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Protein

Ubiquitin-conjugating enzyme E2 6

Gene

UBC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • ubiquitin-dependent protein catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 6 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 6
Ubiquitin carrier protein 6
Ubiquitin-conjugating enzyme E2-21 kDa 3
Ubiquitin-protein ligase 6
Gene namesi
Name:UBC6
Ordered Locus Names:At2g46030
ORF Names:T3F17.32
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G46030
TAIRilocus:2062979 AT2G46030

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825841 – 183Ubiquitin-conjugating enzyme E2 6Add BLAST183

Proteomic databases

PaxDbiP42750
PRIDEiP42750

Expressioni

Tissue specificityi

Expressed in roots, petals, sepals and silique walls.3 Publications

Inductioni

By senescence, but not by heat shock.2 Publications

Gene expression databases

ExpressionAtlasiP42750 baseline and differential
GenevisibleiP42750 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4546, 1 interactor
STRINGi3702.AT2G46030.1

Structurei

3D structure databases

ProteinModelPortaliP42750
SMRiP42750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0416 Eukaryota
ENOG410XRC5 LUCA
HOGENOMiHOG000233452
InParanoidiP42750
KOiK10576
OMAiFANTIYH
OrthoDBiEOG09360ND8
PhylomeDBiP42750

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSKRREM DMMKLMMSDY KVDTVNDDLQ MFYVTFHGPT DSLYQGGVWK
60 70 80 90 100
IKVELPEAYP YKSPSVGFVN KIYHPNVDES SGAVCLDVIN QTWSPMFDLI
110 120 130 140 150
NVFESFLPQL LLYPNPSDPF NGEAASLLMR DRAAYELKVK EYCEKYAKPE
160 170 180
EILSDDDDDD SMSEDGSDSD DDDDDEIVGK ADP
Length:183
Mass (Da):20,785
Last modified:June 20, 2002 - v2
Checksum:iD833BA90995EDEF2
GO

Sequence cautioni

The sequence CAA50503 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → S in AAA32901 (PubMed:8155884).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19355 Genomic DNA Translation: AAA32901.1
X71381 Genomic DNA Translation: CAA50503.1 Sequence problems.
DQ027021 mRNA Translation: AAY44847.1
AC005397 Genomic DNA Translation: AAC62907.1
CP002685 Genomic DNA Translation: AEC10634.1
CP002685 Genomic DNA Translation: ANM62735.1
BT005208 mRNA Translation: AAO63272.1
AK228245 mRNA Translation: BAF00193.1
PIRiS43785
S52661
RefSeqiNP_001318433.1, NM_001337170.1
NP_566062.1, NM_130166.4
UniGeneiAt.48598
At.68190

Genome annotation databases

EnsemblPlantsiAT2G46030.1; AT2G46030.1; AT2G46030
AT2G46030.5; AT2G46030.5; AT2G46030
GeneIDi819211
GrameneiAT2G46030.1; AT2G46030.1; AT2G46030
AT2G46030.5; AT2G46030.5; AT2G46030
KEGGiath:AT2G46030

Similar proteinsi

Entry informationi

Entry nameiUBC6_ARATH
AccessioniPrimary (citable) accession number: P42750
Secondary accession number(s): O49739, O82365, Q4TZ03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 20, 2002
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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