CDKN2C

Functionⁱ

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8001816
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8001816

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
G1/S transition of mitotic cell cycle
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
negative regulation of cell growth
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
negative regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Reactome
negative regulation of phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10208428
oligodendrocyte differentiation Source: Ensembl
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8001816

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559585 Oncogene Induced Senescence R-HSA-69231 Cyclin D associated events in G1
SIGNORⁱ	P42773

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 4 inhibitor C Alternative name(s): Cyclin-dependent kinase 6 inhibitor p18-INK4c p18-INK6
Gene namesⁱ	Name:CDKN2C Synonyms:CDKN6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123080.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1789 CDKN2C
MIMⁱ	603369 gene
neXtProtⁱ	NX_P42773

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1031
MalaCards human disease database More...MalaCardsⁱ	CDKN2C
Open Targets More...OpenTargetsⁱ	ENSG00000123080
Orphanetⁱ	652 Multiple endocrine neoplasia type 1
PharmGKBⁱ	PA26322

Polymorphism and mutation databases

BioMutaⁱ	CDKN2C
DMDMⁱ	1168870

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144186	1 – 168	Cyclin-dependent kinase 4 inhibitor CAdd BLAST		168

Proteomic databases

EPDⁱ	P42773
PaxDbⁱ	P42773
PeptideAtlas More...PeptideAtlasⁱ	P42773
PRIDEⁱ	P42773

PTM databases

iPTMnetⁱ	P42773
PhosphoSitePlusⁱ	P42773

Expressionⁱ

Tissue specificityⁱ

Highest levels found in skeletal muscle. Also found in pancreas and heart.

Gene expression databases

Bgeeⁱ	ENSG00000123080
CleanExⁱ	HS_CDKN2C
ExpressionAtlasⁱ	P42773 baseline and differential
Genevisibleⁱ	P42773 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005303 CAB018398 HPA019057 HPA019764

HPAⁱ

CAB005303
CAB018398
HPA019057
HPA019764

Interactionⁱ

Subunit structureⁱ

Heterodimer of p18 with CDK6.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AHCYL1	O43865	8	EBI-711290,EBI-2371423
CDK4	P11802	17	EBI-711290,EBI-295644
CDK6	Q00534	19	EBI-711290,EBI-295663
NAGK	Q9UJ70	3	EBI-711290,EBI-372578
NAGK	Q9UJ70-2	3	EBI-711290,EBI-11526455
NIF3L1	Q9GZT8	6	EBI-711290,EBI-740897
REL	Q04864	3	EBI-711290,EBI-307352
REL	Q04864-2	3	EBI-711290,EBI-10829018
TCF12	Q99081	3	EBI-711290,EBI-722877
TCF12	Q99081-3	5	EBI-711290,EBI-11952764
TCF4	E9PH57	3	EBI-711290,EBI-11956955
TCF4	P15884	3	EBI-711290,EBI-533224

Show more details

GO - Molecular functionⁱ

protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8001816

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107465, 52 interactors
IntActⁱ	P42773, 41 interactors
Molecular INTeraction database More...MINTⁱ	P42773
STRINGⁱ	9606.ENSP00000262662

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 15	Combined sources	10
Helixⁱ	18 – 24	Combined sources	7
Turnⁱ	36 – 38	Combined sources	3
Helixⁱ	41 – 44	Combined sources	4
Turnⁱ	45 – 48	Combined sources	4
Helixⁱ	50 – 58	Combined sources	9
Helixⁱ	73 – 80	Combined sources	8
Helixⁱ	83 – 91	Combined sources	9
Beta strandⁱ	101 – 103	Combined sources	3
Helixⁱ	106 – 112	Combined sources	7
Helixⁱ	116 – 125	Combined sources	10
Beta strandⁱ	135 – 137	Combined sources	3
Helixⁱ	140 – 146	Combined sources	7
Helixⁱ	150 – 158	Combined sources	9

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BU9	NMR	-	A	1-168	[»]
	1G3N	X-ray	2.90	B/F	1-168	[»]
	1IHB	X-ray	1.95	A/B	1-162	[»]
	1MX2	X-ray	2.25	A/B	1-168	[»]
	1MX4	X-ray	2.00	A/B	1-168	[»]
	1MX6	X-ray	2.00	A/B	1-168	[»]
ProteinModelPortalⁱ	P42773
SMRⁱ	P42773
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P42773

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 33	ANK 1Add BLAST	30
Repeatⁱ	37 – 65	ANK 2Add BLAST	29
Repeatⁱ	69 – 98	ANK 3Add BLAST	30
Repeatⁱ	102 – 132	ANK 4Add BLAST	31

Sequence similaritiesⁱ

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004527
HOGENOMⁱ	HOG000290191
HOVERGENⁱ	HBG050870
InParanoidⁱ	P42773
KEGG Orthology (KO) More...KOⁱ	K06622
OMAⁱ	KHTASKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMC
PhylomeDBⁱ	P42773
TreeFamⁱ	TF333311

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P42773-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP 
        60         70         80         90        100
EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED 
       110        120        130        140        150
NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN 
       160 
EVVSLMQANG AGGATNLQ

Length:168

Mass (Da):18,127

Last modified:November 1, 1995 - v1

Checksum:ⁱ5D66AFA715186E9A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_001490	72	A → P in breast cancer; loss of CDK6 interaction. 2 Publications		1
Natural variantⁱVAR_038604	126	T → M1 PublicationCorresponds to variant dbSNP:rs17851380Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17074 mRNA Translation: AAC50074.1 AF041248 mRNA Translation: AAC39782.1 AF041250, AF041249 Genomic DNA Translation: AAC39783.1 AY094608 Genomic DNA Translation: AAM11873.1 BC000598 mRNA Translation: AAH00598.1 BC005041 mRNA Translation: AAH05041.1 BC016173 mRNA Translation: AAH16173.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS555.1
PIRⁱ	A55479
NCBI Reference Sequences More...RefSeqⁱ	NP_001253.1, NM_001262.2 NP_523240.1, NM_078626.2
UniGeneⁱ	Hs.525324

Genome annotation databases

Ensemblⁱ	ENST00000262662; ENSP00000262662; ENSG00000123080 ENST00000371761; ENSP00000360826; ENSG00000123080 ENST00000396148; ENSP00000379452; ENSG00000123080
GeneIDⁱ	1031
KEGGⁱ	hsa:1031

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
P42773	CDKN2C protein (Fragment)		HUMAN		168
CDKN2C isoform 1		PANTR		168
Cyclin dependent kinase inhibitor 2C		MACMU		168
Cyclin dependent kinase inhibitor 2C		MACNE		168
Cyclin dependent kinase inhibitor 2C		CERAT		168
+8

Protein	Similar proteins		Species	Score	Length
P42773	CDKN2C protein (Fragment)		HUMAN		168
CDKN2C isoform 1		PANTR		168
Cyclin dependent kinase inhibitor 2C		MACMU		168
Cyclin dependent kinase inhibitor 2C		MACNE		168
Cyclin dependent kinase inhibitor 2C		CERAT		168
+89

Protein	Similar proteins		Species	Score	Length
P42773	CDKN2C protein (Fragment)		HUMAN		168
CDKN2C isoform 1		PANTR		168
Cyclin dependent kinase inhibitor 2C		MACMU		168
Cyclin dependent kinase inhibitor 2C		MACNE		168
Cyclin dependent kinase inhibitor 2C		CERAT		168
+115

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U17074 mRNA Translation: AAC50074.1 AF041248 mRNA Translation: AAC39782.1 AF041250, AF041249 Genomic DNA Translation: AAC39783.1 AY094608 Genomic DNA Translation: AAM11873.1 BC000598 mRNA Translation: AAH00598.1 BC005041 mRNA Translation: AAH05041.1 BC016173 mRNA Translation: AAH16173.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS555.1
PIRⁱ	A55479
NCBI Reference Sequences More...RefSeqⁱ	NP_001253.1, NM_001262.2 NP_523240.1, NM_078626.2
UniGeneⁱ	Hs.525324

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BU9	NMR	-	A	1-168	[»]
	1G3N	X-ray	2.90	B/F	1-168	[»]
	1IHB	X-ray	1.95	A/B	1-162	[»]
	1MX2	X-ray	2.25	A/B	1-168	[»]
	1MX4	X-ray	2.00	A/B	1-168	[»]
	1MX6	X-ray	2.00	A/B	1-168	[»]
ProteinModelPortalⁱ	P42773
SMRⁱ	P42773
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107465, 52 interactors
IntActⁱ	P42773, 41 interactors
Molecular INTeraction database More...MINTⁱ	P42773
STRINGⁱ	9606.ENSP00000262662

PTM databases

iPTMnetⁱ	P42773
PhosphoSitePlusⁱ	P42773

Polymorphism and mutation databases

BioMutaⁱ	CDKN2C
DMDMⁱ	1168870

Proteomic databases

EPDⁱ	P42773
PaxDbⁱ	P42773
PeptideAtlas More...PeptideAtlasⁱ	P42773
PRIDEⁱ	P42773

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1031
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262662; ENSP00000262662; ENSG00000123080 ENST00000371761; ENSP00000360826; ENSG00000123080 ENST00000396148; ENSP00000379452; ENSG00000123080
GeneIDⁱ	1031
KEGGⁱ	hsa:1031

Organism-specific databases

CTDⁱ	1031
DisGeNET More...DisGeNETⁱ	1031
EuPathDBⁱ	HostDB:ENSG00000123080.10
GeneCardsⁱ	CDKN2C
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1789 CDKN2C
Human Protein Atlas More...HPAⁱ	CAB005303 CAB018398 HPA019057 HPA019764
MalaCards human disease database More...MalaCardsⁱ	CDKN2C
MIMⁱ	603369 gene
neXtProtⁱ	NX_P42773
Open Targets More...OpenTargetsⁱ	ENSG00000123080
Orphanetⁱ	652 Multiple endocrine neoplasia type 1
PharmGKBⁱ	PA26322
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004527
HOGENOMⁱ	HOG000290191
HOVERGENⁱ	HBG050870
InParanoidⁱ	P42773
KEGG Orthology (KO) More...KOⁱ	K06622
OMAⁱ	KHTASKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMC
PhylomeDBⁱ	P42773
TreeFamⁱ	TF333311

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559585 Oncogene Induced Senescence R-HSA-69231 Cyclin D associated events in G1
SIGNORⁱ	P42773

Miscellaneous databases

EvolutionaryTraceⁱ	P42773
GeneWikiⁱ	CDKN2C
GenomeRNAiⁱ	1031
Protein Ontology More...PROⁱ	PR:P42773
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123080
CleanExⁱ	HS_CDKN2C
ExpressionAtlasⁱ	P42773 baseline and differential
Genevisibleⁱ	P42773 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDN2C_HUMAN
Accessionⁱ	P42773Primary (citable) accession number: P42773 Secondary accession number(s): Q8TB83
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	May 23, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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Help

UniRef

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Supporting data

UniProtKB - P42773 (CDN2C_HUMAN)

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Cyclin-dependent kinase 4 inhibitor C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ