Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xylulose kinase

Gene

XKS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3460 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110SubstrateBy similarity1
Binding sitei184SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei300SubstrateBy similarity1
Binding sitei383ATPBy similarity1
Binding sitei509ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi505 – 506ATPBy similarity2

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xylulokinase activity Source: SGD

GO - Biological processi

  • D-xylose metabolic process Source: UniProtKB-KW
  • xylulose catabolic process Source: SGD

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YGR194C-MONOMER.
BRENDAi2.7.1.17. 984.
ReactomeiR-SCE-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:XKS1
Ordered Locus Names:YGR194C
ORF Names:G7584
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR194C.
SGDiS000003426. XKS1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595631 – 600Xylulose kinaseAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP42826.
PRIDEiP42826.

PTM databases

iPTMnetiP42826.

Interactioni

Protein-protein interaction databases

BioGridi33447. 91 interactors.
DIPiDIP-6764N.
IntActiP42826. 2 interactors.
MINTiMINT-667690.
STRINGi4932.YGR194C.

Structurei

3D structure databases

ProteinModelPortaliP42826.
SMRiP42826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
InParanoidiP42826.
KOiK00854.
OMAiMWVQALD.
OrthoDBiEOG092C1IUM.

Family and domain databases

InterProiView protein in InterPro
IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
PfamiView protein in Pfam
PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.

Sequencei

Sequence statusi: Complete.

P42826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV
60 70 80 90 100
EFEKDLPHYH TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV
110 120 130 140 150
MAVSGSCQQH GSVYWSSQAE SLLEQLNKKP EKDLLHYVSS VAFARQTAPN
160 170 180 190 200
WQDHSTAKQC QEFEECIGGP EKMAQLTGSR AHFRFTGPQI LKIAQLEPEA
210 220 230 240 250
YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE RKFSDELLHL
260 270 280 290 300
IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN
310 320 330 340 350
LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM
360 370 380 390 400
GMICYCNGSL ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE
410 420 430 440 450
LGVYFPLGEI VPSVKAINKR VIFNPKTGMI EREVAKFKDK RHDAKNIVES
460 470 480 490 500
QALSCRVRIS PLLSDSNASS QQRLNEDTIV KFDYDESPLR DYLNKRPERT
510 520 530 540 550
FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC YKAMWSLLYD
560 570 580 590 600
SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI
Length:600
Mass (Da):68,321
Last modified:October 1, 1996 - v2
Checksum:i29A7DC28F92AA527
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti497 – 502PERTFF → QKGLFL in CAA57805 (PubMed:7645350).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72979 Genomic DNA. Translation: CAA97220.1.
X82408 Genomic DNA. Translation: CAA57805.1.
BK006941 Genomic DNA. Translation: DAA08287.1.
PIRiS64512.
RefSeqiNP_011710.3. NM_001181323.3.

Genome annotation databases

EnsemblFungiiYGR194C; YGR194C; YGR194C.
GeneIDi853108.
KEGGisce:YGR194C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiXKS1_YEAST
AccessioniPrimary (citable) accession number: P42826
Secondary accession number(s): D6VUX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names