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Protein

Serum amyloid A protein

Gene

SAA1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A protein
Short name:
SAA
Gene namesi
Name:SAA1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001746701 – 112Serum amyloid A proteinAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1

Keywords - PTMi

Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Structurei

3D structure databases

SMRiP42819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Phylogenomic databases

HOVERGENiHBG016327.

Family and domain databases

InterProiView protein in InterPro
IPR000096. Serum_amyloid_A.
PfamiView protein in Pfam
PF00277. SAA. 1 hit.
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiView protein in SMART
SM00197. SAA. 1 hit.
PROSITEiView protein in PROSITE
PS00992. SAA. 1 hit.

Sequencei

Sequence statusi: Complete.

P42819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QWLSFLGEAY EGAKDMWRAY SDMREANFKG ADKYFHARGN YDAAQRGPGG
60 70 80 90 100
VWAAEVISNG REALQGITDP LFKGMTRDQV REDTKADQFA NEWGRSGKDP
110
NHFRPPGLPD KY
Length:112
Mass (Da):12,688
Last modified:November 1, 1995 - v1
Checksum:i11A37FD59A8C1649
GO

Similar proteinsi

Entry informationi

Entry nameiSAA_SHEEP
AccessioniPrimary (citable) accession number: P42819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families