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P42826

- XKS1_YEAST

UniProt

P42826 - XKS1_YEAST

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Protein

Xylulose kinase

Gene

XKS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101SubstrateBy similarity
Binding sitei184 – 1841SubstrateBy similarity
Binding sitei299 – 2991SubstrateBy similarity
Binding sitei300 – 3001SubstrateBy similarity
Binding sitei383 – 3831ATPBy similarity
Binding sitei509 – 5091ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi505 – 5062ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: SGD

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. D-xylose metabolic process Source: UniProtKB-KW
  3. xylulose catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YGR194C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:XKS1
Ordered Locus Names:YGR194C
ORF Names:G7584
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR194c.
SGDiS000003426. XKS1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Xylulose kinasePRO_0000059563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP42826.
PaxDbiP42826.
PeptideAtlasiP42826.

Expressioni

Gene expression databases

GenevestigatoriP42826.

Interactioni

Protein-protein interaction databases

BioGridi33447. 18 interactions.
DIPiDIP-6764N.
IntActiP42826. 2 interactions.
MINTiMINT-667690.
STRINGi4932.YGR194C.

Structurei

3D structure databases

ProteinModelPortaliP42826.
SMRiP42826. Positions 24-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
InParanoidiP42826.
KOiK00854.
OMAiMICYCNG.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV
60 70 80 90 100
EFEKDLPHYH TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV
110 120 130 140 150
MAVSGSCQQH GSVYWSSQAE SLLEQLNKKP EKDLLHYVSS VAFARQTAPN
160 170 180 190 200
WQDHSTAKQC QEFEECIGGP EKMAQLTGSR AHFRFTGPQI LKIAQLEPEA
210 220 230 240 250
YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE RKFSDELLHL
260 270 280 290 300
IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN
310 320 330 340 350
LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM
360 370 380 390 400
GMICYCNGSL ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE
410 420 430 440 450
LGVYFPLGEI VPSVKAINKR VIFNPKTGMI EREVAKFKDK RHDAKNIVES
460 470 480 490 500
QALSCRVRIS PLLSDSNASS QQRLNEDTIV KFDYDESPLR DYLNKRPERT
510 520 530 540 550
FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC YKAMWSLLYD
560 570 580 590 600
SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI
Length:600
Mass (Da):68,321
Last modified:October 1, 1996 - v2
Checksum:i29A7DC28F92AA527
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti497 – 5026PERTFF → QKGLFL in CAA57805. (PubMed:7645350)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72979 Genomic DNA. Translation: CAA97220.1.
X82408 Genomic DNA. Translation: CAA57805.1.
BK006941 Genomic DNA. Translation: DAA08287.1.
PIRiS64512.
RefSeqiNP_011710.3. NM_001181323.3.

Genome annotation databases

EnsemblFungiiYGR194C; YGR194C; YGR194C.
GeneIDi853108.
KEGGisce:YGR194C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72979 Genomic DNA. Translation: CAA97220.1 .
X82408 Genomic DNA. Translation: CAA57805.1 .
BK006941 Genomic DNA. Translation: DAA08287.1 .
PIRi S64512.
RefSeqi NP_011710.3. NM_001181323.3.

3D structure databases

ProteinModelPortali P42826.
SMRi P42826. Positions 24-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33447. 18 interactions.
DIPi DIP-6764N.
IntActi P42826. 2 interactions.
MINTi MINT-667690.
STRINGi 4932.YGR194C.

Proteomic databases

MaxQBi P42826.
PaxDbi P42826.
PeptideAtlasi P42826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR194C ; YGR194C ; YGR194C .
GeneIDi 853108.
KEGGi sce:YGR194C.

Organism-specific databases

CYGDi YGR194c.
SGDi S000003426. XKS1.

Phylogenomic databases

eggNOGi COG1070.
GeneTreei ENSGT00390000010821.
HOGENOMi HOG000174850.
InParanoidi P42826.
KOi K00854.
OMAi MICYCNG.
OrthoDBi EOG7CRTZN.

Enzyme and pathway databases

BioCyci YEAST:YGR194C-MONOMER.

Miscellaneous databases

NextBioi 973118.
PROi P42826.

Gene expression databases

Genevestigatori P42826.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
    Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez M., Nombela C.
    Yeast 11:587-591(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-502.
    Strain: ATCC 204508 / S288c.
  4. "The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae."
    Rodriguez-Pena J.M., Cid V.J., Arroyo J., Nombela C.
    FEMS Microbiol. Lett. 162:155-160(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXKS1_YEAST
AccessioniPrimary (citable) accession number: P42826
Secondary accession number(s): D6VUX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3460 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3