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P42769

- GSTF1_ARATH

UniProt

P42769 - GSTF1_ARATH

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Protein

Glutathione S-transferase PM239X14

Gene
N/A
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the conjugation of synthetic 1-chloro-2,4-ditrobenzene to GSH. Also functions as a glutathione peroxidase, converting linoleate oxidation products into their corresponding hydroxyacids. This enzyme may thus serve to protect the cell from oxygen toxicity as well as from exogenous toxins such as herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. peroxidase activity Source: UniProtKB-KW

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
  2. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase, Transferase

Keywords - Biological processi

Detoxification, Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase PM239X14 (EC:2.5.1.18)
Alternative name(s):
GST class-phi
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Glutathione S-transferase PM239X14PRO_0000185849Add
BLAST

Expressioni

Tissue specificityi

Expressed in vegetative rosettes.

Developmental stagei

Expressed up until the first flowering buds, after which, levels dramatically decrease.

Gene expression databases

GenevestigatoriP42769.

Structurei

3D structure databases

ProteinModelPortaliP42769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8584GST N-terminalAdd
BLAST
Domaini93 – 218126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 132Glutathione bindingBy similarity
Regioni41 – 422Glutathione bindingBy similarity
Regioni55 – 562Glutathione bindingBy similarity
Regioni69 – 702Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42769-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTVKLYGMA YSTCTKRVYT TAKEIGVDVK IVPVDLMKGE HKEPAYLDNY
60 70 80 90 100
HPFGVIPVLE DEDGTKIYES RAISRYLVAK YGKGSSLLPS PSDPKAYGLF
110 120 130 140 150
EQAASVEYSS FDPPASSLAY ERVFAGMRGL KTNEELAKKY VDTLNAKMDG
160 170 180 190 200
YERILSKQKY LAGNDFTLAD LFHLPYGAMV AQLEPTVLDS KPHVKAWWAA
210
SLRVIPGRLL RNSSKEFM
Length:218
Mass (Da):24,364
Last modified:November 1, 1995 - v1
Checksum:iC7E6B6EC5320C33A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68304 mRNA. Translation: CAA48376.1.
PIRiS36835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68304 mRNA. Translation: CAA48376.1 .
PIRi S36835.

3D structure databases

ProteinModelPortali P42769.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Genevestigatori P42769.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A glutathione S-transferase with glutathione-peroxidase activity from Arabidopsis thaliana. Molecular cloning and functional characterization."
    Bartling D., Radzio R., Steiner U., Weiler E.W.
    Eur. J. Biochem. 216:579-586(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: cv. Landsberg erecta.
    Tissue: Leaf.
  2. Erratum
    Bartling D., Radzio R., Steiner U., Weiler E.W.
    Eur. J. Biochem. 218:1096-1096(1993)
  3. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGSTF1_ARATH
AccessioniPrimary (citable) accession number: P42769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

This protein probably does not originate from A.thaliana, rather it resemble fungal GTSs.Curated

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3