P42757 (BADH_ATRHO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Betaine aldehyde dehydrogenase, chloroplastic Short name=BADH EC=1.2.1.8
Organism	Atriplex hortensis (Mountain spinach)
Taxonomic identifier	34272 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Atriplex

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 7	7	Chloroplast Potential
	Chain	8 – 502	495	Betaine aldehyde dehydrogenase, chloroplastic		PRO_0000007180
Regions
	Nucleotide binding	240 – 245	6	NAD By similarity
Sites
	Active site	262	1	Proton acceptor By similarity
	Active site	296	1	Nucleophile By similarity
	Site	164	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42757 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 54F1A05EBBC4281E	FASTA	502	55,271
	10 20 30 40 50 60 MAFPIPARQL FIDGEWREPL LKNRIPIINP STEEIIGDIP AATAEDVEVA VVAARKAFKR 70 80 90 100 110 120 NKGRDWAALW SHRAKYLRAI AAKITEKKDH FVKLETLDSG KPRDEAVLDI DDVATCFEYF 130 140 150 160 170 180 EYFAGQAEAL DAKQKAPVTL PMERFKSHVL RQPIGVVGLI SPWNYPLLMD TWKIAPALAA 190 200 210 220 230 240 GCTTVLKPSE LASVTCLEFG EVCNEVGLPP GVLNILTGLG PDAGAPIVSH PDIDKVAFTG 250 260 270 280 290 300 SSATGSKIMA SAAQLVKPVT LELGGKSPVI MFEDIDIETA VEWTLFGVFW TNGQICSATS 310 320 330 340 350 360 RLLVHESIAA EFVDRMVKWT KNIKISDPFE EGCRLGPVIS KGQYDKIMKF ISTAKSEGAT 370 380 390 400 410 420 ILCGGSRPEH LKKGYYIEPT IITDITTSMQ IWKEEVFGPV ICVKTFKTED EAIELANDTE 430 440 450 460 470 480 YGLAGAVFSK DLERCERVTK ALEVGAVWVN CSQPCFVHAP WGGVKRSGFG RELGEWGIEN 490 500 YLNIKQVTSD ISDEPWGWYK SP

References

[1]	"cDNA and partial genomic DNA sequence of Mountain spinach (Atriplex hortenis) betaine aldehyde dehydrogenase (BADH)." Xiao G., Zhang G., Liu F., Chen S. Chin. Sci. Bull. 40:741-745(1995) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Leaf and Stem.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69770 mRNA. Translation: CAA49425.1. X69772 Genomic DNA. Translation: CAA49427.1.
PIR	S49205.
3D structure databases
ProteinModelPortal	P42757.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00529; UER00386.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH_ATRHO

Accession

Primary (citable) accession number: P42757

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	March 6, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program