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P42766

- RL35_HUMAN

UniProt

P42766 - RL35_HUMAN

Protein

60S ribosomal protein L35

Gene

RPL35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. mRNA binding Source: ProtInc
    2. poly(A) RNA binding Source: UniProtKB
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L35
    Gene namesi
    Name:RPL35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10344. RPL35.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleolus Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34727.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 12312260S ribosomal protein L35PRO_0000130533Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191N6-acetyllysine1 Publication
    Modified residuei43 – 431N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP42766.
    PaxDbiP42766.
    PRIDEiP42766.

    2D gel databases

    SWISS-2DPAGEP42766.

    PTM databases

    PhosphoSiteiP42766.

    Expressioni

    Gene expression databases

    ArrayExpressiP42766.
    BgeeiP42766.
    CleanExiHS_RPL35.
    GenevestigatoriP42766.

    Organism-specific databases

    HPAiHPA006047.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PSTPIP1O435861EBI-356819,EBI-1050964

    Protein-protein interaction databases

    BioGridi116392. 63 interactions.
    IntActiP42766. 20 interactions.
    MINTiMINT-5000320.
    STRINGi9606.ENSP00000259469.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00h1-123[»]
    ProteinModelPortaliP42766.
    SMRiP42766. Positions 1-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L29P family.Curated

    Phylogenomic databases

    eggNOGiCOG0255.
    HOVERGENiHBG000862.
    InParanoidiP42766.
    KOiK02918.
    OMAiLRAKQTR.
    PhylomeDBiP42766.
    TreeFamiTF314951.

    Family and domain databases

    Gene3Di1.10.287.310. 1 hit.
    HAMAPiMF_00374. Ribosomal_L29.
    InterProiIPR001854. Ribosomal_L29.
    IPR018254. Ribosomal_L29_CS.
    [Graphical view]
    PfamiPF00831. Ribosomal_L29. 1 hit.
    [Graphical view]
    SUPFAMiSSF46561. SSF46561. 1 hit.
    TIGRFAMsiTIGR00012. L29. 1 hit.
    PROSITEiPS00579. RIBOSOMAL_L29. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42766-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV    50
    RKSIARVLTV INQTQKENLR KFYKGKKYKP LDLRPKKTRA MRRRLNKHEE 100
    NLKTKKQQRK ERLYPLRKYA VKA 123
    Length:123
    Mass (Da):14,551
    Last modified:January 23, 2007 - v2
    Checksum:i92B7694A97AC725D
    GO

    Sequence cautioni

    The sequence CAI39638.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221K → R in AAH10919. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12465 mRNA. Translation: AAA51648.1.
    CR456877 mRNA. Translation: CAG33158.1.
    AK291072 mRNA. Translation: BAF83761.1.
    AL354928 Genomic DNA. Translation: CAI39638.1. Sequence problems.
    AL354928 Genomic DNA. Translation: CAI39639.1.
    BC000348 mRNA. Translation: AAH00348.1.
    BC010919 mRNA. Translation: AAH10919.1.
    BC071915 mRNA. Translation: AAH71915.1.
    BC094828 mRNA. Translation: AAH94828.1.
    AB046409 Genomic DNA. Translation: BAB21255.1.
    CCDSiCCDS6858.1.
    PIRiG01477.
    RefSeqiNP_009140.1. NM_007209.3.
    UniGeneiHs.182825.

    Genome annotation databases

    EnsembliENST00000348462; ENSP00000259469; ENSG00000136942.
    GeneIDi11224.
    KEGGihsa:11224.
    UCSCiuc004boy.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12465 mRNA. Translation: AAA51648.1 .
    CR456877 mRNA. Translation: CAG33158.1 .
    AK291072 mRNA. Translation: BAF83761.1 .
    AL354928 Genomic DNA. Translation: CAI39638.1 . Sequence problems.
    AL354928 Genomic DNA. Translation: CAI39639.1 .
    BC000348 mRNA. Translation: AAH00348.1 .
    BC010919 mRNA. Translation: AAH10919.1 .
    BC071915 mRNA. Translation: AAH71915.1 .
    BC094828 mRNA. Translation: AAH94828.1 .
    AB046409 Genomic DNA. Translation: BAB21255.1 .
    CCDSi CCDS6858.1.
    PIRi G01477.
    RefSeqi NP_009140.1. NM_007209.3.
    UniGenei Hs.182825.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 h 1-123 [» ]
    ProteinModelPortali P42766.
    SMRi P42766. Positions 1-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116392. 63 interactions.
    IntActi P42766. 20 interactions.
    MINTi MINT-5000320.
    STRINGi 9606.ENSP00000259469.

    PTM databases

    PhosphoSitei P42766.

    2D gel databases

    SWISS-2DPAGE P42766.

    Proteomic databases

    MaxQBi P42766.
    PaxDbi P42766.
    PRIDEi P42766.

    Protocols and materials databases

    DNASUi 11224.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000348462 ; ENSP00000259469 ; ENSG00000136942 .
    GeneIDi 11224.
    KEGGi hsa:11224.
    UCSCi uc004boy.1. human.

    Organism-specific databases

    CTDi 11224.
    GeneCardsi GC09M127620.
    HGNCi HGNC:10344. RPL35.
    HPAi HPA006047.
    neXtProti NX_P42766.
    PharmGKBi PA34727.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0255.
    HOVERGENi HBG000862.
    InParanoidi P42766.
    KOi K02918.
    OMAi LRAKQTR.
    PhylomeDBi P42766.
    TreeFami TF314951.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL35. human.
    GeneWikii 60S_ribosomal_protein_L35.
    GenomeRNAii 11224.
    NextBioi 42722.
    PROi P42766.

    Gene expression databases

    ArrayExpressi P42766.
    Bgeei P42766.
    CleanExi HS_RPL35.
    Genevestigatori P42766.

    Family and domain databases

    Gene3Di 1.10.287.310. 1 hit.
    HAMAPi MF_00374. Ribosomal_L29.
    InterProi IPR001854. Ribosomal_L29.
    IPR018254. Ribosomal_L29_CS.
    [Graphical view ]
    Pfami PF00831. Ribosomal_L29. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46561. SSF46561. 1 hit.
    TIGRFAMsi TIGR00012. L29. 1 hit.
    PROSITEi PS00579. RIBOSOMAL_L29. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cDNA sequence of ribosomal protein L35."
      Patel S.K., Chandraratna R., Nagpal S.
      Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung, Muscle and Prostate.
    6. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
      Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
      J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-13, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders."
      Uechi T., Tanaka T., Kenmochi N.
      Genomics 72:223-230(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-63.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-19 AND LYS-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL35_HUMAN
    AccessioniPrimary (citable) accession number: P42766
    Secondary accession number(s): A8K4V7
    , Q4VBY5, Q5JTN5, Q6IBC7, Q96QJ7, Q9BYF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3