UniProtKB - P42773 (CDN2C_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Cyclin-dependent kinase 4 inhibitor C
Gene
CDKN2C
Organism
Homo sapiens (Human)
Status
Functioni
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
- protein kinase binding Source: BHF-UCL
GO - Biological processi
- cell cycle arrest Source: BHF-UCL
- G1/S transition of mitotic cell cycle Source: BHF-UCL
- negative regulation of cell growth Source: BHF-UCL
- negative regulation of cell proliferation Source: BHF-UCL
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Reactome
- negative regulation of phosphorylation Source: BHF-UCL
- oligodendrocyte differentiation Source: Ensembl
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Keywordsi
Biological process | Cell cycle |
Enzyme and pathway databases
Reactomei | R-HSA-2559580. Oxidative Stress Induced Senescence. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559585. Oncogene Induced Senescence. R-HSA-69231. Cyclin D associated events in G1. |
SIGNORi | P42773. |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 4 inhibitor CAlternative name(s): Cyclin-dependent kinase 6 inhibitor p18-INK4c p18-INK6 |
Gene namesi | Name:CDKN2C Synonyms:CDKN6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000123080.10. |
HGNCi | HGNC:1789. CDKN2C. |
MIMi | 603369. gene. |
neXtProti | NX_P42773. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1031. |
MalaCardsi | CDKN2C. |
OpenTargetsi | ENSG00000123080. |
Orphaneti | 652. Multiple endocrine neoplasia type 1. |
PharmGKBi | PA26322. |
Polymorphism and mutation databases
BioMutai | CDKN2C. |
DMDMi | 1168870. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144186 | 1 – 168 | Cyclin-dependent kinase 4 inhibitor CAdd BLAST | 168 |
Proteomic databases
EPDi | P42773. |
PaxDbi | P42773. |
PeptideAtlasi | P42773. |
PRIDEi | P42773. |
PTM databases
iPTMneti | P42773. |
PhosphoSitePlusi | P42773. |
Expressioni
Tissue specificityi
Highest levels found in skeletal muscle. Also found in pancreas and heart.
Gene expression databases
Bgeei | ENSG00000123080. |
CleanExi | HS_CDKN2C. |
ExpressionAtlasi | P42773. baseline and differential. |
Genevisiblei | P42773. HS. |
Organism-specific databases
HPAi | CAB005303. CAB018398. HPA019057. HPA019764. |
Interactioni
Subunit structurei
Heterodimer of p18 with CDK6.
Binary interactionsi
GO - Molecular functioni
- protein kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 107465. 51 interactors. |
IntActi | P42773. 41 interactors. |
MINTi | P42773. |
STRINGi | 9606.ENSP00000262662. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 6 – 15 | Combined sources | 10 | |
Helixi | 18 – 24 | Combined sources | 7 | |
Turni | 36 – 38 | Combined sources | 3 | |
Helixi | 41 – 44 | Combined sources | 4 | |
Turni | 45 – 48 | Combined sources | 4 | |
Helixi | 50 – 58 | Combined sources | 9 | |
Helixi | 73 – 80 | Combined sources | 8 | |
Helixi | 83 – 91 | Combined sources | 9 | |
Beta strandi | 101 – 103 | Combined sources | 3 | |
Helixi | 106 – 112 | Combined sources | 7 | |
Helixi | 116 – 125 | Combined sources | 10 | |
Beta strandi | 135 – 137 | Combined sources | 3 | |
Helixi | 140 – 146 | Combined sources | 7 | |
Helixi | 150 – 158 | Combined sources | 9 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BU9 | NMR | - | A | 1-168 | [»] | |
1G3N | X-ray | 2.90 | B/F | 1-168 | [»] | |
1IHB | X-ray | 1.95 | A/B | 1-162 | [»] | |
1MX2 | X-ray | 2.25 | A/B | 1-168 | [»] | |
1MX4 | X-ray | 2.00 | A/B | 1-168 | [»] | |
1MX6 | X-ray | 2.00 | A/B | 1-168 | [»] | |
ProteinModelPortali | P42773. | |||||
SMRi | P42773. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42773. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 33 | ANK 1Add BLAST | 30 | |
Repeati | 37 – 65 | ANK 2Add BLAST | 29 | |
Repeati | 69 – 98 | ANK 3Add BLAST | 30 | |
Repeati | 102 – 132 | ANK 4Add BLAST | 31 |
Sequence similaritiesi
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504. Eukaryota. COG0666. LUCA. |
GeneTreei | ENSGT00390000004527. |
HOGENOMi | HOG000290191. |
HOVERGENi | HBG050870. |
InParanoidi | P42773. |
KOi | K06622. |
OMAi | KHTASKV. |
OrthoDBi | EOG091G0PMC. |
PhylomeDBi | P42773. |
TreeFami | TF333311. |
Family and domain databases
CDDi | cd00204. ANK. 1 hit. |
Gene3Di | 1.25.40.20. 1 hit. |
InterProi | View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. |
SMARTi | View protein in SMART SM00248. ANK. 4 hits. |
SUPFAMi | SSF48403. SSF48403. 1 hit. |
PROSITEi | View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. |
i Sequence
Sequence statusi: Complete.
P42773-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN
160
EVVSLMQANG AGGATNLQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_001490 | 72 | A → P in breast cancer; loss of CDK6 interaction. 2 Publications | 1 | |
Natural variantiVAR_038604 | 126 | T → M1 PublicationCorresponds to variant dbSNP:rs17851380Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17074 mRNA. Translation: AAC50074.1. AF041248 mRNA. Translation: AAC39782.1. AF041250, AF041249 Genomic DNA. Translation: AAC39783.1. AY094608 Genomic DNA. Translation: AAM11873.1. BC000598 mRNA. Translation: AAH00598.1. BC005041 mRNA. Translation: AAH05041.1. BC016173 mRNA. Translation: AAH16173.1. |
CCDSi | CCDS555.1. |
PIRi | A55479. |
RefSeqi | NP_001253.1. NM_001262.2. NP_523240.1. NM_078626.2. |
UniGenei | Hs.525324. |
Genome annotation databases
Ensembli | ENST00000262662; ENSP00000262662; ENSG00000123080. ENST00000371761; ENSP00000360826; ENSG00000123080. ENST00000396148; ENSP00000379452; ENSG00000123080. |
GeneIDi | 1031. |
KEGGi | hsa:1031. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CDN2C_HUMAN | |
Accessioni | P42773Primary (citable) accession number: P42773 Secondary accession number(s): Q8TB83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |