit K.H.
      Biochem. Biophys. Res. Commun. 199:962-968(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Zach O.R.F.
      Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCL2_PIG
    AccessioniPrimary (citable) accession number: P42831
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3