P42826 (XKS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylulose kinase
Short name=Xylulokinase
EC=2.7.1.17

Gene names

Name:	XKS1
Ordered Locus Names:	YGR194C
ORF Names:	G7584

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	600 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
Subcellular location	Cytoplasm Ref.5.
Miscellaneous	Present with 3460 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW xylulose catabolic process Inferred from direct assay PubMed 10981687. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay Ref.5. Source: SGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xylulokinase activity Inferred from mutant phenotype Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 600	600	Xylulose kinase		PRO_0000059563
Experimental info
	Sequence conflict	497 – 502	6	PERTFF → QKGLFL in CAA57805. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P42826 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 29A7DC28F92AA527	FASTA	600	68,321
	10 20 30 40 50 60 MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV EFEKDLPHYH 70 80 90 100 110 120 TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV MAVSGSCQQH GSVYWSSQAE 130 140 150 160 170 180 SLLEQLNKKP EKDLLHYVSS VAFARQTAPN WQDHSTAKQC QEFEECIGGP EKMAQLTGSR 190 200 210 220 230 240 AHFRFTGPQI LKIAQLEPEA YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE 250 260 270 280 290 300 RKFSDELLHL IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN 310 320 330 340 350 360 LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM GMICYCNGSL 370 380 390 400 410 420 ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE LGVYFPLGEI VPSVKAINKR 430 440 450 460 470 480 VIFNPKTGMI EREVAKFKDK RHDAKNIVES QALSCRVRIS PLLSDSNASS QQRLNEDTIV 490 500 510 520 530 540 KFDYDESPLR DYLNKRPERT FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC 550 560 570 580 590 600 YKAMWSLLYD SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII." Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez M., Nombela C. Yeast 11:587-591(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-502. Strain: ATCC 204508 / S288c.
[4]	"The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae." Rodriguez-Pena J.M., Cid V.J., Arroyo J., Nombela C. FEMS Microbiol. Lett. 162:155-160(1998) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72979 Genomic DNA. Translation: CAA97220.1. X82408 Genomic DNA. Translation: CAA57805.1. BK006941 Genomic DNA. Translation: DAA08287.1.
PIR	S64512.
RefSeq	NP_011710.3. NM_001181323.3.
3D structure databases
ProteinModelPortal	P42826.
SMR	P42826. Positions 20-600.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6764N.
IntAct	P42826. 2 interactions.
MINT	MINT-667690.
STRING	4932.YGR194C.
Proteomic databases
PaxDb	P42826.
PeptideAtlas	P42826.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR194C; YGR194C; YGR194C.
GeneID	853108.
KEGG	sce:YGR194C. sce:YGR200C.
Organism-specific databases
CYGD	YGR194c.
SGD	S000003426. XKS1.
Phylogenomic databases
eggNOG	COG1070.
GeneTree	ENSGT00390000010821.
HOGENOM	HOG000174850.
KO	K00854. K11374.
OMA	ACGMNLY.
OrthoDB	EOG4578GH.
Gene expression databases
ArrayExpress	P42826.
Genevestigator	P42826.
GermOnline	YGR194C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 2 hits. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	973118.

Entry information

Entry name

XKS1_YEAST

Accession

Primary (citable) accession number: P42826
Secondary accession number(s): D6VUX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program