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P42828

- MTC1_RHOHA

UniProt

P42828 - MTC1_RHOHA

Protein

Modification methylase CeqI

Gene

ceqIM

Organism
Rhodococcus hoagii (Corynebacterium equii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GATATC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the CeqI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase CeqI (EC:2.1.1.72)
    Short name:
    M.CeqI
    Alternative name(s):
    Adenine-specific methyltransferase CeqI
    Gene namesi
    Name:ceqIM
    Synonyms:mceQI
    OrganismiRhodococcus hoagii (Corynebacterium equii)
    Taxonomic identifieri43767 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Modification methylase CeqIPRO_0000087951Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP42828.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati283 – 31634TPR 1Add
    BLAST
    Repeati361 – 39434TPR 2Add
    BLAST
    Repeati476 – 50934TPR 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PROSITEiPS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42828-1 [UniParc]FASTAAdd to Basket

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    MVVTSSAGCA SRPRGRGRWP RLSRRSGCLE VPGRPRRPFL RPTVPGPTSA    50
    RPRRGRAPHG RSTRCTGWRV QLSFSCPPFI KNRQFQFYLI RSPFSRVGYG 100
    LSDVNSSSLL GLWGIKFFAC WENSNMIYIF KMLGYNQDKL PITSERLVPM 150
    ASSISPEKLG AKIVEWYSCI VSREVEQAEE YKQEIGQLVN QLERSDEKVL 200
    SYYSLVLFRH QLLTEDVQQK RVEPTSLQAV NVEDTIYDGL LAFLYYFMSG 250
    QYEFYEGRYQ SALRLYKIAE QKIDHVHDQS EKAEFYFRLG ESYFAHHQYT 300
    FAVSYLEQAI DLFENNNFIW TILNCRLLLA AIKTELNLFD EAEKEYQSAL 350
    ADATPYPTTH ALLLRALGLN RVRQRKLYEA EMYFAEALTI GDHSKSVEGL 400
    KTKANLANVR LRQNANNAEA IRLLQEAKAG ATAIHLEECM VRCAITEALY 450
    INEGRDERLT SELQRLLERE FYTEYSELAE EIAEYYKQQS LLEKAFYYMK 500
    EALHYRTNMK MIGVEQQ 517
    Length:517
    Mass (Da):59,936
    Last modified:November 1, 1995 - v1
    Checksum:i8F0A259D871EAE39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34099 Genomic DNA. Translation: CAA84006.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34099 Genomic DNA. Translation: CAA84006.1 .

    3D structure databases

    ProteinModelPortali P42828.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PROSITEi PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the genes of the CeqI restriction-modification system."
      Izsvak Z., Jobbagy Z., Takacs I., Duda E.
      Int. J. Biochem. Cell Biol. 29:895-900(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMTC1_RHOHA
    AccessioniPrimary (citable) accession number: P42828
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3