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Protein

Cyclin-D2-1

Gene

CYCD2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts on the G1 phase of the cell cycle to control cell division rate in both shoot and root meristems. The complex formed with CDKA-1 phosphorylates plant retinoblastoma protein.2 Publications

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-D2-1
Alternative name(s):
Cyclin-delta-2
Short name:
Cyclin-d2
G1/S-specific cyclin-D2-1
Short name:
CycD2;1
Gene namesi
Name:CYCD2-1
Synonyms:CYCD2
Ordered Locus Names:At2g22490
ORF Names:F14M13.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804461 – 361Cyclin-D2-1Add BLAST361

Proteomic databases

PaxDbiP42752.

Expressioni

Tissue specificityi

Expressed in roots and leaves.1 Publication

Developmental stagei

Expressed throughout the cell cycle.1 Publication

Inductioni

By sucrose and glucose.2 Publications

Gene expression databases

ExpressionAtlasiP42752. baseline and differential.
GenevisibleiP42752. AT.

Interactioni

Subunit structurei

Interacts with KRP1/ICK1 and with the C-terminal domain of CDKA-1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKA-1P241004EBI-1253160,EBI-371713

Protein-protein interaction databases

BioGridi2135. 30 interactors.
IntActiP42752. 29 interactors.
STRINGi3702.AT2G22490.2.

Structurei

3D structure databases

ProteinModelPortaliP42752.
SMRiP42752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
HOGENOMiHOG000242458.
InParanoidiP42752.
KOiK18810.
PhylomeDBiP42752.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P42752-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENLACGET SESWIIDNDD DDINYGGGFT NEIDYNHQLF AKDDNFGGNG
60 70 80 90 100
SIPMMGSSSS SLSEDRIKEM LVREIEFCPG TDYVKRLLSG DLDLSVRNQA
110 120 130 140 150
LDWILKVCAH YHFGHLCICL SMNYLDRFLT SYELPKDKDW AAQLLAVSCL
160 170 180 190 200
SLASKMEETD VPHIVDLQVE DPKFVFEAKT IKRMELLVVT TLNWRLQALT
210 220 230 240 250
PFSFIDYFVD KISGHVSENL IYRSSRFILN TTKAIEFLDF RPSEIAAAAA
260 270 280 290 300
VSVSISGETE CIDEEKALSS LIYVKQERVK RCLNLMRSLT GEENVRGTSL
310 320 330 340 350
SQEQARVAVR AVPASPVGVL EATCLSYRSE ERTVESCTNS SQSSPDNNNN
360
NNNSNKRRRK Q
Length:361
Mass (Da):40,580
Last modified:December 15, 1998 - v3
Checksum:i6D6DDC767310ED2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94L → S in BAF00198 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83370 mRNA. Translation: CAA58286.1.
AC006592 Genomic DNA. Translation: AAD22352.1.
CP002685 Genomic DNA. Translation: AEC07313.1.
BT025242 mRNA. Translation: ABF18995.1.
AK228250 mRNA. Translation: BAF00198.1.
PIRiC84613.
RefSeqiNP_179835.1. NM_127815.4. [P42752-1]
UniGeneiAt.9.

Genome annotation databases

EnsemblPlantsiAT2G22490.1; AT2G22490.1; AT2G22490. [P42752-1]
GeneIDi816782.
GrameneiAT2G22490.1; AT2G22490.1; AT2G22490.
KEGGiath:AT2G22490.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83370 mRNA. Translation: CAA58286.1.
AC006592 Genomic DNA. Translation: AAD22352.1.
CP002685 Genomic DNA. Translation: AEC07313.1.
BT025242 mRNA. Translation: ABF18995.1.
AK228250 mRNA. Translation: BAF00198.1.
PIRiC84613.
RefSeqiNP_179835.1. NM_127815.4. [P42752-1]
UniGeneiAt.9.

3D structure databases

ProteinModelPortaliP42752.
SMRiP42752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2135. 30 interactors.
IntActiP42752. 29 interactors.
STRINGi3702.AT2G22490.2.

Proteomic databases

PaxDbiP42752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G22490.1; AT2G22490.1; AT2G22490. [P42752-1]
GeneIDi816782.
GrameneiAT2G22490.1; AT2G22490.1; AT2G22490.
KEGGiath:AT2G22490.

Organism-specific databases

AraportiAT2G22490.

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
HOGENOMiHOG000242458.
InParanoidiP42752.
KOiK18810.
PhylomeDBiP42752.

Miscellaneous databases

PROiP42752.

Gene expression databases

ExpressionAtlasiP42752. baseline and differential.
GenevisibleiP42752. AT.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCD21_ARATH
AccessioniPrimary (citable) accession number: P42752
Secondary accession number(s): Q0WRQ1, Q1LYY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 15, 1998
Last modified: February 15, 2017
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.