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P42830

- CXCL5_HUMAN

UniProt

P42830 - CXCL5_HUMAN

Protein

C-X-C motif chemokine 5

Gene

CXCL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei44 – 452Cleavage; by cathepsin G

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. chemotaxis Source: ProtInc
    4. immune response Source: InterPro
    5. positive regulation of cell proliferation Source: ProtInc
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 5
    Alternative name(s):
    ENA-78(1-78)
    Epithelial-derived neutrophil-activating protein 78
    Neutrophil-activating peptide ENA-78
    Small-inducible cytokine B5
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CXCL5
    Synonyms:ENA78, SCYB5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10642. CXCL5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35573.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 36362 PublicationsAdd
    BLAST
    Chaini37 – 11478C-X-C motif chemokine 5PRO_0000005075Add
    BLAST
    Chaini44 – 11471ENA-78(8-78)PRO_0000005076Add
    BLAST
    Chaini45 – 11470ENA-78(9-78)PRO_0000005077Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 75By similarity
    Disulfide bondi51 ↔ 91By similarity

    Post-translational modificationi

    N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP42830.
    PaxDbiP42830.
    PRIDEiP42830.

    PTM databases

    PhosphoSiteiP42830.

    Miscellaneous databases

    PMAP-CutDBP42830.

    Expressioni

    Gene expression databases

    ArrayExpressiP42830.
    BgeeiP42830.
    CleanExiHS_CXCL5.
    GenevestigatoriP42830.

    Interactioni

    Protein-protein interaction databases

    BioGridi112276. 1 interaction.
    DIPiDIP-5911N.
    STRINGi9606.ENSP00000296027.

    Structurei

    Secondary structure

    1
    114
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi60 – 623
    Beta strandi63 – 697
    Beta strandi79 – 879
    Beta strandi89 – 924
    Helixi97 – 10812
    Turni109 – 1124

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MGSNMR-A/B44-114[»]
    ProteinModelPortaliP42830.
    SMRiP42830. Positions 44-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44673.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiP42830.
    KOiK05506.
    OrthoDBiEOG7B5WZS.
    PhylomeDBiP42830.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV    50
    CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK 100
    KVIQKILDGG NKEN 114
    Length:114
    Mass (Da):11,972
    Last modified:November 1, 1995 - v1
    Checksum:i56B21EE86AE952D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78686 mRNA. Translation: CAA55355.1.
    U12709 Genomic DNA. Translation: AAA62475.1.
    L37036 Genomic DNA. Translation: AAA86426.1.
    AF349466 Genomic DNA. Translation: AAK29641.1.
    BC008376 mRNA. Translation: AAH08376.1.
    AJ315732 Genomic DNA. Translation: CAC42884.1.
    CCDSiCCDS34006.1.
    PIRiJC2433. A55010.
    RefSeqiNP_002985.1. NM_002994.4.
    UniGeneiHs.89714.

    Genome annotation databases

    EnsembliENST00000296027; ENSP00000296027; ENSG00000163735.
    GeneIDi6374.
    KEGGihsa:6374.
    UCSCiuc003hhk.4. human.

    Polymorphism databases

    DMDMi1169525.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL5 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78686 mRNA. Translation: CAA55355.1 .
    U12709 Genomic DNA. Translation: AAA62475.1 .
    L37036 Genomic DNA. Translation: AAA86426.1 .
    AF349466 Genomic DNA. Translation: AAK29641.1 .
    BC008376 mRNA. Translation: AAH08376.1 .
    AJ315732 Genomic DNA. Translation: CAC42884.1 .
    CCDSi CCDS34006.1.
    PIRi JC2433. A55010.
    RefSeqi NP_002985.1. NM_002994.4.
    UniGenei Hs.89714.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MGS NMR - A/B 44-114 [» ]
    ProteinModelPortali P42830.
    SMRi P42830. Positions 44-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112276. 1 interaction.
    DIPi DIP-5911N.
    STRINGi 9606.ENSP00000296027.

    PTM databases

    PhosphoSitei P42830.

    Polymorphism databases

    DMDMi 1169525.

    Proteomic databases

    MaxQBi P42830.
    PaxDbi P42830.
    PRIDEi P42830.

    Protocols and materials databases

    DNASUi 6374.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296027 ; ENSP00000296027 ; ENSG00000163735 .
    GeneIDi 6374.
    KEGGi hsa:6374.
    UCSCi uc003hhk.4. human.

    Organism-specific databases

    CTDi 6374.
    GeneCardsi GC04M074851.
    HGNCi HGNC:10642. CXCL5.
    MIMi 600324. gene.
    neXtProti NX_P42830.
    PharmGKBi PA35573.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44673.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi P42830.
    KOi K05506.
    OrthoDBi EOG7B5WZS.
    PhylomeDBi P42830.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CXCL5.
    GenomeRNAii 6374.
    NextBioi 24764.
    PMAP-CutDB P42830.
    PROi P42830.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42830.
    Bgeei P42830.
    CleanExi HS_CXCL5.
    Genevestigatori P42830.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets."
      Power C.A., Furness R.B., Brawand C., Wells T.N.C.
      Gene 151:333-334(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene."
      Chang M.S., McNinch J., Basu R., Simonet S.
      J. Biol. Chem. 269:25277-25282(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)."
      Corbett M.S., Schmitt I., Riess O., Walz A.
      Biochem. Biophys. Res. Commun. 205:612-617(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
      Zhang C., Thornton M.A., Kowalska M.A., Sachis B.S., Feldman M., Poncz M., McKenzie S.E., Reilly M.P.
      Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    6. "Novel polymorphism in ENA-78 gene."
      Amoli M.M., Thomson W., Hajeer A.H., Gonzalez-Gay M.A., Ollier W.E.R.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-80.
    7. "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8."
      Walz A., Burgener R., Car B., Baggiolini M., Kunkel S.L., Strieter R.M.
      J. Exp. Med. 174:1355-1362(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-114.
      Tissue: Epithelium.
    8. "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
      Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J.
      Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 37-51, IDENTIFICATION OF ENA-78(8-78) AND ENA-78(9-78), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
      Tissue: Peripheral blood monocyte.
    9. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 37-45.
      Tissue: Platelet.
    10. "Regulation of the immune response by the interaction of chemokines and proteases."
      Struyf S., Proost P., Van Damme J.
      Adv. Immunol. 81:1-44(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCXCL5_HUMAN
    AccessioniPrimary (citable) accession number: P42830
    Secondary accession number(s): Q96QE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3