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Protein

Betaine aldehyde dehydrogenase, chloroplastic

Gene
N/A
Organism
Atriplex hortensis (Mountain spinach)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathway:ibetaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Betaine aldehyde dehydrogenase, chloroplastic
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei164 – 1641Transition state stabilizerBy similarity
Active sitei262 – 2621Proton acceptorPROSITE-ProRule annotation
Active sitei296 – 2961NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2456NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase, chloroplastic (EC:1.2.1.8)
Short name:
BADH
OrganismiAtriplex hortensis (Mountain spinach)
Taxonomic identifieri34272 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAtripliceaeAtriplex

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 77ChloroplastSequence Analysis
Chaini8 – 502495Betaine aldehyde dehydrogenase, chloroplasticPRO_0000007180Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP42757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPIPARQL FIDGEWREPL LKNRIPIINP STEEIIGDIP AATAEDVEVA
60 70 80 90 100
VVAARKAFKR NKGRDWAALW SHRAKYLRAI AAKITEKKDH FVKLETLDSG
110 120 130 140 150
KPRDEAVLDI DDVATCFEYF EYFAGQAEAL DAKQKAPVTL PMERFKSHVL
160 170 180 190 200
RQPIGVVGLI SPWNYPLLMD TWKIAPALAA GCTTVLKPSE LASVTCLEFG
210 220 230 240 250
EVCNEVGLPP GVLNILTGLG PDAGAPIVSH PDIDKVAFTG SSATGSKIMA
260 270 280 290 300
SAAQLVKPVT LELGGKSPVI MFEDIDIETA VEWTLFGVFW TNGQICSATS
310 320 330 340 350
RLLVHESIAA EFVDRMVKWT KNIKISDPFE EGCRLGPVIS KGQYDKIMKF
360 370 380 390 400
ISTAKSEGAT ILCGGSRPEH LKKGYYIEPT IITDITTSMQ IWKEEVFGPV
410 420 430 440 450
ICVKTFKTED EAIELANDTE YGLAGAVFSK DLERCERVTK ALEVGAVWVN
460 470 480 490 500
CSQPCFVHAP WGGVKRSGFG RELGEWGIEN YLNIKQVTSD ISDEPWGWYK

SP
Length:502
Mass (Da):55,271
Last modified:November 1, 1995 - v1
Checksum:i54F1A05EBBC4281E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69770 mRNA. Translation: CAA49425.1.
X69772 Genomic DNA. Translation: CAA49427.1.
PIRiS49205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69770 mRNA. Translation: CAA49425.1.
X69772 Genomic DNA. Translation: CAA49427.1.
PIRiS49205.

3D structure databases

ProteinModelPortaliP42757.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA and partial genomic DNA sequence of Mountain spinach (Atriplex hortenis) betaine aldehyde dehydrogenase (BADH)."
    Xiao G., Zhang G., Liu F., Chen S.
    Chin. Sci. Bull. 40:741-745(1995)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Leaf and Stem.

Entry informationi

Entry nameiBADH_ATRHO
AccessioniPrimary (citable) accession number: P42757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.