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Protein

Xylulose kinase

Gene

XKS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3460 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110SubstrateBy similarity1
Binding sitei184SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei300SubstrateBy similarity1
Binding sitei383ATPBy similarity1
Binding sitei509ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi505 – 506ATPBy similarity2

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xylulokinase activity Source: SGD

GO - Biological processi

  • D-xylose metabolic process Source: UniProtKB-KW
  • xylulose catabolic process Source: SGD

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YGR194C-MONOMER
BRENDAi2.7.1.17 984
ReactomeiR-SCE-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:XKS1
Ordered Locus Names:YGR194C
ORF Names:G7584
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR194C
SGDiS000003426 XKS1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595631 – 600Xylulose kinaseAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP42826
PaxDbiP42826
PRIDEiP42826

PTM databases

iPTMnetiP42826

Interactioni

Protein-protein interaction databases

BioGridi33447, 93 interactors
DIPiDIP-6764N
IntActiP42826, 2 interactors
STRINGi4932.YGR194C

Structurei

3D structure databases

ProteinModelPortaliP42826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010821
HOGENOMiHOG000174850
InParanoidiP42826
KOiK00854
OMAiMWVQALD
OrthoDBiEOG092C1IUM

Family and domain databases

InterProiView protein in InterPro
IPR018485 Carb_kinase_FGGY_C
IPR018484 Carb_kinase_FGGY_N
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 2 hits

Sequencei

Sequence statusi: Complete.

P42826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV
60 70 80 90 100
EFEKDLPHYH TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV
110 120 130 140 150
MAVSGSCQQH GSVYWSSQAE SLLEQLNKKP EKDLLHYVSS VAFARQTAPN
160 170 180 190 200
WQDHSTAKQC QEFEECIGGP EKMAQLTGSR AHFRFTGPQI LKIAQLEPEA
210 220 230 240 250
YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE RKFSDELLHL
260 270 280 290 300
IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN
310 320 330 340 350
LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM
360 370 380 390 400
GMICYCNGSL ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE
410 420 430 440 450
LGVYFPLGEI VPSVKAINKR VIFNPKTGMI EREVAKFKDK RHDAKNIVES
460 470 480 490 500
QALSCRVRIS PLLSDSNASS QQRLNEDTIV KFDYDESPLR DYLNKRPERT
510 520 530 540 550
FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC YKAMWSLLYD
560 570 580 590 600
SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI
Length:600
Mass (Da):68,321
Last modified:October 1, 1996 - v2
Checksum:i29A7DC28F92AA527
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti497 – 502PERTFF → QKGLFL in CAA57805 (PubMed:7645350).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72979 Genomic DNA Translation: CAA97220.1
X82408 Genomic DNA Translation: CAA57805.1
BK006941 Genomic DNA Translation: DAA08287.1
PIRiS64512
RefSeqiNP_011710.3, NM_001181323.3

Genome annotation databases

EnsemblFungiiYGR194C; YGR194C; YGR194C
GeneIDi853108
KEGGisce:YGR194C

Similar proteinsi

Entry informationi

Entry nameiXKS1_YEAST
AccessioniPrimary (citable) accession number: P42826
Secondary accession number(s): D6VUX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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