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Protein

60S ribosomal protein L11-2

Gene

RPL11B

more
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

Miscellaneous

There are four genes for RPL11 in A.thaliana.

GO - Molecular functioni

  • mRNA binding Source: TAIR
  • RNA binding Source: GO_Central
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-ATH-1799339 SRP-dependent cotranslational protein targeting to membrane
R-ATH-72689 Formation of a pool of free 40S subunits
R-ATH-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-ATH-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-ATH-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11-2
Alternative name(s):
L16
Gene namesi
Name:RPL11B
Ordered Locus Names:At3g58700
ORF Names:T20N10_50
AND
Name:RPL11C
Synonyms:RPL16B
Ordered Locus Names:At4g18730
ORF Names:F28A21.140
AND
Name:RPL11D
Ordered Locus Names:At5g45775
ORF Names:MRA19.26, MRA19_21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 3, Chromosome 4, Chromosome 5

Organism-specific databases

AraportiAT3G58700
AT4G18730
AT5G45775
TAIRilocus:2099024 AT3G58700
locus:2124112 AT4G18730
locus:505006673 AT5G45775

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001250961 – 18260S ribosomal protein L11-2Add BLAST182

Proteomic databases

PaxDbiP42794
PRIDEiP42794

PTM databases

iPTMnetiP42794

Expressioni

Gene expression databases

ExpressionAtlasiP42794 baseline and differential
GenevisibleiP42794 AT

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi10354, 1 interactor
12900, 1 interactor
19866, 1 interactor
STRINGi3702.AT5G45775.2

Structurei

3D structure databases

ProteinModelPortaliP42794
SMRiP42794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0397 Eukaryota
COG0094 LUCA
HOGENOMiHOG000231312
InParanoidiP42794
KOiK02868
OMAiDDSMKWF
OrthoDBiEOG09360P3A
PhylomeDBiP42794

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P42794-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEKKLSNP MRDIKVQKLV LNISVGESGD RLTRASKVLE QLSGQTPVFS
60 70 80 90 100
KARYTVRSFG IRRNEKIACY VTVRGEKAMQ LLESGLKVKE YELLRRNFSD
110 120 130 140 150
TGCFGFGIQE HIDLGIKYDP STGIYGMDFY VVLERPGYRV ARRRRCKTRV
160 170 180
GIQHRVTKDD AMKWFQVKYE GVILNKSQNI TG
Length:182
Mass (Da):20,861
Last modified:January 10, 2003 - v2
Checksum:i03FD62DF294B921B
GO
Isoform 2 (identifier: P42794-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Note: Shown to be produced only by RPL11D so far.
Show »
Length:172
Mass (Da):19,775
Checksum:iB3748FD78135DE24
GO

Sequence cautioni

The sequence CAA57396 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA82293 differs from that shown. Reason: Frameshift at position 79.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46Missing in CAA82293 (PubMed:8580968).Curated1
Sequence conflicti128D → E in CAA57394 (PubMed:7655508).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0089011 – 10Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81798 mRNA Translation: CAA57394.1
X81800 Genomic DNA Translation: CAA57396.1 Sequence problems.
AL035526 Genomic DNA Translation: CAB37458.1
AL161549 Genomic DNA Translation: CAB78875.1
AL353032 Genomic DNA Translation: CAB88287.1
AB012245 Genomic DNA Translation: BAB09220.1
CP002686 Genomic DNA Translation: AEE79819.1
CP002687 Genomic DNA Translation: AEE84082.1
CP002688 Genomic DNA Translation: AED95296.1
CP002688 Genomic DNA Translation: AED95297.1
AF326876 mRNA Translation: AAG41458.1
AF339697 mRNA Translation: AAK00379.1
AY039570 mRNA Translation: AAK62625.1
AY129487 mRNA Translation: AAM91073.1
AF385722 mRNA Translation: AAK60313.1
AY078021 mRNA Translation: AAL77722.1
AY085232 mRNA Translation: AAM62465.1
AY086211 mRNA Translation: AAM64289.1
AY086300 mRNA Translation: AAM64372.1
Z29034 mRNA Translation: CAA82293.1 Frameshift.
PIRiS49033
T49153
RefSeqiNP_191429.1, NM_115732.4 [P42794-1]
NP_567563.1, NM_117989.4 [P42794-1]
NP_568649.2, NM_123945.4 [P42794-1]
NP_851137.1, NM_180806.1 [P42794-2]
UniGeneiAt.18929
At.22889

Genome annotation databases

EnsemblPlantsiAT3G58700.1; AT3G58700.1; AT3G58700 [P42794-1]
AT4G18730.1; AT4G18730.1; AT4G18730 [P42794-1]
AT5G45775.1; AT5G45775.1; AT5G45775 [P42794-2]
AT5G45775.2; AT5G45775.2; AT5G45775 [P42794-1]
GeneIDi825039
827607
834617
GrameneiAT3G58700.1; AT3G58700.1; AT3G58700 [P42794-1]
AT4G18730.1; AT4G18730.1; AT4G18730 [P42794-1]
AT5G45775.1; AT5G45775.1; AT5G45775 [P42794-2]
AT5G45775.2; AT5G45775.2; AT5G45775 [P42794-1]
KEGGiath:AT3G58700
ath:AT4G18730
ath:AT5G45775

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL112_ARATH
AccessioniPrimary (citable) accession number: P42794
Secondary accession number(s): P42796
, Q42195, Q8LD47, Q9LXT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2003
Last modified: April 25, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health