Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase F6

Gene

GSTF6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in camalexin biosynthesis by probably catalyzing the conjugation of GSH with indole-3-acetonitrile (IAN). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • camalexin binding Source: TAIR
  • cobalt ion binding Source: TAIR
  • copper ion binding Source: TAIR
  • glutathione binding Source: TAIR
  • glutathione transferase activity Source: GO_Central
  • quercitrin binding Source: TAIR

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • glutathione metabolic process Source: GO_Central
  • response to cadmium ion Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to salt stress Source: TAIR
  • response to toxic substance Source: UniProtKB-KW
  • response to water deprivation Source: TAIR
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification, Plant defense, Stress response

Enzyme and pathway databases

BioCyciARA:AT1G02930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase F6 (EC:2.5.1.18)
Short name:
AtGSTF6
Alternative name(s):
AtGSTF3
GST class-phi member 6
Glutathione S-transferase 1
Short name:
AtGST1
Protein EARLY RESPONSE TO DEHYDRATION 11
Gene namesi
Name:GSTF6
Synonyms:ERD11, GST1, GSTF3
Ordered Locus Names:At1g02930
ORF Names:F22D16.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G02930.
TAIRilocus:2024690. AT1G02930.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
  • mitochondrion Source: TAIR
  • plasmodesma Source: TAIR
  • vacuole Source: TAIR

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but reduced levels of camalexin production during infection by B.cinerea.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858461 – 208Glutathione S-transferase F6Add BLAST208

Proteomic databases

PaxDbiP42760.
PRIDEiP42760.

2D gel databases

SWISS-2DPAGEiP42760.

Expressioni

Inductioni

By dehydration stress, salicylic acid, ethylene, methyl jasmonate, auxin, H2O2, copper, metolachlor, and the pathogens P.syringae and Hyaloperonospora parasitica.3 Publications

Gene expression databases

ExpressionAtlasiP42760. baseline and differential.
GenevisibleiP42760. AT.

Interactioni

Protein-protein interaction databases

BioGridi24750. 2 interactors.
IntActiP42760. 3 interactors.
STRINGi3702.AT1G02930.1.

Structurei

3D structure databases

ProteinModelPortaliP42760.
SMRiP42760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83GST N-terminalAdd BLAST82
Domaini89 – 208GST C-terminalAdd BLAST120

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 13Glutathione bindingBy similarity2
Regioni41 – 42Glutathione bindingBy similarity2
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125746.
InParanoidiP42760.
KOiK00799.
OMAiYIAHEFS.
OrthoDBiEOG09360M18.
PhylomeDBiP42760.

Family and domain databases

CDDicd03187. GST_C_Phi. 1 hit.
InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR034347. GST_Phi_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P42760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGIKVFGHP ASTATRRVLI ALHEKNVDFE FVHVELKDGE HKKEPFILRN
60 70 80 90 100
PFGKVPAFED GDFKIFESRA ITQYIAHEFS DKGNNLLSTG KDMAIIAMGI
110 120 130 140 150
EIESHEFDPV GSKLVWEQVL KPLYGMTTDK TVVEEEEAKL AKVLDVYEHR
160 170 180 190 200
LGESKYLASD HFTLVDLHTI PVIQYLLGTP TKKLFDERPH VSAWVADITS

RPSAQKVL
Length:208
Mass (Da):23,486
Last modified:November 1, 1997 - v2
Checksum:i113CED008A11902F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12S → F in BAA04553 (PubMed:8253194).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17672 mRNA. Translation: BAA04553.1.
Y11727 Genomic DNA. Translation: CAA72413.1.
L12057 Genomic RNA. No translation available.
AC009525 Genomic DNA. Translation: AAF02873.1.
CP002684 Genomic DNA. Translation: AEE27497.1.
CP002684 Genomic DNA. Translation: AEE27498.1.
AY050332 mRNA. Translation: AAK91349.1.
AY097392 mRNA. Translation: AAM19908.1.
PIRiG86159.
S39541.
RefSeqiNP_001184893.1. NM_001197964.1.
NP_171792.1. NM_100174.3.
UniGeneiAt.20350.
At.23846.

Genome annotation databases

EnsemblPlantsiAT1G02930.1; AT1G02930.1; AT1G02930.
AT1G02930.2; AT1G02930.2; AT1G02930.
GeneIDi839515.
GrameneiAT1G02930.1; AT1G02930.1; AT1G02930.
AT1G02930.2; AT1G02930.2; AT1G02930.
KEGGiath:AT1G02930.

Similar proteinsi

Entry informationi

Entry nameiGSTF6_ARATH
AccessioniPrimary (citable) accession number: P42760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families