P42828 (MTC1_COREQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Modification methylase CeqI
Short name=M.CeqI
EC=2.1.1.72

Alternative name(s):
Adenine-specific methyltransferase CeqI

Gene names

Name:	ceqIM
Synonyms:	mceQI

Organism

Corynebacterium equii (Rhodococcus equi)

Taxonomic identifier

43767 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	This methylase recognizes the double-stranded sequence GATATC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the CeqI endonuclease.
Catalytic activity	S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.
Sequence similarities	Contains 3 TPR repeats.

Ontologies

Keywords
Biological process	Restriction system
Domain	Repeat TPR repeat
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological_process	DNA methylation on adenine Inferred from electronic annotation. Source: GOC DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Modification methylase CeqI		PRO_0000087951
Regions
	Repeat	283 – 316	34	TPR 1
	Repeat	361 – 394	34	TPR 2
	Repeat	476 – 509	34	TPR 3

Sequences

	Sequence		Length	Mass (Da)
	P42828 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 8F0A259D871EAE39	FASTA	517	59,936
	10 20 30 40 50 60 MVVTSSAGCA SRPRGRGRWP RLSRRSGCLE VPGRPRRPFL RPTVPGPTSA RPRRGRAPHG 70 80 90 100 110 120 RSTRCTGWRV QLSFSCPPFI KNRQFQFYLI RSPFSRVGYG LSDVNSSSLL GLWGIKFFAC 130 140 150 160 170 180 WENSNMIYIF KMLGYNQDKL PITSERLVPM ASSISPEKLG AKIVEWYSCI VSREVEQAEE 190 200 210 220 230 240 YKQEIGQLVN QLERSDEKVL SYYSLVLFRH QLLTEDVQQK RVEPTSLQAV NVEDTIYDGL 250 260 270 280 290 300 LAFLYYFMSG QYEFYEGRYQ SALRLYKIAE QKIDHVHDQS EKAEFYFRLG ESYFAHHQYT 310 320 330 340 350 360 FAVSYLEQAI DLFENNNFIW TILNCRLLLA AIKTELNLFD EAEKEYQSAL ADATPYPTTH 370 380 390 400 410 420 ALLLRALGLN RVRQRKLYEA EMYFAEALTI GDHSKSVEGL KTKANLANVR LRQNANNAEA 430 440 450 460 470 480 IRLLQEAKAG ATAIHLEECM VRCAITEALY INEGRDERLT SELQRLLERE FYTEYSELAE 490 500 510 EIAEYYKQQS LLEKAFYYMK EALHYRTNMK MIGVEQQ

References

[1]	"Cloning and characterization of the genes of the CeqI restriction-modification system." Izsvak Z., Jobbagy Z., Takacs I., Duda E. Int. J. Biochem. Cell Biol. 29:895-900(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z34099 Genomic DNA. Translation: CAA84006.1.
3D structure databases
ProteinModelPortal	P42828.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PROSITE	PS00092. N6_MTASE. False negative. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTC1_COREQ

Accession

Primary (citable) accession number: P42828

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program