Reviewed,
UniProtKB/Swiss-Prot P42829 (INHA_MYCS2)
Last modified
November 3, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Enoyl-[acyl-carrier-protein] reductase [NADH] EC=1.3.1.9 Alternative name(s): NADH-dependent enoyl-ACP reductase | ||||
| Gene names |
| ||||
| Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 246196 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 269 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide. |
| Catalytic activity | Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antibiotic resistance Fatty acid biosynthesis Lipid synthesis |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW response to antibioticInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 269 | 269 | Enoyl-[acyl-carrier-protein] reductase [NADH] | PRO_0000054913 | |||||
Regions | |||||||||
| Nucleotide binding | 136 – 165 | 30 | NAD Potential | ||||||
Sites | |||||||||
| Binding site | 158 | 1 | Substrate By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 94 | 1 | S → A in strain: mc(2)651; INH-resistant. | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis." Banerjee A., Dubnau E., Quemard A., Balasubramanian V., Um K.S., Wilson T., Collins D., de Lisle G., Jacobs W.R. Jr. Science 263:227-230(1994) [PubMed: 8284673] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| U02530 Unassigned DNA. Translation: AAC43211.1. CP000480 Genomic DNA. Translation: ABK73247.1. | |
| RefSeq | YP_887466.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BVR based on UniProtKB P46533. |
| SMR | P42829. Positions 3-269. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P42829. |
Genome annotation databases | |
| GeneID | 4537137. |
| GenomeReviews | Gene locus MSMEG_3151 in contig CP000480_GR. |
| KEGG | msm:MSMEG_3151. |
| NMPDR | fig|246196.1.peg.3159. |
| TIGR | MSMEG_3151. |
Phylogenomic databases | |
| OMA | EAGQQMQ. |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | INHA_MYCS2 | ||||||||
| Accession | Primary (citable) accession number: P42829 Secondary accession number(s): A0QX28 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


