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Protein

Cyclin-dependent kinase 4 inhibitor C

Gene

CDKN2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

  • cell cycle arrest Source: BHF-UCL
  • G1/S transition of mitotic cell cycle Source: BHF-UCL
  • negative regulation of cell growth Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  • negative regulation of phosphorylation Source: BHF-UCL
  • oligodendrocyte differentiation Source: Ensembl
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:HS04623-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-69231. Cyclin D associated events in G1.
SIGNORiP42773.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene namesi
Name:CDKN2C
Synonyms:CDKN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1789. CDKN2C.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • nucleus Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1031.
MalaCardsiCDKN2C.
OpenTargetsiENSG00000123080.
Orphaneti652. Multiple endocrine neoplasia type 1.
PharmGKBiPA26322.

Polymorphism and mutation databases

BioMutaiCDKN2C.
DMDMi1168870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441861 – 168Cyclin-dependent kinase 4 inhibitor CAdd BLAST168

Proteomic databases

EPDiP42773.
PaxDbiP42773.
PeptideAtlasiP42773.
PRIDEiP42773.

PTM databases

iPTMnetiP42773.
PhosphoSitePlusiP42773.

Expressioni

Tissue specificityi

Highest levels found in skeletal muscle. Also found in pancreas and heart.

Gene expression databases

BgeeiENSG00000123080.
CleanExiHS_CDKN2C.
ExpressionAtlasiP42773. baseline and differential.
GenevisibleiP42773. HS.

Organism-specific databases

HPAiCAB005303.
CAB018398.
HPA019057.
HPA019764.

Interactioni

Subunit structurei

Heterodimer of p18 with CDK6.

Binary interactionsi

WithEntry#Exp.IntActNotes
AHCYL1O438655EBI-711290,EBI-2371423
CDK4P118029EBI-711290,EBI-295644
CDK6Q0053415EBI-711290,EBI-295663
NAGKQ9UJ703EBI-711290,EBI-372578
NIF3L1Q9GZT83EBI-711290,EBI-740897
RELQ048643EBI-711290,EBI-307352
TCF12Q990813EBI-711290,EBI-722877
TCF4P158843EBI-711290,EBI-533224

GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107465. 44 interactors.
IntActiP42773. 36 interactors.
MINTiMINT-1372629.
STRINGi9606.ENSP00000262662.

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 15Combined sources10
Helixi18 – 24Combined sources7
Turni36 – 38Combined sources3
Helixi41 – 44Combined sources4
Turni45 – 48Combined sources4
Helixi50 – 58Combined sources9
Helixi73 – 80Combined sources8
Helixi83 – 91Combined sources9
Beta strandi101 – 103Combined sources3
Helixi106 – 112Combined sources7
Helixi116 – 125Combined sources10
Beta strandi135 – 137Combined sources3
Helixi140 – 146Combined sources7
Helixi150 – 158Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BU9NMR-A1-168[»]
1G3NX-ray2.90B/F1-168[»]
1IHBX-ray1.95A/B1-162[»]
1MX2X-ray2.25A/B1-168[»]
1MX4X-ray2.00A/B1-168[»]
1MX6X-ray2.00A/B1-168[»]
ProteinModelPortaliP42773.
SMRiP42773.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42773.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 33ANK 1Add BLAST30
Repeati37 – 65ANK 2Add BLAST29
Repeati69 – 98ANK 3Add BLAST30
Repeati102 – 132ANK 4Add BLAST31

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP42773.
KOiK06622.
OMAiLLRHTAC.
OrthoDBiEOG091G0PMC.
PhylomeDBiP42773.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN
160
EVVSLMQANG AGGATNLQ
Length:168
Mass (Da):18,127
Last modified:November 1, 1995 - v1
Checksum:i5D66AFA715186E9A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00149072A → P in breast cancer; loss of CDK6 interaction. 2 Publications1
Natural variantiVAR_038604126T → M.1 PublicationCorresponds to variant rs17851380dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17074 mRNA. Translation: AAC50074.1.
AF041248 mRNA. Translation: AAC39782.1.
AF041250, AF041249 Genomic DNA. Translation: AAC39783.1.
AY094608 Genomic DNA. Translation: AAM11873.1.
BC000598 mRNA. Translation: AAH00598.1.
BC005041 mRNA. Translation: AAH05041.1.
BC016173 mRNA. Translation: AAH16173.1.
CCDSiCCDS555.1.
PIRiA55479.
RefSeqiNP_001253.1. NM_001262.2.
NP_523240.1. NM_078626.2.
UniGeneiHs.525324.

Genome annotation databases

EnsembliENST00000262662; ENSP00000262662; ENSG00000123080.
ENST00000371761; ENSP00000360826; ENSG00000123080.
ENST00000396148; ENSP00000379452; ENSG00000123080.
GeneIDi1031.
KEGGihsa:1031.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17074 mRNA. Translation: AAC50074.1.
AF041248 mRNA. Translation: AAC39782.1.
AF041250, AF041249 Genomic DNA. Translation: AAC39783.1.
AY094608 Genomic DNA. Translation: AAM11873.1.
BC000598 mRNA. Translation: AAH00598.1.
BC005041 mRNA. Translation: AAH05041.1.
BC016173 mRNA. Translation: AAH16173.1.
CCDSiCCDS555.1.
PIRiA55479.
RefSeqiNP_001253.1. NM_001262.2.
NP_523240.1. NM_078626.2.
UniGeneiHs.525324.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BU9NMR-A1-168[»]
1G3NX-ray2.90B/F1-168[»]
1IHBX-ray1.95A/B1-162[»]
1MX2X-ray2.25A/B1-168[»]
1MX4X-ray2.00A/B1-168[»]
1MX6X-ray2.00A/B1-168[»]
ProteinModelPortaliP42773.
SMRiP42773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107465. 44 interactors.
IntActiP42773. 36 interactors.
MINTiMINT-1372629.
STRINGi9606.ENSP00000262662.

PTM databases

iPTMnetiP42773.
PhosphoSitePlusiP42773.

Polymorphism and mutation databases

BioMutaiCDKN2C.
DMDMi1168870.

Proteomic databases

EPDiP42773.
PaxDbiP42773.
PeptideAtlasiP42773.
PRIDEiP42773.

Protocols and materials databases

DNASUi1031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262662; ENSP00000262662; ENSG00000123080.
ENST00000371761; ENSP00000360826; ENSG00000123080.
ENST00000396148; ENSP00000379452; ENSG00000123080.
GeneIDi1031.
KEGGihsa:1031.

Organism-specific databases

CTDi1031.
DisGeNETi1031.
GeneCardsiCDKN2C.
HGNCiHGNC:1789. CDKN2C.
HPAiCAB005303.
CAB018398.
HPA019057.
HPA019764.
MalaCardsiCDKN2C.
MIMi603369. gene.
neXtProtiNX_P42773.
OpenTargetsiENSG00000123080.
Orphaneti652. Multiple endocrine neoplasia type 1.
PharmGKBiPA26322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP42773.
KOiK06622.
OMAiLLRHTAC.
OrthoDBiEOG091G0PMC.
PhylomeDBiP42773.
TreeFamiTF333311.

Enzyme and pathway databases

BioCyciZFISH:HS04623-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-69231. Cyclin D associated events in G1.
SIGNORiP42773.

Miscellaneous databases

EvolutionaryTraceiP42773.
GeneWikiiCDKN2C.
GenomeRNAii1031.
PROiP42773.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123080.
CleanExiHS_CDKN2C.
ExpressionAtlasiP42773. baseline and differential.
GenevisibleiP42773. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2C_HUMAN
AccessioniPrimary (citable) accession number: P42773
Secondary accession number(s): Q8TB83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.