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P42830

- CXCL5_HUMAN

UniProt

P42830 - CXCL5_HUMAN

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Protein

C-X-C motif chemokine 5

Gene

CXCL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei44 – 452Cleavage; by cathepsin G

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemotaxis Source: ProtInc
  4. immune response Source: InterPro
  5. positive regulation of cell proliferation Source: ProtInc
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 5
Alternative name(s):
ENA-78(1-78)
Epithelial-derived neutrophil-activating protein 78
Neutrophil-activating peptide ENA-78
Small-inducible cytokine B5
Cleaved into the following 2 chains:
Gene namesi
Name:CXCL5
Synonyms:ENA78, SCYB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:10642. CXCL5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 36362 PublicationsAdd
BLAST
Chaini37 – 11478C-X-C motif chemokine 5PRO_0000005075Add
BLAST
Chaini44 – 11471ENA-78(8-78)PRO_0000005076Add
BLAST
Chaini45 – 11470ENA-78(9-78)PRO_0000005077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 75By similarity
Disulfide bondi51 ↔ 91By similarity

Post-translational modificationi

N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP42830.
PaxDbiP42830.
PRIDEiP42830.

PTM databases

PhosphoSiteiP42830.

Miscellaneous databases

PMAP-CutDBP42830.

Expressioni

Gene expression databases

BgeeiP42830.
CleanExiHS_CXCL5.
ExpressionAtlasiP42830. baseline and differential.
GenevestigatoriP42830.

Interactioni

Protein-protein interaction databases

BioGridi112276. 1 interaction.
DIPiDIP-5911N.
STRINGi9606.ENSP00000296027.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi60 – 623
Beta strandi63 – 697
Beta strandi79 – 879
Beta strandi89 – 924
Helixi97 – 10812
Turni109 – 1124

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MGSNMR-A/B44-114[»]
ProteinModelPortaliP42830.
SMRiP42830. Positions 44-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44673.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP42830.
KOiK05506.
OrthoDBiEOG7B5WZS.
PhylomeDBiP42830.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42830-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV
60 70 80 90 100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK
110
KVIQKILDGG NKEN
Length:114
Mass (Da):11,972
Last modified:November 1, 1995 - v1
Checksum:i56B21EE86AE952D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78686 mRNA. Translation: CAA55355.1.
U12709 Genomic DNA. Translation: AAA62475.1.
L37036 Genomic DNA. Translation: AAA86426.1.
AF349466 Genomic DNA. Translation: AAK29641.1.
BC008376 mRNA. Translation: AAH08376.1.
AJ315732 Genomic DNA. Translation: CAC42884.1.
CCDSiCCDS34006.1.
PIRiJC2433. A55010.
RefSeqiNP_002985.1. NM_002994.4.
UniGeneiHs.89714.

Genome annotation databases

EnsembliENST00000296027; ENSP00000296027; ENSG00000163735.
GeneIDi6374.
KEGGihsa:6374.
UCSCiuc003hhk.4. human.

Polymorphism databases

DMDMi1169525.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL5 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78686 mRNA. Translation: CAA55355.1 .
U12709 Genomic DNA. Translation: AAA62475.1 .
L37036 Genomic DNA. Translation: AAA86426.1 .
AF349466 Genomic DNA. Translation: AAK29641.1 .
BC008376 mRNA. Translation: AAH08376.1 .
AJ315732 Genomic DNA. Translation: CAC42884.1 .
CCDSi CCDS34006.1.
PIRi JC2433. A55010.
RefSeqi NP_002985.1. NM_002994.4.
UniGenei Hs.89714.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MGS NMR - A/B 44-114 [» ]
ProteinModelPortali P42830.
SMRi P42830. Positions 44-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112276. 1 interaction.
DIPi DIP-5911N.
STRINGi 9606.ENSP00000296027.

PTM databases

PhosphoSitei P42830.

Polymorphism databases

DMDMi 1169525.

Proteomic databases

MaxQBi P42830.
PaxDbi P42830.
PRIDEi P42830.

Protocols and materials databases

DNASUi 6374.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296027 ; ENSP00000296027 ; ENSG00000163735 .
GeneIDi 6374.
KEGGi hsa:6374.
UCSCi uc003hhk.4. human.

Organism-specific databases

CTDi 6374.
GeneCardsi GC04M074851.
HGNCi HGNC:10642. CXCL5.
MIMi 600324. gene.
neXtProti NX_P42830.
PharmGKBi PA35573.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44673.
HOGENOMi HOG000220915.
HOVERGENi HBG107789.
InParanoidi P42830.
KOi K05506.
OrthoDBi EOG7B5WZS.
PhylomeDBi P42830.
TreeFami TF333433.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CXCL5.
GenomeRNAii 6374.
NextBioi 24764.
PMAP-CutDB P42830.
PROi P42830.
SOURCEi Search...

Gene expression databases

Bgeei P42830.
CleanExi HS_CXCL5.
ExpressionAtlasi P42830. baseline and differential.
Genevestigatori P42830.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets."
    Power C.A., Furness R.B., Brawand C., Wells T.N.C.
    Gene 151:333-334(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene."
    Chang M.S., McNinch J., Basu R., Simonet S.
    J. Biol. Chem. 269:25277-25282(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)."
    Corbett M.S., Schmitt I., Riess O., Walz A.
    Biochem. Biophys. Res. Commun. 205:612-617(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
    Zhang C., Thornton M.A., Kowalska M.A., Sachis B.S., Feldman M., Poncz M., McKenzie S.E., Reilly M.P.
    Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  6. "Novel polymorphism in ENA-78 gene."
    Amoli M.M., Thomson W., Hajeer A.H., Gonzalez-Gay M.A., Ollier W.E.R.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-80.
  7. "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8."
    Walz A., Burgener R., Car B., Baggiolini M., Kunkel S.L., Strieter R.M.
    J. Exp. Med. 174:1355-1362(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-114.
    Tissue: Epithelium.
  8. "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
    Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J.
    Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 37-51, IDENTIFICATION OF ENA-78(8-78) AND ENA-78(9-78), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
    Tissue: Peripheral blood monocyte.
  9. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 37-45.
    Tissue: Platelet.
  10. "Regulation of the immune response by the interaction of chemokines and proteases."
    Struyf S., Proost P., Van Damme J.
    Adv. Immunol. 81:1-44(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiCXCL5_HUMAN
AccessioniPrimary (citable) accession number: P42830
Secondary accession number(s): Q96QE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3