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P42826

- XKS1_YEAST

UniProt

P42826 - XKS1_YEAST

Protein

Xylulose kinase

Gene

XKS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101SubstrateBy similarity
    Binding sitei184 – 1841SubstrateBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei300 – 3001SubstrateBy similarity
    Binding sitei383 – 3831ATPBy similarity
    Binding sitei509 – 5091ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi505 – 5062ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: SGD

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. D-xylose metabolic process Source: UniProtKB-KW
    3. xylulose catabolic process Source: SGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:YGR194C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose kinase (EC:2.7.1.17)
    Short name:
    Xylulokinase
    Gene namesi
    Name:XKS1
    Ordered Locus Names:YGR194C
    ORF Names:G7584
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR194c.
    SGDiS000003426. XKS1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Xylulose kinasePRO_0000059563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei244 – 2441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP42826.
    PaxDbiP42826.
    PeptideAtlasiP42826.

    Expressioni

    Gene expression databases

    GenevestigatoriP42826.

    Interactioni

    Protein-protein interaction databases

    BioGridi33447. 18 interactions.
    DIPiDIP-6764N.
    IntActiP42826. 2 interactions.
    MINTiMINT-667690.
    STRINGi4932.YGR194C.

    Structurei

    3D structure databases

    ProteinModelPortaliP42826.
    SMRiP42826. Positions 24-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    GeneTreeiENSGT00390000010821.
    HOGENOMiHOG000174850.
    KOiK00854.
    OMAiMICYCNG.
    OrthoDBiEOG7CRTZN.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42826-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCSVIQRQT REVSNTMSLD SYYLGFDLST QQLKCLAINQ DLKIVHSETV    50
    EFEKDLPHYH TKKGVYIHGD TIECPVAMWL EALDLVLSKY REAKFPLNKV 100
    MAVSGSCQQH GSVYWSSQAE SLLEQLNKKP EKDLLHYVSS VAFARQTAPN 150
    WQDHSTAKQC QEFEECIGGP EKMAQLTGSR AHFRFTGPQI LKIAQLEPEA 200
    YEKTKTISLV SNFLTSILVG HLVELEEADA CGMNLYDIRE RKFSDELLHL 250
    IDSSSKDKTI RQKLMRAPMK NLIAGTICKY FIEKYGFNTN CKVSPMTGDN 300
    LATICSLPLR KNDVLVSLGT STTVLLVTDK YHPSPNYHLF IHPTLPNHYM 350
    GMICYCNGSL ARERIRDELN KERENNYEKT NDWTLFNQAV LDDSESSENE 400
    LGVYFPLGEI VPSVKAINKR VIFNPKTGMI EREVAKFKDK RHDAKNIVES 450
    QALSCRVRIS PLLSDSNASS QQRLNEDTIV KFDYDESPLR DYLNKRPERT 500
    FFVGGASKND AIVKKFAQVI GATKGNFRLE TPNSCALGGC YKAMWSLLYD 550
    SNKIAVPFDK FLNDNFPWHV MESISDVDNE NWDRYNSKIV PLSELEKTLI 600
    Length:600
    Mass (Da):68,321
    Last modified:October 1, 1996 - v2
    Checksum:i29A7DC28F92AA527
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti497 – 5026PERTFF → QKGLFL in CAA57805. (PubMed:7645350)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72979 Genomic DNA. Translation: CAA97220.1.
    X82408 Genomic DNA. Translation: CAA57805.1.
    BK006941 Genomic DNA. Translation: DAA08287.1.
    PIRiS64512.
    RefSeqiNP_011710.3. NM_001181323.3.

    Genome annotation databases

    EnsemblFungiiYGR194C; YGR194C; YGR194C.
    GeneIDi853108.
    KEGGisce:YGR194C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72979 Genomic DNA. Translation: CAA97220.1 .
    X82408 Genomic DNA. Translation: CAA57805.1 .
    BK006941 Genomic DNA. Translation: DAA08287.1 .
    PIRi S64512.
    RefSeqi NP_011710.3. NM_001181323.3.

    3D structure databases

    ProteinModelPortali P42826.
    SMRi P42826. Positions 24-560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33447. 18 interactions.
    DIPi DIP-6764N.
    IntActi P42826. 2 interactions.
    MINTi MINT-667690.
    STRINGi 4932.YGR194C.

    Proteomic databases

    MaxQBi P42826.
    PaxDbi P42826.
    PeptideAtlasi P42826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR194C ; YGR194C ; YGR194C .
    GeneIDi 853108.
    KEGGi sce:YGR194C.

    Organism-specific databases

    CYGDi YGR194c.
    SGDi S000003426. XKS1.

    Phylogenomic databases

    eggNOGi COG1070.
    GeneTreei ENSGT00390000010821.
    HOGENOMi HOG000174850.
    KOi K00854.
    OMAi MICYCNG.
    OrthoDBi EOG7CRTZN.

    Enzyme and pathway databases

    BioCyci YEAST:YGR194C-MONOMER.

    Miscellaneous databases

    NextBioi 973118.
    PROi P42826.

    Gene expression databases

    Genevestigatori P42826.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
      Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez M., Nombela C.
      Yeast 11:587-591(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-502.
      Strain: ATCC 204508 / S288c.
    4. "The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae."
      Rodriguez-Pena J.M., Cid V.J., Arroyo J., Nombela C.
      FEMS Microbiol. Lett. 162:155-160(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiXKS1_YEAST
    AccessioniPrimary (citable) accession number: P42826
    Secondary accession number(s): D6VUX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3460 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3