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Protein

Ubiquitin-conjugating enzyme E2 14

Gene

UBC14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 14 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 14
TAYO29
UbcAt3
Ubiquitin carrier protein 14
Ubiquitin-protein ligase 14
Gene namesi
Name:UBC14
Synonyms:UBC3, UBC7
Ordered Locus Names:At3g55380
ORF Names:T22E16.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G55380

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000825882 – 167Ubiquitin-conjugating enzyme E2 14Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP42747

Expressioni

Developmental stagei

Up-regulated during the G0 to S phase transition.1 Publication

Gene expression databases

ExpressionAtlasiP42747 baseline and differential
GenevisibleiP42747 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi10020, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP42747
SMRiP42747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233454
InParanoidiP42747
KOiK10575
PhylomeDBiP42747

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P42747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANNQASLLL QKQLKDLCKK PVDGFSAGLV DEKNVFQWSV SIMGPPDTLY
60 70 80 90 100
EGGFFNAIMS FPENYPVSPP TVTFTSEMWH PNVYSDGKVC ISILHPPGDD
110 120 130 140 150
PHGYELASER WTPVHTVESI VLSIISMLSG PNDESPANVE AAKEWRDNRA
160
EFRKKVSRCV RRSQEML
Length:167
Mass (Da):18,728
Last modified:November 1, 1995 - v1
Checksum:i15053C16A62C08BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72625 mRNA Translation: CAA51200.1
U33759 Genomic DNA Translation: AAC49323.1
DQ027028 mRNA Translation: AAY44854.1
AL132975 Genomic DNA Translation: CAB75896.1
CP002686 Genomic DNA Translation: AEE79376.1
AY117262 mRNA Translation: AAM51337.1
AY045883 mRNA Translation: AAK76557.1
AY086490 mRNA Translation: AAM63492.1
Z18513 mRNA Translation: CAA79212.1
PIRiS46656
RefSeqiNP_567020.1, NM_115396.4 [P42747-1]
UniGeneiAt.206

Genome annotation databases

EnsemblPlantsiAT3G55380.1; AT3G55380.1; AT3G55380 [P42747-1]
GeneIDi824704
GrameneiAT3G55380.1; AT3G55380.1; AT3G55380 [P42747-1]
KEGGiath:AT3G55380

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBC14_ARATH
AccessioniPrimary (citable) accession number: P42747
Secondary accession number(s): Q4TYZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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