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P42828 (MTC1_COREQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase CeqI

Short name=M.CeqI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase CeqI
Gene names
Name:ceqIM
Synonyms:mceQI
OrganismCorynebacterium equii (Rhodococcus equi)
Taxonomic identifier43767 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GATATC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the CeqI endonuclease.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Contains 3 TPR repeats.

Ontologies

Keywords
   Biological processRestriction system
   DomainRepeat
TPR repeat
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsite-specific DNA-methyltransferase (adenine-specific) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Modification methylase CeqI
PRO_0000087951

Regions

Repeat283 – 31634TPR 1
Repeat361 – 39434TPR 2
Repeat476 – 50934TPR 3

Sequences

Sequence LengthMass (Da)Tools
P42828 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8F0A259D871EAE39

FASTA51759,936
        10         20         30         40         50         60 
MVVTSSAGCA SRPRGRGRWP RLSRRSGCLE VPGRPRRPFL RPTVPGPTSA RPRRGRAPHG 

        70         80         90        100        110        120 
RSTRCTGWRV QLSFSCPPFI KNRQFQFYLI RSPFSRVGYG LSDVNSSSLL GLWGIKFFAC 

       130        140        150        160        170        180 
WENSNMIYIF KMLGYNQDKL PITSERLVPM ASSISPEKLG AKIVEWYSCI VSREVEQAEE 

       190        200        210        220        230        240 
YKQEIGQLVN QLERSDEKVL SYYSLVLFRH QLLTEDVQQK RVEPTSLQAV NVEDTIYDGL 

       250        260        270        280        290        300 
LAFLYYFMSG QYEFYEGRYQ SALRLYKIAE QKIDHVHDQS EKAEFYFRLG ESYFAHHQYT 

       310        320        330        340        350        360 
FAVSYLEQAI DLFENNNFIW TILNCRLLLA AIKTELNLFD EAEKEYQSAL ADATPYPTTH 

       370        380        390        400        410        420 
ALLLRALGLN RVRQRKLYEA EMYFAEALTI GDHSKSVEGL KTKANLANVR LRQNANNAEA 

       430        440        450        460        470        480 
IRLLQEAKAG ATAIHLEECM VRCAITEALY INEGRDERLT SELQRLLERE FYTEYSELAE 

       490        500        510 
EIAEYYKQQS LLEKAFYYMK EALHYRTNMK MIGVEQQ 

« Hide

References

[1]"Cloning and characterization of the genes of the CeqI restriction-modification system."
Izsvak Z., Jobbagy Z., Takacs I., Duda E.
Int. J. Biochem. Cell Biol. 29:895-900(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z34099 Genomic DNA. Translation: CAA84006.1.

3D structure databases

ProteinModelPortalP42828.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTC1_COREQ
AccessionPrimary (citable) accession number: P42828
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries