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Protein

Extracellular subtilisin-like protease

Gene
N/A
Organism
Dichelobacter nodosus (Bacteroides nodosus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Charge relay systemBy similarity1
Active sitei237Charge relay systemBy similarity1
Active sitei409Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS08.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular subtilisin-like protease (EC:3.4.21.-)
OrganismiDichelobacter nodosus (Bacteroides nodosus)
Taxonomic identifieri870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002700122 – 130Sequence analysisAdd BLAST109
ChainiPRO_0000027002131 – 595Extracellular subtilisin-like proteaseAdd BLAST465

Keywords - PTMi

Zymogen

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_0603.

Structurei

3D structure databases

ProteinModelPortaliP42780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 469Peptidase S8Add BLAST304

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated
Contains 1 peptidase S8 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105RX7. Bacteria.
COG1404. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 2 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQSGINGVK TLTLVVCAAL ASQAYAAVNY ESANYIGSQP EGSVRFIIKY
60 70 80 90 100
KDKSQSQQMM TNRSTTSVMN NNNITIAGFN AQFVRTMTIG AGIFAVPDLK
110 120 130 140 150
TTKEAHLVMD TIASNPDVEY VEVDRWLRPF AAPNDPFYND QWHYYSEYGV
160 170 180 190 200
KADKVWDRGI TGKGVTVAVV DTGIVNHPDL NANVIPGSGY DFIQEAEIAQ
210 220 230 240 250
DGDGRDSNPA DAGDWHSNWA CGKYPDPRYE KRNSSWHGSH VAGTIAAVTN
260 270 280 290 300
NRIGVSGVAY DAKIVPVRVL GRCGGYNSDI NEGMYWAAGG HIDGVPDNKH
310 320 330 340 350
PAQVINMSLG GPGVCGSTEQ TLINRATQLG ATIIVAAGND NIDAYGVTPA
360 370 380 390 400
SCDNILTVGA TTSNGTRAYF SNHGSVVDIS APGAGITSTV DSGARYPSGP
410 420 430 440 450
SYSLMDGTSM ATPHVAGVAA LVISAANSVN KEMTPAQVRD VLVRTVSSFN
460 470 480 490 500
GTPDRRIGAG IVDADAAVNA VLDGNVVERP IDELKPQAEY RNPQIKLIRD
510 520 530 540 550
YQMMFSEIKV NGRPGNTKFA VVKADIRHTD PSQLKLRLVS PKGYEYAVHY
560 570 580 590
DNIKNKSSEL ITFPRDEQMN GYWRLKIVDT KRGVTGYTRG WSVAF
Length:595
Mass (Da):64,137
Last modified:November 1, 1995 - v1
Checksum:i744EF9B53187442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08175 Genomic DNA. Translation: AAA99869.1.
RefSeqiWP_012030937.1. NZ_LGVW01000011.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08175 Genomic DNA. Translation: AAA99869.1.
RefSeqiWP_012030937.1. NZ_LGVW01000011.1.

3D structure databases

ProteinModelPortaliP42780.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246195.DNO_0603.

Protein family/group databases

MEROPSiS08.023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105RX7. Bacteria.
COG1404. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 2 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 2 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBPRX_DICNO
AccessioniPrimary (citable) accession number: P42780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.