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P42799

- GSA1_ARATH

UniProt

P42799 - GSA1_ARATH

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic

Gene
GSA1, HEML1, At5g63570, MBK5.3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles.1 Publication

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT5G63570-MONOMER.
MetaCyc:AT5G63570-MONOMER.
UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:GSA1
Synonyms:HEML1
Ordered Locus Names:At5g63570
ORF Names:MBK5.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G63570.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. chloroplast Source: TAIR
  3. chloroplast envelope Source: TAIR
  4. chloroplast stroma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838Chloroplast By similarityAdd
BLAST
Chaini39 – 474436Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplasticUniRule annotationPRO_0000001255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei314 – 3141N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiP42799.
PRIDEiP42799.

Expressioni

Tissue specificityi

Present in all tissues tested.1 Publication

Inductioni

By light. In etiolated seedlings, initial expression is reduced but after further illumination, levels steadily increase.1 Publication

Gene expression databases

GenevestigatoriP42799.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

BioGridi21718. 1 interaction.
IntActiP42799. 1 interaction.
STRINGi3702.AT5G63570.1-P.

Structurei

3D structure databases

ProteinModelPortaliP42799.
SMRiP42799. Positions 52-474.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
InParanoidiP42799.
KOiK01845.
OMAiHGHANAF.
PhylomeDBiP42799.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42799-1 [UniParc]FASTAAdd to Basket

« Hide

MSATLTGSGT ALGFSCSSKI SKRVSSSPAS NRCCIKMSVS VDEKKKSFSL    50
QKSEEAFNAA KNLMPGGVNS PVRAFKSVGG QPVLIDSVKG SKMWDIDGNE 100
YIDYVGSWGP AIIGHADDEV LAALAETMKK GTSFGAPCLL ENVLAEMVIS 150
AVPSIEMVRF VNSGTEACMG VLRLARAFTN KEKFIKFEGC YHGHANAFLV 200
KAGSGVATLG LPDSPGVPKA ATSDTLTAPY NDLEAVEKLF AAHKGEISAV 250
ILEPVVGNSG FIPPTPEFIN GLRQLTKDNG VLLIFDEVMT GFRLAYGGAQ 300
EYFGITPDLT TLGKIIGGGL PVGAYGGRRD IMEMVAPAGP MYQAGTLSGN 350
PLAMTAGIHT LKRLKQAGTY EYLDKITKEL TNGILEAGKK TGHPMCGGYI 400
SGMFGFFFAE GPVYNFADSK KSDTEKFGRF FRGMLEEGVY FAPSQFEAGF 450
TSLAHTPEDI QLTIAAAERV LSRI 474
Length:474
Mass (Da):50,370
Last modified:November 1, 1995 - v1
Checksum:i0D5E1A84F2B7433E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03773 Genomic DNA. Translation: AAA19117.1.
AB005234 Genomic DNA. Translation: BAB10450.1.
CP002688 Genomic DNA. Translation: AED97770.1.
AY102109 mRNA. Translation: AAM26679.1.
AY139804 mRNA. Translation: AAM98110.1.
RefSeqiNP_201162.1. NM_125752.3.
UniGeneiAt.27758.

Genome annotation databases

EnsemblPlantsiAT5G63570.1; AT5G63570.1; AT5G63570.
GeneIDi836476.
KEGGiath:AT5G63570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03773 Genomic DNA. Translation: AAA19117.1 .
AB005234 Genomic DNA. Translation: BAB10450.1 .
CP002688 Genomic DNA. Translation: AED97770.1 .
AY102109 mRNA. Translation: AAM26679.1 .
AY139804 mRNA. Translation: AAM98110.1 .
RefSeqi NP_201162.1. NM_125752.3.
UniGenei At.27758.

3D structure databases

ProteinModelPortali P42799.
SMRi P42799. Positions 52-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 21718. 1 interaction.
IntActi P42799. 1 interaction.
STRINGi 3702.AT5G63570.1-P.

Proteomic databases

PaxDbi P42799.
PRIDEi P42799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G63570.1 ; AT5G63570.1 ; AT5G63570 .
GeneIDi 836476.
KEGGi ath:AT5G63570.

Organism-specific databases

TAIRi AT5G63570.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
InParanoidi P42799.
KOi K01845.
OMAi HGHANAF.
PhylomeDBi P42799.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .
BioCyci ARA:AT5G63570-MONOMER.
MetaCyc:AT5G63570-MONOMER.

Gene expression databases

Genevestigatori P42799.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Light regulation of chlorophyll biosynthesis at the level of 5-aminolevulinate formation in Arabidopsis."
    Ilag L.L., Kumar A.M., Soell D.
    Plant Cell 6:265-275(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION BY LIGHT, TISSUE SPECIFICITY.
    Strain: cv. Columbia.
    Tissue: Leaf.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
    Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
    DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiGSA1_ARATH
AccessioniPrimary (citable) accession number: P42799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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