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Protein

Modification methylase CeqI

Gene

ceqIM

Organism
Rhodococcus hoagii (Corynebacterium equii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GATATC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the CeqI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CeqI (EC:2.1.1.72)
Short name:
M.CeqI
Alternative name(s):
Adenine-specific methyltransferase CeqI
Gene namesi
Name:ceqIM
Synonyms:mceQI
OrganismiRhodococcus hoagii (Corynebacterium equii)
Taxonomic identifieri43767 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Modification methylase CeqIPRO_0000087951Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP42828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati283 – 31634TPR 1Add
BLAST
Repeati361 – 39434TPR 2Add
BLAST
Repeati476 – 50934TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVTSSAGCA SRPRGRGRWP RLSRRSGCLE VPGRPRRPFL RPTVPGPTSA
60 70 80 90 100
RPRRGRAPHG RSTRCTGWRV QLSFSCPPFI KNRQFQFYLI RSPFSRVGYG
110 120 130 140 150
LSDVNSSSLL GLWGIKFFAC WENSNMIYIF KMLGYNQDKL PITSERLVPM
160 170 180 190 200
ASSISPEKLG AKIVEWYSCI VSREVEQAEE YKQEIGQLVN QLERSDEKVL
210 220 230 240 250
SYYSLVLFRH QLLTEDVQQK RVEPTSLQAV NVEDTIYDGL LAFLYYFMSG
260 270 280 290 300
QYEFYEGRYQ SALRLYKIAE QKIDHVHDQS EKAEFYFRLG ESYFAHHQYT
310 320 330 340 350
FAVSYLEQAI DLFENNNFIW TILNCRLLLA AIKTELNLFD EAEKEYQSAL
360 370 380 390 400
ADATPYPTTH ALLLRALGLN RVRQRKLYEA EMYFAEALTI GDHSKSVEGL
410 420 430 440 450
KTKANLANVR LRQNANNAEA IRLLQEAKAG ATAIHLEECM VRCAITEALY
460 470 480 490 500
INEGRDERLT SELQRLLERE FYTEYSELAE EIAEYYKQQS LLEKAFYYMK
510
EALHYRTNMK MIGVEQQ
Length:517
Mass (Da):59,936
Last modified:November 1, 1995 - v1
Checksum:i8F0A259D871EAE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34099 Genomic DNA. Translation: CAA84006.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34099 Genomic DNA. Translation: CAA84006.1.

3D structure databases

ProteinModelPortaliP42828.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the genes of the CeqI restriction-modification system."
    Izsvak Z., Jobbagy Z., Takacs I., Duda E.
    Int. J. Biochem. Cell Biol. 29:895-900(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTC1_RHOHA
AccessioniPrimary (citable) accession number: P42828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.