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P42830 (CXCL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 5
Alternative name(s):
ENA-78(1-78)
Epithelial-derived neutrophil-activating protein 78
Neutrophil-activating peptide ENA-78
Small-inducible cytokine B5

Cleaved into the following 2 chains:

  1. ENA-78(8-78)
  2. ENA-78(9-78)
Gene names
Name:CXCL5
Synonyms:ENA78, SCYB5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. Ref.8

Subcellular location

Secreted.

Post-translational modification

N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Ref.8 Ref.9
Chain37 – 11478C-X-C motif chemokine 5
PRO_0000005075
Chain44 – 11471ENA-78(8-78)
PRO_0000005076
Chain45 – 11470ENA-78(9-78)
PRO_0000005077

Sites

Site44 – 452Cleavage; by cathepsin G

Amino acid modifications

Disulfide bond49 ↔ 75 By similarity
Disulfide bond51 ↔ 91 By similarity

Secondary structure

........... 114
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P42830 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 56B21EE86AE952D3

FASTA11411,972
        10         20         30         40         50         60 
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV CLQTTQGVHP 

        70         80         90        100        110 
KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets."
Power C.A., Furness R.B., Brawand C., Wells T.N.C.
Gene 151:333-334(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene."
Chang M.S., McNinch J., Basu R., Simonet S.
J. Biol. Chem. 269:25277-25282(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)."
Corbett M.S., Schmitt I., Riess O., Walz A.
Biochem. Biophys. Res. Commun. 205:612-617(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
Zhang C., Thornton M.A., Kowalska M.A., Sachis B.S., Feldman M., Poncz M., McKenzie S.E., Reilly M.P.
Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[6]"Novel polymorphism in ENA-78 gene."
Amoli M.M., Thomson W., Hajeer A.H., Gonzalez-Gay M.A., Ollier W.E.R.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-80.
[7]"Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8."
Walz A., Burgener R., Car B., Baggiolini M., Kunkel S.L., Strieter R.M.
J. Exp. Med. 174:1355-1362(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-114.
Tissue: Epithelium.
[8]"Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J.
Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 37-51, IDENTIFICATION OF ENA-78(8-78) AND ENA-78(9-78), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
Tissue: Peripheral blood monocyte.
[9]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 37-45.
Tissue: Platelet.
[10]"Regulation of the immune response by the interaction of chemokines and proteases."
Struyf S., Proost P., Van Damme J.
Adv. Immunol. 81:1-44(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL5 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78686 mRNA. Translation: CAA55355.1.
U12709 Genomic DNA. Translation: AAA62475.1.
L37036 Genomic DNA. Translation: AAA86426.1.
AF349466 Genomic DNA. Translation: AAK29641.1.
BC008376 mRNA. Translation: AAH08376.1.
AJ315732 Genomic DNA. Translation: CAC42884.1.
CCDSCCDS34006.1.
PIRA55010. JC2433.
RefSeqNP_002985.1. NM_002994.4.
UniGeneHs.89714.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2MGSNMR-A/B44-114[»]
ProteinModelPortalP42830.
SMRP42830. Positions 44-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112276. 1 interaction.
DIPDIP-5911N.
STRING9606.ENSP00000296027.

PTM databases

PhosphoSiteP42830.

Polymorphism databases

DMDM1169525.

Proteomic databases

MaxQBP42830.
PaxDbP42830.
PRIDEP42830.

Protocols and materials databases

DNASU6374.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296027; ENSP00000296027; ENSG00000163735.
GeneID6374.
KEGGhsa:6374.
UCSCuc003hhk.4. human.

Organism-specific databases

CTD6374.
GeneCardsGC04M074851.
HGNCHGNC:10642. CXCL5.
MIM600324. gene.
neXtProtNX_P42830.
PharmGKBPA35573.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44673.
HOGENOMHOG000220915.
HOVERGENHBG107789.
InParanoidP42830.
KOK05506.
OrthoDBEOG7B5WZS.
PhylomeDBP42830.
TreeFamTF333433.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP42830.
BgeeP42830.
CleanExHS_CXCL5.
GenevestigatorP42830.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCXCL5.
GenomeRNAi6374.
NextBio24764.
PMAP-CutDBP42830.
PROP42830.
SOURCESearch...

Entry information

Entry nameCXCL5_HUMAN
AccessionPrimary (citable) accession number: P42830
Secondary accession number(s): Q96QE1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM