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Protein

C-X-C motif chemokine 5

Gene

CXCL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.1 Publication

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • neutrophil mediated immunity Source: GO_Central
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of leukocyte chemotaxis Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163735-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 5
Alternative name(s):
ENA-78(1-78)
Epithelial-derived neutrophil-activating protein 78
Neutrophil-activating peptide ENA-78
Small-inducible cytokine B5
Cleaved into the following 2 chains:
Gene namesi
Name:CXCL5
Synonyms:ENA78, SCYB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10642. CXCL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6374.
OpenTargetsiENSG00000163735.
PharmGKBiPA35573.

Polymorphism and mutation databases

DMDMi1169525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 362 PublicationsAdd BLAST36
ChainiPRO_000000507537 – 114C-X-C motif chemokine 5Add BLAST78
ChainiPRO_000000507644 – 114ENA-78(8-78)Add BLAST71
ChainiPRO_000000507745 – 114ENA-78(9-78)Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 75By similarity
Disulfide bondi51 ↔ 91By similarity

Post-translational modificationi

N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei44 – 45Cleavage; by cathepsin G2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP42830.
PeptideAtlasiP42830.
PRIDEiP42830.

PTM databases

iPTMnetiP42830.
PhosphoSitePlusiP42830.

Miscellaneous databases

PMAP-CutDBP42830.

Expressioni

Gene expression databases

BgeeiENSG00000163735.
CleanExiHS_CXCL5.
ExpressionAtlasiP42830. baseline and differential.
GenevisibleiP42830. HS.

Organism-specific databases

HPAiHPA065474.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi112276. 2 interactors.
DIPiDIP-5911N.
IntActiP42830. 1 interactor.
STRINGi9606.ENSP00000296027.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi60 – 62Combined sources3
Beta strandi63 – 69Combined sources7
Beta strandi79 – 87Combined sources9
Beta strandi89 – 92Combined sources4
Helixi97 – 108Combined sources12
Turni109 – 112Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MGSNMR-A/B37-114[»]
ProteinModelPortaliP42830.
SMRiP42830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP42830.
KOiK05506.
OMAiLRCVCLQ.
OrthoDBiEOG091G132U.
PhylomeDBiP42830.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV
60 70 80 90 100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK
110
KVIQKILDGG NKEN
Length:114
Mass (Da):11,972
Last modified:November 1, 1995 - v1
Checksum:i56B21EE86AE952D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78686 mRNA. Translation: CAA55355.1.
U12709 Genomic DNA. Translation: AAA62475.1.
L37036 Genomic DNA. Translation: AAA86426.1.
AF349466 Genomic DNA. Translation: AAK29641.1.
BC008376 mRNA. Translation: AAH08376.1.
AJ315732 Genomic DNA. Translation: CAC42884.1.
CCDSiCCDS34006.1.
PIRiJC2433. A55010.
RefSeqiNP_002985.1. NM_002994.4.
UniGeneiHs.89714.

Genome annotation databases

EnsembliENST00000296027; ENSP00000296027; ENSG00000163735.
GeneIDi6374.
KEGGihsa:6374.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL5 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78686 mRNA. Translation: CAA55355.1.
U12709 Genomic DNA. Translation: AAA62475.1.
L37036 Genomic DNA. Translation: AAA86426.1.
AF349466 Genomic DNA. Translation: AAK29641.1.
BC008376 mRNA. Translation: AAH08376.1.
AJ315732 Genomic DNA. Translation: CAC42884.1.
CCDSiCCDS34006.1.
PIRiJC2433. A55010.
RefSeqiNP_002985.1. NM_002994.4.
UniGeneiHs.89714.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MGSNMR-A/B37-114[»]
ProteinModelPortaliP42830.
SMRiP42830.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112276. 2 interactors.
DIPiDIP-5911N.
IntActiP42830. 1 interactor.
STRINGi9606.ENSP00000296027.

PTM databases

iPTMnetiP42830.
PhosphoSitePlusiP42830.

Polymorphism and mutation databases

DMDMi1169525.

Proteomic databases

PaxDbiP42830.
PeptideAtlasiP42830.
PRIDEiP42830.

Protocols and materials databases

DNASUi6374.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296027; ENSP00000296027; ENSG00000163735.
GeneIDi6374.
KEGGihsa:6374.

Organism-specific databases

CTDi6374.
DisGeNETi6374.
GeneCardsiCXCL5.
HGNCiHGNC:10642. CXCL5.
HPAiHPA065474.
MIMi600324. gene.
neXtProtiNX_P42830.
OpenTargetsiENSG00000163735.
PharmGKBiPA35573.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP42830.
KOiK05506.
OMAiLRCVCLQ.
OrthoDBiEOG091G132U.
PhylomeDBiP42830.
TreeFamiTF333433.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163735-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCXCL5.
GenomeRNAii6374.
PMAP-CutDBP42830.
PROiP42830.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163735.
CleanExiHS_CXCL5.
ExpressionAtlasiP42830. baseline and differential.
GenevisibleiP42830. HS.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL5_HUMAN
AccessioniPrimary (citable) accession number: P42830
Secondary accession number(s): Q96QE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.