##gff-version 3 P42765 UniProtKB Chain 1 397 . . . ID=PRO_0000223299;Note=3-ketoacyl-CoA thiolase%2C mitochondrial P42765 UniProtKB Transit peptide 1 16 . . . Note=Mitochondrion%3B not cleaved P42765 UniProtKB Active site 92 92 . . . Note=Acyl-thioester intermediate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25478839;Dbxref=PMID:25478839 P42765 UniProtKB Active site 382 382 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25478839;Dbxref=PMID:25478839 P42765 UniProtKB Binding site 224 224 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25478839,ECO:0007744|PDB:4C2J;Dbxref=PMID:25478839 P42765 UniProtKB Binding site 227 227 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25478839,ECO:0007744|PDB:4C2J;Dbxref=PMID:25478839 P42765 UniProtKB Binding site 251 251 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25478839,ECO:0007744|PDB:4C2J;Dbxref=PMID:25478839 P42765 UniProtKB Site 352 352 . . . Note=Increases nucleophilicity of active site Cys;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25478839;Dbxref=PMID:25478839 P42765 UniProtKB Modified residue 25 25 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 25 25 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 45 45 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 119 119 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P42765 UniProtKB Modified residue 121 121 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P42765 UniProtKB Modified residue 127 127 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P42765 UniProtKB Modified residue 136 136 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 137 137 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 137 137 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 140 140 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P42765 UniProtKB Modified residue 143 143 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 143 143 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 171 171 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 171 171 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 191 191 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 191 191 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 209 209 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 209 209 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 211 211 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 212 212 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 214 214 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 234 234 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 234 234 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 240 240 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 241 241 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 269 269 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 270 270 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 305 305 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 305 305 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 310 310 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 312 312 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 312 312 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 333 333 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P42765 UniProtKB Modified residue 340 340 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Modified residue 375 375 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BWT1 P42765 UniProtKB Natural variant 217 217 . . . ID=VAR_052577;Note=M->V;Dbxref=dbSNP:rs11549285 P42765 UniProtKB Mutagenesis 92 92 . . . Note=Decreased acyl-CoA hydrolase activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25478839;Dbxref=PMID:25478839 P42765 UniProtKB Mutagenesis 92 92 . . . Note=Decreased acyl-CoA hydrolase activity%3B when associated with A-382. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25478839;Dbxref=PMID:25478839 P42765 UniProtKB Mutagenesis 382 382 . . . Note=Decreased acyl-CoA hydrolase activity%3B when associated with S-92. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25478839;Dbxref=PMID:25478839 P42765 UniProtKB Sequence conflict 2 2 . . . Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P42765 UniProtKB Sequence conflict 169 169 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P42765 UniProtKB Beta strand 7 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Turn 23 26 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 29 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 48 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 53 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 66 68 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 69 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 85 89 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 91 93 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 94 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 112 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 127 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 142 146 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 147 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Turn 155 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 161 172 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 176 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Turn 197 202 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 206 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 215 217 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 229 234 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 238 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Turn 247 249 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 254 264 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 265 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 277 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 289 294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 296 307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 311 313 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 315 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 324 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 340 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 347 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Turn 354 356 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Helix 357 372 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 375 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Turn 384 386 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J P42765 UniProtKB Beta strand 387 395 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4C2J