CDKN2C

Functionⁱ

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8001816
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8001816

Complete GO annotation...

GO - Biological processⁱ

cell cycle arrest
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
G1/S transition of mitotic cell cycle
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
negative regulation of cell growth
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
negative regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
negative regulation of phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
oligodendrocyte differentiation Source: Ensembl
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8001816

Complete GO annotation...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580. Oxidative Stress Induced Senescence. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559585. Oncogene Induced Senescence. R-HSA-69231. Cyclin D associated events in G1.
SIGNORⁱ	P42773.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 4 inhibitor C Alternative name(s): Cyclin-dependent kinase 6 inhibitor p18-INK4c p18-INK6
Gene namesⁱ	Name:CDKN2C Synonyms:CDKN6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1789. CDKN2C.

HGNCⁱ

HGNC:1789. CDKN2C.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm
Source: BHF-UCL
Inferred from direct assayⁱ
- 11800646
cytosol Source: Reactome
nucleus
Source: BHF-UCL
Inferred from direct assayⁱ
- 11800646

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1031.
MalaCards human disease database More...MalaCardsⁱ	CDKN2C.
Open Targets More...OpenTargetsⁱ	ENSG00000123080.
Orphanetⁱ	652. Multiple endocrine neoplasia type 1.
PharmGKBⁱ	PA26322.

Polymorphism and mutation databases

BioMutaⁱ	CDKN2C.
DMDMⁱ	1168870.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144186	1 – 168	Cyclin-dependent kinase 4 inhibitor CAdd BLAST		168

Proteomic databases

EPDⁱ	P42773.
PaxDbⁱ	P42773.
PeptideAtlas More...PeptideAtlasⁱ	P42773.
PRIDEⁱ	P42773.

PTM databases

iPTMnetⁱ	P42773.
PhosphoSitePlusⁱ	P42773.

Expressionⁱ

Tissue specificityⁱ

Highest levels found in skeletal muscle. Also found in pancreas and heart.

Gene expression databases

Bgeeⁱ	ENSG00000123080.
CleanExⁱ	HS_CDKN2C.
ExpressionAtlasⁱ	P42773. baseline and differential.
Genevisibleⁱ	P42773. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005303. CAB018398. HPA019057. HPA019764.

HPAⁱ

CAB005303.
CAB018398.
HPA019057.
HPA019764.

Interactionⁱ

Subunit structureⁱ

Heterodimer of p18 with CDK6.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AHCYL1	O43865	8	EBI-711290,EBI-2371423
CDK4	P11802	17	EBI-711290,EBI-295644
CDK6	Q00534	19	EBI-711290,EBI-295663
NAGK	Q9UJ70	3	EBI-711290,EBI-372578
NAGK	Q9UJ70-2	3	EBI-711290,EBI-11526455
NIF3L1	Q9GZT8	6	EBI-711290,EBI-740897
REL	Q04864	3	EBI-711290,EBI-307352
REL	Q04864-2	3	EBI-711290,EBI-10829018
TCF12	Q99081	3	EBI-711290,EBI-722877
TCF12	Q99081-3	5	EBI-711290,EBI-11952764
TCF4	E9PH57	3	EBI-711290,EBI-11956955
TCF4	P15884	3	EBI-711290,EBI-533224

Show more details

GO - Molecular functionⁱ

protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8001816

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	107465. 44 interactors.
IntActⁱ	P42773. 40 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1372629.
STRINGⁱ	9606.ENSP00000262662.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 15	Combined sources	10
Helixⁱ	18 – 24	Combined sources	7
Turnⁱ	36 – 38	Combined sources	3
Helixⁱ	41 – 44	Combined sources	4
Turnⁱ	45 – 48	Combined sources	4
Helixⁱ	50 – 58	Combined sources	9
Helixⁱ	73 – 80	Combined sources	8
Helixⁱ	83 – 91	Combined sources	9
Beta strandⁱ	101 – 103	Combined sources	3
Helixⁱ	106 – 112	Combined sources	7
Helixⁱ	116 – 125	Combined sources	10
Beta strandⁱ	135 – 137	Combined sources	3
Helixⁱ	140 – 146	Combined sources	7
Helixⁱ	150 – 158	Combined sources	9

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BU9	NMR	-	A	1-168	[»]
	1G3N	X-ray	2.90	B/F	1-168	[»]
	1IHB	X-ray	1.95	A/B	1-162	[»]
	1MX2	X-ray	2.25	A/B	1-168	[»]
	1MX4	X-ray	2.00	A/B	1-168	[»]
	1MX6	X-ray	2.00	A/B	1-168	[»]
ProteinModelPortalⁱ	P42773.
SMRⁱ	P42773.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P42773.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 33	ANK 1Add BLAST	30
Repeatⁱ	37 – 65	ANK 2Add BLAST	29
Repeatⁱ	69 – 98	ANK 3Add BLAST	30
Repeatⁱ	102 – 132	ANK 4Add BLAST	31

Sequence similaritiesⁱ

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504. Eukaryota. COG0666. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004527.
HOGENOMⁱ	HOG000290191.
HOVERGENⁱ	HBG050870.
InParanoidⁱ	P42773.
KEGG Orthology (KO) More...KOⁱ	K06622.
OMAⁱ	KHTASKV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMC.
PhylomeDBⁱ	P42773.
TreeFamⁱ	TF333311.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204. ANK. 1 hit.
Gene3Dⁱ	1.25.40.20. 2 hits.
InterProⁱ	View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom.
SMARTⁱ	View protein in SMART SM00248. ANK. 4 hits.
SUPFAMⁱ	SSF48403. SSF48403. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

P42773-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP 
        60         70         80         90        100
EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED 
       110        120        130        140        150
NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN 
       160 
EVVSLMQANG AGGATNLQ

Length:168

Mass (Da):18,127

Last modified:November 1, 1995 - v1

Checksum:ⁱ5D66AFA715186E9A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_001490	72	A → P in breast cancer; loss of CDK6 interaction. 2 Publications		1
Natural variantⁱVAR_038604	126	T → M1 PublicationCorresponds to variant dbSNP:rs17851380Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17074 mRNA. Translation: AAC50074.1. AF041248 mRNA. Translation: AAC39782.1. AF041250, AF041249 Genomic DNA. Translation: AAC39783.1. AY094608 Genomic DNA. Translation: AAM11873.1. BC000598 mRNA. Translation: AAH00598.1. BC005041 mRNA. Translation: AAH05041.1. BC016173 mRNA. Translation: AAH16173.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS555.1.
PIRⁱ	A55479.
NCBI Reference Sequences More...RefSeqⁱ	NP_001253.1. NM_001262.2. NP_523240.1. NM_078626.2.
UniGeneⁱ	Hs.525324.

Genome annotation databases

Ensemblⁱ	ENST00000262662; ENSP00000262662; ENSG00000123080. ENST00000371761; ENSP00000360826; ENSG00000123080. ENST00000396148; ENSP00000379452; ENSG00000123080.
GeneIDⁱ	1031.
KEGGⁱ	hsa:1031.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17074 mRNA. Translation: AAC50074.1. AF041248 mRNA. Translation: AAC39782.1. AF041250, AF041249 Genomic DNA. Translation: AAC39783.1. AY094608 Genomic DNA. Translation: AAM11873.1. BC000598 mRNA. Translation: AAH00598.1. BC005041 mRNA. Translation: AAH05041.1. BC016173 mRNA. Translation: AAH16173.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS555.1.
PIRⁱ	A55479.
NCBI Reference Sequences More...RefSeqⁱ	NP_001253.1. NM_001262.2. NP_523240.1. NM_078626.2.
UniGeneⁱ	Hs.525324.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BU9	NMR	-	A	1-168	[»]
	1G3N	X-ray	2.90	B/F	1-168	[»]
	1IHB	X-ray	1.95	A/B	1-162	[»]
	1MX2	X-ray	2.25	A/B	1-168	[»]
	1MX4	X-ray	2.00	A/B	1-168	[»]
	1MX6	X-ray	2.00	A/B	1-168	[»]
ProteinModelPortalⁱ	P42773.
SMRⁱ	P42773.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107465. 44 interactors.
IntActⁱ	P42773. 40 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1372629.
STRINGⁱ	9606.ENSP00000262662.

PTM databases

iPTMnetⁱ	P42773.
PhosphoSitePlusⁱ	P42773.

Polymorphism and mutation databases

BioMutaⁱ	CDKN2C.
DMDMⁱ	1168870.

Proteomic databases

EPDⁱ	P42773.
PaxDbⁱ	P42773.
PeptideAtlas More...PeptideAtlasⁱ	P42773.
PRIDEⁱ	P42773.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1031.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262662; ENSP00000262662; ENSG00000123080. ENST00000371761; ENSP00000360826; ENSG00000123080. ENST00000396148; ENSP00000379452; ENSG00000123080.
GeneIDⁱ	1031.
KEGGⁱ	hsa:1031.

Organism-specific databases

CTDⁱ	1031.
DisGeNET More...DisGeNETⁱ	1031.
GeneCardsⁱ	CDKN2C.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1789. CDKN2C.
Human Protein Atlas More...HPAⁱ	CAB005303. CAB018398. HPA019057. HPA019764.
MalaCards human disease database More...MalaCardsⁱ	CDKN2C.
MIMⁱ	603369. gene.
neXtProtⁱ	NX_P42773.
Open Targets More...OpenTargetsⁱ	ENSG00000123080.
Orphanetⁱ	652. Multiple endocrine neoplasia type 1.
PharmGKBⁱ	PA26322.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504. Eukaryota. COG0666. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004527.
HOGENOMⁱ	HOG000290191.
HOVERGENⁱ	HBG050870.
InParanoidⁱ	P42773.
KEGG Orthology (KO) More...KOⁱ	K06622.
OMAⁱ	KHTASKV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMC.
PhylomeDBⁱ	P42773.
TreeFamⁱ	TF333311.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580. Oxidative Stress Induced Senescence. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559585. Oncogene Induced Senescence. R-HSA-69231. Cyclin D associated events in G1.
SIGNORⁱ	P42773.

Miscellaneous databases

EvolutionaryTraceⁱ	P42773.
GeneWikiⁱ	CDKN2C.
GenomeRNAiⁱ	1031.
Protein Ontology More...PROⁱ	PR:P42773.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123080.
CleanExⁱ	HS_CDKN2C.
ExpressionAtlasⁱ	P42773. baseline and differential.
Genevisibleⁱ	P42773. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204. ANK. 1 hit.
Gene3Dⁱ	1.25.40.20. 2 hits.
InterProⁱ	View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom.
SMARTⁱ	View protein in SMART SM00248. ANK. 4 hits.
SUPFAMⁱ	SSF48403. SSF48403. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDN2C_HUMAN
Accessionⁱ	P42773Primary (citable) accession number: P42773 Secondary accession number(s): Q8TB83
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	July 5, 2017
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P42773 (CDN2C_HUMAN)

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Cyclin-dependent kinase 4 inhibitor C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ