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P42799

- GSA1_ARATH

UniProt

P42799 - GSA1_ARATH

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic

Gene

GSA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles.1 Publication

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciARA:AT5G63570-MONOMER.
    MetaCyc:AT5G63570-MONOMER.
    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic (EC:5.4.3.8)
    Short name:
    GSA 1
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 1
    Short name:
    GSA-AT 1
    Gene namesi
    Name:GSA1
    Synonyms:HEML1
    Ordered Locus Names:At5g63570
    ORF Names:MBK5.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G63570.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: TAIR
    2. chloroplast Source: TAIR
    3. chloroplast envelope Source: TAIR
    4. chloroplast stroma Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3838ChloroplastBy similarityAdd
    BLAST
    Chaini39 – 474436Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplasticPRO_0000001255Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei314 – 3141N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PaxDbiP42799.
    PRIDEiP42799.

    Expressioni

    Tissue specificityi

    Present in all tissues tested.1 Publication

    Inductioni

    By light. In etiolated seedlings, initial expression is reduced but after further illumination, levels steadily increase.1 Publication

    Gene expression databases

    GenevestigatoriP42799.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi21718. 1 interaction.
    IntActiP42799. 1 interaction.
    STRINGi3702.AT5G63570.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP42799.
    SMRiP42799. Positions 52-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    InParanoidiP42799.
    KOiK01845.
    OMAiHGHANAF.
    PhylomeDBiP42799.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42799-1 [UniParc]FASTAAdd to Basket

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    MSATLTGSGT ALGFSCSSKI SKRVSSSPAS NRCCIKMSVS VDEKKKSFSL    50
    QKSEEAFNAA KNLMPGGVNS PVRAFKSVGG QPVLIDSVKG SKMWDIDGNE 100
    YIDYVGSWGP AIIGHADDEV LAALAETMKK GTSFGAPCLL ENVLAEMVIS 150
    AVPSIEMVRF VNSGTEACMG VLRLARAFTN KEKFIKFEGC YHGHANAFLV 200
    KAGSGVATLG LPDSPGVPKA ATSDTLTAPY NDLEAVEKLF AAHKGEISAV 250
    ILEPVVGNSG FIPPTPEFIN GLRQLTKDNG VLLIFDEVMT GFRLAYGGAQ 300
    EYFGITPDLT TLGKIIGGGL PVGAYGGRRD IMEMVAPAGP MYQAGTLSGN 350
    PLAMTAGIHT LKRLKQAGTY EYLDKITKEL TNGILEAGKK TGHPMCGGYI 400
    SGMFGFFFAE GPVYNFADSK KSDTEKFGRF FRGMLEEGVY FAPSQFEAGF 450
    TSLAHTPEDI QLTIAAAERV LSRI 474
    Length:474
    Mass (Da):50,370
    Last modified:November 1, 1995 - v1
    Checksum:i0D5E1A84F2B7433E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03773 Genomic DNA. Translation: AAA19117.1.
    AB005234 Genomic DNA. Translation: BAB10450.1.
    CP002688 Genomic DNA. Translation: AED97770.1.
    AY102109 mRNA. Translation: AAM26679.1.
    AY139804 mRNA. Translation: AAM98110.1.
    RefSeqiNP_201162.1. NM_125752.3.
    UniGeneiAt.27758.

    Genome annotation databases

    EnsemblPlantsiAT5G63570.1; AT5G63570.1; AT5G63570.
    GeneIDi836476.
    KEGGiath:AT5G63570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03773 Genomic DNA. Translation: AAA19117.1 .
    AB005234 Genomic DNA. Translation: BAB10450.1 .
    CP002688 Genomic DNA. Translation: AED97770.1 .
    AY102109 mRNA. Translation: AAM26679.1 .
    AY139804 mRNA. Translation: AAM98110.1 .
    RefSeqi NP_201162.1. NM_125752.3.
    UniGenei At.27758.

    3D structure databases

    ProteinModelPortali P42799.
    SMRi P42799. Positions 52-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 21718. 1 interaction.
    IntActi P42799. 1 interaction.
    STRINGi 3702.AT5G63570.1-P.

    Proteomic databases

    PaxDbi P42799.
    PRIDEi P42799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G63570.1 ; AT5G63570.1 ; AT5G63570 .
    GeneIDi 836476.
    KEGGi ath:AT5G63570.

    Organism-specific databases

    TAIRi AT5G63570.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    InParanoidi P42799.
    KOi K01845.
    OMAi HGHANAF.
    PhylomeDBi P42799.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .
    BioCyci ARA:AT5G63570-MONOMER.
    MetaCyc:AT5G63570-MONOMER.

    Gene expression databases

    Genevestigatori P42799.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Light regulation of chlorophyll biosynthesis at the level of 5-aminolevulinate formation in Arabidopsis."
      Ilag L.L., Kumar A.M., Soell D.
      Plant Cell 6:265-275(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION BY LIGHT, TISSUE SPECIFICITY.
      Strain: cv. Columbia.
      Tissue: Leaf.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones."
      Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S.
      DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiGSA1_ARATH
    AccessioniPrimary (citable) accession number: P42799
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3