UniProtKB - P42750 (UBC6_ARATH)
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Protein
Ubiquitin-conjugating enzyme E2 6
Gene
UBC6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.1 Publication
Catalytic activityi
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 85 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: GO_Central
- ubiquitin protein ligase binding Source: GO_Central
- ubiquitin-protein transferase activity Source: TAIR
GO - Biological processi
- ubiquitin-dependent protein catabolic process Source: TAIR
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-ATH-983168. Antigen processing: Ubiquitination & Proteasome degradation. |
UniPathwayi | UPA00143. |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-conjugating enzyme E2 6 (EC:2.3.2.23)Alternative name(s): E2 ubiquitin-conjugating enzyme 6 Ubiquitin carrier protein 6 Ubiquitin-conjugating enzyme E2-21 kDa 3 Ubiquitin-protein ligase 6 |
Gene namesi | Name:UBC6 Ordered Locus Names:At2g46030 ORF Names:T3F17.32 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G46030. |
TAIRi | locus:2062979. AT2G46030. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082584 | 1 – 183 | Ubiquitin-conjugating enzyme E2 6Add BLAST | 183 |
Proteomic databases
PaxDbi | P42750. |
Expressioni
Tissue specificityi
Expressed in roots, petals, sepals and silique walls.3 Publications
Inductioni
By senescence, but not by heat shock.2 Publications
Gene expression databases
ExpressionAtlasi | P42750. baseline and differential. |
Genevisiblei | P42750. AT. |
Interactioni
GO - Molecular functioni
- ubiquitin protein ligase binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 4546. 1 interactor. |
STRINGi | 3702.AT2G46030.1. |
Structurei
3D structure databases
ProteinModelPortali | P42750. |
SMRi | P42750. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0416. Eukaryota. ENOG410XRC5. LUCA. |
HOGENOMi | HOG000233452. |
InParanoidi | P42750. |
KOi | K10576. |
OMAi | FANTIYH. |
OrthoDBi | EOG09360ND8. |
PhylomeDBi | P42750. |
Family and domain databases
CDDi | cd00195. UBCc. 1 hit. |
Gene3Di | 3.10.110.10. 1 hit. |
InterProi | View protein in InterPro IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD. |
Pfami | View protein in Pfam PF00179. UQ_con. 1 hit. |
SUPFAMi | SSF54495. SSF54495. 1 hit. |
PROSITEi | View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P42750-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPSKRREM DMMKLMMSDY KVDTVNDDLQ MFYVTFHGPT DSLYQGGVWK
60 70 80 90 100
IKVELPEAYP YKSPSVGFVN KIYHPNVDES SGAVCLDVIN QTWSPMFDLI
110 120 130 140 150
NVFESFLPQL LLYPNPSDPF NGEAASLLMR DRAAYELKVK EYCEKYAKPE
160 170 180
EILSDDDDDD SMSEDGSDSD DDDDDEIVGK ADP
Sequence cautioni
The sequence CAA50503 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | A → S in AAA32901 (PubMed:8155884).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19355 Genomic DNA. Translation: AAA32901.1. X71381 Genomic DNA. Translation: CAA50503.1. Sequence problems. DQ027021 mRNA. Translation: AAY44847.1. AC005397 Genomic DNA. Translation: AAC62907.1. CP002685 Genomic DNA. Translation: AEC10634.1. CP002685 Genomic DNA. Translation: ANM62735.1. BT005208 mRNA. Translation: AAO63272.1. AK228245 mRNA. Translation: BAF00193.1. |
PIRi | S43785. S52661. |
RefSeqi | NP_001318433.1. NM_001337170.1. NP_566062.1. NM_130166.4. |
UniGenei | At.48598. At.68190. |
Genome annotation databases
EnsemblPlantsi | AT2G46030.1; AT2G46030.1; AT2G46030. AT2G46030.5; AT2G46030.5; AT2G46030. |
GeneIDi | 819211. |
Gramenei | AT2G46030.1; AT2G46030.1; AT2G46030. AT2G46030.5; AT2G46030.5; AT2G46030. |
KEGGi | ath:AT2G46030. |
Similar proteinsi
Entry informationi
Entry namei | UBC6_ARATH | |
Accessioni | P42750Primary (citable) accession number: P42750 Secondary accession number(s): O49739, O82365, Q4TZ03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | June 20, 2002 | |
Last modified: | March 28, 2018 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |