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P42760

- GSTF6_ARATH

UniProt

P42760 - GSTF6_ARATH

Protein

Glutathione S-transferase F6

Gene

GSTF6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Involved in camalexin biosynthesis by probably catalyzing the conjugation of GSH with indole-3-acetonitrile (IAN). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. camalexin binding Source: TAIR
    2. cobalt ion binding Source: TAIR
    3. copper ion binding Source: TAIR
    4. glutathione binding Source: TAIR
    5. glutathione transferase activity Source: UniProtKB-EC
    6. quercitrin binding Source: TAIR

    GO - Biological processi

    1. defense response to bacterium Source: TAIR
    2. response to cadmium ion Source: TAIR
    3. response to oxidative stress Source: TAIR
    4. response to salt stress Source: TAIR
    5. response to toxic substance Source: UniProtKB-KW
    6. response to water deprivation Source: TAIR
    7. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification, Plant defense, Stress response

    Enzyme and pathway databases

    BioCyciARA:AT1G02930-MONOMER.
    ARA:GQT-844-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase F6 (EC:2.5.1.18)
    Short name:
    AtGSTF6
    Alternative name(s):
    AtGSTF3
    GST class-phi member 6
    Glutathione S-transferase 1
    Short name:
    AtGST1
    Protein EARLY RESPONSE TO DEHYDRATION 11
    Gene namesi
    Name:GSTF6
    Synonyms:ERD11, GST1, GSTF3
    Ordered Locus Names:At1g02930
    ORF Names:F22D16.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G02930.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cell wall Source: TAIR
    2. cytoplasm Source: TAIR
    3. cytosol Source: TAIR
    4. mitochondrion Source: TAIR
    5. plasmodesma Source: TAIR
    6. vacuole Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype under normal growth conditions, but reduced levels of camalexin production during infection by B.cinerea.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 208207Glutathione S-transferase F6PRO_0000185846Add
    BLAST

    Proteomic databases

    PaxDbiP42760.
    PRIDEiP42760.

    2D gel databases

    SWISS-2DPAGEP42760.

    Expressioni

    Inductioni

    By dehydration stress, salicylic acid, ethylene, methyl jasmonate, auxin, H2O2, copper, metolachlor, and the pathogens P.syringae and Hyaloperonospora parasitica.3 Publications

    Gene expression databases

    GenevestigatoriP42760.

    Interactioni

    Protein-protein interaction databases

    BioGridi24750. 2 interactions.
    IntActiP42760. 3 interactions.
    STRINGi3702.AT1G02930.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP42760.
    SMRiP42760. Positions 3-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8382GST N-terminalAdd
    BLAST
    Domaini89 – 208120GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni12 – 132Glutathione bindingBy similarity
    Regioni41 – 422Glutathione bindingBy similarity
    Regioni54 – 552Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Phi family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125746.
    InParanoidiP42760.
    KOiK00799.
    OMAiLWLEVES.
    PhylomeDBiP42760.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGIKVFGHP ASTATRRVLI ALHEKNVDFE FVHVELKDGE HKKEPFILRN    50
    PFGKVPAFED GDFKIFESRA ITQYIAHEFS DKGNNLLSTG KDMAIIAMGI 100
    EIESHEFDPV GSKLVWEQVL KPLYGMTTDK TVVEEEEAKL AKVLDVYEHR 150
    LGESKYLASD HFTLVDLHTI PVIQYLLGTP TKKLFDERPH VSAWVADITS 200
    RPSAQKVL 208
    Length:208
    Mass (Da):23,486
    Last modified:November 1, 1997 - v2
    Checksum:i113CED008A11902F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121S → F in BAA04553. (PubMed:8253194)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17672 mRNA. Translation: BAA04553.1.
    Y11727 Genomic DNA. Translation: CAA72413.1.
    L12057 Genomic RNA. No translation available.
    AC009525 Genomic DNA. Translation: AAF02873.1.
    CP002684 Genomic DNA. Translation: AEE27497.1.
    CP002684 Genomic DNA. Translation: AEE27498.1.
    AY050332 mRNA. Translation: AAK91349.1.
    AY097392 mRNA. Translation: AAM19908.1.
    PIRiG86159.
    S39541.
    RefSeqiNP_001184893.1. NM_001197964.1.
    NP_171792.1. NM_100174.2.
    UniGeneiAt.20350.
    At.23846.

    Genome annotation databases

    EnsemblPlantsiAT1G02930.1; AT1G02930.1; AT1G02930.
    AT1G02930.2; AT1G02930.2; AT1G02930.
    GeneIDi839515.
    KEGGiath:AT1G02930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17672 mRNA. Translation: BAA04553.1 .
    Y11727 Genomic DNA. Translation: CAA72413.1 .
    L12057 Genomic RNA. No translation available.
    AC009525 Genomic DNA. Translation: AAF02873.1 .
    CP002684 Genomic DNA. Translation: AEE27497.1 .
    CP002684 Genomic DNA. Translation: AEE27498.1 .
    AY050332 mRNA. Translation: AAK91349.1 .
    AY097392 mRNA. Translation: AAM19908.1 .
    PIRi G86159.
    S39541.
    RefSeqi NP_001184893.1. NM_001197964.1.
    NP_171792.1. NM_100174.2.
    UniGenei At.20350.
    At.23846.

    3D structure databases

    ProteinModelPortali P42760.
    SMRi P42760. Positions 3-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 24750. 2 interactions.
    IntActi P42760. 3 interactions.
    STRINGi 3702.AT1G02930.1-P.

    2D gel databases

    SWISS-2DPAGE P42760.

    Proteomic databases

    PaxDbi P42760.
    PRIDEi P42760.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G02930.1 ; AT1G02930.1 ; AT1G02930 .
    AT1G02930.2 ; AT1G02930.2 ; AT1G02930 .
    GeneIDi 839515.
    KEGGi ath:AT1G02930.

    Organism-specific databases

    TAIRi AT1G02930.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125746.
    InParanoidi P42760.
    KOi K00799.
    OMAi LWLEVES.
    PhylomeDBi P42760.

    Enzyme and pathway databases

    BioCyci ARA:AT1G02930-MONOMER.
    ARA:GQT-844-MONOMER.

    Gene expression databases

    Genevestigatori P42760.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two cDNAs (ERD11 and ERD13) for dehydration-inducible genes that encode putative glutathione S-transferases in Arabidopsis thaliana L."
      Kiyosue T., Yamaguchi-Shinozaki K., Shinozaki K.
      FEBS Lett. 335:189-192(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Characterization of a glutathione S-transferase gene ATGST1 in Arabidopsis thaliana."
      Yang K.Y., Kim E.Y., Kim K.S., Choi S.N., Guh J.O., Kim K.C., Cho B.-H.
      Plant Cell Rep. 17:700-704(1999)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Landsberg erecta.
    3. Yu G.-L., Ausubel F.M.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    4. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    5. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    7. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, GENE FAMILY, NOMENCLATURE.
    8. "The rapid induction of glutathione S-transferases AtGSTF2 and AtGSTF6 by avirulent Pseudomonas syringae is the result of combined salicylic acid and ethylene signaling."
      Lieberherr D., Wagner U., Dubuis P.H., Metraux J.P., Mauch F.
      Plant Cell Physiol. 44:750-757(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "Proteomic analysis of Arabidopsis glutathione S-transferases from benoxacor- and copper-treated seedlings."
      Smith A.P., DeRidder B.P., Guo W.J., Seeley E.H., Regnier F.E., Goldsbrough P.B.
      J. Biol. Chem. 279:26098-26104(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY COPPER.
    10. "Glutathione-indole-3-acetonitrile is required for camalexin biosynthesis in Arabidopsis thaliana."
      Su T., Xu J., Li Y., Lei L., Zhao L., Yang H., Feng J., Liu G., Ren D.
      Plant Cell 23:364-380(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiGSTF6_ARATH
    AccessioniPrimary (citable) accession number: P42760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3